{"id":5138,"date":"2024-08-04T17:30:44","date_gmt":"2024-08-04T17:30:44","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5138"},"modified":"2024-08-04T17:30:44","modified_gmt":"2024-08-04T17:30:44","slug":"camel-blood-protein","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/deve-kani-proteini\/","title":{"rendered":"Deve kan\u0131 proteinindeki pankreatik lipaz inhibit\u00f6r peptitlerin bilgisayar sim\u00fclasyonuyla de\u011ferlendirilmesi"},"content":{"rendered":"<p>Deve kan\u0131 proteinindeki pankreatik lipaz inhibit\u00f6r peptitlerin bilgisayar sim\u00fclasyonuyla de\u011ferlendirilmesi<br \/>\nSon y\u0131llarda, insanlar\u0131n ya\u015fam standartlar\u0131n\u0131n iyile\u015fmesi ve beslenme al\u0131\u015fkanl\u0131klar\u0131ndaki de\u011fi\u015fikliklerle birlikte, hiperlipidemi (HLP) giderek insan sa\u011fl\u0131\u011f\u0131n\u0131 tehlikeye atan \"bir numaral\u0131 katil\" haline gelmi\u015ftir. Bu hastal\u0131\u011fa v\u00fccuttaki lipit metabolizmas\u0131n\u0131n d\u00fczensizli\u011fi neden olmaktad\u0131r. Kolesterol emilimi ve lipid metabolizmas\u0131 aras\u0131ndaki yak\u0131n ili\u015fki g\u00f6z \u00f6n\u00fcne al\u0131nd\u0131\u011f\u0131nda, kolesterol emilim yolu, ba\u011f\u0131rsakta kolesterol emilimini azaltarak hiperlipidemiyi etkili bir \u015fekilde \u00f6nleyebilen hiperlipidemi tedavisi i\u00e7in \u00f6nemli bir m\u00fcdahale hedefi haline gelmi\u015ftir. Diyetle al\u0131nan lipitler \u00f6nce pankreatik lipaz taraf\u0131ndan hidrolize edilir, ya\u011f asitlerine ve monogliseritlere ayr\u0131l\u0131r, kolesterol, safra tuzlar\u0131 vb. ile miseller olu\u015fturur ve son olarak ba\u011f\u0131rsaktaki h\u00fccreler taraf\u0131ndan emilir. Bu nedenle, pankreatik lipaz (PL) aktivitesini etkili bir \u015fekilde inhibe etmek, v\u00fccudun lipid emilimini azaltabilir, durumu kayna\u011f\u0131ndan hafifletebilir ve hastal\u0131klar\u0131 \u00f6nleyebilir. Piyasadaki baz\u0131 ila\u00e7lar\u0131n hastalarda rahats\u0131zl\u0131\u011fa neden olabilecek belirli yan etkileri vard\u0131r. Bu nedenle, hiperlipidemi tedavisine yard\u0131mc\u0131 olmak i\u00e7in do\u011fal olarak olu\u015fan biyoaktif maddelerin geli\u015ftirilmesi acildir.<\/p>\n<p>Biyoaktif peptitler, geni\u015f kaynaklar\u0131 ve y\u00fcksek g\u00fcvenlik fakt\u00f6rleri nedeniyle son y\u0131llarda ara\u015ft\u0131rmalar\u0131n odak noktas\u0131 haline gelmi\u015ftir. Deve kan\u0131, 6,80 g\/dL toplam protein i\u00e7eri\u011fi ve 141,11 g\/L hemoglobin i\u00e7eri\u011fi ile di\u011fer \u00e7iftlik hayvanlar\u0131ndan daha y\u00fcksek bir protein i\u00e7eri\u011fine sahiptir. Ayr\u0131ca WHO\/FAO\/UNU'nun tavsiye etti\u011fi de\u011ferleri kar\u015f\u0131layan zengin bir amino asit \u00e7e\u015fitlili\u011fine sahiptir ve y\u00fcksek kaliteli biyoaktif peptitlerin potansiyel bir kayna\u011f\u0131d\u0131r. Ara\u015ft\u0131rmalar, deve kan\u0131 proteaz hidrolizatlar\u0131n\u0131n yorgunluk giderici, antioksidan ve kan bas\u0131nc\u0131n\u0131 d\u00fc\u015f\u00fcr\u00fcc\u00fc etkileri oldu\u011funu g\u00f6stermi\u015ftir. Bu nedenle, deve kan\u0131 proteininden pankreatik lipaz inhibit\u00f6r peptitlerin haz\u0131rlanmas\u0131 belirli bir ara\u015ft\u0131rma de\u011ferine sahiptir.<\/p>\n<p>Bu \u00e7al\u0131\u015fmada, deve kan\u0131 proteinini hidrolize etmek i\u00e7in n\u00f6tr proteaz kullan\u0131lm\u0131\u015f ve enzimatik hidroliz s\u00fcrecini optimize etmek i\u00e7in de\u011ferlendirme indeksi olarak pankreatik lipaz inhibisyon oran\u0131 kullan\u0131lm\u0131\u015ft\u0131r. Deve kan\u0131 peptitlerinin molek\u00fcler a\u011f\u0131rl\u0131k da\u011f\u0131l\u0131m\u0131n\u0131 belirlemek i\u00e7in matris destekli lazer desorpsiyon\/iyonizasyon u\u00e7u\u015f s\u00fcresi k\u00fctle spektrometrisi (MALDI-TOF-MS) ve deve kan\u0131 peptitlerini tan\u0131mlamak ve analiz etmek i\u00e7in s\u0131v\u0131 kromatografi-k\u00fctle spektrometrisi (LC-MS) kullan\u0131lm\u0131\u015ft\u0131r. Ba\u011flanma b\u00f6lgelerini modellemek ve tahmin etmek i\u00e7in PepSite2 kullan\u0131lm\u0131\u015f ve taranan peptitlerin ba\u011flanma b\u00f6lgelerini ve etki \u015fekillerini de\u011ferlendirmek i\u00e7in molek\u00fcler dinamik sim\u00fclasyonu kullan\u0131larak gelecekte deve kan\u0131 peptitlerinin tan\u0131mlanmas\u0131 ve analizi i\u00e7in bir temel sa\u011flanm\u0131\u015ft\u0131r. Lipaz inhibe edici peptitlerin incelenmesi, deve kan\u0131n\u0131n geli\u015ftirilmesi ve kullan\u0131m\u0131 i\u00e7in referans ve yeni fikirler sa\u011flamaktad\u0131r.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5139\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-121.png\" alt=\"\" width=\"363\" height=\"250\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5140\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-107.png\" alt=\"\" width=\"775\" height=\"445\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-107.png 775w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-107-768x441.png 768w\" sizes=\"(max-width: 775px) 100vw, 775px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5141\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-101.png\" alt=\"\" width=\"778\" height=\"435\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-101.png 778w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-101-768x429.png 768w\" sizes=\"(max-width: 778px) 100vw, 778px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5142\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-90.png\" alt=\"\" width=\"781\" height=\"187\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-90.png 781w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-90-768x184.png 768w\" sizes=\"(max-width: 781px) 100vw, 781px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5143\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-83.png\" alt=\"\" width=\"781\" height=\"198\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-83.png 781w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-83-768x195.png 768w\" sizes=\"(max-width: 781px) 100vw, 781px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5144\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-75.png\" alt=\"\" width=\"776\" height=\"630\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-75.png 776w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-75-768x624.png 768w\" sizes=\"(max-width: 776px) 100vw, 776px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5145\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-68.png\" alt=\"\" width=\"774\" height=\"410\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-68.png 774w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-68-768x407.png 768w\" sizes=\"(max-width: 774px) 100vw, 774px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5146\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-63.png\" alt=\"\" width=\"776\" height=\"231\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-63.png 776w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-63-768x229.png 768w\" sizes=\"(max-width: 776px) 100vw, 776px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5147\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-57.png\" alt=\"\" width=\"775\" height=\"277\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-57.png 775w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-57-768x274.png 768w\" sizes=\"(max-width: 775px) 100vw, 775px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5148\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-47.png\" alt=\"\" width=\"771\" height=\"297\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-47.png 771w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-47-768x296.png 768w\" sizes=\"(max-width: 771px) 100vw, 771px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5149\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-42.png\" alt=\"\" width=\"777\" height=\"341\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-42.png 777w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-42-768x337.png 768w\" sizes=\"(max-width: 777px) 100vw, 777px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5150\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-36.png\" alt=\"\" width=\"779\" height=\"216\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-36.png 779w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-36-768x213.png 768w\" sizes=\"(max-width: 779px) 100vw, 779px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5151\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-31.png\" alt=\"\" width=\"774\" height=\"291\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-31.png 774w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-31-768x289.png 768w\" sizes=\"(max-width: 774px) 100vw, 774px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5152\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-26.png\" alt=\"\" width=\"774\" height=\"261\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-26.png 774w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-26-768x259.png 768w\" sizes=\"(max-width: 774px) 100vw, 774px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5153\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-20.png\" alt=\"\" width=\"761\" height=\"684\" \/><br \/>\nPankreatik lipaz\u0131n inhibisyonu, hiperlipidemi ve obezite i\u00e7in \u00f6nemli terap\u00f6tik m\u00fcdahalelerden biri olarak kabul edilmektedir. Bu \u00e7al\u0131\u015fmada, deve kan\u0131 pankreatik lipaz inhibit\u00f6r peptitlerinin n\u00f6tr proteaz hidrolizi ile haz\u0131rlanmas\u0131 s\u00fcreci, pankreatik lipaz inhibit\u00f6r aktivitesine dayal\u0131 olarak tek fakt\u00f6r ve yan\u0131t y\u00fczeyi deneyleri ile optimize edilmi\u015ftir. Optimal ko\u015fullar alt\u0131nda, deve kan\u0131 peptidinin pankreatik lipaz inhibisyon oran\u0131 42.13% idi. MALDI-TOF-MS, LC-MS ve biyoinformatik teknolojisi kullan\u0131larak enzimatik hidroliz \u00fcr\u00fcnleri analiz edilerek, ALERMFLGF, GQPAVPVRF ve WDPSKVPPR olmak \u00fczere \u00fc\u00e7 peptit segmentinin pankreatik lipaza \u00f6nemli \u00f6l\u00e7\u00fcde ba\u011fland\u0131\u011f\u0131 tespit edilmi\u015ftir. Molek\u00fcler dinamik sim\u00fclasyonlar\u0131 arac\u0131l\u0131\u011f\u0131yla, \u00fc\u00e7 peptit segmentinin esas olarak hidrojen ba\u011f\u0131 ve hidrofobik etkile\u015fimler yoluyla PL aktif b\u00f6lgesinin amino asit kal\u0131nt\u0131lar\u0131na ba\u011fland\u0131\u011f\u0131, pankreatik lipaz N-terminal alan valfinin i\u015flevini bozdu\u011fu ve aktivitesini inhibe etti\u011fi bulunmu\u015ftur. Bunlar aras\u0131nda, GQPAVPVRF y\u00fcksek bir ba\u011flanma serbest enerjisine ve 100ns i\u00e7inde \u00e7ok say\u0131da hidrojen ba\u011f\u0131na sahiptir, bu da 1ETH'ye s\u0131k\u0131ca ba\u011flanabilece\u011fi anlam\u0131na gelir ve pankreatik lipaz inhibit\u00f6rlerinin bir bile\u015feni olmas\u0131 beklenir. Ara\u015ft\u0131rma sonu\u00e7lar\u0131, deve kan\u0131 proteininin pankreatik lipaz inhibe edici peptitlerin kayna\u011f\u0131 olarak kullan\u0131labilece\u011fini g\u00f6stermektedir. Bununla birlikte, sanal tarama sonu\u00e7lar\u0131nda baz\u0131 s\u0131n\u0131rlamalar vard\u0131r ve gelecekte, peptit segmentlerinin suda \u00e7\u00f6z\u00fcn\u00fcrl\u00fc\u011f\u00fcn\u00fc ve sindirim stabilitesini optimize etmek gerekir. Yapay sentezden sonra, anti hiperlipidemi etkisi in vitro ve in vivo deneylerle do\u011frulanmal\u0131d\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"<p>Computer simulation evaluation of pancreatic lipase inhibitory peptides in camel blood protein In recent years, with the improvement of people&#8217;s living standards and changes in dietary habits, hyperlipidemia (HLP) has gradually become the &#8220;number one killer&#8221; that endangers human health. This disease is caused by dysregulation of lipid metabolism in the body. Given the close [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Computer simulation evaluation of pancreatic lipase inhibitory peptides in camel blood protein - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/deve-kani-proteini\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Computer simulation evaluation of pancreatic lipase inhibitory peptides in camel blood protein - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Computer simulation evaluation of pancreatic lipase inhibitory peptides in camel blood protein In recent years, with the improvement of people&#8217;s living standards and changes in dietary habits, hyperlipidemia (HLP) has gradually become the &#8220;number one killer&#8221; that endangers human health. This disease is caused by dysregulation of lipid metabolism in the body. 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This disease is caused by dysregulation of lipid metabolism in the body. 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