{"id":5245,"date":"2024-08-04T18:00:50","date_gmt":"2024-08-04T18:00:50","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5245"},"modified":"2024-08-04T18:00:50","modified_gmt":"2024-08-04T18:00:50","slug":"atherosclerosis","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/ateroskleroz\/","title":{"rendered":"Morinda officinalis'in ateroskleroza kar\u015f\u0131 mekanizmas\u0131n\u0131n a\u011f farmakolojisi ve deneysel do\u011frulamaya dayal\u0131 olarak ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"

Morinda officinalis'in ateroskleroza kar\u015f\u0131 mekanizmas\u0131n\u0131n a\u011f farmakolojisi ve deneysel do\u011frulamaya dayal\u0131 olarak ara\u015ft\u0131r\u0131lmas\u0131
\nAteroskleroz (AS), b\u00fcy\u00fck ve orta arterlerin intimas\u0131nda aterosklerotik plak veya fibr\u00f6z plak olu\u015fumu ile karakterize yayg\u0131n bir kronik kardiyovask\u00fcler hastal\u0131kt\u0131r. Lipidlerin arteriyel intimaya infiltrasyonu aterosklerozun ana patogenezi haline gelmi\u015ftir. \u0130ntima ve medyada toplanan makrofajlar, k\u00f6p\u00fck h\u00fccreleri olu\u015fturmak i\u00e7in h\u00fccre zar\u0131ndaki \u00e7\u00f6p\u00e7\u00fc resept\u00f6rleri arac\u0131l\u0131\u011f\u0131yla b\u00fcy\u00fck miktarda oksitlenmi\u015f d\u00fc\u015f\u00fck yo\u011funluklu lipoproteini (ox LDL) yutar, bu da h\u00fccrelerin h\u00fccreler aras\u0131 bo\u015flukta \u00e7ok say\u0131da proinflamatuar fakt\u00f6r ve matris metaloproteinaz salg\u0131lamas\u0131na neden olur, arter duvar\u0131nda plak birikiminin artmas\u0131n\u0131 te\u015fvik eder, daha sonra stabil olmayan pla\u011fa d\u00f6n\u00fc\u015f\u00fcr ve son olarak miyokard enfarkt\u00fcs\u00fcne ilerler. Bununla birlikte, AS'nin ilerlemesini etkili bir \u015fekilde geciktirmek her zaman akademik toplulu\u011fu rahats\u0131z eden zorluklardan biri olmu\u015ftur. Son y\u0131llarda, yeni ortaya \u00e7\u0131kan pop\u00fcler t\u0131bbi ve yenilebilir \u00fcr\u00fcn olan Morinda officinalis'in kan lipitlerini d\u00fczenlemede ve aterosklerozu iyile\u015ftirmede iyi etkileri oldu\u011fu kan\u0131tlanm\u0131\u015ft\u0131r.
\nNoni olarak da bilinen Morinda citrifolia, Rubiaceae familyas\u0131nda yer alan Euphorbia cinsine ait bir bitkidir. Anti-enflamatuar, antioksidan ve lipid d\u00fc\u015f\u00fcr\u00fcc\u00fc gibi farmakolojik etkileri vard\u0131r. Geleneksel \u00c7in t\u0131bb\u0131 teorisine g\u00f6re, Morinda officinalis ek\u015fi ve tatl\u0131 bir tada, dengeli bir t\u0131bbi \u00f6zelli\u011fe sahiptir ve b\u00f6brek \u00f6z\u00fcn\u00fc besleme, yin ve yang'\u0131 dengeleme ve ya\u015flanmay\u0131 geciktirme etkilerine sahiptir. Kardiyovask\u00fcler ve serebrovask\u00fcler hastal\u0131klar\u0131 etkili bir \u015fekilde \u00f6nleyebilir. Bununla birlikte, Hai Ba Ji'nin AS tedavisindeki spesifik mekanizmas\u0131 hala belirsizdir. Morinda officinalis'in esas olarak antrakinonlar, flavonoidler, fenilpropanoidler, fenolik asitler ve di\u011fer bile\u015fenlerden olu\u015fan karma\u015f\u0131k kimyasal bile\u015fimi g\u00f6z \u00f6n\u00fcne al\u0131nd\u0131\u011f\u0131nda, geleneksel \u00c7in t\u0131bb\u0131n\u0131n \u00e7ok bile\u015fenli ve \u00e7ok hedefli \u00f6zellikleri do\u011frultusunda, a\u011f farmakolojisi Morinda officinalis'in farmakolojik etkilerinin molek\u00fcler mekanizmas\u0131n\u0131 a\u00e7\u0131k\u00e7a ayd\u0131nlatmak i\u00e7in kullan\u0131labilir. Son y\u0131llarda, a\u011f farmakolojisi bilgisayar bilimi, biyoinformatik ve veri madencili\u011fini entegre eden geli\u015fmekte olan bir disiplin haline gelmi\u015ftir. Bir \"ila\u00e7 etken maddesi hastal\u0131k hedef hastal\u0131\u011f\u0131\" a\u011f\u0131 olu\u015fturur ve biyolojik i\u015flevlerini a\u00e7\u0131klayarak insanlar\u0131n hastal\u0131klar i\u00e7in ila\u00e7 tedavisinin mekanizmalar\u0131n\u0131 ve mekanizmalar\u0131n\u0131 daha net bir \u015fekilde anlamalar\u0131n\u0131 sa\u011flar. Bu \u00e7al\u0131\u015fma, Morinda officinalis'in \u00e7e\u015fitli aktif bile\u015fenlerine ve zengin hedeflerine dayanmaktad\u0131r ve AS tedavisinde Morinda officinalis'in hedeflerini, biyolojik s\u00fcre\u00e7lerini ve sinyal yollar\u0131n\u0131 tahmin etmek ve analiz etmek i\u00e7in a\u011f farmakolojisi y\u00f6ntemlerini kullanmay\u0131 ama\u00e7lamaktad\u0131r. Ayn\u0131 zamanda, ila\u00e7 geli\u015ftirme ve AS tedavisi i\u00e7in farmakolojik temel sa\u011flamak amac\u0131yla do\u011frulama i\u00e7in in vitro deneyler kullan\u0131lacakt\u0131r.<\/p>\n

 <\/p>\n

\"\"ateroskleroz\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nAS yayg\u0131n bir kardiyovask\u00fcler hastal\u0131kt\u0131r ve h\u0131zl\u0131 ilerlemesi hastalarda do\u011frudan miyokard enfarkt\u00fcs\u00fc gibi k\u00f6t\u00fc huylu kardiyovask\u00fcler olaylara yol a\u00e7abilir. Modern t\u0131p, lipid teorisinin hala AS olu\u015fumunun ana mekanizmas\u0131 oldu\u011funa inanmaktad\u0131r. Statinler, PCSK9 inhibit\u00f6rleri ve di\u011fer lipid d\u00fc\u015f\u00fcr\u00fcc\u00fc ila\u00e7lar, aterosklerozun ilerlemesini yava\u015flatmak i\u00e7in klinik uygulamada yayg\u0131n olarak kullan\u0131lmaktad\u0131r. Bununla birlikte, terap\u00f6tik dozlarda hala ortaya \u00e7\u0131kan kas a\u011fr\u0131s\u0131 ve karaci\u011fer fonksiyon hasar\u0131 gibi advers reaksiyonlar nedeniyle, bir\u00e7ok hasta bu ila\u00e7lar\u0131 tolere edememektedir. Bu nedenle AS tedavisi i\u00e7in yeni, daha g\u00fcvenli ve daha az toksik ila\u00e7lar\u0131n ara\u015ft\u0131r\u0131lmas\u0131 olumlu bir \u00f6neme sahiptir. Geli\u015fmekte olan bir t\u0131bbi ve yenilebilir \u00fcr\u00fcn olarak Morinda officinalis, geleneksel \u00c7in t\u0131bb\u0131n\u0131n \u00e7ok hedefli ve \u00e7ok yollu hastal\u0131k tedavisinin tipik \u00f6zelliklerine uygun olarak \u00e7ok \u00e7e\u015fitli aktif bile\u015fenlere ve farmakolojik etkilere sahiptir. Bu \u00e7al\u0131\u015fmada, AS tedavisinde Morinda officinalis'in etkili bile\u015fenlerini ve hedeflerini tahmin etmek i\u00e7in a\u011f farmakolojisi kullan\u0131lm\u0131\u015f ve Morinda officinalis'in PPAR \u03b3 sinyal yolu arac\u0131l\u0131\u011f\u0131yla h\u00fccre i\u00e7i kolesterol ak\u0131\u015f\u0131n\u0131 destekledi\u011fini do\u011frulamak i\u00e7in THP-1 t\u00fcrevi bir makrofaj modeli olu\u015fturulmu\u015ftur.<\/p>\n

\u00c7e\u015fitli veri tabanlar\u0131 taranarak, flavonoidler, fenilpropanoidler ve fenolik asitler dahil olmak \u00fczere 59 bile\u015fi\u011fin esas olarak AS tedavisinde terap\u00f6tik bir rol oynad\u0131\u011f\u0131 bulunmu\u015ftur. Son y\u0131llarda, \u00e7ok say\u0131da ara\u015ft\u0131rma raporu flavonoidlerin SA tedavisinde \u00f6nemli bir rol oynad\u0131\u011f\u0131n\u0131 ve bitki t\u0131bb\u0131n\u0131n ana aktif b\u00f6lgeleri oldu\u011funu g\u00f6stermi\u015ftir. Sahib ve arkada\u015flar\u0131, Morinda officinalis'in meyvesindeki kate\u015fin, kuersetin ve kaempferol i\u00e7eriklerinin s\u0131ras\u0131yla 53,68 mg\/g, 7,4 mg\/g ve 6,4 mg\/g oldu\u011funu ve bilinen ilk \u00fc\u00e7 aktif flavonoid aras\u0131nda yer ald\u0131\u011f\u0131n\u0131 tespit etmi\u015ftir. Bu \u00fc\u00e7 bile\u015fen kan lipit anormalliklerinin d\u00fczenlenmesinde ve aterosklerozun geciktirilmesinde \u00f6nemli bir rol oynamaktad\u0131r. Ara\u015ft\u0131rmalar, Yixin Tongmai gran\u00fcllerinin ana bile\u015feni olan kate\u015finlerin PPAR \u03b3 yolunu do\u011frudan aktive edebilece\u011fini ve molek\u00fcler yerle\u015ftirme ve in vitro ve in vivo deneyler yoluyla AS'yi iyile\u015ftirebilece\u011fini bulmu\u015ftur. Quercetin, Morinda officinalis'te \u00f6nemli bir oranda olmak \u00fczere \u00e7e\u015fitli bitkilerde yayg\u0131n olarak bulunur. Jia ve arkada\u015flar\u0131 ile Li ve arkada\u015flar\u0131, kuersetinin y\u00fcksek ya\u011fl\u0131 diyetle ind\u00fcklenen Apoe -\/- fare AS modelinin torasik aortundaki plak i\u00e7eri\u011fini \u00f6nemli \u00f6l\u00e7\u00fcde azaltabildi\u011fini bildirmi\u015ftir. Mekanizma, ATP ba\u011flay\u0131c\u0131 kaset ta\u015f\u0131y\u0131c\u0131 A1'in (ABCA1) artan ekspresyonu ile ilgilidir. Ara\u015ft\u0131rmalar, kaempferol\u00fcn g\u00fc\u00e7l\u00fc anti-enflamatuar aktiviteye sahip oldu\u011funu ve PI3K\/AKT\/Nrf2 yolunu aktive ederek aterosklerozun ilerlemesini geciktirebilece\u011fini do\u011frulam\u0131\u015ft\u0131r.<\/p>\n

Daha sonra, GO zenginle\u015ftirme analizi, Morinda officinalis'in esas olarak h\u00fccrelerdeki membran resept\u00f6rleri ve n\u00fckleer resept\u00f6rler gibi biyolojik fonksiyonlar\u0131 d\u00fczenledi\u011fini ortaya koymu\u015ftur; KEGG sinyal yollar\u0131n\u0131n zenginle\u015ftirme analizi, AS'nin Morinda officinalis ile tedavisinin, PPAR sinyal yolunun bunlardan biri oldu\u011fu lipid metabolizmas\u0131 ile ilgili sinyal yollar\u0131yla ili\u015fkili oldu\u011funu ortaya koymu\u015ftur. Ara\u015ft\u0131rmalar, lipid metabolizmas\u0131yla ilgili sinyal yollar\u0131n\u0131n, \u00f6zellikle de PPAR sinyal yolunun, h\u00fccre zar\u0131ndaki lipid ta\u015f\u0131y\u0131c\u0131lar\u0131 ve \u00e7ekirdekteki resept\u00f6rlerle yak\u0131ndan ili\u015fkili oldu\u011funu g\u00f6stermi\u015ftir. Hepimizin bildi\u011fi gibi PPAR'lar \u00e7ekirdekte bulunan klasik n\u00fckleer resept\u00f6rlerdir. PPAR'lar ikinci haberci sinyalini ald\u0131ktan sonra, a\u015fa\u011f\u0131 y\u00f6nl\u00fc transkripsiyon fakt\u00f6rlerini aktive ederek h\u00fccre zar\u0131ndaki kolesterol ta\u015f\u0131y\u0131c\u0131lar\u0131n\u0131n ekspresyonunu art\u0131r\u0131r, b\u00f6ylece h\u00fccrelerde kolesterol birikimini azalt\u0131r ve makrofajlar\u0131n k\u00f6p\u00fck h\u00fccrelerine d\u00f6n\u00fc\u015fmesini \u00f6nler. Dolay\u0131s\u0131yla PPAR sinyal yolu, lipid \u00e7ekirdeklerinde k\u00f6p\u00fck h\u00fccrelerinin olu\u015fumunun azalt\u0131lmas\u0131nda ve AS'nin geciktirilmesinde \u00f6nemli bir rol oynamaktad\u0131r. Ayr\u0131ca, PPARG geni de bu \u00e7al\u0131\u015fmada bile\u015fen hedef a\u011f\u0131n\u0131n \u00e7ekirdek a\u011f\u0131nda \u00f6nemli bir d\u00fc\u011f\u00fcmd\u00fcr.<\/p>\n

Yukar\u0131daki a\u011f farmakolojik analizine dayanarak, bu \u00e7al\u0131\u015fma in vitro aterosklerotik plaklardaki k\u00f6p\u00fck h\u00fccrelerini sim\u00fcle etmek i\u00e7in THP-1 t\u00fcrevi makrofajlar olu\u015fturmu\u015ftur. Morinda officinalis THP-1 t\u00fcrevi makrofajlara m\u00fcdahale ettikten sonra, h\u00fccre i\u00e7i kolesterol i\u00e7eri\u011finin \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131 ve h\u00fccrelerdeki PPAR \u03b3 ifadesinin \u00f6nemli \u00f6l\u00e7\u00fcde yukar\u0131 reg\u00fcle oldu\u011fu bulunmu\u015ftur. Inada ve arkada\u015flar\u0131 ile Nerurkar ve arkada\u015flar\u0131, Morinda officinalis'in lipid d\u00fc\u015f\u00fcr\u00fcc\u00fc etkisini hayvan deneyleri ile do\u011frulam\u0131\u015flard\u0131r. Klinik bir \u00e7al\u0131\u015fmada, Morinda officinalis'in a\u011f\u0131r sigara i\u00e7en bireylerde serum LDL seviyelerini \u00f6nemli \u00f6l\u00e7\u00fcde azaltabildi\u011fi ve y\u00fcksek yo\u011funluklu lipoprotein (HDL) seviyelerini art\u0131rabildi\u011fi bulunmu\u015ftur. Son zamanlarda, Chong ve arkada\u015flar\u0131 Morinda officinalis'in termal olarak oksitlenmi\u015f palmiye ya\u011f\u0131 diyetiyle ind\u00fcklenmi\u015f AS s\u0131\u00e7an modelinin aortundaki lipid plaklar\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azaltabildi\u011fini do\u011frulam\u0131\u015ft\u0131r, ancak spesifik mekanizma ayd\u0131nlat\u0131lmam\u0131\u015ft\u0131r. Daha \u00f6nce, Lee ve arkada\u015flar\u0131 Morinda officinalis meyvesinin kurutulmu\u015f tozunu 70% metanol ile ekstrakte etmi\u015f ve C2C12 iskelet kas\u0131 h\u00fccrelerinde PPAR \u03b3 resept\u00f6rlerini uyarabildi\u011fini bulmu\u015flard\u0131r. Bu deneysel rapor bizim sonu\u00e7lar\u0131m\u0131zla tutarl\u0131d\u0131r. Bu \u00e7al\u0131\u015fma, Morinda officinalis'in THP-1 t\u00fcrevi makrofajlardan kolesterol ak\u0131\u015f\u0131n\u0131 te\u015fvik edebilece\u011fini ilk kez buldu ve a\u011f farmakolojisi ile birlikte, PPAR \u03b3 sinyal yolunu aktive ederek ters kolesterol ta\u015f\u0131ma (RCT) etkisini \u00f6ng\u00f6rd\u00fc. RCT'nin lipid anormalliklerini d\u00fczenledi\u011fi ve in vivo AS'yi iyile\u015ftirdi\u011fi \u00f6nemli mekanizmalardan biri, kolesterol\u00fcn h\u00fccre zar\u0131ndaki \u00e7\u00f6p\u00e7\u00fc resept\u00f6rleri arac\u0131l\u0131\u011f\u0131yla h\u00fccrelerden aktar\u0131lmas\u0131 ve daha sonra apolipoprotein A, apoE ve plazmadaki di\u011fer proteinlere ba\u011flanarak metabolizma i\u00e7in karaci\u011fere ta\u015f\u0131nmas\u0131d\u0131r. Daha sonra safra asitlerine d\u00f6n\u00fc\u015ft\u00fcr\u00fcl\u00fcr ve v\u00fccuttan at\u0131l\u0131r, b\u00f6ylece lipid metabolizmas\u0131 anormallikleri iyile\u015ftirilir. Makrofaj membran\u0131nda \u00f6nemli bir \u00e7\u00f6p\u00e7\u00fc resept\u00f6r\u00fc olan ABCA1, yukar\u0131 ak\u0131\u015f n\u00fckleer transkripsiyon fakt\u00f6r\u00fc PPAR \u03b3 taraf\u0131ndan hassas bir \u015fekilde d\u00fczenlenir ve h\u00fccre i\u00e7i kolesterol\u00fcn RCT s\u00fcreci yoluyla h\u00fccre d\u0131\u015f\u0131 alana ta\u015f\u0131nmas\u0131ndan sorumludur. Bu \u00e7al\u0131\u015fmada, ABCA1'in ifade d\u00fczeyi PPAR \u03b3'n\u0131n aktivasyonu ile artm\u0131\u015ft\u0131r. PPAR \u03b3 inhibit\u00f6r\u00fc GW9662 kullan\u0131ld\u0131\u011f\u0131nda, THP-1 t\u00fcrevi makrofajlarda ABCA1 resept\u00f6r ifadesinin art\u0131\u015f e\u011filimi engellenmi\u015f ve h\u00fccre i\u00e7i kolesterol i\u00e7eri\u011finde \u00f6nemli bir azalma olmam\u0131\u015ft\u0131r, bu da PPAR \u03b3'n\u0131n arac\u0131l\u0131k etti\u011fi ABCA1'in h\u00fccre i\u00e7i kolesterol ta\u015f\u0131nmas\u0131n\u0131n ana ta\u015f\u0131y\u0131c\u0131s\u0131 oldu\u011funu g\u00f6stermektedir. Benzer \u015fekilde, kuersetin, baicalin ve dihidromirisetin PPAR \u03b3\/ABCA1 sinyal yolunu aktive ederek RCT'yi te\u015fvik edebilir ve anti AS etkiler g\u00f6sterebilir. Bu nedenle, Morinda officinalis PPAR \u03b3 sinyal yolunu aktive ederek THP-1 t\u00fcrevi makrofajlardan kolesterol \u00e7\u0131k\u0131\u015f\u0131n\u0131 te\u015fvik edebilir.<\/p>\n

\u00d6zetle, Morinda officinalis dengeli t\u0131bbi \u00f6zellikleri ile tatl\u0131 ve ek\u015fi bir tada sahiptir. B\u00f6brek \u00f6z\u00fcn\u00fc besleyebilir, yin ve yang'\u0131 dengeleyebilir ve kardiyovask\u00fcler ve serebrovask\u00fcler hastal\u0131klar\u0131 \u00f6nleyebilir. Bu \u00e7al\u0131\u015fma, Morinda officinalis'in AS tedavisindeki mekanizmas\u0131n\u0131 ortaya \u00e7\u0131karmak i\u00e7in in vitro deneylerle birlikte a\u011f farmakolojisini kulland\u0131 ve ilk kez Morinda officinalis'in THP-1 t\u00fcrevi makrofajlardan kolesterol ak\u0131\u015f\u0131n\u0131 te\u015fvik edebilece\u011fini ve PPAR \u03b3 sinyal yolunu aktive ederek RCT'yi te\u015fvik edebilece\u011fini g\u00f6sterdi. Dolay\u0131s\u0131yla, bu \u00e7al\u0131\u015fma Morinda officinalis ile AS'nin etkili bir \u015fekilde \u00f6nlenmesi ve tedavisi i\u00e7in yeni bir farmakolojik mekanizma sa\u011flamaktad\u0131r. Bununla birlikte, bu \u00e7al\u0131\u015fman\u0131n baz\u0131 s\u0131n\u0131rlamalar\u0131 bulunmaktad\u0131r: (1) TCMSP veri taban\u0131 Morinda officinalis bitki ilac\u0131n\u0131 i\u00e7ermedi\u011finden, aktif bile\u015fenlerinin taranmas\u0131na yard\u0131mc\u0131 olmak i\u00e7in CAMUP veri taban\u0131 ve SwissADME veri taban\u0131 kullan\u0131lm\u0131\u015ft\u0131r. Geleneksel \u00c7in t\u0131bb\u0131 bile\u015fenlerini birlikte taramak i\u00e7in birden fazla veri taban\u0131 kullanan \u00e7al\u0131\u015fmalar olmas\u0131na ra\u011fmen, farkl\u0131 veri tabanlar\u0131ndaki aktif bile\u015fenlerin tarama kriterleri farkl\u0131d\u0131r, bu nedenle tarama g\u00fcvenilirli\u011fi a\u00e7\u0131s\u0131ndan daha fazla do\u011frulamaya ihtiya\u00e7 vard\u0131r; (2) Bu \u00e7al\u0131\u015fmada hastal\u0131klarla ilgili 5 veri taban\u0131 taranm\u0131\u015f ve sonu\u00e7lar her veri taban\u0131ndaki AS hedeflerinin say\u0131s\u0131nda \u00f6nemli farkl\u0131l\u0131klar oldu\u011funu g\u00f6stermi\u015ftir; bu farkl\u0131l\u0131klar her veri taban\u0131nda yer alan hastal\u0131k t\u00fcrlerindeki farkl\u0131l\u0131klarla ilgili olabilir; (3) \u0130n vitro deneylerin sonu\u00e7lar\u0131na dayanarak, ara\u015ft\u0131rma grubumuz in vivo deneyler perspektifinden Morinda officinalis taraf\u0131ndan RCT'nin te\u015fvik edilmesi ve AS'nin geciktirilmesi i\u00e7in daha eksiksiz bir deneysel temel sa\u011flamak \u00fczere bir AS hayvan modeli olu\u015fturacakt\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

Exploring the mechanism of Morinda officinalis against atherosclerosis based on network pharmacology and experimental verification Atherosclerosis (AS) is a common chronic cardiovascular disease characterized by the formation of atherosclerotic plaque or fibrous plaque in the intima of large and middle arteries. The infiltration of lipids into the arterial intima has become the main pathogenesis of […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExploring the mechanism of Morinda officinalis against atherosclerosis based on network pharmacology and experimental verification - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/ateroskleroz\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the mechanism of Morinda officinalis against atherosclerosis based on network pharmacology and experimental verification - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the mechanism of Morinda officinalis against atherosclerosis based on network pharmacology and experimental verification Atherosclerosis (AS) is a common chronic cardiovascular disease characterized by the formation of atherosclerotic plaque or fibrous plaque in the intima of large and middle arteries. 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