{"id":5289,"date":"2024-08-04T18:15:20","date_gmt":"2024-08-04T18:15:20","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5289"},"modified":"2024-08-04T18:15:20","modified_gmt":"2024-08-04T18:15:20","slug":"dihydromyricetin-2","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/dihidromirisetin-2\/","title":{"rendered":"Dihidromirisetinin db\/db farelerde renal fibrozisi iyile\u015ftirme mekanizmas\u0131n\u0131n a\u011f farmakolojisi ve deneysel do\u011frulamaya dayal\u0131 olarak ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"<p>Dihidromirisetinin db\/db farelerde renal fibrozisi iyile\u015ftirme mekanizmas\u0131n\u0131n a\u011f farmakolojisi ve deneysel do\u011frulamaya dayal\u0131 olarak ara\u015ft\u0131r\u0131lmas\u0131<br \/>\nDiyabet nefropatisi (DKH), tip 2 diabetes mellitusun (T2DM) ba\u015fl\u0131ca mikrovask\u00fcler komplikasyonlar\u0131ndan biridir ve son d\u00f6nem b\u00f6brek hastal\u0131\u011f\u0131n\u0131n ana nedenidir. Ba\u015fl\u0131ca \u00f6zellikleri glomer\u00fcler bazal membran\u0131n kal\u0131nla\u015fmas\u0131, mezenter ve tubulointerstisyel matriksin geni\u015flemesi ve podosit kayb\u0131 olup mikroalb\u00fcmin\u00fcri geli\u015fimine ve b\u00f6brek fonksiyonlar\u0131nda azalmaya yol a\u00e7ar. Diyabetik b\u00f6brek hastal\u0131\u011f\u0131n\u0131n (DKH) s\u00fcrekli geli\u015fmesiyle birlikte, b\u00f6brek dokusunun mikro yap\u0131s\u0131 kal\u0131c\u0131 inflamasyon ve hasara u\u011frayarak normal b\u00f6brek mikro yap\u0131s\u0131n\u0131 tahrip eden ve nihayetinde renal fibrozise (RF) d\u00f6n\u00fc\u015fen yayg\u0131n interstisyel fibrozise yol a\u00e7ar. \u015eu anda, DKH'nin RF'ye ilerlemesini hafifletme ara\u00e7lar\u0131 esas olarak DKH'yi iyile\u015ftirmeye odaklanmaktad\u0131r. Bununla birlikte, DKD de dahil olmak \u00fczere diyabetin \u00e7o\u011fu komplikasyonunun mekanizmas\u0131 hen\u00fcz a\u00e7\u0131kl\u0131\u011fa kavu\u015fturulmam\u0131\u015ft\u0131r, bu nedenle DKD'nin RF'ye d\u00f6n\u00fc\u015fme s\u00fcrecindeki karma\u015f\u0131k mekanizma net de\u011fildir ve bu da DKD ve RF'nin tatmin edici olmayan terap\u00f6tik etkilerine yol a\u00e7maktad\u0131r. Bu nedenle, DKD'nin patogenezini ara\u015ft\u0131rmak ve geli\u015fimini engellemek i\u00e7in yeni terap\u00f6tik hedefler ke\u015ffetmek acildir.<br \/>\nDihidromirisetin (DHM), anti-enflamatuar, antioksidan, serbest radikal temizleme, mitokondriyal disfonksiyonun iyile\u015ftirilmesi ve otofajinin d\u00fczenlenmesi dahil olmak \u00fczere \u00e7e\u015fitli farmakolojik etkilere sahip do\u011fal bir flavonoid bile\u015fiktir. \u015eu anda, bir\u00e7ok \u00e7al\u0131\u015fma DHM'nin metabolik hastal\u0131klar\u0131n tedavisinde b\u00fcy\u00fck bir potansiyele sahip oldu\u011funu g\u00f6stermi\u015ftir. Otofajiyi ind\u00fckleyerek, oksidatif stresi iyile\u015ftirerek, inflamasyonu inhibe ederek ve mitokondriyal aktiviteyi art\u0131rarak sadece ins\u00fclin direncini iyile\u015ftirmek ve kan glukoz seviyelerini d\u00fc\u015f\u00fcrmekle kalmaz, ayn\u0131 zamanda; diyabet ensefalopatisi, diyabet kardiyomiyopatisi gibi diyabetin bir\u00e7ok komplikasyonunu da iyile\u015ftirebilir. Bununla birlikte, diyabetin komplikasyonlar\u0131n\u0131 iyile\u015ftiren DHM \u00fczerine yap\u0131lan ara\u015ft\u0131rmalar yeterli de\u011fildir ve ilgili farmakolojik mekanizman\u0131n hala daha fazla ara\u015ft\u0131r\u0131lmas\u0131 gerekmektedir. Buna ek olarak, DHM'nin DHM'nin neden oldu\u011fu RF'yi daha da iyile\u015ftirip iyile\u015ftiremeyece\u011fi konusunda s\u0131n\u0131rl\u0131 ara\u015ft\u0131rma vard\u0131r ve terap\u00f6tik etki hala belirsizdir.<br \/>\nA\u011f farmakolojisi, geleneksel \u00c7in t\u0131bb\u0131 bile\u015fenlerinin yap\u0131s\u0131na, biyolojik etkilerine ve geni\u015f bir biyolojik s\u00fcre\u00e7 a\u011f\u0131 ba\u011flam\u0131nda hastal\u0131kla ilgili hedeflere dayal\u0131 bir \"ila\u00e7 bile\u015feni hedef hastal\u0131\u011f\u0131\" etkile\u015fim a\u011f\u0131 olu\u015fturabilir. Geleneksel \u00c7in t\u0131bb\u0131n\u0131n etkili bile\u015fenlerini, molek\u00fcler mekanizmalar\u0131n\u0131 ve potansiyel hedeflerini ke\u015ffetmenin etkili bir yoludur. Molek\u00fcler yerle\u015ftirme, molek\u00fcller ve proteinler aras\u0131ndaki etkile\u015fimi sim\u00fcle edebilir, ligandlar\u0131n ve resept\u00f6rlerin konformasyonunu tahmin edebilir, ila\u00e7 bile\u015fenlerinin ana hedefler \u00fczerindeki spesifik etki \u015feklini do\u011frulamak i\u00e7in afinite ve ba\u011flanma modlar\u0131n\u0131 hesaplayabilir ve tahmin edebilir. Bu nedenle, bu \u00e7al\u0131\u015fmada DHM'nin DKD ve RF \u00fczerindeki potansiyel hedeflerini taramak ve tahmin etmek i\u00e7in a\u011f farmakolojisi kullan\u0131lm\u0131\u015f, bir \"bile\u015fen hedef hastal\u0131\u011f\u0131\" etkile\u015fim a\u011f\u0131 olu\u015fturulmu\u015f ve tahmin edilen ana hedefler molek\u00fcler yerle\u015ftirme ve in vivo deneyler yoluyla do\u011frulanm\u0131\u015ft\u0131r. Dihidromirisetinin db\/db farelerde renal fibrozu iyile\u015ftirmesinin molek\u00fcler mekanizmas\u0131 ara\u015ft\u0131r\u0131lm\u0131\u015f ve DHM'nin klinik uygulamas\u0131 i\u00e7in teorik bir temel sa\u011flanm\u0131\u015ft\u0131r.<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5290\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-134.png\" alt=\"\" width=\"342\" height=\"209\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5291\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-121.png\" alt=\"\" width=\"355\" height=\"214\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5292\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-115.png\" alt=\"\" width=\"758\" height=\"279\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5293\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-103.png\" alt=\"\" width=\"769\" height=\"320\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5294\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-92.png\" alt=\"\" width=\"759\" height=\"196\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5295\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-85.png\" alt=\"\" width=\"726\" height=\"928\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-85.png 726w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-85-563x720.png 563w\" sizes=\"(max-width: 726px) 100vw, 726px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5296\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-76.png\" alt=\"\" width=\"642\" height=\"280\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5297\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-71.png\" alt=\"\" width=\"635\" height=\"302\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5298\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-64.png\" alt=\"\" width=\"698\" height=\"718\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5299\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-52.png\" alt=\"\" width=\"703\" height=\"339\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5300\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-46.png\" alt=\"\" width=\"742\" height=\"256\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5301\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-39.png\" alt=\"\" width=\"693\" height=\"318\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5302\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-34.png\" alt=\"\" width=\"699\" height=\"350\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5303\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-29.png\" alt=\"\" width=\"694\" height=\"292\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5304\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-22.png\" alt=\"\" width=\"735\" height=\"479\" \/><br \/>\nG\u00fcn\u00fcm\u00fczde, diyabetin yayg\u0131n tedavisi esas olarak kan \u015fekerinin kontrol\u00fcne ba\u011fl\u0131yken, diyabetin en ciddi komplikasyonlar\u0131ndan biri olan DKH'nin etkili bir tedavi stratejisi yoktur. Bu nedenle, DKH'nin patogenezini derinlemesine anlamak ve DKH'nin renal fibrozise d\u00f6n\u00fc\u015fme e\u011filimini bast\u0131rmak i\u00e7in etkili tedavi stratejileri bulmak \u00e7ok \u00f6nemlidir. Do\u011fal ila\u00e7lar\u0131n daha az yan etki ve \u00e7ok hedefli etkinlik gibi benzersiz avantajlara sahip oldu\u011fu kan\u0131tlanm\u0131\u015ft\u0131r ve bu da onlar\u0131 son y\u0131llarda kronik hastal\u0131klara y\u00f6nelik yeni ila\u00e7lar\u0131n geli\u015ftirilmesi i\u00e7in \u00f6nemli bir kaynak haline getirmektedir. DHM \u00fczerine yap\u0131lan ileri ara\u015ft\u0131rmalar, metabolik hastal\u0131klar\u0131n iyile\u015ftirilmesinde \u00f6nemli bir terap\u00f6tik potansiyel ortaya koymu\u015ftur. Bu nedenle, DHM ile db\/db farelerde renal fibrozisin iyile\u015ftirilmesine dayanan bu \u00e7al\u0131\u015fma, db\/db farelerde renal fibrozisin iyile\u015ftirilmesinde DHM'nin potansiyel terap\u00f6tik hedeflerini ve molek\u00fcler mekanizmalar\u0131n\u0131 ke\u015ffetmek i\u00e7in a\u011f farmakolojisi ve molek\u00fcler yerle\u015ftirme teknolojisini birle\u015ftirmekte ve bunlar\u0131 hayvan deneyleri yoluyla do\u011frulamaktad\u0131r.<\/p>\n<p>\u0130lk olarak, 10 haftal\u0131k DHM m\u00fcdahalesinin db\/db farelerde kan \u015fekeri, v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131, kreatinin, \u00fcre nitrojen, idrar proteini ve b\u00f6brek patolojik belirtilerini etkili bir \u015fekilde hafifletebildi\u011fini g\u00f6zlemledik; bu da DHM'nin b\u00f6brek fonksiyon hasar\u0131n\u0131 hafifletebilece\u011fini ve db\/db farelerde DKD geli\u015fimini yava\u015flatabilece\u011fini g\u00f6stermektedir. DHM, DKD ve RF'nin kesi\u015fen 37 hedefi analiz edilip tarand\u0131ktan sonra, AKT1, ALB, CASP3, EGFR, MMP9, IGF1, PPARG, KDR, MMP2, ACE dahil olmak \u00fczere 10 hedefin DHM'nin DKD'yi iyile\u015ftirmesi i\u00e7in anahtar hedefler olabilece\u011fi bulunmu\u015ftur. AKT1, CASP3, EGFR, MMP9, IGF1, MMP2, ACE'nin diyabet ortam\u0131nda aktive oldu\u011fu do\u011frulanm\u0131\u015ft\u0131r ve spesifik inhibisyon DKD'nin hasarl\u0131 durumunu iyile\u015ftirebilir ve fibrozis geli\u015fme e\u011filimini yava\u015flatabilir. PPARG ve KDR diyabetin fizyolojik ortam\u0131nda inhibe edilir ve aktivasyondan sonra renal korumada rol oynar. ALB, diyabet geli\u015fimi s\u0131ras\u0131nda b\u00f6brek hasar\u0131n\u0131n derecesini g\u00f6zlemlemek i\u00e7in \u00f6nemli bir biyokimyasal g\u00f6stergedir. Genellikle DKH'nin ortaya \u00e7\u0131kmas\u0131yla artar ve DKH'nin iyile\u015fmesinden sonra azal\u0131r. Bu, tarad\u0131\u011f\u0131m\u0131z 10 anahtar genin yaln\u0131zca DKD i\u00e7in potansiyel biyobelirte\u00e7ler olarak de\u011fil, ayn\u0131 zamanda DKD'nin patogenezini ve tedavisini daha fazla ara\u015ft\u0131rmak i\u00e7in anahtar hedefler olarak da hizmet edebilece\u011fi anlam\u0131na gelir.<\/p>\n<p>KEGG yolak zenginle\u015ftirme analizi, DHM'nin DKD \u00fczerindeki iyile\u015fmesinin AGE-RAGE sinyal yola\u011f\u0131, diyabet kardiyomiyopatisi ve FoxO sinyal yola\u011f\u0131n\u0131 i\u00e7erebilece\u011fini g\u00f6stermi\u015ftir. AGE-RAGE sinyal yolu ve FoxO sinyal yolu, DKD'nin geli\u015fiminde kilit d\u00fczenleyici roller oynamaktad\u0131r. Ara\u015ft\u0131rmalar, AGE'lerin \u00f6zellikle endotel h\u00fccrelerinde, renal t\u00fcb\u00fcllerde, mezangial h\u00fccrelerde ve DKD hastalar\u0131n\u0131n podositlerinde aktive oldu\u011funu ve RAGE ile etkile\u015fimlerinin artt\u0131\u011f\u0131n\u0131, b\u00f6breklerde oksidatif stres ve inflamasyonu daha da \u015fiddetlendirerek DKD'nin bozulmas\u0131na yol a\u00e7t\u0131\u011f\u0131n\u0131 bulmu\u015ftur. Buna ek olarak, aktive edilmi\u015f FoxO3a diyabet s\u0131\u00e7anlar\u0131n\u0131n b\u00f6bre\u011findeki oksidatif stres seviyesini inhibe edebilir, inflamasyonu iyile\u015ftirebilir ve ard\u0131ndan DKD olu\u015fumunu engelleyebilir. Bu da AGE-RAGE sinyal yolunun veya FoxO sinyal yolunun spesifik olarak d\u00fczenlenmesinin DKD'nin \u00f6nlenmesi ve tedavisi i\u00e7in b\u00fcy\u00fck \u00f6nem ta\u015f\u0131yabilece\u011fini g\u00f6stermektedir.<\/p>\n<p>Molek\u00fcler yerle\u015ftirme sonu\u00e7lar\u0131 DHM'nin se\u00e7ilen ilk 5 hedefle iyi bir ba\u011flanma afinitesi sergiledi\u011fini g\u00f6stererek DHM'nin DKD tedavisindeki etkinli\u011finin molek\u00fcler d\u00fczeyde do\u011fruland\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Ayr\u0131ca, taramada ilk s\u0131rada yer alan kilit hedef gen AKT1'in, KEGG yolunun zenginle\u015ftirme analizi yoluyla DKD geli\u015fiminde AGE-RAGE sinyal yolu ve FoxO sinyal yolu ile yak\u0131ndan ili\u015fkili oldu\u011funu fark ettik. AGE-RAGE sinyal yolu, PI3K\/Akt sinyal yolu ile sinerji olu\u015fturarak b\u00f6breklerde oksidatif stresi ve kronik enflamasyonu ind\u00fckleyebilir ve b\u00f6brek hastal\u0131\u011f\u0131na yol a\u00e7abilir. PI3K\/Akt\/FoxO3a yola\u011f\u0131n\u0131n aktivasyonu diyabette b\u00f6bre\u011fin fizyolojik i\u015flevini iyile\u015ftirebilir. Bu nedenle, AKT1 ve DHM'nin yukar\u0131 ak\u0131\u015f\u0131ndaki Notch yolu aras\u0131ndaki etkile\u015fimi ara\u015ft\u0131rmaya \u00e7al\u0131\u015ft\u0131k ve molek\u00fcler yerle\u015ftirme do\u011frulamas\u0131 yapt\u0131k. Molek\u00fcler kenetlenme sonu\u00e7lar\u0131 DHM'nin Notch1 ve PTEN ile iyi bir ba\u011flanma afinitesi sergiledi\u011fini g\u00f6stermi\u015ftir.<\/p>\n<p>\u00d6nceki \u00e7al\u0131\u015fmalar, Notch1, NICD, Hes1 ve Hey1'in artan ekspresyonu ile kendini g\u00f6steren DKD geli\u015fimi s\u0131ras\u0131nda Notch yola\u011f\u0131n\u0131n a\u015f\u0131r\u0131 aktive oldu\u011funu g\u00f6stermi\u015ftir. Notch1 inhibit\u00f6rleri Hes1 aktivasyonunu azaltarak PTEN'i aktive edebilir, b\u00f6ylece otofaji bozukluklar\u0131n\u0131 iyile\u015ftirebilir ve RF olu\u015fumunu yava\u015flatabilir. Buna ek olarak, di\u011fer \u00e7al\u0131\u015fmalar PTEN aktivasyonunun PI3K\/Akt yolunu inhibe ederek DKD'nin ilerlemesini de hafifletebilece\u011fini bulmu\u015ftur. Yukar\u0131daki sonu\u00e7lara dayanarak, DHM'nin Notch\/PTEN\/AKT yolunu d\u00fczenleyerek DKD'yi iyile\u015ftirebilece\u011fini d\u00fc\u015f\u00fcn\u00fcyoruz. Western blot sonu\u00e7lar\u0131, db\/db farelerin b\u00f6breklerinde Notch yolunun aktivasyonunda anormal bir art\u0131\u015f, PTEN ekspresyonunda bir azalma ve AKT fosforilasyonunda bir art\u0131\u015f oldu\u011funu g\u00f6stermi\u015ftir. DHM al\u0131m\u0131 Notch yolunun aktivasyonunu engelleyebilir, PTEN'i aktive edebilir ve AKT fosforilasyonunu inhibe edebilir. B\u00fct\u00fcn bir yol olarak Notch\/PTEN\/AKT sinyal ekseni diyabette b\u00f6brek korumas\u0131 \u00fczerine nadiren \u00e7al\u0131\u015f\u0131lm\u0131\u015f olsa da, ara\u015ft\u0131rmam\u0131z ilgili ara\u015ft\u0131rmalar\u0131 belirli bir \u00f6l\u00e7\u00fcde geli\u015ftirmi\u015f ve DHM'nin biyolojik korumas\u0131n\u0131n molek\u00fcler mekanizmas\u0131n\u0131 birden fazla hedef arac\u0131l\u0131\u011f\u0131yla zenginle\u015ftirmi\u015ftir.<\/p>\n<p>\u00d6zetle, DHM'nin DKD'nin patolojik belirtilerini iyile\u015ftirdi\u011fi g\u00f6zlemine dayanan bu \u00e7al\u0131\u015fma, DHM'nin DKD'nin ilerlemesini iyile\u015ftirmedeki rol\u00fcn\u00fcn AKT1, ALB, CASP3, EGFR, MMP9, IGF1, PPARG, KDR, MMP2, ACE gibi kilit hedefler arac\u0131l\u0131\u011f\u0131yla elde edilebilece\u011fini \u00f6nceden g\u00f6stermek i\u00e7in a\u011f farmakolojisi ve molek\u00fcler yerle\u015ftirme teknolojisini birle\u015ftirdi ve ilgili yollar\u0131 analiz etti; Son olarak, hayvan deneyleri yoluyla DHM'nin potansiyel AKT hedefleri \u00fczerinde \u00f6n do\u011frulama ve analizler yap\u0131lm\u0131\u015f ve DHM'nin Notch\/PTEN\/AKT yolunu d\u00fczenleyerek DKD'nin \u00f6nlenmesi ve tedavisinde rol oynayabilece\u011fi bulunmu\u015ftur (bkz. \u015eekil 14). Ancak \u015fu anda DHM'nin T2DM'deki komplikasyonlar\u0131 hakk\u0131nda nispeten az ara\u015ft\u0131rma bulunmaktad\u0131r ve tedavi potansiyelinin hala daha fazla ara\u015ft\u0131r\u0131lmas\u0131 gerekmektedir.<\/p>","protected":false},"excerpt":{"rendered":"<p>Exploring the mechanism of dihydromyricetin in improving renal fibrosis in db\/db mice based on network pharmacology and experimental verification Diabetes nephropathy (DKD) is one of the major microvascular complications of type 2 diabetes mellitus (T2DM) and the main cause of end-stage renal disease. Its main characteristics are thickening of the glomerular basement membrane, expansion of [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Exploring the mechanism of dihydromyricetin in improving renal fibrosis in db\/db mice based on network pharmacology and experimental verification - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/dihidromirisetin-2\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the mechanism of dihydromyricetin in improving renal fibrosis in db\/db mice based on network pharmacology and experimental verification - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the mechanism of dihydromyricetin in improving renal fibrosis in db\/db mice based on network pharmacology and experimental verification Diabetes nephropathy (DKD) is one of the major microvascular complications of type 2 diabetes mellitus (T2DM) and the main cause of end-stage renal disease. 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