{"id":5071,"date":"2024-08-04T17:11:23","date_gmt":"2024-08-04T17:11:23","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5071"},"modified":"2024-08-04T17:11:23","modified_gmt":"2024-08-04T17:11:23","slug":"chinese-herbs","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/chinese-herbs\/","title":{"rendered":"Diyabet etki hedeflerine etki eden \u00c7in bitkileri ve aktif bile\u015fenlerin ara\u015ft\u0131rma ilerlemesi"},"content":{"rendered":"<p>Diyabet etki hedeflerine etki eden \u00c7in bitkileri ve aktif bile\u015fenlerin ara\u015ft\u0131rma ilerlemesi<br \/>\nDiyabet (DM), ins\u00fclin eksikli\u011fi veya yetersiz salg\u0131lanmas\u0131ndan kaynaklanan ve hiperglisemi ile karakterize, 90%~95%'sini tip 2 diyabetin olu\u015fturdu\u011fu metabolik bir bozukluktur. Uluslararas\u0131 Diyabet Federasyonu'nun (IDF) 2021 y\u0131l\u0131ndaki son verilerine g\u00f6re, 2045 y\u0131l\u0131nda 783 milyonu (12.2%) a\u015fmas\u0131 beklenen d\u00fcnyadaki DM say\u0131s\u0131n\u0131n 537 milyona ula\u015fmas\u0131 ve \u00c7in'in 2045 y\u0131l\u0131nda 175 milyonu a\u015fmas\u0131 beklenmektedir. DM, t\u00fcm\u00f6rler ve kardiyovask\u00fcler hastal\u0131klardan sonra d\u00fcnyada insan sa\u011fl\u0131\u011f\u0131n\u0131 tehdit eden en ciddi \u00fc\u00e7\u00fcnc\u00fc kronik hastal\u0131k haline gelmi\u015ftir. Y\u00fcksek kan \u015fekerinin neden oldu\u011fu \u00e7e\u015fitli akut ve kronik komplikasyonlar insan dokular\u0131na, organlar\u0131na vb. zarar verebilir. Bu nedenle, erken \u00f6nlenmesi ve tedavi edilmesi i\u00e7in aktif \u00f6nlemler al\u0131nmas\u0131 acildir.<br \/>\n\u015eu anda, klinik uygulamada DM'yi tamamen tedavi edebilecek herhangi bir ila\u00e7 rapor edilmemi\u015ftir. \u0130ns\u00fclin ve analoglar\u0131, s\u00fclfonil\u00fcreler, biguanidler, gliptidler, tiazolidindionlar, alfa glukozidaz inhibit\u00f6rleri, dipeptidil peptidaz inhibit\u00f6rleri, sodyum glukoz kotransporter 2 inhibit\u00f6rleri, glukagon benzeri peptid-1 resept\u00f6r agonistleri vb. dahil olmak \u00fczere kan \u015fekerini kontrol etmek i\u00e7in kullan\u0131lan bir\u00e7ok Bat\u0131 t\u0131bb\u0131 t\u00fcr\u00fc vard\u0131r. \u015eekeri h\u0131zl\u0131 ve etkili bir \u015fekilde kontrol edebilmelerine ra\u011fmen, uzun s\u00fcreli kullan\u0131m kolayca hipoglisemi, gastrointestinal reaksiyonlar ve kardiyovask\u00fcler hastal\u0131klar gibi bir dizi soruna neden olabilir. Geleneksel \u00c7in t\u0131bb\u0131n\u0131n ve aktif bile\u015fenlerinin taranmas\u0131 ve farmakolojik etkilerinin incelenmesiyle, geleneksel \u00c7in t\u0131bb\u0131n\u0131n \u00e7ok bile\u015fenli ve \u00e7ok hedefli etkilerinin \u00f6zellikleri s\u00fcrekli olarak ortaya \u00e7\u0131kar\u0131lm\u0131\u015f ve DM tedavisinde hafif etkinlik, minimum toksik yan etki ve genel d\u00fczenleme avantajlar\u0131 g\u00f6sterilmi\u015ftir. Ayn\u0131 zamanda, DM'nin \u00e7e\u015fitli komplikasyonlar\u0131n\u0131 da \u00f6nleyebilir ve tedavi edebilir. Son y\u0131llarda, DM tedavisi i\u00e7in yeni ila\u00e7lar\u0131n geli\u015ftirilmesi esas olarak alfa glukozidaz, alfa amilaz, dipeptidil peptidaz-4 (DPP-4), glukokinaz (GK) dahil olmak \u00fczere efekt\u00f6r hedeflere dayanmaktad\u0131r, sodyum glukoz kotransporter 2 (SGLT2), matriks metalloproteinazlar (MMP), protein tirozin fosfataz 1B (PTP1B), aldoz red\u00fcktaz (AR), peroksizom proliferat\u00f6r aktive resept\u00f6r (Peroxisome proliferator activated receptor). PPAR), adenozin monofosfat aktive protein kinaz (AMPK) yolu, ATP duyarl\u0131 potasyum kanal\u0131, KATP gibi belirli hedefleri ve yollar\u0131 hedefleyen DM tedavisi i\u00e7in geleneksel \u00c7in t\u0131bb\u0131 ve aktif bile\u015fenlerinin taranmas\u0131, ila\u00e7 etkisinin se\u00e7icili\u011fini art\u0131rabilir ve toksik yan etkileri azaltabilir veya en aza indirebilir; Ayn\u0131 zamanda, aktif bile\u015fenlerin etki mekanizmas\u0131n\u0131 da ayd\u0131nlatabilir ve geleneksel \u00c7in t\u0131bb\u0131n\u0131n daha da geli\u015ftirilmesi ve kullan\u0131lmas\u0131 i\u00e7in referans y\u00f6ntemler ve fikirler sa\u011flayabilir. Bu nedenle bu makale, DM ve komplikasyonlar\u0131n\u0131n tedavisinde geleneksel \u00c7in t\u0131bb\u0131 \u00e7al\u0131\u015fmalar\u0131na referans sa\u011flamak amac\u0131yla, geleneksel \u00c7in t\u0131bb\u0131 ve etken maddelerinin DM hedefleri ve yollar\u0131 \u00fczerindeki etkilerine ili\u015fkin ilgili literat\u00fcr\u00fc yurti\u00e7i ve yurtd\u0131\u015f\u0131nda d\u00fczenleyecek ve \u00f6zetleyecektir.<\/p>\n<p>&nbsp;<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5072\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-116.png\" alt=\"\" width=\"773\" height=\"256\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-116.png 773w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-116-768x254.png 768w\" sizes=\"(max-width: 773px) 100vw, 773px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5073\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-102.png\" alt=\"\" width=\"773\" height=\"231\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-102.png 773w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-102-768x230.png 768w\" sizes=\"(max-width: 773px) 100vw, 773px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5074\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-96.png\" alt=\"\" width=\"782\" height=\"462\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-96.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-96-768x454.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5075\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-85.png\" alt=\"\" width=\"782\" height=\"342\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-85.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-85-768x336.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5076\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-78.png\" alt=\"\" width=\"784\" height=\"236\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-78.png 784w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-78-768x231.png 768w\" sizes=\"(max-width: 784px) 100vw, 784px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5077\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-70.png\" alt=\"\" width=\"780\" height=\"362\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-70.png 780w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-70-768x356.png 768w\" sizes=\"(max-width: 780px) 100vw, 780px\" \/><\/p>\n<p>Bu makale, \u03b1-glukozidaz, \u03b1-amilaz, DPP-4, GK, PTP1B, SGLT2, PPAR gibi efekt\u00f6r hedefleri olan DM tedavisi i\u00e7in geleneksel \u00c7in t\u0131bb\u0131 ve aktif bile\u015fenleri \u00f6zetlemektedir. Farkl\u0131 do\u011fal \u00fcr\u00fcnlerin farkl\u0131 kimyasal yap\u0131lara sahip oldu\u011fu ve efekt\u00f6r hedeflerini rekabet\u00e7i, rekabet\u00e7i olmayan ve karma y\u00f6ntemlerle inhibe veya aktive edebildi\u011fi bulunmu\u015ftur. Farmakolojik aktiviteleri de de\u011fi\u015fiklik g\u00f6stermektedir.<\/p>\n<p>Yurti\u00e7inde ve yurtd\u0131\u015f\u0131nda ilgili alanlarda yap\u0131lan ara\u015ft\u0131rma sonu\u00e7lar\u0131n\u0131n g\u00f6zden ge\u00e7irilmesiyle, geleneksel \u00c7in t\u0131bb\u0131n\u0131n alkaloidler, flavonoidler, terpenler ve polisakkaritler gibi \u00e7e\u015fitli hipoglisemik aktif bile\u015fenler i\u00e7erdi\u011fi bulunmu\u015ftur. Enzimler, resept\u00f6rler, iyon kanallar\u0131 vb. \u00fczerinde etki ederek ins\u00fclin salg\u0131lanmas\u0131n\u0131 d\u00fczenler, ins\u00fclin duyarl\u0131l\u0131\u011f\u0131n\u0131 art\u0131r\u0131r ve DM'yi tedavi eder. Sinerjik ve tamamlay\u0131c\u0131 hipoglisemik mekanizmalar\u0131 sayesinde toksisiteyi azalt\u0131r ve etkinli\u011fi art\u0131r\u0131r. \u015eu anda klinik uygulamada kullan\u0131lan kimyasal ila\u00e7larla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, etkileri daha hafif ve daha g\u00fcvenlidir. Bu nedenle, hedef etkiler \u00fczerinde etkili olan do\u011fal \u00fcr\u00fcnlerden aktif bile\u015fenler elde etmek, \u00c7in'de DM i\u00e7in yenilik\u00e7i ila\u00e7 geli\u015ftirmenin temel odak noktas\u0131 haline gelmi\u015ftir.<\/p>\n<p>\u015eu anda, DM'nin geleneksel \u00c7in t\u0131bb\u0131 ile tedavisi \u00fczerine yap\u0131lan ara\u015ft\u0131rmalar belirli bir ilerleme kaydetmi\u015ftir, ancak hala ke\u015fif a\u015famas\u0131ndad\u0131r. Gelecekte, \u015fu konularda derinlemesine ara\u015ft\u0131rmalar yapabiliriz: DM tedavisinde kullan\u0131lan bir\u00e7ok bitki ve etken madde yaln\u0131zca tek bir hedef \u00fczerinde etkilidir ve geleneksel \u00c7in t\u0131bb\u0131 ile \u00e7ok hedefli ve \u00e7ok yollu tedavinin avantajlar\u0131 tam olarak ayd\u0131nlat\u0131lmam\u0131\u015ft\u0131r ve spesifik etki mekanizmas\u0131n\u0131n hala geli\u015ftirilmesi gerekmektedir. Ara\u015ft\u0131rmalar, enflamasyonun neden oldu\u011fu ba\u011f\u0131\u015f\u0131kl\u0131k tepkisinin ins\u00fclin direncini tetikleyerek DM olu\u015fumuna yol a\u00e7abilece\u011fini ortaya koymu\u015ftur. Enflamasyon ve ins\u00fclin direnci mekanizmas\u0131n\u0131n daha fazla ayd\u0131nlat\u0131lmas\u0131, DM tedavisi i\u00e7in etkili ara\u00e7lar sa\u011flayabilir. Geleneksel \u00c7in t\u0131bb\u0131 form\u00fcllerindeki bile\u015fenlerin karma\u015f\u0131kl\u0131\u011f\u0131, \u00e7oklu etki hedefleri ve etki mekanizmas\u0131n\u0131n ayd\u0131nlat\u0131lmas\u0131ndaki zorluk, ara\u015ft\u0131rmalar\u0131n\u0131 zorla\u015ft\u0131rmaktad\u0131r. DM tedavisi \u00fczerine yap\u0131lan ara\u015ft\u0131rmalar \u00e7o\u011funlukla tekil \u00c7in t\u0131bb\u0131 ekstrelerinin ve aktif bile\u015fenlerinin temel in vitro deneylerine dayanmaktad\u0131r. Bu nedenle, gelecekteki \u00e7al\u0131\u015fmalarda, DM tedavisi i\u00e7in geleneksel \u00c7in t\u0131bb\u0131 form\u00fclleri ve bile\u015fenleri \u00fczerine ara\u015ft\u0131rma ana g\u00f6rev olabilir. Buna ek olarak, geleneksel \u00c7in t\u0131bb\u0131 ve aktif bile\u015fenler, DM'yi tedavi etmek i\u00e7in efekt\u00f6r hedefler arac\u0131l\u0131\u011f\u0131yla ilgili sinyal yollar\u0131n\u0131 da d\u00fczenleyebilir. \u00c7e\u015fitli modern bilimsel teknolojiler arac\u0131l\u0131\u011f\u0131yla \"bile\u015fenler hastal\u0131k hedefleri yollar\u0131\" aras\u0131ndaki ili\u015fkiyi kapsaml\u0131 bir \u015fekilde ara\u015ft\u0131rarak, DM tedavisi i\u00e7in daha iyi geleneksel \u00c7in t\u0131bb\u0131n\u0131n daha fazla ara\u015ft\u0131r\u0131lmas\u0131 ve geli\u015ftirilmesi i\u00e7in bir temel sa\u011flayacakt\u0131r.<\/p>\n<p>Teknolojinin geli\u015fmesi ve ara\u015ft\u0131rmalar\u0131n derinle\u015fmesiyle, DM tedavisinde geleneksel \u00c7in t\u0131bb\u0131n\u0131n etki mekanizmas\u0131n\u0131n daha net hale gelece\u011fine ve DM tedavisi i\u00e7in daha g\u00fcvenli ve etkili do\u011fal ila\u00e7lar\u0131n ve etken maddelerin ke\u015ffedilece\u011fine inan\u0131yorum.<\/p>","protected":false},"excerpt":{"rendered":"<p>Research progress of Chinese herbs and active ingredients acting on diabetes effect targets Diabetes (DM) is a metabolic disorder caused by insulin deficiency or insufficient secretion, and is characterized by hyperglycemia, of which type 2 diabetes accounts for 90%~95%. According to the latest data of International diabetes Federation (IDF) in 2021, the number of DM [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research progress of Chinese herbs and active ingredients acting on diabetes effect targets - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/chinese-herbs\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research progress of Chinese herbs and active ingredients acting on diabetes effect targets - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Research progress of Chinese herbs and active ingredients acting on diabetes effect targets Diabetes (DM) is a metabolic disorder caused by insulin deficiency or insufficient secretion, and is characterized by hyperglycemia, of which type 2 diabetes accounts for 90%~95%. 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