{"id":5729,"date":"2024-08-04T20:53:53","date_gmt":"2024-08-04T20:53:53","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5729"},"modified":"2024-08-04T20:53:53","modified_gmt":"2024-08-04T20:53:53","slug":"poria-cocos-peel-and-poria-cocos","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/poria-cocos-peel-and-poria-cocos\/","title":{"rendered":"Poria cocos kabu\u011fu ve Poria cocos'taki triterpenoidlerin HPLC karakteristik spektrumlar\u0131 ve kimyasal desen tan\u0131ma \u00fczerine \u00e7al\u0131\u015fma"},"content":{"rendered":"

Poria cocos kabu\u011fu ve Poria cocos'taki triterpenoidlerin HPLC karakteristik spektrumlar\u0131 ve kimyasal desen tan\u0131ma \u00fczerine \u00e7al\u0131\u015fma
\nFutu, Fuling, Songfu, vb. olarak da bilinen Poria cocos, Poria cocos (Schw.) Wolf ailesinden kurutulmu\u015f bir mantard\u0131r. Tatl\u0131 ve hafif bir tada, yumu\u015fak bir yap\u0131ya sahiptir ve kalp, akci\u011ferler, dalak ve b\u00f6brek meridyenlerinde bulunabilir. Su infiltrasyonunu te\u015fvik etme, dala\u011f\u0131 g\u00fc\u00e7lendirme ve kalbi sakinle\u015ftirme etkilerine sahiptir. Fuling, \u00c7in Halk Cumhuriyeti Farmakopesi'nin (\"\u00c7in Farmakopesi\" olarak an\u0131l\u0131r) 2020 bask\u0131s\u0131nda yer al\u0131r ve \"On Form\u00fcl ve Dokuz Ling\" olarak bilinen Geleneksel \u00c7in T\u0131bb\u0131n\u0131n D\u00f6rt Hazinesi ve Sekiz Hazinesinden biridir. Poria cocos'un ana farmakolojik maddeleri Poria cocos polisakkaritleri ve Poria cocos triterpenoidleridir. Modern farmakolojik \u00e7al\u0131\u015fmalar, Poria cocos triterpenoidlerinin di\u00fcretik, anti-t\u00fcm\u00f6r, ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenleyici, anti-inflamatuar, anti-aging, hipoglisemik ve lipid d\u00fc\u015f\u00fcr\u00fcc\u00fc etkilere sahip oldu\u011funu ve \u015fu anda Poria cocos'un kalitesini ve etkinli\u011fini karakterize etmek i\u00e7in kullan\u0131lan \u00f6nemli g\u00f6stergeler oldu\u011funu g\u00f6stermi\u015ftir. \u015eu anda, piyasada dola\u015fan ana Poria cocos \u00e7e\u015fitleri ekili \u00e7e\u015fitlerdir ve farkl\u0131 k\u00f6kenler, i\u015fleme y\u00f6ntemleri ve Poria cocos dilimlerinin \u00f6zellikleri, Poria cocos t\u0131bbi malzemelerinin ve dilimlerinin kalitesini etkileyebilir. \u00c7in Farmakopesi'nin 2020 bask\u0131s\u0131, Poria cocos ve Poria cocos kabu\u011fu t\u0131bbi malzemelerinin kalitesini tan\u0131mlamak ve kontrol etmek i\u00e7in yaln\u0131zca ince tabaka kromatografisini kullanmaktad\u0131r, bu da kalitelerini tam olarak yans\u0131tmas\u0131 zordur. Parmak izi analizi, modern \u00c7in t\u0131bb\u0131 alan\u0131nda geleneksel \u00c7in t\u0131bb\u0131n\u0131n kalite kontrol\u00fc i\u00e7in yayg\u0131n olarak tan\u0131nan ve yayg\u0131n olarak kullan\u0131lan y\u00f6ntemlerden biridir. Y\u00fcksek b\u00fct\u00fcnl\u00fck ve g\u00fc\u00e7l\u00fc \u00f6zellikler gibi avantajlara sahiptir ve geleneksel \u00c7in t\u0131bb\u0131ndaki \u00e7oklu bile\u015fenlerin kapsaml\u0131 etkileri ile uyumludur. Daha fazla tan\u0131mlama, tan\u0131ma ve s\u0131n\u0131fland\u0131rma potansiyeline sahiptir. Kimyasal \u00f6r\u00fcnt\u00fc tan\u0131ma, parmak izi spektrumlar\u0131n\u0131n \u00e7ok boyutlu bilgilerini analiz edebilir, t\u0131bbi malzemelerin kalite farkl\u0131l\u0131klar\u0131n\u0131 do\u011fru bir \u015fekilde yans\u0131tabilir ve t\u0131bbi malzeme kalitesinin genel tan\u0131m\u0131 ve makul de\u011ferlendirmesi hedefine ula\u015fabilir. Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, Poria cocos (Poria cocos'un epidermisinden elde edilen) ve Poria cocos'un (Poria cocos'un soyulmu\u015f k\u0131sm\u0131ndan elde edilen) HPLC parmak izi spektrumlar\u0131n\u0131 olu\u015fturmak ve \u00f6r\u00fcnt\u00fc tan\u0131ma y\u00f6ntemlerini kullanarak her bir ortak pikin parmak izi spektrumlar\u0131 \u00fczerindeki etkilerini analiz etmektir. Ana pikler ve karakteristik pikler, Poria cocos ve Poria cocos aras\u0131ndaki \u00e7e\u015fitli kimyasal maddelerdeki farkl\u0131l\u0131klar\u0131 bir b\u00fct\u00fcn olarak de\u011ferlendirmek i\u00e7in tan\u0131mlanacak ve Poria cocos t\u0131bbi malzemelerinin kalite kontrol\u00fc i\u00e7in bir temel sa\u011flayacakt\u0131r.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"<\/p>\n

Bu \u00e7al\u0131\u015fmada ekstraksiyon \u00e7\u00f6z\u00fcc\u00fcs\u00fc olarak metanol ve farkl\u0131 mobil fazlar\u0131 (asetonitril su, asetonitril-0.1% formik asit su, asetonitril-0.1% fosforik asit su, asetonitril-0.2% fosforik asit su, asetonitril-0.3% fosforik asit su) ara\u015ft\u0131rmak i\u00e7in 30 dakika ultrason i\u015flemi kullan\u0131lm\u0131\u015ft\u0131r.3% fosforik asit suyu), farkl\u0131 kromatografik kolonlar [Agilent 5 TC-C18 (2) (250mm \u00d7 4.6mm, 5 \u03bc m), Welch Ultimate XB-C18 (250mm \u00d7 4.6mm, 5 \u03bc m), Agilent Eclipse Plus C18 (250mm \u00d7 4.6mm, 5 \u03bcm)], farkl\u0131 hacim ak\u0131\u015f h\u0131zlar\u0131 (1.0, 1.1, 1.2mL\/dak), farkl\u0131 kolon s\u0131cakl\u0131klar\u0131 (22, 25, 28 \u2103) ve farkl\u0131 toplama dalga boylar\u0131 (203, 210, 242)]. Nm'nin parmak izi spektrumu \u00fczerindeki etkisi nihai olarak belirlenmi\u015f ve kromatografik ko\u015fullar mobil faz olarak asetonitril 0.3% fosforik asit su, Agilent 5 TC-C18 (2) (250mm \u00d7 4.6mm, 5 \u03bc m) kromatografik kolon, 1.0mL\/dak hacim ak\u0131\u015f h\u0131z\u0131, 25\u00b0C kolon s\u0131cakl\u0131\u011f\u0131 ve de\u011fi\u015fken dalga boyu al\u0131m\u0131 olarak belirlenmi\u015ftir. Bu ko\u015fullar alt\u0131nda, taban \u00e7izgisi sabittir, kromatografik pik \u015fekli iyidir ve ay\u0131rma etkisi iyidir.
\nBu temelde, HPLC y\u00f6ntemi, farkl\u0131 k\u00f6kenlerden gelen Poria cocos ve Poria cocos'un 14 parti parmak izi spektrumunu olu\u015fturmak i\u00e7in kullan\u0131lm\u0131\u015ft\u0131r. Poria cocos ve Poria cocos parmak izi spektrumlar\u0131n\u0131n ortak modunda toplam 15 ortak pik kalibre edilmi\u015f ve 6 kimyasal bile\u015fen kimyasal referans standartlar\u0131 ile tan\u0131mlanm\u0131\u015ft\u0131r: Poria cocos asit B, dehidrofumarik asit, Poria cocos asit A, dehidrofumarik asit, Poria cocos asit ve Poria cocos asit. Farkl\u0131 k\u00f6kenlerden gelen 14 grup Poria cocos deri ve beyaz Poria cocos \u00f6rneklerinin k\u00fcmeleme analizi ve benzerlik verileriyle birlikte, farkl\u0131 t\u0131bbi k\u0131s\u0131mlardan gelen Poria cocos \u00f6rneklerinin gruplar\u0131 aras\u0131nda \u00f6nemli farkl\u0131l\u0131klar oldu\u011fu ve gruplar i\u00e7inde k\u00fc\u00e7\u00fck farkl\u0131l\u0131klar oldu\u011fu sonucuna var\u0131labilir. Beyaz Poria cocos \u00f6rnekleri ile men\u015fei aras\u0131ndaki korelasyon g\u00fc\u00e7l\u00fcd\u00fcr. Bu nedenle, \u00f6r\u00fcnt\u00fc tan\u0131ma i\u00e7in denetimsiz PCA y\u00f6ntemi kullan\u0131lm\u0131\u015f ve PCA sonu\u00e7lar\u0131 15 ortak tepe de\u011fi\u015fkenini Y1 ve Y2 olmak \u00fczere 2 temel bile\u015fene ay\u0131rm\u0131\u015ft\u0131r. Y1, dehidrofumarik asit, dehidroporik asit ve porik asit bile\u015fenleri dahil olmak \u00fczere 7 ortak kromatografik pikin kapsaml\u0131 reaksiyonudur ve 7 ortak kromatografik pikin poria cocos derisi ve beyaz poria cocos parmak izi spektrumlar\u0131n\u0131 incelemek i\u00e7in gerekli oldu\u011funu g\u00f6sterir; Y2, Poria cocos asit B, Poria cocos asit A ve Poria cocos asit dahil olmak \u00fczere 8 kromatografik pikin kapsaml\u0131 bir reaksiyonudur ve bu 8 kromatografik pikin ayn\u0131 zamanda Poria cocos derisi ve Poria cocos kalitesini de\u011ferlendirirken Poria cocos derisi i\u00e7in karakteristik tan\u0131mlama pikleri olarak hizmet edebilece\u011fini g\u00f6sterir. Parmak izi spektrumu \u00fczerinde \u00f6nemli bir etkiye sahip olan ortak pik de\u011fi\u015fken parametreleri 1, 2 (Poria cocos asit B) ve kromatografik pik 7'dir. Poria cocos'un 15 ortak pik bile\u015feni aras\u0131ndaki i\u00e7erik fark\u0131 Poria cocos derisinden daha azd\u0131r. Asl\u0131nda, beyaz Poria cocos'taki bu 15 ortak pik bile\u015feninin i\u00e7eri\u011fi Poria cocos derisindekinden \u00e7ok daha d\u00fc\u015f\u00fckt\u00fcr. Poria cocos derisi ve beyaz Poria cocos parmak izinin ortak desenini daha eksiksiz ve \u00f6l\u00e7\u00fclebilir hale getirmek i\u00e7in, beyaz Poria cocos'un haz\u0131rlanmas\u0131na bir konsantrasyon ad\u0131m\u0131 eklenmi\u015ftir.
\nAra\u015ft\u0131rmalar, bu makalede olu\u015fturulan y\u00f6ntemin basit, g\u00fcvenilir ve do\u011fru oldu\u011funu ve Poria cocos ve Poria cocos'un kalite de\u011ferlendirmesi, standart form\u00fclasyonu ve rasyonel kullan\u0131m\u0131 i\u00e7in referans sa\u011flayabilece\u011fini g\u00f6stermi\u015ftir.<\/p>","protected":false},"excerpt":{"rendered":"

Study on HPLC characteristic spectra and chemical pattern recognition of triterpenoids in Poria cocos peel and Poria cocos Poria cocos, also known as Futu, Fuling, Songfu, etc., is a dried fungus of the Poria cocos (Schw.) Wolf family. It has a sweet and light taste, a mild nature, and can be found in the heart, […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on HPLC characteristic spectra and chemical pattern recognition of triterpenoids in Poria cocos peel and Poria cocos - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/poria-cocos-peel-and-poria-cocos\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on HPLC characteristic spectra and chemical pattern recognition of triterpenoids in Poria cocos peel and Poria cocos - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on HPLC characteristic spectra and chemical pattern recognition of triterpenoids in Poria cocos peel and Poria cocos Poria cocos, also known as Futu, Fuling, Songfu, etc., is a dried fungus of the Poria cocos (Schw.) 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