{"id":5066,"date":"2024-08-04T17:08:27","date_gmt":"2024-08-04T17:08:27","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5066"},"modified":"2024-08-04T17:08:27","modified_gmt":"2024-08-04T17:08:27","slug":"a-new-amide-alkaloid-in-the-root-of-fake-konjac","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/a-new-amide-alkaloid-in-the-root-of-fake-konjac\/","title":{"rendered":"Sahte konjac k\u00f6k\u00fcnde yeni bir amid alkaloidi"},"content":{"rendered":"

Sahte konjac k\u00f6k\u00fcnde yeni bir amid alkaloidi
\nPiper sarmentosum, Piperaceae familyas\u0131ndan \u00e7ok y\u0131ll\u0131k, s\u00fcr\u00fcngen, bo\u011fum bo\u011fum k\u00f6kl\u00fc bir bitkidir ve genellikle toprak alt\u0131 veya yol kenar\u0131 sulak alanlarda bulunur. \u00c7o\u011funlukla \u00c7in'de Yunnan, Fujian ve Guizhou gibi eyaletlerde \u00fcretilir ve Hindistan, Vietnam, Filipinler ve Malezya'da da da\u011f\u0131t\u0131l\u0131r. Sahte konjac sadece zengin t\u0131bbi de\u011fere sahip olmakla kalmaz, ayn\u0131 zamanda y\u00fcksek s\u00fcs, yenilebilir ve ekonomik de\u011fere de sahiptir. \"Chinese Materia Medica\" gibi klasiklere g\u00f6re, sahte konjak s\u0131cak bir yap\u0131ya ve ac\u0131 ve keskin bir tada sahiptir. K\u00f6kleri, yapraklar\u0131 ve meyveleri, ortay\u0131 \u0131s\u0131tma ve so\u011fu\u011fu da\u011f\u0131tma, r\u00fczgar\u0131 ve rutubeti giderme, \u015fi\u015fli\u011fi ve a\u011fr\u0131y\u0131 azaltma etkileriyle ila\u00e7 olarak kullan\u0131labilir. Mide so\u011fuk alg\u0131nl\u0131\u011f\u0131 a\u011fr\u0131s\u0131, romatizmal s\u0131rt a\u011fr\u0131s\u0131, gebelik \u00f6demi ve travmatik kanama tedavisinde yayg\u0131n olarak kullan\u0131l\u0131r ve \u00f6nemli terap\u00f6tik etkileri vard\u0131r. Sahte konjak yapraklar\u0131, e\u015fsiz keskin aromalar\u0131 nedeniyle G\u00fcney \u00c7in'in Jiangsu, Zhejiang ve Guangdong b\u00f6lgelerinde baharat olarak yayg\u0131n bir \u015fekilde kullan\u0131lmakta ve yeti\u015ftirilmektedir.
\nModern farmakolojik \u00e7al\u0131\u015fmalar, sahte konjak \u00f6zlerinin antioksidan, anti-enflamatuar, antibakteriyel, b\u00f6cek \u00f6ld\u00fcr\u00fcc\u00fc, hipoglisemik ve n\u00f6roprotektif \u00f6zellikler gibi \u00e7ok \u00e7e\u015fitli biyolojik aktivitelere sahip oldu\u011funu g\u00f6stermi\u015ftir. \u015eu anda, hem yurt i\u00e7inde hem de yurt d\u0131\u015f\u0131nda sahte konjak\u0131n kimyasal bile\u015fimi \u00fczerine yap\u0131lan ara\u015ft\u0131rmalar \u00e7o\u011funlukla yapraklar\u0131na ve toprak \u00fcst\u00fc k\u0131s\u0131mlar\u0131na odaklanm\u0131\u015f olup, toprak alt\u0131 k\u00f6kleri \u00fczerine nispeten daha az ara\u015ft\u0131rma yap\u0131lm\u0131\u015ft\u0131r. Sahte konjaktan izole edilen ve tan\u0131mlanan kimyasal bile\u015fenler aras\u0131nda alkaloidler, lignanlar, flavonoidler ve steroller bulunmaktad\u0131r. Ara\u015ft\u0131rma grubumuz erken a\u015famada sahte konjak yapraklar\u0131ndan 7 alkaloid bile\u015fi\u011fi izole etmi\u015f ve bunlardan baz\u0131lar\u0131 Staphylococcus aureus'a kar\u015f\u0131 iyi antibakteriyel aktivite g\u00f6stermi\u015ftir. Sahte konjak\u0131n kimyasal bile\u015fimi ve biyolojik aktivitesi \u00fczerine devam eden ara\u015ft\u0131rmalarda, sahte konjak k\u00f6k\u00fcn\u00fcn 95% etanol \u00f6z\u00fct\u00fcn\u00fcn, karragenan taraf\u0131ndan ind\u00fcklenen fare aya\u011f\u0131 \u015fi\u015fmesinin semptomlar\u0131n\u0131 hafifletebildi\u011fi ve doza ba\u011fl\u0131 bir etkiye sahip oldu\u011fu bulunmu\u015ftur. Bu nedenle, ekstrakt\u0131n anti-enflamatuar aktif bile\u015fenler i\u00e7erdi\u011fi tahmin edilmektedir. \u0130lgili \u00e7al\u0131\u015fmalar sahte konjac k\u00f6k\u00fcndeki ana aktif bile\u015fenlerin alkaloidler oldu\u011funu g\u00f6stermi\u015ftir. Bu deneyde, sahte konjak k\u00f6k\u00fcn\u00fcn 95% etanol ekstresinin kimyasal bile\u015fimi incelenmi\u015f ve elde edilen monomerik bile\u015fiklerin anti-enflamatuar aktivitesini taramak i\u00e7in LPS ile ind\u00fcklenen RAW264.7 in vitro h\u00fccre enflamasyon modeli kullan\u0131lm\u0131\u015ft\u0131r. Ama\u00e7, sahte konjak bitki kaynaklar\u0131n\u0131n daha rasyonel bir \u015fekilde geli\u015ftirilmesi ve kullan\u0131lmas\u0131 i\u00e7in referans sa\u011flamak amac\u0131yla sahte konjak k\u00f6k\u00fcn\u00fcn kimyasal bile\u015fimini ve ilgili farmakolojik madde temelini a\u00e7\u0131kl\u0131\u011fa kavu\u015fturmakt\u0131r.<\/p>\n

\"\"\"\"\"\"
\nBu deneyde, sahte konjac k\u00f6k\u00fcnden 10 alkaloid bile\u015fi\u011fi izole etmek ve tan\u0131mlamak i\u00e7in modern kromatografik ay\u0131rma teknikleri ve spektroskopik y\u00f6ntemler kullan\u0131lm\u0131\u015ft\u0131r. Bunlar aras\u0131nda, bile\u015fik 1 yeni bir amid alkaloiddir ve bile\u015fik 5 d\u0131\u015f\u0131ndaki t\u00fcm bile\u015fikler bu bitkiden ilk kez izole edilmi\u015ftir. \u0130zole edilen bile\u015fiklerin anti-enflamatuar aktivitesi, LPS ile uyar\u0131lm\u0131\u015f RAW264.7 makrofaj enflamasyon modeli kullan\u0131larak de\u011ferlendirilmi\u015ftir. Sonu\u00e7lar, bile\u015fik 1, 2, 4 ve 10'un NO \u00fcretimi \u00fczerinde inhibit\u00f6r etkilere sahip oldu\u011funu ve test edilen konsantrasyonlarda \u00f6nemli sitotoksisite sergilemedi\u011fini g\u00f6stermi\u015ftir. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, sahte konjak k\u00f6k\u00fcn\u00fcn kimyasal bile\u015fimini daha da zenginle\u015ftirmekte ve sahte konjak k\u00f6k\u00fcndeki baz\u0131 anti-enflamatuar aktif maddelerin temelini \u00f6nceden a\u00e7\u0131kl\u0131\u011fa kavu\u015fturarak, bu bitki kayna\u011f\u0131n\u0131n gelecekteki geli\u015fimi ve kullan\u0131m\u0131 i\u00e7in belirli referans ve teorik temel sa\u011flamaktad\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

A new amide alkaloid in the root of fake konjac Piper sarmentosum is a perennial, creeping, node by node rooted herb of the Piperaceae family, commonly found in understory or roadside wetlands. It is mainly produced in provinces such as Yunnan, Fujian, and Guizhou in China, and is also distributed in India, Vietnam, the Philippines, […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nA new amide alkaloid in the root of fake konjac - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/a-new-amide-alkaloid-in-the-root-of-fake-konjac\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A new amide alkaloid in the root of fake konjac - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"A new amide alkaloid in the root of fake konjac Piper sarmentosum is a perennial, creeping, node by node rooted herb of the Piperaceae family, commonly found in understory or roadside wetlands. 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