{"id":5155,"date":"2024-08-04T17:33:55","date_gmt":"2024-08-04T17:33:55","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5155"},"modified":"2024-08-04T17:33:55","modified_gmt":"2024-08-04T17:33:55","slug":"diabetes-kidney-disease-with-qi-yin","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/qi-yin-ile-diyabet-bobrek-hastaligi\/","title":{"rendered":"Ba\u011f\u0131rsak Mikrofloras\u0131na Dayal\u0131 Qi Yin Eksikli\u011fi Sendromlu Diyabet B\u00f6brek Hastal\u0131\u011f\u0131 Hayvan Modeli \u00dczerine \u00c7al\u0131\u015fma"},"content":{"rendered":"

Ba\u011f\u0131rsak Mikrofloras\u0131na Dayal\u0131 Qi Yin Eksikli\u011fi Sendromlu Diyabet B\u00f6brek Hastal\u0131\u011f\u0131 Hayvan Modeli \u00dczerine \u00c7al\u0131\u015fma
\nG\u00fcn\u00fcm\u00fczde \u00e7o\u011fu bilim insan\u0131 diyabet b\u00f6brek hastal\u0131\u011f\u0131nda (DKH) hem qi hem de yin eksikli\u011finin DKH'nin temel etiyolojisi ve patogenezi oldu\u011funa ve patolojik de\u011fi\u015fikliklerinin yin eksikli\u011fi, kuruluk ve susuzluk \u0131s\u0131s\u0131ndan geli\u015fti\u011fine inanmaktad\u0131r; bunlardan hem qi hem de yin eksikli\u011fi DKH'nin seyri boyunca devam eden en temel durumdur. Bu makale, hem qi hem de yin sendromunun eksikli\u011fini DKD'nin temel patogenezi olarak ele almaktad\u0131r. Y\u00fcksek ya\u011fl\u0131 diyet ve d\u00fc\u015f\u00fck doz streptozotosin (STZ) enjeksiyonu ile diyabet b\u00f6brek hastal\u0131\u011f\u0131 s\u0131\u00e7an model grubu olu\u015fturmaya dayanarak, Qingpi, Zhishi ve Fuzi'nin intragastrik uygulama y\u00f6ntemini kullan\u0131yoruz (Qingpi ve Zhishi, karaci\u011feri yat\u0131\u015ft\u0131rma ve qi'yi k\u0131rma i\u015flevine sahiptir ve kullan\u0131ld\u0131\u011f\u0131nda pozitif qi'yi da\u011f\u0131tabilir; Fuzi b\u00f6brek kanal\u0131na girer ve y\u00fcksek ate\u015fle kullan\u0131ld\u0131\u011f\u0131nda b\u00f6brek yinini t\u00fcketebilir) DN'nin hem qi hem de yin sendromunun kombinasyonunun hayvan modelinin olu\u015fturulmas\u0131n\u0131 ara\u015ft\u0131rmak ve g\u00f6stergeleri incelemek.<\/p>\n

Klinik \u00e7al\u0131\u015fmalar, Qi Yin eksikli\u011finin DN hastalar\u0131nda ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fc\u015f\u00fc\u015f\u00fcne yol a\u00e7abilece\u011fini g\u00f6stermi\u015ftir. \u0130nsan imm\u00fcnoglobulin G (IgG) ve imm\u00fcnoglobulin M (IgM) konsantrasyonlar\u0131ndaki de\u011fi\u015fiklikler s\u0131\u00e7anlar\u0131n ba\u011f\u0131\u015f\u0131kl\u0131k durumunu yans\u0131tabilir. CAMP ve cGMP v\u00fccudun n\u00f6roendokrin sisteminin i\u015fleviyle ilgilidir. Baz\u0131 ara\u015ft\u0131rmac\u0131lar, hastalar yin eksikli\u011fi ve i\u00e7 \u0131s\u0131 durumunda yin-yang dengesizli\u011fi ve yin s\u0131v\u0131s\u0131 kayb\u0131 ya\u015fad\u0131klar\u0131nda, siklik adenozin monofosfat (cAMP), siklik guanozin monofosfat (cGMP) ve cAMP\/cGMP oran\u0131n\u0131n anormal olaca\u011f\u0131n\u0131 incelemi\u015flerdir. Qi eksikli\u011fi ayr\u0131ca hastalar\u0131n enerji metabolizmas\u0131 ile de ili\u015fkilidir. Sodyum potasyum pompa enzimi (Na+\/K+- ATP) ve kalsiyum magnezyum pompa enzimi (Ca2+\/Mg2+- ATP), adenozin trifosfat\u0131 (ATP) adenozin difosfata (ADP) par\u00e7alay\u0131p enerji a\u00e7\u0131\u011fa \u00e7\u0131karabilen enerji metabolizmas\u0131yla ilgili enzimlerdir. \u0130drar proteini, diyabet nefropatisi testinde hastalar\u0131n sa\u011fl\u0131k durumunu de\u011ferlendirmek i\u00e7in \u00f6nemli bir test indeksidir. \u0130drar proteini yard\u0131m\u0131yla diyabet nefropatisinin farkl\u0131l\u0131klar\u0131n\u0131 ay\u0131rt edebilir ve tan\u0131 ve tedavisi i\u00e7in bilimsel referans sa\u011flayabiliriz.
\nAra\u015ft\u0131rmalar, ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131n bozulmas\u0131n\u0131n DKD olu\u015fumu ile ili\u015fkili oldu\u011funu ve ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131n DKD fare modellerinde b\u00f6brek fonksiyonunu d\u00fczenleyebildi\u011fini g\u00f6stermi\u015ftir. DKD hastalar\u0131n\u0131n glomer\u00fcler filtrasyon h\u0131z\u0131 azal\u0131r ve \u00fcrik asit ve oksalat gibi b\u00fcy\u00fck miktarda metabolik at\u0131k kolonda birikir. Ba\u011f\u0131rsak ortam\u0131ndaki de\u011fi\u015fiklikler ba\u011f\u0131rsak mikrobiyotas\u0131nda disbiyoza yol a\u00e7ar. \u00c7al\u0131\u015fmalar, DKD hastalar\u0131n\u0131n ba\u011f\u0131rsaklar\u0131ndaki yararl\u0131 bakterilerin azal\u0131rken patojenik bakterilerin artt\u0131\u011f\u0131n\u0131, bunun da v\u00fccut dola\u015f\u0131m\u0131ndaki enflamatuar fakt\u00f6rlerde \u00f6nemli bir art\u0131\u015fa neden oldu\u011funu ve b\u00f6brek enflamatuar hasar\u0131n\u0131 \u015fiddetlendirdi\u011fini g\u00f6stermi\u015ftir. \u015eu anda, bat\u0131 t\u0131bb\u0131 DKD modeli \u00e7o\u011funlukla DKD ile ilgili geleneksel \u00c7in t\u0131bb\u0131 ara\u015ft\u0131rmalar\u0131nda kullan\u0131lmaktad\u0131r ve bu alanda diyabet ve b\u00f6brek hastal\u0131\u011f\u0131 ile ilgili ara\u015ft\u0131rma eksikli\u011fi belirli bir \u00f6l\u00e7\u00fcde s\u0131n\u0131rl\u0131d\u0131r. Bu nedenle, hastal\u0131k ve sendromu birle\u015ftiren hayvan modellerinin nas\u0131l olu\u015fturulaca\u011f\u0131, geleneksel \u00c7in t\u0131bb\u0131ndaki hayvan modellerinin ara\u015ft\u0131r\u0131lmas\u0131nda s\u0131cak bir konu haline gelmi\u015ftir.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nDiyabetin s\u00fcrekli geli\u015fim s\u00fcrecinde, en yayg\u0131n olan\u0131 DKD geli\u015fimi olmak \u00fczere \u00e7e\u015fitli komplikasyonlar ortaya \u00e7\u0131kacakt\u0131r. Deneysel sonu\u00e7lar, DKD s\u0131\u00e7anlar\u0131ndaki idrar protein seviyelerinin Nor s\u0131\u00e7anlar\u0131na g\u00f6re \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek oldu\u011funu ve DKD s\u0131\u00e7anlar\u0131nda b\u00f6brek ve kolondaki patolojik hasar\u0131n Nor s\u0131\u00e7anlar\u0131ndan \u00f6nemli \u00f6l\u00e7\u00fcde farkl\u0131 oldu\u011funu g\u00f6stermi\u015ftir. Bu nedenle, DKD modeli temelde ba\u015far\u0131l\u0131 bir \u015fekilde olu\u015fturulmu\u015ftur.<\/p>\n

Ba\u011f\u0131rsak mikrobiyotas\u0131 ve DKD Qi Yin eksikli\u011fi aras\u0131ndaki ili\u015fki son y\u0131llarda g\u00fcndemdeki konulardan biri haline gelmi\u015ftir ve ba\u011f\u0131rsak ve b\u00f6breklerin ba\u011f\u0131\u015f\u0131kl\u0131k ve enflamatuar yan\u0131tlar\u0131n yan\u0131 s\u0131ra ba\u011f\u0131rsak mukozal bariyerinde de \u00f6nemli bir rol oynad\u0131\u011f\u0131na inan\u0131lmaktad\u0131r. Ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131n bile\u015fimi ve i\u015flevi de\u011fi\u015firse, ba\u011f\u0131rsak mukozas\u0131nda hasara yol a\u00e7abilir, toksinleri v\u00fccuttan kan dola\u015f\u0131m\u0131na aktarabilir, imm\u00fcn inflamatuar reaksiyonlar\u0131 ind\u00fckleyebilir veya \u015fiddetlendirebilir ve DKD'nin ilerlemesini h\u0131zland\u0131rabilir. Hem qi hem de yin eksikli\u011fi olan 160 diyabet nefropatisi vakas\u0131 incelenmi\u015ftir. Klinik \u00e7al\u0131\u015fma, DKD hastalar\u0131nda Bacteroides, Bifidobacterium ve Lactobacillus'un kontrol grubundakilerden \u00f6nemli \u00f6l\u00e7\u00fcde d\u00fc\u015f\u00fck oldu\u011funu, Enterobacteriaceae, Enterococcus, Yeast ve Fusobacterium'un ise kontrol grubundakilerden daha y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir. Deneysel sonu\u00e7lar, DKD ve Mod'da Bacteroidetes, Lactobacillus, Bifidobacterium ve Clostridium gibi faydal\u0131 bakterilerin i\u00e7eri\u011finin azald\u0131\u011f\u0131n\u0131, Clostridium, Molluscaceae, Escherichia coli ve Enterococcus gibi patojen bakterilerin i\u00e7eri\u011finin ise artt\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Sonu\u00e7lar \u00f6nceki \u00e7al\u0131\u015fmalarla tutarl\u0131d\u0131r. Ayn\u0131 zamanda, DKD'nin aksine, Mod'da Firmicutes, Clostridium, Molluscum ve Enterococcus bollu\u011funun \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131, Lactobacillus, Clostridium ve Bifidobacterium bollu\u011funun ise \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131 tespit edilmi\u015ftir; bu da bu bakteri cinslerinin Qi Yin eksikli\u011fi sendromuyla yak\u0131ndan ili\u015fkili olabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir.<\/p>\n

Ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131n bozulmas\u0131 ba\u011f\u0131rsakta endotoksin sentezinin artmas\u0131na, enflamatuar reaksiyonlar\u0131n \u015fiddetlenmesine, ba\u011f\u0131rsak bariyerinin bozulmas\u0131na ve zararl\u0131 maddelerin transferine yol a\u00e7arak b\u00f6brek enflamasyonunu \u015fiddetlendirebilir ve diyabetik b\u00f6brek hastal\u0131\u011f\u0131n\u0131n (DKH) ilerlemesini h\u0131zland\u0131rabilir. Deneysel sonu\u00e7lar, b\u00f6breklerde ve kolonda IL-6 ve TNF - \u03b1 proteinlerinin ekspresyonunun \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015f ve bu da bu sonucu do\u011frulam\u0131\u015ft\u0131r. Occludin ve ZO-1 proteinleri ba\u011f\u0131rsak dokusunun s\u0131k\u0131 ba\u011flant\u0131 durumu ile ili\u015fkilidir. M3R ayr\u0131ca ba\u011f\u0131rsak sitokinlerini ind\u00fckleyerek ba\u011f\u0131rsak mukozal homeostaz\u0131n\u0131 koruyabilirken, 5-HT3A ba\u011f\u0131\u015f\u0131kl\u0131k sistemi h\u00fccrelerinin ekspresyonu yoluyla ba\u011f\u0131rsak ba\u011f\u0131\u015f\u0131kl\u0131k sistemini koruyabilir. Nor ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, Mod kolon dokusunda M3R, 5-HT3A, Occludin ve ZO-1 proteinlerinin ekspresyonu \u00f6nemli \u00f6l\u00e7\u00fcde azalm\u0131\u015ft\u0131r, bu da ba\u011f\u0131rsak bariyerinin homeostaz\u0131n\u0131n bozulmu\u015f olabilece\u011fini g\u00f6stermektedir. Bu durum, faydal\u0131 ve patojenik bakterilerin i\u00e7eri\u011findeki de\u011fi\u015fikliklerden kaynaklanabilir ve sonu\u00e7ta DKD Qi Yin eksikli\u011fi sendromunun geli\u015fmesine yol a\u00e7abilir.<\/p>\n

Qi eksikli\u011fi v\u00fccudun ya\u015famsal enerjisinin eksikli\u011finden kaynaklan\u0131r. Qi'nin te\u015fvik etme, peki\u015ftirme, ta\u015f\u0131ma ve \u0131s\u0131tma i\u015flevleri vard\u0131r. Qi eksikli\u011fi i\u00e7 organlar\u0131n i\u015flevinin azalmas\u0131na yol a\u00e7abilir. Klinik \u00e7al\u0131\u015fmalar, diyabet nefropatisi olan hastalarda idrar mikroalb\u00fcmin ve imm\u00fcnoglobulin G i\u00e7eri\u011finin sa\u011fl\u0131kl\u0131 hastalara g\u00f6re \u00f6nemli \u00f6l\u00e7\u00fcde d\u00fc\u015f\u00fck oldu\u011funu g\u00f6stermektedir. Deneysel sonu\u00e7lar, Mod'daki IgG ve IgM protein konsantrasyonunun \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131n\u0131 g\u00f6stermektedir, bu da Mod s\u0131\u00e7anlar\u0131n\u0131n v\u00fccut ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131n\u0131n azald\u0131\u011f\u0131n\u0131 g\u00f6stermektedir; DN'li 172 hasta \u00fczerinde yap\u0131lan \u00e7al\u0131\u015fmada, cAMP seviyesinin diyabet nefropatisi olan hastalarda b\u00f6brek hasar\u0131 derecesi ile pozitif ili\u015fkili oldu\u011fu bulunmu\u015ftur. Deneyde, Nor ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda Mod, cAMP i\u00e7eri\u011finde ve cAMP\/cGMP oran\u0131nda \u00f6nemli bir art\u0131\u015f g\u00f6stermi\u015ftir. CAMP\/cGMP oran\u0131 anormal derecede y\u00fcksek veya d\u00fc\u015f\u00fck g\u00f6r\u00fcnd\u00fc. CAMP i\u00e7eri\u011fi artt\u0131\u011f\u0131nda, b\u00fcy\u00fck miktarda tirozin hidroksilaz aktive oldu, sinir sistemi \u00fczerinde etkili olmak i\u00e7in b\u00fcy\u00fck miktarda dopamin \u00fcretti, insan duygular\u0131n\u0131 etkiledi ve heyecanda art\u0131\u015fa yol a\u00e7t\u0131. Bu nedenle, sanal \u0131s\u0131 sendromu genellikle heyecana yol a\u00e7ar; \u00c7al\u0131\u015fma ayr\u0131ca diyabet nefropati hastalar\u0131nda Na+\/K+- ATPaz ve Ca2+- Mg2+- ATPaz aktivitelerinin \u00f6nemli \u00f6l\u00e7\u00fcde hasar g\u00f6rd\u00fc\u011f\u00fcn\u00fc, bunun da h\u00fccre yap\u0131s\u0131 ve fonksiyonunun hasar g\u00f6rmesine, mikrosirk\u00fclasyon blo\u011funa, a\u011f\u0131rla\u015ft\u0131r\u0131lm\u0131\u015f renal hipoksi iskemisine, vask\u00fcler ge\u00e7irgenli\u011fin artmas\u0131na ve idrar protein s\u0131z\u0131nt\u0131s\u0131n\u0131n artmas\u0131na neden olarak b\u00f6brek hastal\u0131\u011f\u0131n\u0131n daha da geli\u015fmesine yol a\u00e7t\u0131\u011f\u0131n\u0131 buldu. Deneysel sonu\u00e7lar ayr\u0131ca Mod b\u00f6bre\u011findeki Na+\/K+- ATPaz ve Ca2+- Mg2+- ATPaz aktivitelerinin Nor ve DKD'dekilerden \u00f6nemli \u00f6l\u00e7\u00fcde daha d\u00fc\u015f\u00fck oldu\u011funu g\u00f6stermi\u015ftir. Kronik b\u00f6brek hastal\u0131\u011f\u0131, hastal\u0131\u011f\u0131n uzun s\u00fcrmesi nedeniyle hayati enerjinin t\u00fckenmesine yol a\u00e7m\u0131\u015f ve yin s\u0131v\u0131s\u0131 hasar\u0131 hem qi hem de yin eksikli\u011fi sendromunu olu\u015fturmu\u015ftur, bu nedenle hem qi hem de yin eksikli\u011fi olan diyabet b\u00f6brek hastal\u0131\u011f\u0131 v\u00fccudun enerji metabolizmas\u0131na yol a\u00e7acakt\u0131r. Bozukluk meydana gelir.<\/p>\n

\u00d6zetle, s\u0131\u00e7anlar\u0131n 4 hafta boyunca y\u00fcksek glikoz ve y\u00fcksek ya\u011f ile beslenmesi ve 8 hafta boyunca streptozotosin, akonit, ye\u015fil kabuk ve fructus aurantii'nin intraperitoneal enjeksiyonu ile hem qi hem de yin eksikli\u011fi olan diyabet b\u00f6brek hastal\u0131\u011f\u0131n\u0131n temel sendrom \u00f6zellikleri k\u0131smen olu\u015fturulabilir. S\u0131\u00e7anlardaki sembolik ba\u011f\u0131rsak floras\u0131n\u0131n ve \u00f6l\u00e7\u00fclen g\u00f6stergelerin fark\u0131, hastal\u0131k sendromu kombinasyon modelinin temel \u00f6zelliklerini belirli bir \u00f6l\u00e7\u00fcde yans\u0131tabilir ve hem qi hem de yin eksikli\u011fi olan diyabet b\u00f6brek hastal\u0131\u011f\u0131 modelinin \u00f6zelliklerini de\u011ferlendirmek i\u00e7in kullan\u0131labilir.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the Animal Model of diabetes Kidney Disease with Qi Yin Deficiency Syndrome Based on Intestinal Microflora At present, most scholars believe that the deficiency of both qi and yin in diabetes kidney disease (DKD) is the basic etiology and pathogenesis of DKD, and its pathological changes are evolved from the deficiency of yin […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the Animal Model of diabetes Kidney Disease with Qi Yin Deficiency Syndrome Based on Intestinal Microflora - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/qi-yin-ile-diyabet-bobrek-hastaligi\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the Animal Model of diabetes Kidney Disease with Qi Yin Deficiency Syndrome Based on Intestinal Microflora - 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