{"id":5055,"date":"2024-08-04T17:06:57","date_gmt":"2024-08-04T17:06:57","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5055"},"modified":"2024-08-04T17:06:57","modified_gmt":"2024-08-04T17:06:57","slug":"cisplatin","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/sisplatin\/","title":{"rendered":"Meyan k\u00f6k\u00fcndeki endofitik bakterilerin sisplatin kaynakl\u0131 HEK293 h\u00fccre hasar\u0131na kar\u015f\u0131 koruyucu etkisi ve mekanizmas\u0131"},"content":{"rendered":"<p>Meyan k\u00f6k\u00fcndeki endofitik bakterilerin sisplatin kaynakl\u0131 HEK293 h\u00fccre hasar\u0131na kar\u015f\u0131 koruyucu etkisi ve mekanizmas\u0131<br \/>\nKlinik uygulamada yayg\u0131n olarak kullan\u0131lan bir anti-t\u00fcm\u00f6r ila\u00e7 olan sisplatin (CP), \u00f6nemli terap\u00f6tik etkilere ancak g\u00fc\u00e7l\u00fc toksik yan etkilere sahiptir. Ba\u015fl\u0131ca belirtileri nefrotoksisite, hepatotoksisite, ototoksisite ve kardiyotoksisite olup, b\u00f6brek hasar\u0131 \u00f6zellikle \u015fiddetlidir. Zamana ba\u011fl\u0131 doz ba\u011f\u0131ml\u0131l\u0131\u011f\u0131 vard\u0131r. CP'nin neden oldu\u011fu nefrotoksisite, mitokondriyal disfonksiyon, h\u00fccre apoptozunun ind\u00fcksiyonu, oksidatif stres vb. dahil olmak \u00fczere \u00e7oklu patojenik mekanizmalar\u0131 i\u00e7erebilir. Bu nedenle, CP'nin toksik yan etkilerinin nas\u0131l etkili bir \u015fekilde azalt\u0131laca\u011f\u0131, CP'nin klinik dozaj\u0131n\u0131n geni\u015fletilmesinde birincil sorun haline gelmi\u015ftir ve CP toksisitesini sinerjik olarak azaltmak ve etkinli\u011fi art\u0131rmak i\u00e7in uygun tedavi planlar\u0131 veya ila\u00e7lar bulmak \u015fu anda ana ara\u015ft\u0131rma y\u00f6n\u00fc haline gelmi\u015ftir.<br \/>\nSon y\u0131llarda, geleneksel \u00c7in t\u0131bb\u0131n\u0131n geli\u015fmesiyle birlikte, etkinli\u011fi art\u0131rmak ve toksisiteyi azaltmak i\u00e7in geleneksel \u00c7in t\u0131bb\u0131n\u0131n kombinasyonu \u00f6nemli bir ara\u015ft\u0131rma noktas\u0131 haline gelmi\u015ftir. \"Detoksifiye edici kutsal bitki\" olarak meyan k\u00f6k\u00fc, tatl\u0131 ve hafif bir tada sahiptir, dalak ve qi'yi beslemek ve \u00e7e\u015fitli ila\u00e7lar\u0131 uyumlu hale getirmek i\u00e7in i\u015flev g\u00f6r\u00fcr. Aktif bile\u015fenleri zehirlenme semptomlar\u0131n\u0131 hafifletebilir, \u00f6l\u00fcm oran\u0131n\u0131 azaltabilir ve ila\u00e7lar ve toksinler \u00fczerinde \u00f6nemli detoksifiye edici etkilere sahiptir. Endofitik bakteriler, sa\u011fl\u0131kl\u0131 bitki dokular\u0131 ve organlar\u0131 i\u00e7inde ya\u015fayan mantar veya bakterileri ifade eden t\u0131bbi mikrobiyal kaynaklar kategorisine aittir. Uzun s\u00fcreli evrim s\u00fcrecinde, konak\u00e7\u0131 ile genetik rekombinasyona u\u011frarlar ve konak\u00e7\u0131 bitkinin genlerini alarak, konak\u00e7\u0131 ile ayn\u0131 veya benzer t\u0131bbi etken maddeler \u00fcretirler. Man ve arkada\u015flar\u0131, meyan k\u00f6k\u00fc endofitik su\u015flar\u0131n\u0131n konak\u00e7\u0131 ile ayn\u0131 fizyolojik etkilere sahip oldu\u011funu ve antibakteriyel ve antioksidan farmakolojik etkileri ile meyan k\u00f6k\u00fcne benzer saponin ve flavonoid aktif bile\u015fenleri metabolize edebildi\u011fini bulmu\u015ftur. Yang ve arkada\u015flar\u0131, meyan k\u00f6k\u00fcndeki endofitik bakterilerin fermantasyon suyunun, konak kaynatma, toplam flavonoidler ve toplam saponinlerinkine benzer bir \u00f6ks\u00fcr\u00fck durdurucu etkiye sahip oldu\u011funu bulmu\u015ftur. \u00d6n deneysel ara\u015ft\u0131rmalar\u0131m\u0131z meyan k\u00f6k\u00fcndeki endofitik bakterilerin antibakteriyel, anti-inflamatuar, balgam s\u00f6kt\u00fcr\u00fcc\u00fc ve anti-t\u00fcm\u00f6r gibi \u00e7e\u015fitli farmakolojik etkilere sahip oldu\u011funu do\u011frulam\u0131\u015ft\u0131r. Ana meyan k\u00f6k\u00fcne benzer \u015fekilde amonyum glisirizinat, glisirizin ve glisirizini metabolize edebilirler. Bu nedenle meyan k\u00f6k\u00fcndeki endofitik bakteriler meyan k\u00f6k\u00fcne benzer detoksifikasyon etkilerine sahip olabilir. \u00d6nceki detoksifikasyon deneyleri meyan k\u00f6k\u00fcn\u00fcn CP'nin neden oldu\u011fu renal toksisiteyi etkili bir \u015fekilde hafifletebildi\u011fini g\u00f6stermi\u015ftir. Bununla birlikte, meyan k\u00f6k\u00fcndeki endofitik bakterilerin CP'nin neden oldu\u011fu nefrotoksisite \u00fczerine sistematik bir mekanizma \u00e7al\u0131\u015fmas\u0131 yap\u0131lmam\u0131\u015ft\u0131r.<\/p>\n<p>Bu nedenle, bu makale in vitro deneyler yoluyla CP kaynakl\u0131 bir HEK293 h\u00fccre hasar\u0131 modeli olu\u015fturmay\u0131 ve meyan k\u00f6k\u00fc endofitik bakterilerinin CP kaynakl\u0131 HEK293 h\u00fccreleri \u00fczerindeki koruyucu etkisini ve mekanizmas\u0131n\u0131 ara\u015ft\u0131rmay\u0131 ama\u00e7lamaktad\u0131r. Meyan k\u00f6k\u00fc endofitik bakterileri ve CP'nin birlikte uygulanarak verimlili\u011fin art\u0131r\u0131lmas\u0131 ve toksisitenin azalt\u0131lmas\u0131 i\u00e7in bir temel olu\u015fturmak ve meyan k\u00f6k\u00fc endofitik bakterilerinin detoksifikasyon etkisi i\u00e7in teorik referans sa\u011flayarak meyan k\u00f6k\u00fc endofitik bakterilerinin farmakolojik etkilerini daha da geni\u015fletmek.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5056\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-114.png\" alt=\"\" width=\"782\" height=\"192\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-114.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-114-768x189.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5057\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-100.png\" alt=\"\" width=\"782\" height=\"219\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-100.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-100-768x215.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5058\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-95.png\" alt=\"\" width=\"777\" height=\"254\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-95.png 777w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-95-768x251.png 768w\" sizes=\"(max-width: 777px) 100vw, 777px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5059\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-84.png\" alt=\"\" width=\"783\" height=\"228\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-84.png 783w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-84-768x224.png 768w\" sizes=\"(max-width: 783px) 100vw, 783px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5060\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-77.png\" alt=\"\" width=\"778\" height=\"282\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-77.png 778w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-77-768x278.png 768w\" sizes=\"(max-width: 778px) 100vw, 778px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5061\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-6.jpg\" alt=\"\" width=\"600\" height=\"276\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5062\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-4.jpg\" alt=\"\" width=\"780\" height=\"543\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-4.jpg 780w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-4-768x535.jpg 768w\" sizes=\"(max-width: 780px) 100vw, 780px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5063\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-58.png\" alt=\"\" width=\"774\" height=\"534\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-58.png 774w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-58-768x530.png 768w\" sizes=\"(max-width: 774px) 100vw, 774px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5064\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-52.png\" alt=\"\" width=\"779\" height=\"635\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-52.png 779w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-52-768x626.png 768w\" sizes=\"(max-width: 779px) 100vw, 779px\" \/><br \/>\nV\u00fccudun ana bo\u015falt\u0131m organ\u0131 olan CP, esas olarak b\u00f6brekler yoluyla at\u0131l\u0131r ve proksimal t\u00fcb\u00fcllerde birikerek y\u00fcksek konsantrasyon ve uzun s\u00fcreli birikim durumu olu\u015fturur, ROS olu\u015fumunu te\u015fvik eder ve metabolik enzim bozunmas\u0131n\u0131 inhibe eder, bu da v\u00fccutta b\u00fcy\u00fck bir ROS birikimine neden olur ve bu da h\u00fccre apoptozunu ind\u00fckler ve b\u00f6brek hasar\u0131na neden olur. Meyan k\u00f6k\u00fc, ROS olu\u015fumunu azaltabilen ve h\u00fccre apoptoz durumunu iyile\u015ftirebilen anti-t\u00fcm\u00f6r, anti-inflamatuar, antioksidan ve serbest radikal temizleyici farmakolojik etkilere sahiptir. Meyan k\u00f6k\u00fc endofitik bakterileri meyan k\u00f6k\u00fc ile birlikte bulunur ve t\u0131bbi mikrobiyal kaynaklara aittir. Ev sahibi meyan k\u00f6k\u00fcne benzer farmakolojik aktivitelere sahiptirler ve at k\u0131l\u0131n\u0131n neden oldu\u011fu b\u00f6brek hasar\u0131n\u0131 azaltabilirler. Ayr\u0131ca sisplatin nefrotoksisitesini iyile\u015ftirme potansiyeline de sahiptirler. Bu \u00e7al\u0131\u015fmada, farkl\u0131 ila\u00e7 m\u00fcdahale gruplar\u0131n\u0131n absorbans\u0131n\u0131 \u00f6l\u00e7mek i\u00e7in MTT deneyi kullan\u0131lm\u0131\u015ft\u0131r. Sonu\u00e7lar CP kaynakl\u0131 HEK293 h\u00fccre hasar\u0131n\u0131n zamana ve doza ba\u011fl\u0131 oldu\u011funu g\u00f6stermi\u015ftir. CP grubu ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, meyan k\u00f6k\u00fc endofitik bakteri tedavi grubu h\u00fccre hasar\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde iyile\u015ftirdi ve fark istatistiksel olarak anlaml\u0131yd\u0131 (P&lt;0.01). Ters mikroskop alt\u0131nda, kombinasyon tedavisi grubundaki h\u00fccrelerin b\u00fcz\u00fclme morfolojisinin \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131 ve literat\u00fcr raporlar\u0131yla tutarl\u0131 olarak yap\u0131\u015fma yetene\u011finin geri kazan\u0131ld\u0131\u011f\u0131 g\u00f6zlenmi\u015ftir. Ak\u0131\u015f sitometrisi analizi, Con grubu ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, CP grubunun apoptoz oran\u0131n\u0131n \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131n\u0131 ortaya koymu\u015ftur (P&lt;0.01). CP grubu ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, kombinasyon tedavisi grubunun apoptoz oran\u0131 azalm\u0131\u015f ve CPJT-H grubu en \u00f6nemli etkiye sahip olmu\u015ftur (P&lt;0.01). MTT testi sonu\u00e7lar\u0131yla tutarl\u0131 olarak, meyan k\u00f6k\u00fc endofitik bakterilerinin CP kaynakl\u0131 HEK293 h\u00fccre hasar\u0131na kar\u015f\u0131 koruyucu bir etkiye sahip oldu\u011funu g\u00f6stermektedir.<br \/>\nH\u00fccre apoptoz s\u00fcreci \u00e7ok karma\u015f\u0131kt\u0131r ve endojen yollar, eksojen yollar ve endoplazmik retikulum stres yollar\u0131 olarak ikiye ayr\u0131labilir. Bcl-2 ailesi, Bcl-2 gibi anti apoptotik proteinler ve Bax gibi pro apoptotik proteinler dahil olmak \u00fczere h\u00fccre apoptozunda \u00f6nemli bir rol oynar. Bcl-2, mitokondriyal apoptoz yolunda \u00f6nemli bir d\u00fczenleyici rol oynar ve a\u015fa\u011f\u0131 ak\u0131\u015f genlerini aktive ederek h\u00fccre apoptozuna neden olabilir. Kaspaz-3, Kaspaz-8 ve Kaspaz-9, Kaspaz ailesinin ana bile\u015fenleridir ve genellikle h\u00fccre apoptozunun derecesini tespit etmek i\u00e7in \u00f6nemli g\u00f6stergeler olarak kullan\u0131l\u0131rlar. GRP78 ve CHOP, endoplazmik retikulum stresi i\u00e7in i\u015faret proteinleridir ve endoplazmik retikulum stresi ile ind\u00fcklenen h\u00fccre apoptozunun \u00f6nemli bile\u015fenleridir. Bcl-2 ailesi, Caspase ailesi ve endoplazmik retikulum stresi ile ind\u00fcklenen apoptoz proteinleri incelenerek, meyan k\u00f6k\u00fc endofitik bakterilerinin HEK293 h\u00fccrelerinde CP ile ind\u00fcklenen apoptoza kar\u015f\u0131 koruyucu mekanizmas\u0131 ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r. Deneysel sonu\u00e7lar, Con grubu ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, CP m\u00fcdahalesinin Bax, Caspase-3, Caspase-8, Caspase-9, GRP78 ve CHOP mRNA ve proteininin g\u00f6receli ekspresyon seviyelerini art\u0131rd\u0131\u011f\u0131n\u0131 (P&lt;0.05, P&lt;0.01), Bcl-2 mRNA ve proteininin g\u00f6receli ekspresyon seviyelerini ise azaltt\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir (P&lt;0.01). CP grubu ile kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, meyan k\u00f6k\u00fc endofitik bakterileri i\u00e7in \u00e7e\u015fitli terap\u00f6tik ila\u00e7lar\u0131n m\u00fcdahalesi, CP kaynakl\u0131 HEK293 h\u00fccre hasar\u0131nda belirli bir derecede iyile\u015fme g\u00f6stermi\u015ftir. CPJT-H grubunda Bax, Caspase-3, Caspase-8, Caspase-9, GRP78 ve CHOP mRNA ve proteininin g\u00f6receli ifade d\u00fczeyleri \u00f6nemli \u00f6l\u00e7\u00fcde azal\u0131rken (P&lt;0.05, P&lt;0.01), Bcl-2 mRNA ve proteininin g\u00f6receli ifade d\u00fczeyleri artm\u0131\u015ft\u0131r (P&lt;0.01).<br \/>\n\u00d6zetle, meyan k\u00f6k\u00fc endofitik bakterileri HEK293 h\u00fccrelerinde CP kaynakl\u0131 apoptozu azaltabilir ve pro apoptotik proteinler Bax, Caspase-3, Caspase-8, Caspase-9, GRP78, CHOP ekspresyonunu inhibe ederek ve anti apoptotik protein Bcl-2 ekspresyonunu te\u015fvik ederek CP kaynakl\u0131 nefrotoksisiteyi hafifletebilir. Bu, meyan k\u00f6k\u00fc endofitik bakterilerinin ve CP'nin detoksifikasyon i\u00e7in birlikte kullan\u0131m\u0131 i\u00e7in bir temel sa\u011flar ve meyan k\u00f6k\u00fc endofitik bakterilerinin farmakolojik etkilerini geni\u015fletir.<\/p>","protected":false},"excerpt":{"rendered":"<p>Protective effect and mechanism of endophytic bacteria in licorice against cisplatin induced HEK293 cell damage Cisplatin (CP), as a commonly used anti-tumor drug in clinical practice, has significant therapeutic effects but strong toxic side effects. The main manifestations are nephrotoxicity, hepatotoxicity, ototoxicity, and cardiotoxicity, with renal injury being particularly severe. It has a time dose [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Protective effect and mechanism of endophytic bacteria in licorice against cisplatin induced HEK293 cell damage - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/sisplatin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Protective effect and mechanism of endophytic bacteria in licorice against cisplatin induced HEK293 cell damage - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Protective effect and mechanism of endophytic bacteria in licorice against cisplatin induced HEK293 cell damage Cisplatin (CP), as a commonly used anti-tumor drug in clinical practice, has significant therapeutic effects but strong toxic side effects. The main manifestations are nephrotoxicity, hepatotoxicity, ototoxicity, and cardiotoxicity, with renal injury being particularly severe. 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