{"id":5231,"date":"2024-08-04T17:55:12","date_gmt":"2024-08-04T17:55:12","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5231"},"modified":"2024-08-04T17:55:12","modified_gmt":"2024-08-04T17:55:12","slug":"bletilla-striata","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/bletilla-striata\/","title":{"rendered":"Bai Ji Zhong'daki Kimyasal Bile\u015fenlerin Tan\u0131mlanmas\u0131 ve Staphylococcus aureus'un \u0130nhibisyon Mekanizmas\u0131 \u00dczerine \u00c7al\u0131\u015fma"},"content":{"rendered":"<p>Bai Ji Zhong'daki Kimyasal Bile\u015fenlerin Tan\u0131mlanmas\u0131 ve Staphylococcus aureus'un \u0130nhibisyon Mekanizmas\u0131 \u00dczerine \u00c7al\u0131\u015fma<br \/>\nAntibiyotikler 20. y\u00fczy\u0131l\u0131n en \"mucize ila\u00e7lar\u0131\" olarak kabul edilmektedir. Ancak antibiyotiklerin insanlar taraf\u0131ndan a\u015f\u0131r\u0131 kullan\u0131m\u0131 nedeniyle bakteriyel diren\u00e7 ortaya \u00e7\u0131km\u0131\u015ft\u0131r. Bakteriyel enfeksiyonlar\u0131n insanlarda yol a\u00e7t\u0131\u011f\u0131 k\u00fcresel maddi kay\u0131plar\u0131n 2050 y\u0131l\u0131na kadar $100 trilyona ula\u015fmas\u0131 beklenmektedir. Staphylococcus aureus, solunum, sindirim ve idrar yolu enfeksiyonlar\u0131na neden olabilen, g\u0131da kaynakl\u0131 yayg\u0131n bir patojen bakteridir. G\u00fcn\u00fcm\u00fczde, klinik uygulamada kullan\u0131lan antibakteriyel ila\u00e7lar\u0131n s\u0131n\u0131rl\u0131 yap\u0131sal tipleri, s\u0131k g\u00f6r\u00fclen toksik yan etkileri ve artan ila\u00e7 direnci gibi sorunlar\u0131 bulunmaktad\u0131r. Bu nedenle, insanlar\u0131n yeni tip antibakteriyel ila\u00e7lar geli\u015ftirmesine acil ihtiya\u00e7 vard\u0131r.<br \/>\nDo\u011fal \u00fcr\u00fcnler, yeni ila\u00e7lar\u0131n ke\u015ffi i\u00e7in hala bir kaynak hazinesi olarak kabul edilmektedir. ABD G\u0131da ve \u0130la\u00e7 Dairesi'ne (FDA) g\u00f6re, klinik ila\u00e7lar\u0131n yar\u0131s\u0131ndan fazlas\u0131 do\u011fal \u00fcr\u00fcnlerden veya bunlar\u0131n sentetik t\u00fcrevlerinden elde edilmektedir ve mikrobiyal kaynaklardan elde edilen yakla\u015f\u0131k 200 do\u011fal antibiyotik do\u011frudan ila\u00e7 olarak kullan\u0131lmaktad\u0131r.<br \/>\nS\u00fcmb\u00fcl orkidesi, s\u00fcmb\u00fcl baiji veya Ulan olarak da bilinen Baiji'nin yumrular\u0131 genellikle t\u0131bbi par\u00e7alar olarak kullan\u0131l\u0131r. Tad\u0131 tatl\u0131, ac\u0131 ve buruktur, hafif so\u011fuk bir yap\u0131ya sahiptir. S\u0131k\u0131\u015ft\u0131rma, hemostaz, \u015fi\u015flik azaltma ve kas rejenerasyonu etkilerine sahiptir. Genellikle \u00f6ks\u00fcrme ve kan kusma, d\u0131\u015f kanama, \u00fclser ve toksinler, cilt \u00e7atlamas\u0131, \u00fclser kanamas\u0131 vb. tedavisinde kullan\u0131l\u0131r. Ana bile\u015fenleri aras\u0131nda polisakkaritler, fenantren, fenantrenkinon, dibenzen, triterpenoidler, lignanlar ve organik asitler bulunur. Farmakolojik \u00e7al\u0131\u015fmalar, Bai Ji'nin anti-enflamatuar, anti-fibrotik, anti-t\u00fcm\u00f6r ve ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenlemesi gibi \u00e7e\u015fitli biyolojik aktivitelere sahip oldu\u011funu g\u00f6stermi\u015ftir, ancak antibakteriyel mekanizmas\u0131 hakk\u0131nda \u00e7ok az rapor vard\u0131r. Bu nedenle, bu deneyde, Staphylococcus aureus, ekstrakt ve monomer bile\u015fi\u011fi aras\u0131ndaki antibakteriyel aktivite fark\u0131n\u0131 ara\u015ft\u0131rmak i\u00e7in ara\u015ft\u0131rma nesnesi olarak al\u0131nm\u0131\u015ft\u0131r. Bakteri \u00e7\u00f6zeltisindeki alkalin fosfataz (AKP), DNA s\u0131z\u0131nt\u0131 derecesi ve bakteriyel elektron mikroskobu morfolojisi \u00f6l\u00e7\u00fclerek, bile\u015fi\u011fin Staphylococcus aureus'un h\u00fccre zar\u0131 duvar\u0131 \u00fczerindeki etkisi incelenmi\u015f ve Staphylococcus aureus'un kapsaml\u0131 kullan\u0131m\u0131 ve yeni antibakteriyel ajanlar\u0131n geli\u015ftirilmesi i\u00e7in teorik bir temel sa\u011flanm\u0131\u015ft\u0131r.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5232\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-128.png\" alt=\"\" width=\"774\" height=\"262\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-128.png 774w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-128-768x260.png 768w\" sizes=\"(max-width: 774px) 100vw, 774px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5233\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-115.png\" alt=\"\" width=\"777\" height=\"302\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-115.png 777w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-115-768x299.png 768w\" sizes=\"(max-width: 777px) 100vw, 777px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5234\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-109.png\" alt=\"\" width=\"776\" height=\"269\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-109.png 776w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-109-768x266.png 768w\" sizes=\"(max-width: 776px) 100vw, 776px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5235\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-97.png\" alt=\"\" width=\"772\" height=\"282\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-97.png 772w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-97-768x281.png 768w\" sizes=\"(max-width: 772px) 100vw, 772px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5236\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-89.png\" alt=\"\" width=\"775\" height=\"209\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-89.png 775w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-89-768x207.png 768w\" sizes=\"(max-width: 775px) 100vw, 775px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5237\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-82.png\" alt=\"\" width=\"777\" height=\"207\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-82.png 777w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-82-768x205.png 768w\" sizes=\"(max-width: 777px) 100vw, 777px\" \/>Bu deney antibakteriyel aktiviteye odaklanmakta ve geleneksel \u00c7in ilac\u0131 Baiji'nin kimyasal bile\u015fenlerini izole etmek ve safla\u015ft\u0131rmak i\u00e7in kromatografik ay\u0131rma teknolojisini kullanmaktad\u0131r. 6 fenantren bile\u015fi\u011fi (1-6) ve 4 kumarik asit analo\u011fu (7-10) dahil olmak \u00fczere toplam 10 bile\u015fik (1-10) izole edilmi\u015f ve tan\u0131mlanm\u0131\u015ft\u0131r. Kumarik asit analoglar\u0131n\u0131n Platycodon cinsi bitkilerde ilk kez ke\u015ffedilmesi, Orchidaceae familyas\u0131ndaki bitkilerin zengin kimyasal bile\u015fimi i\u00e7in \u00f6nemli bir yol g\u00f6sterici \u00f6neme sahiptir.<br \/>\nBile\u015fiklerin antibakteriyel mekanizmas\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131nda, ilk olarak ekstraktlar\u0131n ve monomer bile\u015fiklerin antibakteriyel aktivitesi taranm\u0131\u015ft\u0131r. Test sonu\u00e7lar\u0131, bile\u015fik 6'n\u0131n test edilen bile\u015fikler aras\u0131nda Staphylococcus aureus'a (MIC0.01mh\/mL) kar\u015f\u0131 en iyi antibakteriyel aktiviteye sahip oldu\u011funu ve antibakteriyel etkinin doza ba\u011fl\u0131 oldu\u011funu g\u00f6stermi\u015ftir. SEM sonu\u00e7lar\u0131, bile\u015fi\u011fin bakteriyel h\u00fccre duvar\u0131na ve membran\u0131na zarar vererek h\u00fccre i\u00e7i maddelerin s\u0131zmas\u0131na neden oldu\u011funu g\u00f6stermi\u015ftir. Buna ek olarak, AKP enzim i\u00e7eri\u011findeki ve PI probunun floresan yo\u011funlu\u011fundaki de\u011fi\u015fiklikler, bile\u015fik 6'n\u0131n bakteriyel membranlara verdi\u011fi zarar\u0131 daha da g\u00f6stermi\u015ftir. Klinik kullan\u0131mda, Atractylodes macrocephala \u00f6z\u00fctleri yara iyile\u015fmesini h\u0131zland\u0131rabilir ve enfeksiyonu \u00f6nleyebilir, bu da Atractylodes macrocephala'n\u0131n antibakteriyel \u00f6zelliklerinin bile\u015fik 6 ve di\u011fer fenantren t\u00fcrevleriyle ili\u015fkili olabilece\u011fini g\u00f6sterir.<br \/>\nYap\u0131sal tipler a\u00e7\u0131s\u0131ndan bak\u0131ld\u0131\u011f\u0131nda, fenantren bile\u015fikleri ticari olarak mevcut antibiyotiklerden (\u03b2 - laktamlar, makrolidler, kinolonlar) tamamen farkl\u0131 yap\u0131lara sahip do\u011fal \u00fcr\u00fcnlerdir. Bu \u00e7al\u0131\u015fmada, fenantren bile\u015fikleri, mevcut antibakteriyel ila\u00e7lar\u0131n bollu\u011fu i\u00e7in ilham sa\u011flayan iyi antibakteriyel etkiler g\u00f6stermi\u015ftir. Yeni fenantren antibiyotiklerin geli\u015ftirilmesinin ilaca diren\u00e7li bakteri sorununu \u00e7\u00f6zmesi beklenmektedir. Literat\u00fcr raporlar\u0131na g\u00f6re, ayn\u0131 tip fenantren bile\u015fikleri bile farkl\u0131 antibakteriyel mekanizmalar sergileyebilmektedir. \u00d6rne\u011fin, blestricin esas olarak bakteriyel membran potansiyelini ve b\u00fct\u00fcnl\u00fc\u011f\u00fcn\u00fc bozarak Staphylococcus'un b\u00fcy\u00fcmesini engellerken, aristoloxazine C h\u00fccre duvar\u0131 bozulmas\u0131n\u0131 ve ablasyonunu ind\u00fckleyerek Pseudomonas aeruginosa'n\u0131n b\u00fcy\u00fcmesini engeller. Yap\u0131sal olarak, fenantren bile\u015fikleri canl\u0131 organizmalarda kolayca kinonlara d\u00f6n\u00fc\u015ft\u00fcr\u00fcl\u00fcr, bu da yar\u0131 kinon serbest radikallerinin \u00fcretilmesine ve antibakteriyel aktivitenin olu\u015fmas\u0131na yol a\u00e7ar. Bu durum, fenantren bile\u015fiklerinin antibakteriyel mekanizmas\u0131n\u0131n daha fazla ara\u015ft\u0131r\u0131lmas\u0131 gerekti\u011fini g\u00f6stermektedir. \u00d6zet olarak, ara\u015ft\u0131rmam\u0131z bakteri membranlar\u0131n\u0131 bozarak fenantrenin antibakteriyel mekanizmas\u0131n\u0131 \u00f6nceden do\u011frulam\u0131\u015f, beyaz ve antibakteriyel ajanlar\u0131n farmakolojik madde temeli i\u00e7in deneysel veriler sa\u011flam\u0131\u015ft\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"<p>Identification of Chemical Components in Bai Ji Zhong and Study on the Inhibition Mechanism of Staphylococcus aureus Antibiotics are considered the most &#8220;miracle drugs&#8221; of the 20th century. However, due to the overuse of antibiotics by people, bacterial resistance has emerged. It is expected that by 2050, the global property losses caused by bacterial infections [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Identification of Chemical Components in Bai Ji Zhong and Study on the Inhibition Mechanism of Staphylococcus aureus - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/bletilla-striata\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identification of Chemical Components in Bai Ji Zhong and Study on the Inhibition Mechanism of Staphylococcus aureus - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Identification of Chemical Components in Bai Ji Zhong and Study on the Inhibition Mechanism of Staphylococcus aureus Antibiotics are considered the most &#8220;miracle drugs&#8221; of the 20th century. 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However, due to the overuse of antibiotics by people, bacterial resistance has emerged. 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