{"id":5608,"date":"2024-08-04T20:07:31","date_gmt":"2024-08-04T20:07:31","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5608"},"modified":"2024-08-04T20:07:31","modified_gmt":"2024-08-04T20:07:31","slug":"olibanum","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/olibanum\/","title":{"rendered":"A\u011f farmakolojisi ve in vitro h\u00fccre deneylerine dayal\u0131 olarak akut b\u00f6brek hasar\u0131n\u0131n tedavisinde buhur mekanizmas\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"<p>A\u011f farmakolojisi ve in vitro h\u00fccre deneylerine dayal\u0131 olarak akut b\u00f6brek hasar\u0131n\u0131n tedavisinde buhur mekanizmas\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131<br \/>\nAkut b\u00f6brek hasar\u0131 (ABH), \u00e7e\u015fitli nedenlerden ve patogenezden kaynaklanan b\u00f6brek fonksiyonlar\u0131n\u0131n ani ve s\u00fcrekli olarak azalmas\u0131 anlam\u0131na gelir. Y\u00fcksek insidans oran\u0131, n\u00fcks oran\u0131 ve mortalite ile klinik pratikte s\u0131k g\u00f6r\u00fclen kritik hastal\u0131klardan biridir. \u0130statistiklere g\u00f6re, her y\u0131l d\u00fcnya \u00e7ap\u0131nda yakla\u015f\u0131k 13 milyon hastal\u0131k vakas\u0131 g\u00f6r\u00fclmekte ve tedavi ila\u00e7lar\u0131 ve stratejilerinin eksikli\u011fi nedeniyle, 85%'si geli\u015fmekte olan \u00fclkelerde olmak \u00fczere, her y\u0131l yakla\u015f\u0131k 1,7 milyon hasta hayat\u0131n\u0131 kaybetmektedir. Kan bas\u0131nc\u0131n\u0131n dengelenmesi ve etkili dola\u015f\u0131mdaki kan hacminin art\u0131r\u0131lmas\u0131, AKI'nin \u00f6nlenmesi ve tedavisinde \u00e7ok \u00f6nemlidir. Bu nedenle, AKI'yi \u00f6nleyecek ve tedavi edecek ila\u00e7lar\u0131n bulunmas\u0131, bu hastal\u0131\u011fa sahip hastalar\u0131n hayatlar\u0131n\u0131n kurtar\u0131lmas\u0131nda b\u00fcy\u00fck \u00f6nem ta\u015f\u0131maktad\u0131r. Geleneksel \u00c7in t\u0131bb\u0131 \u00e7oklu bile\u015fen ve hedef \u00f6zelliklerine sahiptir ve AKI'nin \u00f6nlenmesi ve tedavisinde \u00f6nemli ilerlemeler kaydetmi\u015ftir.<\/p>\n<p>Olibanum, zeytin familyas\u0131 bitkisi Boswellia carterii Birdw ve B Bhaw dajiana Birdw cinsinden t\u00fcretilmi\u015ftir. Kabuktan s\u0131zan re\u00e7ine. Do\u011fada s\u0131cak, tad\u0131 keskin ve ac\u0131d\u0131r, \"kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etme ve a\u011fr\u0131y\u0131 hafifletme, \u015fi\u015fli\u011fi azaltma ve kas b\u00fcy\u00fcmesini te\u015fvik etme\" etkisine sahiptir. Buhurun kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik eden ve a\u011fr\u0131y\u0131 dindiren ana bile\u015feni buhur asidi bile\u015fikleridir. Modern ara\u015ft\u0131rmalar buhurun antibakteriyel, antikanser, anti-enflamatuar, antioksidan ve di\u011fer aktivitelere sahip oldu\u011funu g\u00f6stermi\u015ftir. \u0130\u015flevsel \u00f6zelliklerine dayanarak, buhurun AKI \u00fczerindeki mekanizmas\u0131n\u0131 ara\u015ft\u0131rmak i\u00e7in daha fazla ara\u015ft\u0131rmaya ihtiya\u00e7 vard\u0131r.<\/p>\n<p>Bu \u00e7al\u0131\u015fma, a\u011f farmakolojisi yoluyla buhurun aktif bile\u015fenlerini taram\u0131\u015f, bir ila\u00e7 aktif bile\u015fen hastal\u0131k hedef a\u011f\u0131 olu\u015fturmu\u015f ve bunu in vitro h\u00fccre deneyleriyle do\u011frulam\u0131\u015ft\u0131r. Buhurun AKI'yi \u00f6nleme ve tedavi etme mekanizmas\u0131 ayd\u0131nlat\u0131lm\u0131\u015f ve akut b\u00f6brek hasar\u0131 kar\u015f\u0131t\u0131 bir ila\u00e7 olarak geli\u015ftirilmesi i\u00e7in g\u00fcvenilir bir teorik temel sa\u011flanm\u0131\u015ft\u0131r.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5609\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-161.png\" alt=\"\" width=\"784\" height=\"141\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-161.png 784w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-161-768x138.png 768w\" sizes=\"(max-width: 784px) 100vw, 784px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5610\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-148.png\" alt=\"\" width=\"1157\" height=\"415\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-148.png 1157w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-148-768x275.png 768w\" sizes=\"(max-width: 1157px) 100vw, 1157px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5611\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-139.png\" alt=\"\" width=\"733\" height=\"249\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5612\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-124.png\" alt=\"\" width=\"715\" height=\"328\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5613\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-111.png\" alt=\"\" width=\"355\" height=\"261\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5614\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-103.png\" alt=\"\" width=\"683\" height=\"313\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5615\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-93.png\" alt=\"\" width=\"768\" height=\"409\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5616\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-4.jpg\" alt=\"\" width=\"1078\" height=\"446\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-4.jpg 1078w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-4-768x318.jpg 768w\" sizes=\"(max-width: 1078px) 100vw, 1078px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5617\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-80.png\" alt=\"\" width=\"1153\" height=\"638\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-80.png 1153w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-80-768x425.png 768w\" sizes=\"(max-width: 1153px) 100vw, 1153px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5618\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-62.png\" alt=\"\" width=\"761\" height=\"243\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5619\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-57.png\" alt=\"\" width=\"762\" height=\"836\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-57.png 762w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-57-656x720.png 656w\" sizes=\"(max-width: 762px) 100vw, 762px\" \/><br \/>\nBat\u0131 t\u0131bb\u0131, AKI olu\u015fumunun renal iskemi ve hipoksi ile yak\u0131ndan ili\u015fkili oldu\u011funa inanmaktad\u0131r. Halen klinik uygulamada, esas olarak hastan\u0131n hastal\u0131k durumunu iyile\u015ftirmek i\u00e7in semptomatik tedavi yoluyla etkili tedavi y\u00f6ntemleri ve m\u00fcdahale \u00f6nlemleri eksikli\u011fi bulunmaktad\u0131r. Geleneksel \u00c7in T\u0131bb\u0131, AKI'nin klinik \u00f6zelliklerini \"Longbi\", \"Guange\", \"\u00d6dem\" ve \"Bo\u011fulma Zehri\" gibi kategorilere ay\u0131r\u0131r. Bu nedenle, tedavinin temel ilkeleri aras\u0131nda \u0131s\u0131y\u0131 temizlemek ve detoksifiye etmek, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmek ve kan staz\u0131n\u0131 gidermek, \u0131s\u0131y\u0131 temizlemek ve suyu gidermek ve organlar\u0131n dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmek ve bulan\u0131kl\u0131\u011f\u0131 ortadan kald\u0131rmak yer al\u0131r. Buhur, kas b\u00fcy\u00fcmesini te\u015fvik etme, kanamay\u0131 durdurma, kan dola\u015f\u0131m\u0131n\u0131 aktive etme, kan staz\u0131n\u0131 giderme, \u015fi\u015fli\u011fi azaltma ve a\u011fr\u0131y\u0131 hafifletme etkilerine sahiptir. Klinik uygulamada kan staz\u0131n\u0131 veya romatizmay\u0131 tedavi etmek i\u00e7in yayg\u0131n olarak kullan\u0131l\u0131r. Bu nedenle, akut b\u00f6brek hasar\u0131n\u0131n erken ve orta a\u015famalar\u0131nda kan aktive edici ve staz giderici ila\u00e7lar\u0131n eklenmesi, hastalar\u0131n b\u00f6brek fonksiyonlar\u0131n\u0131n iyile\u015ftirilmesi, hemat\u00fcri gibi klinik belirtilerin azalt\u0131lmas\u0131 ve hastal\u0131\u011f\u0131n ilerlemesinin yava\u015flat\u0131lmas\u0131 \u00fczerinde \u00f6nemli \u00f6nleyici ve tedavi edici etkilere sahiptir.<br \/>\nBu \u00e7al\u0131\u015fma, a\u011f farmakolojisi y\u00f6ntemlerini kullanarak AKI i\u00e7in buhurun \"\u00e7ok bile\u015fenli \u00e7ok hedefli \u00e7ok yollu\" tedavisinin maddi temelini ve etki mekanizmas\u0131n\u0131 sistematik olarak analiz etmi\u015ftir. \u00c7ok say\u0131da deney, buhur asidinin buhurdaki biyolojik olarak en aktif bile\u015fen olarak kabul edildi\u011fini g\u00f6stermi\u015ftir. En \u00f6nemlileri anti-enflamatuar ve anti-t\u00fcm\u00f6r \u00f6zelliklerinin yan\u0131 s\u0131ra anti \u00fclser, ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenleme, lipid d\u00fc\u015f\u00fcr\u00fcc\u00fc, b\u00f6brek koruma, antibakteriyel etkiler vb. gibi di\u011fer bir\u00e7ok farmakolojik aktivitedir. Ara\u015ft\u0131rma sonu\u00e7lar\u0131 AK-BA, \u03b1 - BA ve di\u011fer aktif bile\u015fenlerin AKI tedavisinde ana aktif bile\u015fenler oldu\u011funu g\u00f6stermektedir. Literat\u00fcrde \u03b1 - BA'n\u0131n U937 makrofajlar\u0131nda LPS taraf\u0131ndan uyar\u0131lan pro-enflamatuar sitokinlerin (TNF - \u03b1 ve IL-1 \u03b2) \u00fcretimini inhibe edebildi\u011fi ve in vitro anti-enflamatuar \u00f6zelliklerini do\u011frulayan raporlar bulunmaktad\u0131r. Buhurun biyoaktif bile\u015feni olan pentasiklik triterpenoidler, 5-lipoksijenaz yoluyla l\u00f6kotrienlerin biyosentezini bloke eder ve anti-enflamatuar etkisini g\u00f6sterir. \u00c7al\u0131\u015fmalar, s\u0131\u011fla asidinin antioksidan ve anti-inflamatuar etkileri yoluyla siklofosfamid ile ind\u00fcklenmi\u015f sistit s\u0131\u00e7anlar\u0131 \u00fczerinde idrar yollar\u0131n\u0131 koruyucu bir etki g\u00f6sterdi\u011fini ortaya koymu\u015ftur.<br \/>\nPPI a\u011f\u0131na g\u00f6re, MAPK3, PPARG, PTGS2, HIF1 \u03b1 ve ESR1, akut b\u00f6brek hasar\u0131n\u0131n tedavisinde buhurun temel hedefleridir. MAPK3, mitojenle aktive olan protein kinaz MAPK ailesine aittir. MAPK kaskad aktivasyonu, h\u00fccre b\u00fcy\u00fcmesi, farkl\u0131la\u015fma ve apoptoz gibi fizyolojik s\u00fcre\u00e7lerde yer alan \u00e7oklu sinyal yollar\u0131n\u0131n merkezidir. PPARG, n\u00fckleer transkripsiyon fakt\u00f6r\u00fc s\u00fcper ailesine aittir. Deneyler, PPARG eksikli\u011fi olan farelerde glikoz\u00fcri ve alb\u00fcmin\u00fcrinin artt\u0131\u011f\u0131n\u0131 kan\u0131tlam\u0131\u015ft\u0131r. Ya\u015f\u0131n b\u00fcy\u00fcmesiyle birlikte farelerde b\u00f6brek yetmezli\u011fi ve tip 2 diyabetin daha da a\u011f\u0131rla\u015fmas\u0131 g\u00f6r\u00fcl\u00fcr. Raporlara g\u00f6re PPARG agonistleri, I\/R hasar\u0131n\u0131n neden oldu\u011fu yayg\u0131n t\u00fcb\u00fcler nekrozu ve akut enflamasyonu inhibe ederek ve plazma nitrik oksit seviyelerini ve ED-1+ h\u00fccre infiltrasyonunu azaltarak b\u00f6brekleri I\/R hasar\u0131ndan korumaktad\u0131r. PPAR agonistleri AKI tedavisinde \u00f6nemli bir potansiyel g\u00f6stermi\u015ftir. PTGS2, ara\u015fidonik asidi inflamatuvar mediyat\u00f6r prostaglandine d\u00f6n\u00fc\u015ft\u00fcren ve esas olarak n\u00fckleer membranda da\u011f\u0131lan anahtar bir enzimdir. Ekspresyonu, enflamatuar fakt\u00f6rler ve t\u00fcm\u00f6r b\u00fcy\u00fcme fakt\u00f6rleri gibi uyaranlar taraf\u0131ndan ind\u00fcklenir. Ara\u015ft\u0131rmalar, Golden Bone Lotus \u00f6z\u00fct\u00fcn\u00fcn PTGS2\/COX-2 mRNA ekspresyonunu doza ba\u011fl\u0131 olarak azaltt\u0131\u011f\u0131n\u0131 ve b\u00f6ylece anti-enflamatuar etkiler g\u00f6sterdi\u011fini ortaya koymu\u015ftur. HIF1 \u03b1, hipoksiye adaptif yan\u0131t\u0131n ana d\u00fczenleyici fakt\u00f6r\u00fcd\u00fcr ve renal iskemi-reperf\u00fczyon ile ind\u00fcklenen AKI modelinde, HIF1 \u03b1 ekspresyonu renal t\u00fcb\u00fcllerde \u00f6nemli \u00f6l\u00e7\u00fcde artm\u0131\u015ft\u0131r.<br \/>\nGO zenginle\u015ftirme analizi s\u00fcrecinde, esas olarak hipoksiye yan\u0131t, apoptoz, enflamatuar yan\u0131t, mitokondri gibi molek\u00fcler i\u015flevler ve endopeptidaz aktivitesi gibi h\u00fccresel bile\u015fenler gibi biyolojik s\u00fcre\u00e7leri i\u00e7erir, bu da AKI tedavisinde s\u0131\u011fla biyolojik yollar\u0131n\u0131n zengin ve karma\u015f\u0131k oldu\u011funu g\u00f6sterir. KEGG yol zenginle\u015ftirme analizine g\u00f6re, buhurun AKI tedavisindeki sinyal yolu Toll benzeri resept\u00f6r sinyal yolu, TNF sinyal yolu ve NF - \u03ba B sinyal yolu ile ili\u015fkilidir. Bunlar aras\u0131nda, Toll benzeri resept\u00f6r (TLR) bir membran protein resept\u00f6r\u00fcd\u00fcr ve TLR4 AKI enflamatuar yan\u0131t\u0131na neden olan \u00f6nemli bir molek\u00fcld\u00fcr. \u00c7e\u015fitli sitokinleri ve enflamatuar mediat\u00f6rleri transkribe edip salg\u0131layarak imm\u00fcn enflamatuar yan\u0131t\u0131 tetikleyebilir. \u00c7al\u0131\u015fmalar, akut b\u00f6brek hasar\u0131n\u0131n \u015fiddetinin TLR4 ve NF - \u03ba B'nin serum seviyeleriyle yak\u0131ndan ili\u015fkili oldu\u011funu g\u00f6stermi\u015ftir. TLR4 NF - \u03ba B sinyal yolunun inhibe edilmesi, akut b\u00f6brek hasar\u0131n\u0131n \u015fiddetini hafifletebilir. T\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc (TNF) \u00e7ok \u00e7e\u015fitli biyolojik etkileri olan bir sitokindir. Genel olarak TNF, makrofajlar taraf\u0131ndan \u00fcretilen TNF - \u03b1'y\u0131 ifade eder. Aktivasyondan sonra, esas olarak h\u00fccre b\u00fcy\u00fcmesini, farkl\u0131la\u015fmas\u0131n\u0131, apoptozu te\u015fvik etmede ve inflamasyonu ind\u00fcklemede \u00f6nemli bir rol oynar. AKI, TLR4 NF - \u03ba B sinyal yolunu aktive ederek pro-enflamatuar sitokin TNF - \u03b1 sal\u0131n\u0131m\u0131n\u0131 ind\u00fckler. Bu nedenle, TLR4, NF - \u03ba B ve TNF - \u03b1 seviyelerinin kontrol\u00fcn\u00fcn g\u00fc\u00e7lendirilmesi akut b\u00f6brek hasar\u0131n\u0131 hafifletebilir ve hasta prognozunun iyile\u015fmesini sa\u011flayabilir.<br \/>\nBuhurdaki ana aktif bile\u015fenlerin MAPK3 ve PPARG'ye ba\u011flanma enerjileri molek\u00fcler yerle\u015ftirme y\u00f6ntemi kullan\u0131larak belirlenmi\u015ftir. Sonu\u00e7lar, AKBA ve \u03b1 - BA'n\u0131n MAPK3 ve PPARG'ye iyi ba\u011flanma yeteneklerine sahip oldu\u011funu g\u00f6stermi\u015ftir.<br \/>\nSon olarak, bu \u00e7al\u0131\u015fmada \u03b1 - BA'n\u0131n etki mekanizmas\u0131n\u0131 ara\u015ft\u0131rmak i\u00e7in h\u00fccre k\u00fclt\u00fcr\u00fc yoluyla renal I\/R hasar\u0131 sim\u00fcle edilmi\u015ftir. Ara\u015ft\u0131rma sonu\u00e7lar\u0131, \u03b1 - BA'n\u0131n HK-2 h\u00fccreleri \u00fczerinde toksik etkisi olmad\u0131\u011f\u0131n\u0131 ve I\/R hasar\u0131 modelinde h\u00fccre canl\u0131l\u0131\u011f\u0131n\u0131 doza ba\u011fl\u0131 olarak art\u0131rarak b\u00f6brek koruyucu bir etki g\u00f6sterdi\u011fini ortaya koymu\u015ftur. Ho-echst 33258 boyamas\u0131, I\/R tedavisinin apoptotik h\u00fccrelerin oran\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rd\u0131\u011f\u0131n\u0131, \u03b1 - BA'n\u0131n ise apoptotik h\u00fccrelerini konsantrasyona ba\u011fl\u0131 bir \u015fekilde \u00f6nemli \u00f6l\u00e7\u00fcde azaltt\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Alfa BA, I\/R taraf\u0131ndan ind\u00fcklenen HK-2 h\u00fccreleri taraf\u0131ndan \u00fcretilen enflamatuar fakt\u00f6rleri \u00f6nemli \u00f6l\u00e7\u00fcde inhibe edebilir. Bu arada, ger\u00e7ek zamanl\u0131 floresan kantitatif RT-PCR tespiti, \u03b1 - BA'n\u0131n AKI s\u00fcrecinde temel hedefler olan MAPK3 ve PPARG genlerinin ekspresyonunu azaltabildi\u011fini g\u00f6stermi\u015ftir ki bu da a\u011f farmakolojisi taraf\u0131ndan \u00f6ng\u00f6r\u00fclen sonu\u00e7larla tutarl\u0131d\u0131r.<br \/>\nBu \u00e7al\u0131\u015fmada, buhurun etken maddelerini ve potansiyel hedeflerini ve ayr\u0131ca AKI'nin ilgili hedeflerini ara\u015ft\u0131rmak i\u00e7in geleneksel \u00c7in t\u0131bb\u0131 a\u011f farmakolojisi kullan\u0131lm\u0131\u015ft\u0131r. Etken maddeler ve hastal\u0131k hedefleri aras\u0131nda toplam 72 kesi\u015fim elde edilmi\u015ftir. GO ve KEGG sinyal yolu zenginle\u015ftirme analizi daha sonra ana etken maddeleri AKBA, \u03b1 - BA, vb. tahmin etmek i\u00e7in bu hedefler \u00fczerinde ger\u00e7ekle\u015ftirildi. AKI tedavisi esas olarak iskemi, hipoksi hasar\u0131n\u0131 hafifletmek ve h\u00fccre apoptozunu d\u00fczenlemek i\u00e7in MAPK3, PPARG, PTGS2, Toll benzeri resept\u00f6rler, TNF ve NF - \u03ba B sinyal yolaklar\u0131 gibi hedefleri d\u00fczenleyerek sa\u011flanm\u0131\u015ft\u0131r. Bu arada, in vitro h\u00fccre deneyleri, tahminin do\u011frulu\u011funu ve g\u00fcvenilirli\u011fini \u00f6nceden do\u011frulam\u0131\u015f ve geleneksel \u00c7in t\u0131bb\u0131n\u0131n sonraki ara\u015ft\u0131rmalar\u0131 ve klinik tan\u0131t\u0131m\u0131 i\u00e7in bir referans temeli sa\u011flam\u0131\u015ft\u0131r. Ancak hala baz\u0131 s\u0131n\u0131rlamalar\u0131 vard\u0131r ve hayvan deneyleri yoluyla daha fazla do\u011frulamaya ihtiya\u00e7 duyar.<\/p>","protected":false},"excerpt":{"rendered":"<p>Exploring the mechanism of frankincense in treating acute kidney injury based on network pharmacology and in vitro cell experiments Acute kidney injury (AKI) refers to the sudden and continuous decline of renal function caused by a variety of causes and pathogenesis. 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