{"id":5277,"date":"2024-08-04T18:08:09","date_gmt":"2024-08-04T18:08:09","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5277"},"modified":"2024-08-04T18:08:09","modified_gmt":"2024-08-04T18:08:09","slug":"grass-fruit-on-%ce%b1-glucosidase","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/\u03b1-glukozidaz-uzerinde-cim-meyvesi\/","title":{"rendered":"\u00c7im Meyvesinin Kimyasal Bile\u015fimi ve \u03b1 - Glukozidaz \u00dczerindeki \u0130nhibisyon Aktivitesi \u00dczerine \u00c7al\u0131\u015fma"},"content":{"rendered":"

\u00c7im Meyvesinin Kimyasal Bile\u015fimi ve \u03b1 - Glukozidaz \u00dczerindeki \u0130nhibisyon Aktivitesi \u00dczerine \u00c7al\u0131\u015fma
\nAmomum tsao ko Crevost&Lemarie, zencefil ailesinin ve kakule cinsinin \u00e7ok y\u0131ll\u0131k otsu bitkileridir ve \u00e7o\u011funlukla \u00c7in'de Yunnan, Guangxi ve Guizhou gibi eyaletlerde da\u011f\u0131l\u0131m g\u00f6sterir. \u0130la\u00e7 olarak kullan\u0131lan meyveleri rutubeti kurutma, dala\u011f\u0131 canland\u0131rma, balgam\u0131 giderme ve s\u0131tmay\u0131 durdurma i\u015flevlerine sahiptir; aromatik ya\u011flar\u0131 \u00e7\u0131karmak i\u00e7in baharat olarak da kullan\u0131labilir ve bir t\u00fcr t\u0131bbi ve yenilebilir \u00e7ift kullan\u0131ml\u0131 \u00e7e\u015fittir. \u00c7in'de yayg\u0131n bir t\u0131bbi ve yenilebilir \u00e7e\u015fit olarak, \u00e7im meyvesinin kimyasal bile\u015fimi ve farmakolojik etkileri yayg\u0131n olarak incelenmi\u015ftir. Kimyasal bile\u015fim a\u00e7\u0131s\u0131ndan, u\u00e7ucu ya\u011f bile\u015fenlerine ek olarak, esas olarak flavonoidler, fenoller ve difenilheptanlar i\u00e7erir. Bunlar aras\u0131nda, flavonoidler \u00e7o\u011funlukla anti-enflamatuar ve antioksidan aktiviteleri, fenoller \u00e7o\u011funlukla antioksidan aktiviteleri ve difenilheptanlar anti-t\u00fcm\u00f6r ve \u03b1-glukozidaz inhibit\u00f6r aktiviteleri i\u00e7in yayg\u0131n olarak rapor edilmi\u015ftir.<\/p>\n

Diyabet, hiperglisemi ve \u00e7oklu komplikasyonlarla karakterize metabolik bir hastal\u0131kt\u0131r. Son y\u0131llarda, kardiyovask\u00fcler ve serebrovask\u00fcler hastal\u0131klar ve kanserden sonra \u00fc\u00e7\u00fcnc\u00fc \"sa\u011fl\u0131k katili\" haline gelmi\u015ftir. \u03b1 - glukozidaz inhibit\u00f6r\u00fc, yemek sonras\u0131 kan glikozunun zirvesini azaltarak diyabet geli\u015fimini, \u00f6zellikle komplikasyonlar\u0131n olu\u015fumunu kontrol edebilir. Diyabet tedavisi i\u00e7in umut verici bir ila\u00e7t\u0131r. Akarboz, vogliboz ve miglitol \u015fu anda klinik uygulamada en yayg\u0131n kullan\u0131lan \u03b1-glukozidaz inhibit\u00f6rleridir, ancak pahal\u0131d\u0131rlar, sindirim sistemi bozukluklar\u0131, \u015foka yol a\u00e7an hipoglisemi gibi yan etkileri vard\u0131r ve diyabet komplikasyonlar\u0131n\u0131 etkili bir \u015fekilde tedavi edemezler. Yeni \u03b1 - glukozidaz inhibit\u00f6rlerinin ke\u015ffedilmesi b\u00fcy\u00fck \u00f6nem ta\u015f\u0131maktad\u0131r. Ara\u015ft\u0131rmalar, \u00e7im meyvesinin kuru tozunun ve \u00f6z\u00fct\u00fcn\u00fcn hipoglisemik i\u015flevlere sahip oldu\u011funu ve \u03b1-glukozidaz ile ilgili aktiviteleri inhibe etti\u011fini g\u00f6stermi\u015ftir, ancak monomer bile\u015fenlerinin hipoglisemik etkileri \u00fczerine ilgili bir \u00e7al\u0131\u015fma yoktur. Bu \u00e7al\u0131\u015fmada \u00e7im meyvesi sistematik olarak ekstrakte edilip ayr\u0131\u015ft\u0131r\u0131lm\u0131\u015f ve monomer bile\u015fenlerinin t\u00fcr\u00fcn kimyasal \u00e7e\u015fitlili\u011fini zenginle\u015ftirdi\u011fi bulunmu\u015ftur. Geleneksel \u00c7in t\u0131bb\u0131n\u0131n klinik kullan\u0131m\u0131 i\u00e7in yeni fikirler sa\u011flamas\u0131 beklenen alfa glukozidaz\u0131 inhibe eden bile\u015fikler de ke\u015ffedilmi\u015ftir.<\/p>\n

\"\"\"\"\"\"\"\"
\nBu \u00e7al\u0131\u015fmada, geleneksel \u00c7in t\u0131bb\u0131 otu meyvesinden 11 bile\u015fik izole edilmi\u015ftir. Bile\u015fik 1, ilk kez do\u011fal bir \u00fcr\u00fcn olarak rapor edilen fenolik bir bile\u015fiktir. Bile\u015fik 2, 8 ve 9, kakule cinsinden ilk kez izole edilen fenolik ve ya\u011f asidi bile\u015fikleridir; \u03b1 - glukozidaz inhibisyon aktivitesi testi yoluyla, iki difenilheptan bile\u015fi\u011finin pazarlanan ila\u00e7 akarbozdan daha g\u00fc\u00e7l\u00fc aktiviteye sahip oldu\u011fu bulunmu\u015ftur. \u00d6nceki \u00e7al\u0131\u015fmalar, \u00e7im meyvesinin alkol ekstrakt\u0131n\u0131n \u03b1-glukozidaza kar\u015f\u0131 inhibit\u00f6r aktiviteye sahip oldu\u011funu g\u00f6sterirken, bu \u00e7al\u0131\u015fmadaki di\u011fer monomer bile\u015fenleri \u00f6nemli inhibit\u00f6r aktivite g\u00f6stermemi\u015ftir. Bu difenilheptan bile\u015fiklerinin, \u00e7im meyvesinin in vitro hipoglisemik etkisinin maddi temellerinden biri oldu\u011fu tahmin edilmektedir. \u03b1 - glukozidaz inhibit\u00f6r\u00fc, son y\u0131llarda tip 2 diyabetin klinik tedavisi i\u00e7in bir ila\u00e7 olarak yayg\u0131n bir \u015fekilde ilgilenilmektedir. Bu \u00e7al\u0131\u015fma sadece geleneksel bir \u00c7in ilac\u0131 olan Caoguo'nun bile\u015fenlerinin \u00e7e\u015fitlili\u011fini zenginle\u015ftirmekle kalmay\u0131p, ayn\u0131 zamanda monomer bile\u015fenleri ile \u03b1-glukozidaz aktivitesini inhibe ederek geleneksel bir \u00c7in ilac\u0131 olan Caoguo'nun yeni bir klinik uygulama yolunu ke\u015ffetmesi beklenmektedir.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the Chemical Composition and Inhibition Activity of Grass Fruit on \u03b1 – Glucosidase Amomum tsao ko Crevost&Lemarie are perennial herbaceous plants of the ginger family and cardamom genus, mainly distributed in provinces such as Yunnan, Guangxi, and Guizhou in China. Fruits used as medicine have the functions of drying dampness, invigorating the spleen, […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the Chemical Composition and Inhibition Activity of Grass Fruit on \u03b1 - Glucosidase - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/\u03b1-glukozidaz-uzerinde-cim-meyvesi\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the Chemical Composition and Inhibition Activity of Grass Fruit on \u03b1 - Glucosidase - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the Chemical Composition and Inhibition Activity of Grass Fruit on \u03b1 – Glucosidase Amomum tsao ko Crevost&Lemarie are perennial herbaceous plants of the ginger family and cardamom genus, mainly distributed in provinces such as Yunnan, Guangxi, and Guizhou in China. 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