{"id":5435,"date":"2024-08-04T18:58:34","date_gmt":"2024-08-04T18:58:34","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5435"},"modified":"2024-08-04T18:58:34","modified_gmt":"2024-08-04T18:58:34","slug":"research-on-non-coumarin-components-in-bai-zhi","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/bai-zhideki\u0307-kumari\u0307n-olmayan-bi\u0307lesenler-uzeri\u0307ne-arastirma\/","title":{"rendered":"Bai Zhi'deki Kumarin Olmayan Bile\u015fenler \u00dczerine Ara\u015ft\u0131rma"},"content":{"rendered":"<p>Bai Zhi'deki Kumarin Olmayan Bile\u015fenler \u00dczerine Ara\u015ft\u0131rma<br \/>\nBai Zhi, Umbelliferae familyas\u0131ndan bir bitki olan Angelica dahurica (Fisch. ex Hoffm.) Benth Et Hook. f. veya Hangbaizhi A dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. var. formosana (Boiss.) Shan et Yuan'\u0131n kurutulmu\u015f k\u00f6kleridir. Baharatl\u0131 tat, s\u0131cak do\u011fa. Semptomlar\u0131 hafifletme, so\u011fu\u011fu giderme, r\u00fczgar\u0131 giderme ve a\u011fr\u0131y\u0131 hafifletme, burun a\u00e7may\u0131 te\u015fvik etme, nemi kurutma ve kemerleri durdurma, \u015fi\u015flik ve irini azaltma etkilerine sahiptir. Klinik uygulamada, so\u011fuk alg\u0131nl\u0131\u011f\u0131, ba\u015f a\u011fr\u0131s\u0131, ka\u015f a\u011fr\u0131s\u0131, burun t\u0131kan\u0131kl\u0131\u011f\u0131, burun ak\u0131nt\u0131s\u0131, burun t\u0131kan\u0131kl\u0131\u011f\u0131, burun sin\u00fcziti, di\u015f a\u011fr\u0131s\u0131, vajinal ak\u0131nt\u0131, bo\u011faz ve a\u011fr\u0131l\u0131 yaralar vb. tedavisinde kullan\u0131l\u0131r. Angelica dahurica klinik uygulamada yayg\u0131n olarak kullan\u0131lan d\u00f6kme t\u0131bbi malzemelerden biridir. \u0130statistiklere g\u00f6re, bug\u00fcne kadar, Angelica dahurica i\u00e7eren 565 \u00e7e\u015fit geleneksel \u00c7in patentli ila\u00e7 ve basit preparat, geleneksel \u00c7in patentli ila\u00e7lar ve basit preparatlar re\u00e7ete veri taban\u0131na dahil edilmi\u015f ve Angelica dahurica i\u00e7eren 1836 re\u00e7ete geleneksel \u00c7in t\u0131bb\u0131 re\u00e7ete veri taban\u0131na dahil edilmi\u015ftir. Farmakolojik madde temelini ayd\u0131nlatmak i\u00e7in, bilim adamlar\u0131 Bai Zhi'den bir dizi kumarin bile\u015fenini izole etmi\u015f ve tan\u0131mlam\u0131\u015ft\u0131r. Buna ek olarak, Bai Zhi'nin bol miktarda flavonoid i\u00e7erdi\u011fine dair literat\u00fcr raporlar\u0131 vard\u0131r, ancak \u015fu anda Bai Zhi'den flavonoid monomerlerin izolasyonu ve safla\u015ft\u0131r\u0131lmas\u0131yla ilgili herhangi bir rapor bulunmamaktad\u0131r. Angelica dahurica'n\u0131n kimyasal bile\u015fimi \u00fczerine yap\u0131lan \u00f6n sistematik \u00e7al\u0131\u015fmada, ara\u015ft\u0131rma ekibi Angelica dahurica'n\u0131n b\u00fcy\u00fck miktarda kumarin bile\u015fenine ek olarak, alkaloidler ve flavonoidler gibi kumarin olmayan bile\u015fenler de i\u00e7erebilece\u011fini bulmu\u015ftur. LC-MS k\u0131lavuzlu ay\u0131rma teknolojisi kullan\u0131larak, Angelica dahurica'dan yap\u0131sal olarak \u00e7ok say\u0131da yeni kumarin dimeri ba\u015far\u0131yla ke\u015ffedildi ve Hangbai dahurica'n\u0131n etanol \u00f6z\u00fct\u00fcn\u00fcn y\u00fcksek polariteli k\u0131s\u0131mlar\u0131 incelendi. On alt\u0131 pirol alkaloidi ba\u015far\u0131yla izole edilmi\u015f ve tan\u0131mlanm\u0131\u015ft\u0131r. Bu makalede ayr\u0131ca Angelica dahurica'n\u0131n suda \u00e7\u00f6z\u00fcnen k\u0131s\u0131mlar\u0131ndan kumarin olmayan bile\u015fiklerin izolasyonu ve tan\u0131mlanmas\u0131 rapor edilmektedir.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5436\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-146.png\" alt=\"\" width=\"1213\" height=\"600\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-146.png 1213w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-146-768x380.png 768w\" sizes=\"(max-width: 1213px) 100vw, 1213px\" \/>Angelica dahurica'n\u0131n kimyasal bile\u015fimi hakk\u0131ndaki literat\u00fcrde, genellikle Angelica dahurica'daki ana kimyasal bile\u015fenlerin kumarin bile\u015fikleri oldu\u011funa inan\u0131l\u0131rken, Angelica dahurica'daki kumarin olmayan bile\u015fikler hakk\u0131nda \u00e7ok az rapor vard\u0131r. Lu ve arkada\u015flar\u0131 bir keresinde Angelica dahurica'dan pirolik bir alkaloid olan kumarini izole etmi\u015f ve tan\u0131mlam\u0131\u015flard\u0131r. Angelica dahurica \u00fczerine yapt\u0131\u011f\u0131m\u0131z sistematik \u00e7al\u0131\u015fmada, ara\u015ft\u0131rma grubumuz sadece \u00e7ok miktarda kumarin ve kumarin dimeri izole etmekle kalmam\u0131\u015f, ayn\u0131 zamanda Angelica dahurica'dan 16 pirolik alkaloid izole ederek kimyasal bile\u015fimi hakk\u0131ndaki anlay\u0131\u015f\u0131m\u0131z\u0131 zenginle\u015ftirmi\u015ftir. Bai Zhi'nin kimyasal bile\u015fimi \u00fczerine yap\u0131lan daha ileri ara\u015ft\u0131rmalarda, bu makalede bildirilen kumarin olmayan 18 bile\u015fen beklenmedik bir \u015fekilde izole edilmi\u015ftir. Daha \u00f6nce bildirilen Jin Qian Cao alkaloidine ek olarak, 9 flavonoid, 5 lignan, 2 basit fenolik ester ve 1-H-imidazo [4,5-d] pyridazin-2-amin dahil olmak \u00fczere di\u011fer 17 kumarin olmayan bile\u015fenin t\u00fcm\u00fc ilk kez Bai Zhi'den izole edilmi\u015ftir. Bile\u015fik 3 ve 18, n\u00f6trofillerden zimosan kaynakl\u0131 s\u00fcperoksit sal\u0131n\u0131m\u0131 \u00fczerinde belirli inhibit\u00f6r etkilere sahipken, bile\u015fik 1 ve 18, RAW 264.7 h\u00fccrelerinden NO aktivitesinin sal\u0131n\u0131m\u0131 \u00fczerinde inhibit\u00f6r etkilere sahiptir. Angelica dahurica'da flavonoidlerin varl\u0131\u011f\u0131na ili\u015fkin \u00e7ok say\u0131da literat\u00fcr raporu olmas\u0131na ra\u011fmen, bunlar\u0131n hepsinin toplam flavonoid i\u00e7eri\u011finin belirlenmesine ili\u015fkin \u00f6n raporlar oldu\u011funu belirtmek gerekir. \u015eu anda, Angelica dahurica'dan monomerik flavonoidlerin izolasyonu ile ilgili herhangi bir rapor bulunmamaktad\u0131r. Ancak bu \u00e7al\u0131\u015fmada, Angelica dahurica'dan ilk kez \u00e7oklu flavonoidler ve flavonoid glikozit monomerleri elde edildi ve bu bizi \u00e7ok \u015fa\u015f\u0131rtt\u0131. Bunun t\u0131bbi malzemelerle ilgili bir sorun olup olmad\u0131\u011f\u0131ndan \u015f\u00fcphe etmi\u015ftik, ancak bu makalede izole edilen ve rapor edilen 1, 6, 7 ve 8 numaral\u0131 bile\u015fiklerin ileri analizi, LC-MS kullan\u0131larak \u00fc\u00e7 farkl\u0131 k\u00f6kenden, Hangbai, Chuanbai ve Yubai'den Angelica dahurica'da bulundu. Bu durum, 1, 6, 7 ve 8 numaral\u0131 bile\u015fiklerin farkl\u0131 k\u00f6kenlerden gelen Angelica dahurica'da tespit edilebilece\u011fini g\u00f6stermektedir. Bai Zhi ger\u00e7ekten de flavonoidler i\u00e7erebilir. Ara\u015ft\u0131rma sonu\u00e7lar\u0131 Angelica dahurica'n\u0131n kimyasal bile\u015fiminin anla\u015f\u0131lmas\u0131n\u0131 zenginle\u015ftirmi\u015f ve kalite kontrol\u00fc, geli\u015ftirilmesi ve kullan\u0131m\u0131 i\u00e7in \u00f6nemli referanslar sa\u011flam\u0131\u015ft\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"<p>Research on Non coumarin Components in Bai Zhi Bai Zhi is a plant in the Umbelliferae family, Angelica dahurica (Fisch. ex Hoffm.) Benth Et Hook. f. or Hangbaizhi A dahurica (Fisch. ex Hoffm.) Benth. et Hook. f. var. formosana (Boiss.) Shan et Yuan&#8217;s dried roots. Spicy taste, warm nature. It has the effects of relieving [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research on Non coumarin Components in Bai Zhi - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/bai-zhideki\u0307-kumari\u0307n-olmayan-bi\u0307lesenler-uzeri\u0307ne-arastirma\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research on Non coumarin Components in Bai Zhi - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Research on Non coumarin Components in Bai Zhi Bai Zhi is a plant in the Umbelliferae family, Angelica dahurica (Fisch. ex Hoffm.) 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