{"id":5203,"date":"2024-08-04T17:48:42","date_gmt":"2024-08-04T17:48:42","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5203"},"modified":"2024-08-04T17:48:42","modified_gmt":"2024-08-04T17:48:42","slug":"mushroom","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/mantar\/","title":{"rendered":"Kadife boynuzlu mantar\u0131n meyve veren g\u00f6vdesinden yeni fibrinolitik enzimin verimli bir \u015fekilde ayr\u0131lmas\u0131 ve safla\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"<p>Kadife boynuzlu mantar\u0131n meyve veren g\u00f6vdesinden yeni fibrinolitik enzimin verimli bir \u015fekilde ayr\u0131lmas\u0131 ve safla\u015ft\u0131r\u0131lmas\u0131<br \/>\nTromboembolik hastal\u0131klar y\u00fcksek sakatl\u0131k ve \u00f6l\u00fcm oran\u0131na sahiptir. Fibrin kan p\u0131ht\u0131lar\u0131n\u0131n ana bile\u015fenidir, bu nedenle fibrin y\u0131k\u0131m\u0131n\u0131 te\u015fvik etmek trombotik hastal\u0131klar\u0131 \u00f6nlemenin ve tedavi etmenin yayg\u0131n bir yoludur. \u00dcrokinaz (UK) ve streptokinaz (SK) gibi eksojen fibrinolitik enzimler, fibrini dolayl\u0131 veya do\u011frudan hidrolize etme yetenekleri nedeniyle tromboembolik hastal\u0131klar\u0131n klinik tedavisinde yayg\u0131n olarak kullan\u0131lmaktad\u0131r. \u00d6nemli trombolitik etkinli\u011fe sahip olmalar\u0131na ra\u011fmen, k\u0131sa yar\u0131 \u00f6m\u00fcr ve \u00f6nemli yan etkiler gibi baz\u0131 uygulama s\u0131n\u0131rlamalar\u0131na da sahiptirler. Bu nedenle, g\u00fc\u00e7l\u00fc \u00f6zg\u00fcll\u00fc\u011fe, iyi g\u00fcvenli\u011fe ve d\u00fc\u015f\u00fck yan etkilere sahip yeni fibrinolitik enzimlerin ara\u015ft\u0131r\u0131lmas\u0131 g\u00fcncel bir ara\u015ft\u0131rma noktas\u0131 haline gelmi\u015ftir.<\/p>\n<p>Yenilebilir mantarlar proteinler, polisakkaritler, terpenler, amino asitler, steroller, n\u00fckleozitler ve antioksidan, anti-t\u00fcm\u00f6r, ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenlemesi ve sinirsel d\u00fczenleme gibi \u00e7e\u015fitli fizyolojik i\u015flevlere sahip di\u011fer maddeler bak\u0131m\u0131ndan zengindir. G\u00fcn\u00fcm\u00fczde, yenilebilir mantarlardan elde edilen fibrinolitik enzimler ve bunlar\u0131n fonksiyonel \u00f6zellikleri \u00fczerine yap\u0131lan ara\u015ft\u0131rmalar yayg\u0131n ilgi g\u00f6rmektedir. Fibrinolitik enzimlerin Lentinus edodes, Cordyceps Militaris, Agrocybe aegerita, Tricholoma sejunctum, Lepista nuda, Pleurotus ferulae gibi \u00e7e\u015fitli yenilebilir mantarlardan izole edildi\u011fi ve ekstrakte edildi\u011fi bildirilmi\u015ftir.<\/p>\n<p>Geyik boynuzu mantar\u0131, Kuzey Yar\u0131mk\u00fcre'nin \u0131l\u0131man b\u00f6lgelerinde yayg\u0131n olarak da\u011f\u0131lan, odun \u00e7\u00fcr\u00fcten yenilebilir ve t\u0131bbi bir mantard\u0131r. Antioksidan, ba\u011f\u0131\u015f\u0131kl\u0131k sistemini g\u00fc\u00e7lendirme, t\u00fcm\u00f6r bask\u0131lama ve kan lipidini d\u00fc\u015f\u00fcrme gibi fizyolojik i\u015flevlere sahiptir. \u00d6n deneylerde, kadife boynuz mantar\u0131 meyve g\u00f6vdesi \u00f6z\u00fct\u00fcn\u00fcn, di\u011fer yenilebilir mantar kaynaklar\u0131ndan bildirilen plazminden \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek olan y\u00fcksek aktiviteli plazmin i\u00e7erdi\u011fi bulunmu\u015ftur. Bu makale, kadife boynuz mantar\u0131n\u0131n meyve g\u00f6vdesindeki fibrinolitik enzimin ayr\u0131\u015ft\u0131rma ve safla\u015ft\u0131rma y\u00f6ntemini tan\u0131tmakta ve enzimi ilk olarak tan\u0131mlamaktad\u0131r. \u015eu anda, ara\u015ft\u0131rma grubumuz kadife boynuz mantar\u0131ndaki fibrinolitik enzimle ilgili ba\u015fka bir rapor g\u00f6rmemi\u015ftir. Bu \u00e7al\u0131\u015fma, kadife boynuz mantar\u0131 fibrinolitik enziminin trombolitik ve antitrombotik fonksiyonel testlerinin yap\u0131lmas\u0131 i\u00e7in bir temel sa\u011flayabilir ve ayr\u0131ca fonksiyonel g\u0131dalar\u0131n geli\u015ftirilmesinde kullan\u0131m\u0131 i\u00e7in teorik bir temel olu\u015fturabilir.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5204\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-126.png\" alt=\"\" width=\"751\" height=\"299\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5205\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-112.png\" alt=\"\" width=\"764\" height=\"668\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5206\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-106.png\" alt=\"\" width=\"765\" height=\"307\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5207\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-95.png\" alt=\"\" width=\"760\" height=\"301\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5208\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-87.png\" alt=\"\" width=\"767\" height=\"337\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5209\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-80.png\" alt=\"\" width=\"744\" height=\"339\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5210\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-72.png\" alt=\"\" width=\"760\" height=\"353\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5211\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-67.png\" alt=\"\" width=\"743\" height=\"232\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5212\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-61.png\" alt=\"\" width=\"381\" height=\"548\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5213\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-50.png\" alt=\"\" width=\"335\" height=\"321\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5214\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-44.png\" alt=\"\" width=\"763\" height=\"264\" \/>Bu \u00e7al\u0131\u015fmada, modern kromatografik ay\u0131rma teknolojisi kullan\u0131larak kadife boynuz mantar\u0131n\u0131n meyve veren g\u00f6vdesinden bir fibrinolitik enzim izole edilmi\u015f ve safla\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r. Fibrinolitik enzimin N-terminal on iki amino asit dizisi Gly Ala Val Thr Gln Asn Ala Pro Trp Gly Leu'dur. NCBI veri taban\u0131 ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131ktan sonra, fibrinolitik enzim yeni bir fibrinolitik enzim olarak tan\u0131mlanm\u0131\u015ft\u0131r. Fibrinolitik enzimin spesifik aktivitesi 4105.78U\/mg, safla\u015ft\u0131rma fakt\u00f6r\u00fc 206.09 ve aktivite geri kazan\u0131m oran\u0131 30.91%'dir. Native PAGE elektroforezi ve SDS-PAGE elektroforez tespiti yoluyla, fibrinolitik enzimin ba\u011f\u0131l molek\u00fcler a\u011f\u0131rl\u0131\u011f\u0131n\u0131n 30.9 kDa oldu\u011fu bulunmu\u015ftur. Yukar\u0131daki sonu\u00e7lar, kadife boynuzlu mantarlar\u0131n meyve veren g\u00f6vdesinden elde edilen yeni fibrinolitik enzimin iyi bir trombolitik potansiyele sahip oldu\u011funu ve trombofili e\u011filimini azaltmak i\u00e7in fonksiyonel g\u0131dalar\u0131n geli\u015ftirilmesinde kullan\u0131labilece\u011fini g\u00f6stermektedir.<\/p>","protected":false},"excerpt":{"rendered":"<p>Efficient separation and purification of novel fibrinolytic enzyme from the fruiting body of velvet antler mushroom Thromboembolic diseases have a high disability and mortality rate. Fibrin is the main component of blood clots, therefore, promoting fibrin degradation is a common means of preventing and treating thrombotic diseases. Exogenous fibrinolytic enzymes, such as urokinase (UK) and [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Efficient separation and purification of novel fibrinolytic enzyme from the fruiting body of velvet antler mushroom - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/mantar\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Efficient separation and purification of novel fibrinolytic enzyme from the fruiting body of velvet antler mushroom - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Efficient separation and purification of novel fibrinolytic enzyme from the fruiting body of velvet antler mushroom Thromboembolic diseases have a high disability and mortality rate. Fibrin is the main component of blood clots, therefore, promoting fibrin degradation is a common means of preventing and treating thrombotic diseases. 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