{"id":5501,"date":"2024-08-04T19:27:28","date_gmt":"2024-08-04T19:27:28","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5501"},"modified":"2024-08-04T19:27:28","modified_gmt":"2024-08-04T19:27:28","slug":"three-volatile-oils","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/three-volatile-oils\/","title":{"rendered":"Kekikten elde edilen \u00fc\u00e7 u\u00e7ucu ya\u011f\u0131n bile\u015fenleri, antibakteriyel aktivitesi ve insan karaci\u011fer kanseri h\u00fccreleri \u00fczerindeki sitotoksisitesi \u00fczerine \u00e7al\u0131\u015fma"},"content":{"rendered":"

Kekikten elde edilen \u00fc\u00e7 u\u00e7ucu ya\u011f\u0131n bile\u015fenleri, antibakteriyel aktivitesi ve insan karaci\u011fer kanseri h\u00fccreleri \u00fczerindeki sitotoksisitesi \u00fczerine \u00e7al\u0131\u015fma
\nKekik, \u0130\u00e7 Mo\u011folistan, Heilongjiang ve di\u011fer b\u00f6lgelerde yayg\u0131n olarak da\u011f\u0131t\u0131lan Lamiaceae ailesinin k\u00fc\u00e7\u00fck bir yar\u0131 \u00e7al\u0131s\u0131d\u0131r. Kekik u\u00e7ucu ya\u011f\u0131, keki\u011fin e\u015fsiz bir u\u00e7ucu maddesidir ve i\u00e7eri\u011fi b\u00fcy\u00fcme ortam\u0131na ve t\u00fcr\u00fcne ba\u011fl\u0131 olarak de\u011fi\u015fir. \u00c7o\u011funlukla terpenler ve aromatik bile\u015fiklerden olu\u015fur, timol ve karvakrol en y\u00fcksek i\u00e7eri\u011fe sahiptir. Kekik u\u00e7ucu ya\u011f\u0131, m\u00fckemmel antioksidan \u00f6zellikleri nedeniyle g\u0131da katk\u0131 maddelerinde, g\u00fczellik ve cilt bak\u0131m \u00fcr\u00fcnlerinde yayg\u0131n olarak kullan\u0131lmaktad\u0131r. Ayr\u0131ca Streptococcus pneumoniae, Staphylococcus aureus, Candida albicans ve Salmonella typhimurium gibi patojenik bakteriler \u00fczerinde g\u00fc\u00e7l\u00fc inhibit\u00f6r etkilere sahiptir. Bu nedenle t\u0131p alan\u0131nda b\u00fcy\u00fck ilgi g\u00f6rm\u00fc\u015ft\u00fcr. Bitki u\u00e7ucu ya\u011f\u0131n\u0131n kanser h\u00fccresi apoptozunu ind\u00fckleme mekanizmas\u0131 hakk\u0131nda bir\u00e7ok literat\u00fcr raporu olmas\u0131na ra\u011fmen, Kekik bitkilerinin u\u00e7ucu ya\u011f\u0131 hakk\u0131nda \u00e7ok az ara\u015ft\u0131rma raporu vard\u0131r ve kanser h\u00fccresi nekrozuna ve apoptozuna nas\u0131l yol a\u00e7t\u0131\u011f\u0131na dair \u00e7ok az rapor ve sistematik ara\u015ft\u0131rma eksikli\u011fi vard\u0131r.<\/p>\n

Bu \u00e7al\u0131\u015fmada Thymus citriodorus, Thymus mongolicus ve Thymus vulgaris, buhar distilasyonu kullan\u0131larak kekikten \u00fc\u00e7 u\u00e7ucu ya\u011f elde etmek i\u00e7in materyal olarak kullan\u0131lm\u0131\u015ft\u0131r. Kimyasal bile\u015fenlerinin gaz kromatografisi-k\u00fctle spektrometresi (GC-MS) analizi ile birlikte, karaci\u011fer kanseri h\u00fccrelerine kar\u015f\u0131 antibakteriyel etki ve toksisite incelenmi\u015f ve kekik u\u00e7ucu ya\u011flar\u0131n\u0131n daha kapsaml\u0131 geli\u015ftirilmesi i\u00e7in daha temel teorik temel sa\u011flanm\u0131\u015ft\u0131r.<\/p>\n

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\nAromatik bitkilerden bitki u\u00e7ucu ya\u011flar\u0131n\u0131n \u00e7\u0131kar\u0131lmas\u0131, nispeten g\u00fcvenli, d\u00fc\u015f\u00fck toksisite, kolay bozunma ve \u00e7evre dostu \u00f6zellikleri nedeniyle kimyasal fungisitlere ve kanser bask\u0131lay\u0131c\u0131lara etkili bir alternatiftir. U\u00e7ucu ya\u011flar\u0131n bile\u015fimi, genellikle \u00e7e\u015fitli terpenoidler, aromatik bile\u015fikler, alifatik bile\u015fikler ve azot i\u00e7eren ve s\u00fclf\u00fcr i\u00e7eren bile\u015fikler i\u00e7eren farkl\u0131 t\u0131bbi bitkiler aras\u0131nda de\u011fi\u015fiklik g\u00f6sterir. \u015eu anda, kekik u\u00e7ucu ya\u011f\u0131ndaki aktif bile\u015fenlerin anti-t\u00fcm\u00f6r etkileri \u00fczerine s\u0131n\u0131rl\u0131 ara\u015ft\u0131rma bulunmaktad\u0131r. Bu \u00e7al\u0131\u015fmada, \u00fc\u00e7 tip kekik u\u00e7ucu ya\u011f\u0131 elde etmek i\u00e7in geleneksel buhar distilasyonu kullan\u0131lm\u0131\u015f ve bile\u015fimlerindeki farkl\u0131l\u0131klar GC-MS ile analiz edilmi\u015ftir. En belirgin olan\u0131, limon keki\u011fi u\u00e7ucu ya\u011f\u0131n\u0131n sitral ve izositral olmak \u00fczere iki bile\u015fik i\u00e7ermesi, di\u011fer iki u\u00e7ucu ya\u011f\u0131n ise bu iki maddeyi i\u00e7ermemesiydi. Deneyde farkl\u0131 bitki patojenlerini tedavi etmek i\u00e7in \u00fc\u00e7 t\u00fcr kekik u\u00e7ucu ya\u011f\u0131 kullan\u0131lm\u0131\u015f ve antibakteriyel aktivitede farkl\u0131 yetenekler sergiledikleri g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. Bunlar aras\u0131nda limon keki\u011fi u\u00e7ucu ya\u011f\u0131, \u00f6zellikle Escherichia coli \u00fczerinde en iyi antibakteriyel etkiye sahipti. Buna kar\u015f\u0131l\u0131k, Frans\u0131z keki\u011fi u\u00e7ucu ya\u011f\u0131n\u0131n antibakteriyel yetene\u011fi daha zay\u0131ft\u0131r ve bunu kekik u\u00e7ucu ya\u011f\u0131 takip etmektedir. Deneyde ayr\u0131ca CCK-8 y\u00f6ntemi kullan\u0131larak karaci\u011fer kanseri h\u00fccre hatlar\u0131n\u0131n \u00e7o\u011falmas\u0131 ve apoptozisi \u00fczerindeki etkileri analiz edilmi\u015ftir. Sonu\u00e7lar, \u00fc\u00e7 t\u00fcr kekik u\u00e7ucu ya\u011f\u0131n\u0131n karaci\u011fer kanseri h\u00fccresi HepG2'nin \u00e7o\u011falmas\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde inhibe edebilece\u011fini ve anti-t\u00fcm\u00f6r ila\u00e7lar\u0131n\u0131n geli\u015ftirilmesinde belirli ara\u015ft\u0131rma potansiyeline sahip olan apoptozunu ind\u00fckleyebilece\u011fini g\u00f6stermi\u015ftir. Bu antibakteriyel ve antikanser i\u015flevi, kekik cinsindeki u\u00e7ucu ya\u011flar\u0131n bile\u015fimiyle yak\u0131ndan ili\u015fkilidir. En y\u00fcksek i\u00e7eri\u011fe sahip olan timol, sadece bitki mantarlar\u0131, dermatofitler ve insan iltihab\u0131 \u00fczerinde \u00f6nemli terap\u00f6tik etkilere sahip olmakla kalmaz, ayn\u0131 zamanda iyi bir anti-t\u00fcm\u00f6r farmakolojik aktivite g\u00f6sterir. \u00d6rne\u011fin, timol karaci\u011fer kanseri h\u00fccrelerinde, prostat kanseri h\u00fccrelerinde ve mide kanseri h\u00fccrelerinde mitojen aktive protein kinaz (MAPK), h\u00fccre d\u0131\u015f\u0131 d\u00fczenlenmi\u015f protein kinaz (ERK) ve apoptotik gen Bax'tan apoptozu ind\u00fckleyebilir ve ROS'un mitokondriyal transmembran ind\u00fcksiyonunu azaltarak, Caspase ekspresyonunu art\u0131rarak ve Bcl-2 ekspresyonunu a\u015fa\u011f\u0131 d\u00fczenleyerek antikanser etkiler g\u00f6sterebilir. Ek olarak, sitral oksidatif stres reaksiyonunu ind\u00fckleyerek, h\u00fccre i\u00e7i malondialdehit seviyesini art\u0131rarak, indirgenmi\u015f glutatyonu azaltarak ve l\u00f6semi h\u00fccrelerinin apoptozunu ind\u00fckleyerek l\u00f6semi h\u00fccrelerinin apoptozunu ind\u00fckleyebilir. Ayr\u0131ca pro apoptotik protein BAK'\u0131n ekspresyonunu yukar\u0131 ve anti apoptotik protein Bcl xL'nin ekspresyonunu a\u015fa\u011f\u0131 d\u00fczenleyerek lenfoma h\u00fccrelerinin proliferasyonunu inhibe edebilir ve meme kanseri h\u00fccrelerinin proliferasyonunu inhibe etmek i\u00e7in h\u00fccre d\u00f6ng\u00fcs\u00fcn\u00fc bloke edebilir. Zhao ve arkada\u015flar\u0131, insan karaci\u011fer kanseri h\u00fccre hatt\u0131 HepG2'nin b\u00fcy\u00fcmesini engellemek i\u00e7in lavanta esansiyel ya\u011f\u0131 kullanm\u0131\u015ft\u0131r. Sonu\u00e7lar, lavanta esansiyel ya\u011f\u0131n\u0131n HepG2 h\u00fccrelerinin proliferasyonunu konsantrasyona ba\u011fl\u0131 bir \u015fekilde \u00f6nemli \u00f6l\u00e7\u00fcde inhibe edebilece\u011fini g\u00f6stermi\u015ftir. Tedaviden sonra, lavanta esansiyel ya\u011f\u0131n\u0131n farkl\u0131 konsantrasyonlar\u0131 HepG2 h\u00fccrelerinde \u00f6nemli apoptoz ve nekroz g\u00f6stermi\u015ftir. Jia ve arkada\u015flar\u0131 limonenin Bax ve sitokrom i\u00e7eri\u011fini art\u0131rabildi\u011fini, Bcl-2 ekspresyonunu azaltabildi\u011fini ve insan kolon kanseri h\u00fccre hatt\u0131 LS174T'de apoptozu ind\u00fckleyebildi\u011fini bulmu\u015ftur; Jaganathan ve arkada\u015flar\u0131 fenol\u00fcn p53 ve Caspase-3'\u00fc aktive ederek kolon kanseri h\u00fccrelerinde apoptozu ind\u00fckleyebildi\u011fini do\u011frulam\u0131\u015ft\u0131r.<\/p>\n

Do\u011fal bitki u\u00e7ucu ya\u011flar\u0131 olduk\u00e7a potansiyel bir biyolojik kaynakt\u0131r. Kekik bitkisinin u\u00e7ucu ya\u011flar\u0131 \u00fczerine ara\u015ft\u0131rmalar\u0131n derinle\u015ftirilmesiyle, klinik t\u0131p, farmas\u00f6tik bak\u0131m ve g\u0131da g\u00fcvenli\u011fi i\u00e7in daha fazla olanak sa\u011flanacak ve yeni do\u011fal antioksidanlar ve anti-t\u00fcm\u00f6r ila\u00e7lar\u0131n\u0131n geli\u015ftirilmesi i\u00e7in yeni yollar a\u00e7\u0131lacakt\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the components, antibacterial activity, and cytotoxicity of three volatile oils from thyme on human liver cancer cells Thyme is a small semi shrub of the Lamiaceae family, widely distributed in Inner Mongolia, Heilongjiang and other regions. Thyme volatile oil is a unique volatile substance of thyme, and its content varies depending on the […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the components, antibacterial activity, and cytotoxicity of three volatile oils from thyme on human liver cancer cells - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/three-volatile-oils\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the components, antibacterial activity, and cytotoxicity of three volatile oils from thyme on human liver cancer cells - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the components, antibacterial activity, and cytotoxicity of three volatile oils from thyme on human liver cancer cells Thyme is a small semi shrub of the Lamiaceae family, widely distributed in Inner Mongolia, Heilongjiang and other regions. 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