{"id":5636,"date":"2024-08-04T20:17:48","date_gmt":"2024-08-04T20:17:48","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5636"},"modified":"2024-08-04T20:17:48","modified_gmt":"2024-08-04T20:17:48","slug":"hibiscus-mutabilis","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/hibiscus-mutabilis\/","title":{"rendered":"Ebeg\u00fcmeci yapraklar\u0131nda etil asetat\u0131n antioksidan ve anti-inflamatuar etkileri \u00fczerine \u00e7al\u0131\u015fma ve UPLC-Q-Orbitrap HRMS analizi"},"content":{"rendered":"

Ebeg\u00fcmeci yapraklar\u0131nda etil asetat\u0131n antioksidan ve anti-inflamatuar etkileri \u00fczerine \u00e7al\u0131\u015fma ve UPLC-Q-Orbitrap HRMS analizi
\nHibiscus mutabilis yapraklar\u0131, Malvaceae familyas\u0131ndan bir bitki olan Hibiscus mutabilis L.'nin kurutulmu\u015f yapraklar\u0131d\u0131r. \u00c7in Farmakopesi'nin 2020 bask\u0131s\u0131na dahil edilmi\u015ftir ve \u00e7o\u011funlukla Sichuan, Hunan, Guangdong, Yunnan ve \u00c7in'in di\u011fer b\u00f6lgelerinde \u00fcretilmektedir. Qi hafiftir, tad\u0131 keskin ve d\u00fczd\u00fcr ve kan\u0131 so\u011futma, detoksifikasyon, \u015fi\u015fli\u011fi azaltma ve a\u011fr\u0131y\u0131 hafifletme etkilerine sahiptir. \"Shennong Bencao Jing\" kay\u0131tlar\u0131na g\u00f6re: \"Yaz sonu ve sonbahar ba\u015f\u0131 qi'si ile keskin bir tada sahiptir ve akci\u011ferleri temizleyebilen Jin Hua kategorisine aittir. Qi'si sakin ve serindir, kan\u0131 so\u011futabilir, \u0131s\u0131y\u0131 da\u011f\u0131tabilir, detoks yapabilir ve her t\u00fcrl\u00fc karbonk\u00fcl, \u015fi\u015flik, toksin ve \u00fclseri tedavi edebilir, ayr\u0131ca irin ve a\u011fr\u0131y\u0131 ve \u00e7ocuklar\u0131n yetersiz beslenmesini hafifletebilir.\" Modern farmakolojik ara\u015ft\u0131rmalar, Mufu Rong Ye'nin iyi antibakteriyel, anti enfektif ve antiviral etkilere sahip oldu\u011funu ve renal iskemi-reperf\u00fczyon hasar\u0131 ve kronik karaci\u011fer hasar\u0131 \u00fczerinde koruyucu bir etkiye sahip oldu\u011funu g\u00f6stermi\u015ftir. Hibiskus yapraklar\u0131ndaki ana kimyasal bile\u015fenler aras\u0131nda flavonoidler, organik asitler, fenoller, amino asitler, tanenler, \u015fekerler, steroidler ve u\u00e7ucu ya\u011flar bulunur.
\nAra\u015ft\u0131rma ekibi, hibiskus yapraklar\u0131n\u0131n etil asetat fraksiyonunun DPPH ve ABTS serbest radikallerine kar\u015f\u0131 s\u00fcp\u00fcrme oranlar\u0131na dayanarak iyi antioksidan aktiviteye sahip oldu\u011funu \u00f6nceden belirlemi\u015ftir. Flavonoidler hibiskus yapraklar\u0131n\u0131n farmakolojik maddelerinden biri olabilir. Bununla birlikte, in vitro kimyasal y\u00f6ntemler organizmalardaki aktif maddelerin ger\u00e7ek rol\u00fcn\u00fc tam olarak yans\u0131tamaz. Bu nedenle, bu \u00e7al\u0131\u015fmada HaCaT h\u00fccrelerinde H2O2 kaynakl\u0131 oksidatif stres hasar modeli olu\u015fturulmu\u015f, reaktif oksijen t\u00fcrlerinin (ROS) \u00fcretimi \u00f6l\u00e7\u00fclm\u00fc\u015f, Hibiscus yapraklar\u0131n\u0131n farkl\u0131 polar k\u0131s\u0131mlar\u0131n\u0131n HaCaT h\u00fccrelerinde oksidatif stres hasar\u0131 \u00fczerindeki koruyucu etkisi ara\u015ft\u0131r\u0131lm\u0131\u015f, LPS kaynakl\u0131 RAW 264.7 h\u00fccre inflamasyon modeli olu\u015fturulmu\u015f, etil asetat k\u0131sm\u0131 taraf\u0131ndan h\u00fccre inflamatuar fakt\u00f6r ekspresyonunun inhibisyon derecesi \u00f6l\u00e7\u00fclm\u00fc\u015f ve ayr\u0131ca h\u00fccresel d\u00fczeyde antioksidan ve anti-inflamatuar etkileri incelenmi\u015ftir. UPLC-Q-Orbitrap HRMS teknolojisine dayanarak, Hibiscus yapraklar\u0131n\u0131n etil asetat k\u0131sm\u0131n\u0131n kimyasal bile\u015fimi tan\u0131mlanm\u0131\u015f ve aktif k\u0131s\u0131mlar\u0131n hassas analizi, etil asetat k\u0131sm\u0131n\u0131n ana bile\u015fenlerinin flavonoidler ve bunlar\u0131n glikozitleri oldu\u011funu ortaya koymu\u015ftur. Bu \u00e7al\u0131\u015fma, Hibiskus yapraklar\u0131n\u0131n farmakolojik madde temelini kapsaml\u0131 bir \u015fekilde a\u00e7\u0131klamay\u0131 ama\u00e7lamaktad\u0131r. Geli\u015ftirilmesi ve kullan\u0131m\u0131 i\u00e7in bilimsel temel sa\u011flamak.<\/p>\n

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ROS h\u00fccresel oksidatif metabolizman\u0131n bir \u00fcr\u00fcn\u00fcd\u00fcr ve a\u015f\u0131r\u0131 art\u0131\u015f\u0131 veya s\u00fcrekli varl\u0131\u011f\u0131 h\u00fccresel oksidatif hasara neden olabilir. H2O2 a\u015f\u0131r\u0131 ROS \u00fcretimini ind\u00fckleyebilir, bu da onu oksidatif stres hasar\u0131 modellerinde ideal bir ind\u00fckleyici yapar. HaCaT h\u00fccrelerinin elde edilmesi kolay, uyarlanabilir ve stabildir. HaCaT h\u00fccre oksidatif stres hasar\u0131 modellerini ind\u00fcklemek i\u00e7in H2O2 kullan\u0131m\u0131, antioksidan aktiviteyi de\u011ferlendirmek i\u00e7in yayg\u0131n bir h\u00fccre modelidir. TNF - \u03b1, IL-6, iNOS ve COX-2 tipik enflamatuar fakt\u00f6rlerdir, LPS yayg\u0131n bir pro-enflamatuar fakt\u00f6rd\u00fcr ve makrofajlar enflamatuar yan\u0131tta \u00f6nemli kat\u0131l\u0131mc\u0131lard\u0131r ve enflamasyon s\u0131ras\u0131nda \u00e7e\u015fitli imm\u00fcnopatolojik s\u00fcre\u00e7lerin geli\u015fmesine arac\u0131l\u0131k ederler. RAW 264.7 h\u00fccrelerini ind\u00fcklemek i\u00e7in LPS kullan\u0131m\u0131, enflamatuar fakt\u00f6rleri incelemek i\u00e7in klasik bir h\u00fccre modelidir. G\u00fcn\u00fcm\u00fczde bu iki y\u00f6ntem, yay\u0131nlanm\u0131\u015f grup standartlar\u0131nda kozmetiklerin k\u0131r\u0131\u015f\u0131kl\u0131k kar\u015f\u0131t\u0131 ve yat\u0131\u015ft\u0131r\u0131c\u0131 etkileri i\u00e7in isimlendirilmesini destekleyen kan\u0131tlar olarak kabul edilmi\u015ftir. Bu \u00e7al\u0131\u015fmada HaCaT h\u00fccre oksidatif hasar modeli olu\u015fturulmu\u015f ve hibiskus yapraklar\u0131n\u0131n farkl\u0131 polar k\u0131s\u0131mlar\u0131ndaki etil asetat fraksiyonunun g\u00fc\u00e7l\u00fc antioksidan aktiviteye sahip oldu\u011fu bulunmu\u015ftur. 25-200 \u03bcg\/mL konsantrasyon aral\u0131\u011f\u0131nda, ebeg\u00fcmeci yapraklar\u0131ndaki etil asetat fraksiyonu ROS (P<0.001) i\u00e7eri\u011fini \u00f6nemli \u00f6l\u00e7\u00fcde azaltm\u0131\u015f, oksidatif stresi hafifletmi\u015f ve h\u00fccre oksidatif hasar modeli \u00fczerinde iyi bir koruyucu etkiye sahip olmu\u015ftur; Hibiscus syringae yapraklar\u0131ndan elde edilen etil asetat ekstrakt\u0131n\u0131n anti-enflamatuar etkisinin daha fazla ara\u015ft\u0131r\u0131lmas\u0131 yap\u0131lm\u0131\u015f ve bir RAW264.7 h\u00fccre enflamasyon modeli olu\u015fturulmu\u015ftur. Etil asetat ekstresi konsantrasyonu 200 \u03bcg\/mL oldu\u011funda, RAW 264.7 h\u00fccrelerinde TNF - \u03b1, IL-6, iNOS ve COX-2 mRNA ekspresyonunu \u00f6nemli \u00f6l\u00e7\u00fcde inhibe ederek (P<0.001) iyi bir anti-inflamatuar aktivite g\u00f6stermi\u015ftir. Bu da Hibiscus syringae yapraklar\u0131n\u0131n antioksidan ve anti-inflamatuar aktif b\u00f6lgelerini daha da ayd\u0131nlatarak farmakolojik aktivite ve kozmetik uygulama geli\u015ftirme \u00fczerine daha fazla ara\u015ft\u0131rma i\u00e7in teorik bir temel sa\u011flam\u0131\u015ft\u0131r.<\/p>\n

Ultra y\u00fcksek performansl\u0131 s\u0131v\u0131 kromatografisi kuadrupol elektrostatik alan orbital tuzak y\u00fcksek \u00e7\u00f6z\u00fcn\u00fcrl\u00fckl\u00fc k\u00fctle spektrometresi teknolojisi, geleneksel \u00c7in t\u0131bb\u0131ndaki karma\u015f\u0131k \u00e7ok bile\u015fenli sistemlerin analizi i\u00e7in uygundur ve y\u00fcksek \u00e7\u00f6z\u00fcn\u00fcrl\u00fck, y\u00fcksek kalite do\u011frulu\u011fu ve y\u00fcksek tespit verimlili\u011fi \u00f6zelliklerine sahiptir. Bu \u00e7al\u0131\u015fmada ilk kez UPLC-Q-Orbitrap HRMS teknolojisi kullan\u0131larak ebeg\u00fcmeci yapraklar\u0131ndaki etil asetat\u0131n etkili k\u0131s\u0131mlar\u0131ndaki karma\u015f\u0131k bile\u015fenler kapsaml\u0131 bir \u015fekilde kalitatif olarak analiz edilmi\u015ftir. Ba\u015fta rutin, naringin, isoquercitrin olmak \u00fczere 10 flavonoid dahil 28 kimyasal bile\u015fen tan\u0131mlanm\u0131\u015ft\u0131r; Ba\u015fta ferulik asit, kafeik asit, salisilik asit vb. olmak \u00fczere 9 organik asit bile\u015feni vard\u0131r; Ayr\u0131ca kumarinler, fenoller, n\u00fckleositler, her biri 2 ve ebeg\u00fcmeci yapraklar\u0131n\u0131n flavonoidler ve fenolik asitler a\u00e7\u0131s\u0131ndan zengin oldu\u011fu raporlar\u0131yla tutarl\u0131 olan di\u011fer 3 bile\u015fen vard\u0131r. Flavonoidler, hidrojen don\u00f6r\u00fc olarak hareket edebilen fenolik hidrojen molek\u00fclleri i\u00e7erir ve bu da onlar\u0131 m\u00fckemmel anti-enflamatuar aktiviteye sahip g\u00fc\u00e7l\u00fc antioksidanlar haline getirir. Rutin, Parkinson hastal\u0131\u011f\u0131 (PD) modellerinde katalaz (CAT) ve s\u00fcperoksit dismutaz (SOD) aktivitesini art\u0131rabilir; G\u00fcm\u00fc\u015f \u0131hlamur prostaglandin E2 (PGE2) \u00fcretimini ve NF - \u03ba B ve MAPK sinyal yollar\u0131n\u0131n aktivasyonunu inhibe edebilir; Quercetin, SOD ve CAT gibi enzimlerin yan\u0131 s\u0131ra glutatyon (GSH) gibi enzimatik olmayan antioksidan savunma sistemlerini yukar\u0131 do\u011fru d\u00fczenleyerek ROS arac\u0131l\u0131 karaci\u011fer kanserini inhibe edebilir; Isoquercetin, SOD'yi art\u0131rabilir ve MDA seviyelerini d\u00fc\u015f\u00fcrebilir, MEK \/ ERK sinyal yolunu inhibe edebilir ve oksidatif stres yan\u0131t\u0131n\u0131 bask\u0131layabilir. Azelaik asit hari\u00e7, t\u00fcm organik asit bile\u015fenleri fenolik asitlerdir. \u00c7ok say\u0131da \u00e7al\u0131\u015fma, fenolik asitlerin molek\u00fcler yap\u0131lar\u0131ndaki polifenolik hidroksil gruplar\u0131 nedeniyle g\u00fc\u00e7l\u00fc indirgeyici \u00f6zelliklere sahip oldu\u011funu g\u00f6stermi\u015ftir, bu da onlar\u0131 serbest radikal s\u00fcp\u00fcr\u00fcc\u00fc etkilere sahip tipik bir bile\u015fik s\u0131n\u0131f\u0131 haline getirmektedir. \u00d6rne\u011fin, ferulik asit fare serumunun antioksidan kapasitesini art\u0131rabilir ve antibiyotiklerin ba\u011f\u0131rsak metabolizmas\u0131 ve farelerde enflamatuar yan\u0131t \u00fczerindeki olumsuz etkilerini iyile\u015ftirebilir; Salisilik asit antioksidan enzim aktivitesinin iyile\u015fmesini ind\u00fckleyebilir ve reaktif oksijen t\u00fcrlerinin biyolojik oksidasyonunu hafifletebilir. Bu \u00e7al\u0131\u015fma, bu iki t\u00fcr bile\u015fenin ebeg\u00fcmeci yapraklar\u0131n\u0131n etil asetat k\u0131sm\u0131n\u0131n ana kimyasal bile\u015fenleri oldu\u011funu bulmu\u015f ve ebeg\u00fcmeci yapraklar\u0131n\u0131n antioksidan ve anti-enflamatuar etkileri i\u00e7in farmakolojik madde temelinin esas olarak flavonoidler ve organik asitlerden olu\u015ftu\u011funu ortaya koymu\u015ftur. \u00c7al\u0131\u015fma ayn\u0131 zamanda Hibiscus syringae yapraklar\u0131nda daha \u00f6nce rapor edilmemi\u015f yeni bir flavonoid bile\u015fen olan trifoliat glukozit, iki yeni fenolik bile\u015fen olan 4-nitrofenol ve 4-nitrokate\u015fol, bir yeni n\u00fckleozit bile\u015fen olan adenin ve iki yeni aldehit bile\u015fen olan 2,5-dihidroksibenzaldehit ve vanilin ke\u015ffederek Hibiscus syringae yapraklar\u0131n\u0131n kimyasal bile\u015fim k\u00fct\u00fcphanesini zenginle\u015ftirmi\u015ftir.<\/p>\n

\u00d6zetle, Hibiscus syringae yapraklar\u0131ndan elde edilen etil asetat ekstresi, h\u00fccresel oksidatif hasar\u0131 b\u00fcy\u00fck \u00f6l\u00e7\u00fcde hafifletebilir, oksidatif stres tepkisine direnebilir ve enflamatuar fakt\u00f6rlerin ekspresyonunu engelleyebilir. Flavonoidler ve organik asitler, farmakolojik maddelerinin temeli olabilir ve Hibiscus syringae yapraklar\u0131n\u0131n antioksidan ve anti-enflamatuar mekanizmalar\u0131 ve do\u011fal \u00fcr\u00fcnlerin geli\u015ftirilmesi ve kullan\u0131m\u0131 \u00fczerine daha fazla ara\u015ft\u0131rma i\u00e7in teorik bir temel sa\u011flar.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the antioxidant and anti-inflammatory effects of ethyl acetate in hibiscus leaves and UPLC-Q-Orbitrap HRMS analysis Hibiscus mutabilis leaves are dried leaves of Hibiscus mutabilis L., a plant in the Malvaceae family. They are included in the 2020 edition of the Chinese Pharmacopoeia and are mainly produced in Sichuan, Hunan, Guangdong, Yunnan, and other […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the antioxidant and anti-inflammatory effects of ethyl acetate in hibiscus leaves and UPLC-Q-Orbitrap HRMS analysis - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/hibiscus-mutabilis\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the antioxidant and anti-inflammatory effects of ethyl acetate in hibiscus leaves and UPLC-Q-Orbitrap HRMS analysis - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the antioxidant and anti-inflammatory effects of ethyl acetate in hibiscus leaves and UPLC-Q-Orbitrap HRMS analysis Hibiscus mutabilis leaves are dried leaves of Hibiscus mutabilis L., a plant in the Malvaceae family. 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