{"id":5099,"date":"2024-08-04T17:19:25","date_gmt":"2024-08-04T17:19:25","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5099"},"modified":"2024-08-04T17:19:25","modified_gmt":"2024-08-04T17:19:25","slug":"tumor-cell","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/tumor-hucresi\/","title":{"rendered":"Fukoidan nano selenyumun haz\u0131rlanmas\u0131 ve t\u00fcm\u00f6r h\u00fccresi proliferasyonunu inhibe etmesi"},"content":{"rendered":"<p>Fukoidan nano selenyumun haz\u0131rlanmas\u0131 ve t\u00fcm\u00f6r h\u00fccresi proliferasyonunu inhibe etmesi<br \/>\nG\u00fcn\u00fcm\u00fczde kanser, kardiyovask\u00fcler hastal\u0131klar\u0131n yan\u0131 s\u0131ra insan \u00f6l\u00fcmlerinin ikinci \u00f6nde gelen nedeni haline gelmi\u015ftir. Zor tedavisi, uzun tedavi d\u00f6ng\u00fcs\u00fc ve y\u00fcksek tedavi maliyeti nedeniyle insanlar\u0131n hayat\u0131na a\u011f\u0131r bir y\u00fck getirmektedir. Kemoterapi, modern Bat\u0131 t\u0131bb\u0131nda kanser tedavisinde kullan\u0131lan ana y\u00f6ntemlerden biridir, ancak kemoterapi ila\u00e7lar\u0131n\u0131n ciddi yan etkileri ve ila\u00e7 direnci nedeniyle tedavi etkisi ideal de\u011fildir. Bu nedenle, y\u00fcksek etkinli\u011fe sahip ve toksik yan etkisi olmayan geni\u015f spektrumlu bir anti-t\u00fcm\u00f6r ilac\u0131 geli\u015ftirmek hala \u00e7\u00f6z\u00fclmesi gereken acil bir sorundur.<br \/>\nSelenyum (Se), glutatyon peroksidaz, tiyoredoksin red\u00fcktaz ve di\u011fer enzimlerin sentezinde \u00f6nemli bir rol oynayan, insan v\u00fccudu i\u00e7in gerekli bir eser elementtir. \u00c7e\u015fitli ya\u015fam aktivitelerine kat\u0131l\u0131r ve insan sa\u011fl\u0131\u011f\u0131 i\u00e7in b\u00fcy\u00fck \u00f6nem ta\u015f\u0131r. Ayn\u0131 zamanda selenyum, antioksidan ve anti-t\u00fcm\u00f6r gibi \u00e7e\u015fitli fonksiyonel aktivitelere de sahiptir. Ara\u015ft\u0131rmalar, kanser hastalar\u0131n\u0131n v\u00fccutlar\u0131nda selenyum eksikli\u011finden muzdarip oldu\u011funu ortaya koymu\u015ftur. Yeterli selenyum al\u0131m\u0131 normal h\u00fccreleri koruyabilir ve kanser olu\u015fumunu azaltabilir. Bununla birlikte, organizmalarda kullan\u0131labilecek Se'nin g\u00fcvenli dozaj aral\u0131\u011f\u0131 \u00e7ok dard\u0131r ve a\u015f\u0131r\u0131 kullan\u0131m nedeniyle zehirlenmeye neden olmak kolayd\u0131r. Bu nedenle, toksisitesini azaltmak i\u00e7in Se'nin g\u00fcvenli formlar\u0131n\u0131 ke\u015ffetmek ve geli\u015ftirmek \u00e7ok \u00f6nemlidir. Ara\u015ft\u0131rmalar, geleneksel Se formlar\u0131yla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, selenyum nanopartik\u00fcllerinin (SeNPs) benzersiz boyutlar\u0131 ve y\u00fczey etkileri nedeniyle daha d\u00fc\u015f\u00fck toksisiteye ve daha iyi biyoyararlan\u0131ma sahip oldu\u011funu bulmu\u015ftur. Bununla birlikte, SeNP'ler, y\u00fczeylerinde kom\u015fu koordine edici atomlar\u0131n bulunmamas\u0131 nedeniyle y\u00fcksek aktiviteye sahiptir, bu da onlar\u0131 oda s\u0131cakl\u0131\u011f\u0131nda son derece karars\u0131z hale getirir ve daha toksik elemental Se olu\u015fturmak i\u00e7in toplanmaya e\u011filimlidir. Bu nedenle, SeNP'lerin haz\u0131rlanmas\u0131nda genellikle da\u011f\u0131labilirliklerini art\u0131rmak i\u00e7in da\u011f\u0131t\u0131c\u0131lar kullan\u0131l\u0131r. Polisakkaritlerin molek\u00fcler yap\u0131lar\u0131nda, SeNP'lerin toplanmas\u0131n\u0131 \u00f6nlemek i\u00e7in molek\u00fcller aras\u0131 hidrojen ba\u011flar\u0131 yoluyla Se ile ba\u011flanabilen hidroksil gruplar\u0131 vard\u0131r. Bu nedenle, polisakkaritler genellikle SeNP'leri da\u011f\u0131tmak i\u00e7in kullan\u0131l\u0131r. \u015eu anda, nano selenyum modifiye edici olarak kullan\u0131lan polisakkaritler aras\u0131nda astragalus polisakkaritleri, konjak glukomannan vb. bulunmaktad\u0131r.<br \/>\nFukoidan (FD) kahverengi alglerden elde edilen, s\u00fclfatlanm\u0131\u015f fukoidan, mannoz, arabinoz, glukuronik asit ve di\u011fer monosakkaritlerden olu\u015fan suda \u00e7\u00f6z\u00fcnebilen do\u011fal bir polisakkarittir. Ara\u015ft\u0131rmac\u0131lar, fukoidan\u0131n anti-t\u00fcm\u00f6r, antioksidan ve anti-inflamatuar etkiler gibi \u00e7e\u015fitli fonksiyonel aktivitelere sahip oldu\u011funu bulmu\u015flard\u0131r. Ancak, \u015fu anda nano selenyumun fukoidan ile modifikasyonu hakk\u0131nda herhangi bir rapor bulunmamaktad\u0131r. Bu nedenle, bu makale redoks reaksiyonlar\u0131 yoluyla fukoidan selenyum nanopartik\u00fclleri (FD SeNPs) haz\u0131rlamak i\u00e7in stabilizat\u00f6r olarak FD kullanmaktad\u0131r. Haz\u0131rlama s\u00fcreci parametrelerini optimize etmek i\u00e7in tek fakt\u00f6r ve yan\u0131t y\u00fczeyi deneyleri kullan\u0131lm\u0131\u015f ve t\u00fcm\u00f6r h\u00fccresi proliferasyonunun daha fazla yap\u0131sal tan\u0131mlanmas\u0131 ve inhibisyonu incelenerek FD SeNP'lerin t\u00fcm\u00f6r h\u00fccresi inhibit\u00f6rleri olarak geli\u015ftirilmesi ve uygulanmas\u0131 i\u00e7in teorik veri deste\u011fi sa\u011flanm\u0131\u015ft\u0131r.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5100\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-118.png\" alt=\"\" width=\"783\" height=\"179\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-118.png 783w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-118-768x176.png 768w\" sizes=\"(max-width: 783px) 100vw, 783px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5101\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-104.png\" alt=\"\" width=\"778\" height=\"338\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-104.png 778w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-104-768x334.png 768w\" sizes=\"(max-width: 778px) 100vw, 778px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5102\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-98.png\" alt=\"\" width=\"782\" height=\"531\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-98.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-98-768x521.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5103\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-87.png\" alt=\"\" width=\"780\" height=\"355\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-87.png 780w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-87-768x350.png 768w\" sizes=\"(max-width: 780px) 100vw, 780px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5104\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-80.png\" alt=\"\" width=\"782\" height=\"262\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-80.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-80-768x257.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5105\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-72.png\" alt=\"\" width=\"779\" height=\"198\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-72.png 779w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-72-768x195.png 768w\" sizes=\"(max-width: 779px) 100vw, 779px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5106\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-65.png\" alt=\"\" width=\"780\" height=\"213\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-65.png 780w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-65-768x210.png 768w\" sizes=\"(max-width: 780px) 100vw, 780px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5107\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-60.png\" alt=\"\" width=\"770\" height=\"250\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-60.png 770w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-60-768x249.png 768w\" sizes=\"(max-width: 770px) 100vw, 770px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5108\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-54.png\" alt=\"\" width=\"367\" height=\"263\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5109\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-45.png\" alt=\"\" width=\"365\" height=\"244\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-45.png 365w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-45-325x217.png 325w\" sizes=\"(max-width: 365px) 100vw, 365px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5110\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-40.png\" alt=\"\" width=\"769\" height=\"231\" \/><br \/>\nBu makalede, tek fakt\u00f6r ve yan\u0131t y\u00fczeyi optimizasyon deneyleri yoluyla FD SeNP'ler i\u00e7in optimum haz\u0131rlama s\u00fcreci parametreleri elde edilmi\u015ftir; bunlar 35 \u2103 reaksiyon s\u0131cakl\u0131\u011f\u0131, 1 saatlik reaksiyon s\u00fcresi, 14:1 askorbik asit-sodyum selenit molar oran\u0131 ve 0,8 mg\/mL FD konsantrasyonudur. Bu ko\u015fullar alt\u0131nda, minimum partik\u00fcl boyutu (83.40 \u00b1 0.55) nm, potansiyel (-31.89 \u00b1 0.47) mV ve selenyum i\u00e7eri\u011fi 29.93% olarak \u00f6l\u00e7\u00fclm\u00fc\u015ft\u00fcr. Yap\u0131s\u0131n\u0131n daha ileri d\u00fczeyde tan\u0131mlanmas\u0131, FD'nin hidroksil adsorpsiyonu yoluyla SeNP'lerin y\u00fczeyinde d\u00fczg\u00fcn k\u00fcresel nanopartik\u00fcller olu\u015fturdu\u011funu ortaya koymu\u015ftur; bu da polisakkaritlerin polar gruplar\u0131n\u0131n SeNP'lerin agregasyonunu etkili bir \u015fekilde inhibe edebilece\u011fini g\u00f6stermektedir.<\/p>\n<p>Mevcut ara\u015ft\u0131rmalar, anti-t\u00fcm\u00f6r mekanizmalar\u0131n\u0131n temel olarak t\u00fcm\u00f6r h\u00fccresi b\u00fcy\u00fcmesini inhibe etmeyi, t\u00fcm\u00f6r h\u00fccresi metastaz\u0131n\u0131 veya invazyonunu inhibe etmeyi ve anti-t\u00fcm\u00f6r etkileri elde etmek i\u00e7in v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenleme yetene\u011fini artt\u0131rmay\u0131 i\u00e7erdi\u011fini bulmu\u015ftur. Ara\u015ft\u0131rmalar, polisakkaritleri \u015fablon olarak kullanan SeNP'lerin ilgili apoptotik proteinlerin ve otofaji marker proteinlerinin ekspresyonunu te\u015fvik edebilece\u011fini ve b\u00f6ylece t\u00fcm\u00f6r h\u00fccresi apoptozunu ve otofajisini ind\u00fckleyebilece\u011fini g\u00f6stermi\u015ftir. Bu \u00e7al\u0131\u015fman\u0131n in vitro anti-t\u00fcm\u00f6r deneyi, FD modifiye SeNP'lerin SeNP'lerin t\u00fcm\u00f6r h\u00fccresi proliferasyonunu inhibe etme yetene\u011fini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rabildi\u011fini ve iyi h\u00fccre se\u00e7icili\u011fine sahip oldu\u011funu, ancak spesifik etki mekanizmas\u0131n\u0131n daha fazla \u00e7al\u0131\u015f\u0131lmas\u0131 gerekti\u011fini ortaya koymu\u015ftur.<\/p>","protected":false},"excerpt":{"rendered":"<p>Preparation of fucoidan nano selenium and its inhibition of tumor cell proliferation At present, besides cardiovascular disease, cancer has become the second leading cause of human death. Due to its difficult treatment, long treatment cycle, and high treatment cost, it brings a heavy burden to people&#8217;s lives. Chemotherapy is one of the main methods for [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Preparation of fucoidan nano selenium and its inhibition of tumor cell proliferation - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/tumor-hucresi\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation of fucoidan nano selenium and its inhibition of tumor cell proliferation - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Preparation of fucoidan nano selenium and its inhibition of tumor cell proliferation At present, besides cardiovascular disease, cancer has become the second leading cause of human death. 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