{"id":5474,"date":"2024-08-04T19:20:51","date_gmt":"2024-08-04T19:20:51","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5474"},"modified":"2024-08-04T19:20:51","modified_gmt":"2024-08-04T19:20:51","slug":"solanum-nigrum","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/solanum-nigrum\/","title":{"rendered":"Solanum nigrum'un meme kanseri tedavisindeki mekanizmas\u0131n\u0131 a\u011f farmakolojisi, molek\u00fcler yerle\u015ftirme teknolojisi ve in vitro deneysel do\u011frulamaya dayal\u0131 olarak ke\u015ffetmek"},"content":{"rendered":"<section>Solanum nigrum'un meme kanseri tedavisindeki mekanizmas\u0131n\u0131 a\u011f farmakolojisi, molek\u00fcler yerle\u015ftirme teknolojisi ve in vitro deneysel do\u011frulamaya dayal\u0131 olarak ke\u015ffetmek<br \/>\nMeme kanseri d\u00fcnyada kad\u0131nlar aras\u0131nda en s\u0131k g\u00f6r\u00fclen k\u00f6t\u00fc huylu t\u00fcm\u00f6rlerden biridir ve ayn\u0131 zamanda kad\u0131nlar aras\u0131nda kansere ba\u011fl\u0131 \u00f6l\u00fcmlerin ana nedenidir. Meme kanseri riski ya\u015f, genetik, \u00fcreme fakt\u00f6rleri ve obezite gibi bir\u00e7ok fakt\u00f6rle ili\u015fkilidir. G\u00fcn\u00fcm\u00fczde hormon tedavisi, cerrahi, kemoterapi ve radyoterapi meme kanserinin tedavisinde kullan\u0131lan ana stratejilerdir. Ancak, meme kanseri karma\u015f\u0131k ve olduk\u00e7a heterojen bir hastal\u0131k oldu\u011fundan, \u00e7oklu ila\u00e7 direnci ve ciddi yan etkiler bu tedavi y\u00f6ntemlerinin terap\u00f6tik etkisini s\u0131n\u0131rlamaktad\u0131r. Bu nedenle, daha etkili ve daha g\u00fcvenli anti meme kanseri ila\u00e7lar\u0131n\u0131n geli\u015ftirilmesine acil ihtiya\u00e7 vard\u0131r. Kanser tedavisinde, geleneksel \u00c7in t\u0131bb\u0131 ve do\u011fal \u00fcr\u00fcnler \u00e7ok seviyeli, \u00e7ok yollu, \u00e7ok hedefli, y\u00fcksek verimlilik ve minimum yan etki avantajlar\u0131na sahiptir ve iyi anti-t\u00fcm\u00f6r etkiler g\u00f6sterir. Geleneksel \u00c7in t\u0131bb\u0131 ve aktif bile\u015fikleri, meme kanserine kar\u015f\u0131 kesin iyile\u015ftirici etki, k\u00fc\u00e7\u00fck toksik ve yan etkiler, zengin hedefler ve \u00e7e\u015fitli mekanizmalar \u00f6zelliklerine sahiptir. Geleneksel \u00c7in t\u0131bb\u0131ndan elde edilen anti meme kanseri ila\u00e7lar\u0131, geli\u015ftirme ve uygulama i\u00e7in iyi beklentilere sahiptir.<br \/>\nSolanum nigrum L., Solanaceae familyas\u0131ndan Avrupa, Asya ve Amerika'da yayg\u0131n olarak bulunan t\u0131bbi bir bitkidir. Longkui anti-kanser, anti-enflamatuar, antioksidan, antibakteriyel ve antiepileptik etkilere sahiptir. Ana biyoaktif bile\u015fenleri aras\u0131nda steroidal saponinler, alkaloidler, fenoller ve polisakkaritler bulunur. Modern ara\u015ft\u0131rmalar, Solanum nigrum ve aktif bile\u015fenlerinin (esas olarak steroidler, organik asitler, lignanlar ve di\u011ferleri) karaci\u011fer kanseri, rahim a\u011fz\u0131 kanseri, pankreas kanseri, meme kanseri gibi farkl\u0131 kanser t\u00fcrlerini tedavi etmek i\u00e7in kullan\u0131labilece\u011fini g\u00f6stermektedir. Solanum nigrum metanol ekstresi, meme kanseri h\u00fccre hatt\u0131 MDA-MB-468'in otofajisini ve apoptozunu ind\u00fckleyebilir. Solanum nigrum su ekstresi ve etanol ekstresi, meme kanseri h\u00fccre hatt\u0131 MCF-7'ye sitotoksisiteye sahiptir ve MCF-7 h\u00fccre hatt\u0131n\u0131n apoptozunu ve d\u00f6ng\u00fc durmas\u0131n\u0131 ind\u00fckler. Ayr\u0131ca, Solanum nigrum epigenetik mod\u00fclasyon yoluyla meme kanseri kar\u015f\u0131t\u0131 bir rol de oynayabilir. Diosgenin, Dioscorea bitkilerinden elde edilen ve iyi bir anti-t\u00fcm\u00f6r aktivitesine sahip olan bir t\u00fcr do\u011fal steroid saponindir. Ara\u015ft\u0131rmalar, diosgenin'in Vav2 aktivitesini inhibe ederek MDA-MB-231 meme kanseri h\u00fccrelerinin g\u00f6\u00e7\u00fcn\u00fc engelleyebildi\u011fini ve h\u00fccrelerin g\u00f6\u00e7 davran\u0131\u015f\u0131n\u0131 etkileyebildi\u011fini g\u00f6stererek diosgenin'in anti metastaz potansiyeline sahip olabilece\u011fini ortaya koymaktad\u0131r. Yukar\u0131daki ara\u015ft\u0131rmalar baz\u0131 ilerlemeler kaydetmi\u015f olsa da, Solanum nigrum'un meme kanserine kar\u015f\u0131 maddi temeli, etki hedefleri ve ayr\u0131nt\u0131l\u0131 molek\u00fcler mekanizmas\u0131 tamamen a\u00e7\u0131k de\u011fildir. A\u011f farmakolojisi ve molek\u00fcler yerle\u015ftirme teknik y\u00f6ntemlerine dayanan bu \u00e7al\u0131\u015fma, \u00e7ok seviyeli ve \u00e7ok a\u00e7\u0131l\u0131 bir \"ila\u00e7 hedef yolu hastal\u0131\u011f\u0131\" a\u011f ili\u015fkisi olu\u015fturmu\u015f ve bunu in vitro h\u00fccre deneylerini birle\u015ftirerek do\u011frulam\u0131\u015ft\u0131r. Solanum nigrum'un etkili bile\u015feninin meme kanserinde MDA-MB-231 h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 inhibe edebilece\u011fi ve h\u00fccre apoptozunu ind\u00fckleyebilece\u011fi a\u00e7\u0131kt\u0131 ve diosgenin'in molek\u00fcler etki mekanizmas\u0131n\u0131 \u00f6nceden ara\u015ft\u0131rarak meme kanseri tedavisinde Solanum nigrum'un daha fazla ara\u015ft\u0131r\u0131lmas\u0131 i\u00e7in bir referans sa\u011flad\u0131.<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5475\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-151.png\" alt=\"\" width=\"1125\" height=\"419\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-151.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-151-768x286.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5476\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-137.png\" alt=\"\" width=\"1125\" height=\"396\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-137.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-137-768x270.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5477\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-130.png\" alt=\"\" width=\"1125\" height=\"734\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-130.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-130-768x501.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-130-1104x720.png 1104w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5478\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-115.png\" alt=\"\" width=\"1125\" height=\"521\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-115.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-115-768x356.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5479\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-102.png\" alt=\"\" width=\"1125\" height=\"545\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-102.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-102-768x372.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5480\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-95.png\" alt=\"\" width=\"1125\" height=\"523\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-95.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-95-768x357.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5481\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-85.png\" alt=\"\" width=\"1125\" height=\"546\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-85.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-85-768x373.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5482\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-79.png\" alt=\"\" width=\"1125\" height=\"430\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-79.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-79-768x294.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5483\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-72.png\" alt=\"\" width=\"1125\" height=\"485\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-72.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-72-768x331.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5484\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-3.jpg\" alt=\"\" width=\"1223\" height=\"805\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-3.jpg 1223w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-3-768x506.jpg 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-3-1094x720.jpg 1094w\" sizes=\"(max-width: 1223px) 100vw, 1223px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5485\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-54.png\" alt=\"\" width=\"1125\" height=\"468\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-54.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-54-768x319.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5486\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-44.png\" alt=\"\" width=\"1125\" height=\"553\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-44.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-44-768x378.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5487\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-39.png\" alt=\"\" width=\"1125\" height=\"706\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-39.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-39-768x482.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5488\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-33.png\" alt=\"\" width=\"1125\" height=\"677\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-33.png 1125w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-33-768x462.png 768w\" sizes=\"(max-width: 1125px) 100vw, 1125px\" \/><br \/>\nSolanum nigrum geleneksel bir \u00c7in bitkisel ilac\u0131d\u0131r. Modern farmakoloji, Solanum nigrum'un \u00e7o\u011fu anti-t\u00fcm\u00f6r alan\u0131nda yo\u011funla\u015fan \u00e7e\u015fitli biyolojik aktivitelere sahip oldu\u011funu bulmu\u015ftur. \u00c7al\u0131\u015fmalar, aktif bile\u015feni olan diosgenin'in \u00e7e\u015fitli h\u00fccresel sinyal yollar\u0131n\u0131 d\u00fczenleyerek anti-t\u00fcm\u00f6r etkiler g\u00f6sterebilece\u011fini ve h\u00fccre b\u00fcy\u00fcmesi, farkl\u0131la\u015fma ve apoptoz gibi bir\u00e7ok \u00f6nemli molek\u00fcler hedefle yak\u0131ndan ili\u015fkili oldu\u011funu g\u00f6stermi\u015ftir.<br \/>\nTCMSP a\u011f farmakolojisi veri taban\u0131n\u0131n analizi yoluyla, bu \u00e7al\u0131\u015fmada fraxinol, \u03b2 - karoten, sitosterol, diosgenin, solanin, kolesterol ve kuersetin olmak \u00fczere yedi etkili aktif bile\u015fen taranm\u0131\u015ft\u0131r. Kesi\u015fim, Solanum nigrum'un aktif bile\u015fenlerinin ilgili hedeflerinin meme kanseri hastal\u0131\u011f\u0131 hedef tan\u0131t\u0131m hatt\u0131 yaz\u0131l\u0131m\u0131 VENNY 2.1 ile haritalanmas\u0131yla elde edilmi\u015ftir. Ayn\u0131 zamanda, PPI a\u011f analizi bu kesi\u015fim hedefleri aras\u0131nda yak\u0131n ili\u015fki oldu\u011funu g\u00f6stermi\u015ftir. \u00c7al\u0131\u015fmalar, kuersetin, Avustralya solanini ve sitosterol\u00fcn t\u00fcm\u00f6r h\u00fccresi proliferasyonunu inhibe etme ve t\u00fcm\u00f6r h\u00fccresi apoptozunu ind\u00fckleme gibi farmakolojik etkilere sahip oldu\u011funu g\u00f6stermi\u015ftir. Diosgenin, meme kanseri MCF-7 h\u00fccrelerinin ve Skp2 h\u00fccrelerinin apoptozunu te\u015fvik edebilir. Buradan, Solanum nigrum'un kuersetin, solanin, sitosterol ve dioscin gibi aktif bile\u015fenlerinin anti-t\u00fcm\u00f6r etkiler g\u00f6sterebilece\u011fi g\u00f6r\u00fclebilir.<br \/>\nBile\u015fik hedef a\u011f\u0131 diyagram\u0131na g\u00f6re, Solanum nigrum ve hastal\u0131k hedeflerinin kesi\u015fiminden sonra 110 hedef elde edilmi\u015ftir. Daha ileri taramalar, ERBB2, EGFR, KIT, SRC, ESR1, AKT1, MAPK1, PIK3CA, vb'nin Solanum nigrum'un meme kanseri tedavisinde etkili bile\u015fenlerinin hedef proteinleri oldu\u011funu buldu. Bunlar aras\u0131nda resveratrol, diosgenin ve kuersetin AKT1 ve EGFR hedefleri \u00fczerinde etkilidir ve AKT (serin\/treonin kinaz) ve EGFR (epidermal b\u00fcy\u00fcme fakt\u00f6r\u00fc resept\u00f6r\u00fc) h\u00fccre proliferasyonu, g\u00f6\u00e7\u00fc ve metabolizmas\u0131nda \u00f6nemli roller oynar. Bu nedenle, AKT ve EGFR'nin hedeflenmesi meme kanseri i\u00e7in \u00e7ok cazip bir tedavi stratejisidir. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, AKT1 ve EGFR ve di\u011fer hedeflerin meme kanseri geli\u015fiminde \u00f6nemli bir rol oynad\u0131\u011f\u0131n\u0131 ve Solanum nigrum'un meme kanseri tedavisinde potansiyel hedefler olabilece\u011fini g\u00f6stermektedir. GO zenginle\u015ftirme analizi, Solanum nigrum'un meme kanserine kar\u015f\u0131 hedef genlerinin, kinaz aktivitesinin pozitif d\u00fczenlenmesi, ba\u011flay\u0131c\u0131 protein serin \/ treonin kinaz aktivitesi, MAPK kaskad\u0131n\u0131n pozitif d\u00fczenlenmesi, PI3K sinyalinin pozitif d\u00fczenlenmesi, ATP ba\u011flanmas\u0131 gibi biyolojik s\u00fcre\u00e7leri i\u00e7erdi\u011fini g\u00f6stermektedir. Bu kilit s\u00fcre\u00e7ler Solanum nigrum'un meme kanseri tedavisinde \u00f6nemli bir rol oynamaktad\u0131r. KEGG sonu\u00e7lar\u0131, kanser yolu, PI3K\/Akt sinyal yolu, EGFR tirozin kinaz inhibit\u00f6r\u00fc diren\u00e7 sinyal yolu, ErbB sinyal yolu, MAPK sinyal yolu, Ras sinyal yolu, Rap1 sinyal yolu vb. dahil olmak \u00fczere toplam 137 sinyal yolunun zenginle\u015ftirildi\u011fini g\u00f6stermi\u015ftir.<br \/>\nSolanum nigrum'un temel aktif bile\u015fenleri ve hedef proteinleri aras\u0131ndaki yak\u0131nl\u0131\u011f\u0131 ara\u015ft\u0131rmak i\u00e7in molek\u00fcler yerle\u015ftirme teknolojisi kullan\u0131lm\u0131\u015ft\u0131r. Sonu\u00e7lar, kuersetin, sitosterol ve diosgenin gibi aktif bile\u015fenlerin hedef AKT1, EGFR, ESR1, SRC ve MAPK ile iyi ba\u011flanma aktivitesine sahip oldu\u011funu g\u00f6stermi\u015ftir; bu da Solanum nigrum, sitosterol ve kuersetinin ana aktif bile\u015fenlerinin meme kanseri tedavisindeki ana mekanizmas\u0131n\u0131n yukar\u0131daki aktif bile\u015fenler ve hedeflerle yak\u0131ndan ili\u015fkili olabilece\u011fini yans\u0131tmaktad\u0131r. Solanum nigrum, birden fazla hedef ve birden fazla sinyal yolu arac\u0131l\u0131\u011f\u0131yla meme kanseri \u00fczerinde belirli bir terap\u00f6tik etkiye sahip olabilir.<br \/>\nMolek\u00fcler yerle\u015ftirme ara\u015ft\u0131rmas\u0131n\u0131n sonu\u00e7lar\u0131na dayanarak, Solanum nigrum'un ana aktif bile\u015feni olan Diosgenin, anti-t\u00fcm\u00f6r deneyleri i\u00e7in se\u00e7ildi ve Diosgenin'in \u00f6ng\u00f6r\u00fclen hedefleri EGFR ve AKT1 \u00fczerindeki d\u00fczenleyici etkisi do\u011fruland\u0131. Diosgenin'in meme kanserine kar\u015f\u0131 potansiyel mekanizmas\u0131n\u0131 ara\u015ft\u0131rmak. Deneysel sonu\u00e7lar, diosgenin'in MDA-MB-231 h\u00fccrelerinin proliferasyonunu inhibe edebilece\u011fini ve MDA-MB-231 h\u00fccrelerinin apoptozunu ind\u00fckleyebilece\u011fini g\u00f6stermi\u015ftir. Dioscin, h\u00fccrelerde EGFR proteininin ekspresyonunu azaltabilir ve AKT1 proteininin ekspresyonunu art\u0131rabilir. Dioscin'in AKT'nin fosforilasyon seviyesini d\u00fc\u015f\u00fcrebilece\u011fini ve ayn\u0131 zamanda pro apoptotik protein Bax'\u0131n ekspresyonunu yukar\u0131 ve anti apoptotik protein Bcl-2'nin ekspresyonunu a\u015fa\u011f\u0131 d\u00fczenleyebilece\u011fini belirtmek gerekir.<br \/>\n\u00d6zetle, bu \u00e7al\u0131\u015fma Solanum nigrum'un ana aktif bile\u015fenlerini analiz etmek ve taramak i\u00e7in a\u011f farmakolojisi veri platformunu uygulam\u0131\u015f ve Solanum nigrum'un meme kanseri tedavisinde \u00e7ok bile\u015fenli, \u00e7ok hedefli, \u00e7ok yollu mekanizmas\u0131n\u0131 analiz etmi\u015f ve in vitro deneysel do\u011frulama ger\u00e7ekle\u015ftirmi\u015ftir. Sonu\u00e7lar, Solanum nigrum'un meme kanseri tedavisinde rol oynamak i\u00e7in AKT1, EGFR ve di\u011fer hedefler \u00fczerinde etkili olabilece\u011fini g\u00f6stererek, meme kanseri tedavisinde Solanum nigrum'un ilgili mekanizmas\u0131 ve Solanum nigrum'un sonraki klinik uygulama ara\u015ft\u0131rmalar\u0131 hakk\u0131nda daha derinlemesine ara\u015ft\u0131rma i\u00e7in fikir ve temel sa\u011flam\u0131\u015ft\u0131r.<\/p>\n<\/section>","protected":false},"excerpt":{"rendered":"<p>Solanum nigrum'un meme kanseri tedavisindeki mekanizmas\u0131n\u0131 a\u011f farmakolojisi, molek\u00fcler yerle\u015ftirme teknolojisi ve in vitro deneysel do\u011frulamaya dayal\u0131 olarak ke\u015ffedin Meme kanseri, d\u00fcnyadaki kad\u0131nlar aras\u0131nda en yayg\u0131n malign t\u00fcm\u00f6rlerden biridir ve ayn\u0131 zamanda kad\u0131nlar aras\u0131nda kansere ba\u011fl\u0131 \u00f6l\u00fcmlerin ana nedenidir. Risk [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Explore the mechanism of Solanum nigrum in the treatment of breast cancer based on network pharmacology, molecular docking technology and in vitro experimental verification - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/solanum-nigrum\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Explore the mechanism of Solanum nigrum in the treatment of breast cancer based on network pharmacology, molecular docking technology and in vitro experimental verification - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Explore the mechanism of Solanum nigrum in the treatment of breast cancer based on network pharmacology, molecular docking technology and in vitro experimental verification Breast cancer is one of the most common malignant tumors among women in the world, and it is also the main cause of cancer related deaths among women. 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