{"id":5043,"date":"2024-08-04T16:58:49","date_gmt":"2024-08-04T16:58:49","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=5043"},"modified":"2024-08-04T16:58:49","modified_gmt":"2024-08-04T16:58:49","slug":"yam","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/yam\/","title":{"rendered":"Yer elmas\u0131ndaki allantoinin siklofosfamid kaynakl\u0131 premat\u00fcre yumurtal\u0131k yetmezli\u011fi \u00fczerindeki koruyucu etkisi"},"content":{"rendered":"

Yer elmas\u0131ndaki allantoinin siklofosfamid kaynakl\u0131 premat\u00fcre yumurtal\u0131k yetmezli\u011fi \u00fczerindeki koruyucu etkisi
\nPremat\u00fcre yumurtal\u0131k yetmezli\u011fi (POF) jinekolojik endokrin sistemin yayg\u0131n bir hastal\u0131\u011f\u0131d\u0131r. Son y\u0131llarda, do\u011furganl\u0131k \u00e7a\u011f\u0131ndaki kad\u0131nlarda POF g\u00f6r\u00fclme oran\u0131 artm\u0131\u015f ve yumurtal\u0131k fonksiyonunun azalmas\u0131 hastalar\u0131n ya\u015fam kalitesini ciddi \u015fekilde etkilemi\u015f ve kardiyovask\u00fcler hastal\u0131k, osteoporoz, metabolik bozukluklar ve di\u011fer ilgili hastal\u0131klar\u0131n riskini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rm\u0131\u015ft\u0131r. Kanser ve sistemik lupus eritematozus hastalar\u0131nda, POF ve siklofosfamidin (CP) klinik uygulamas\u0131 yak\u0131ndan ili\u015fkilidir. CP, oksidatif stres, hormon salg\u0131lanmas\u0131 ve inflamasyon yoluyla yumurtal\u0131k fonksiyonuna m\u00fcdahale edebilir. G\u00fcvenli ve etkili bir yumurtal\u0131k fonksiyonu koruyucusu bulmak, sonraki klinik ila\u00e7 geli\u015ftirmenin anahtar\u0131d\u0131r.
\nAyn\u0131 ila\u00e7 ve g\u0131da k\u00f6kenine sahip geleneksel \u00c7in t\u0131bbi malzemelerinden biri olan yam, steroidal saponinler, polisakkaritler, allantoin, flavonoidler ve fenolik glikozitler gibi zengin aktif bile\u015fenler i\u00e7erir. Kimyasal bile\u015fiminin \u00e7e\u015fitlili\u011fi ona antioksidan, anti-enflamatuar, ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenleme, \u00fcrik asit d\u00fc\u015f\u00fcrme, anti-t\u00fcm\u00f6r ve b\u00f6brek hastal\u0131\u011f\u0131 \u00fczerinde terap\u00f6tik etkiler gibi \u00e7e\u015fitli farmakolojik etkiler sa\u011flar. Ara\u015ft\u0131rmalar, \u00c7in t\u0131bbi malzemelerinin ve g\u0131da ve ila\u00e7 olarak ayn\u0131 k\u00f6keni payla\u015fan do\u011fal \u00fcr\u00fcnlerin geli\u015ftirilmesi ve kullan\u0131lmas\u0131n\u0131n yumurtal\u0131klar\u0131n korunmas\u0131nda b\u00fcy\u00fck \u00f6neme sahip oldu\u011funu g\u00f6stermi\u015ftir. Allantoin (ALL) yer elmas\u0131n\u0131n ana etken maddesidir ve anti stres, anti-enflamatuar, ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131 d\u00fczenleme ve h\u00fccre b\u00fcy\u00fcmesini te\u015fvik etme gibi i\u015flevlere sahiptir. \u00d6nceki \u00e7al\u0131\u015fmalarda ara\u015ft\u0131rma ekibi, yer elmas\u0131 ve ALL'nin uterus dokusunda \u00f6strojen resept\u00f6r\u00fc alfa ve G proteinine ba\u011fl\u0131 \u00f6strojen resept\u00f6rlerinin ekspresyonu yoluyla \u00f6strojen benzeri etkilere sahip oldu\u011funu bulmu\u015ftur. Do\u011fal bitki \u00f6strojenleri s\u0131\u00e7anlarda yumurtal\u0131k folik\u00fcllerinin geli\u015fimi \u00fczerinde olumlu bir etkiye sahiptir. Bu nedenle, bu \u00e7al\u0131\u015fma, ALL'nin POF s\u0131\u00e7anlar\u0131nda hormon seviyelerini, folik\u00fcl geli\u015fimini ve olgunla\u015fma seviyelerini nas\u0131l iyile\u015ftirdi\u011fini ara\u015ft\u0131rmak i\u00e7in CP ile ind\u00fcklenen premat\u00fcre yumurtal\u0131k yetmezli\u011fi s\u0131\u00e7an modelini kullanm\u0131\u015f ve POF'yi iyile\u015ftirme mekanizmas\u0131n\u0131 oksidatif stres perspektifinden ara\u015ft\u0131rarak, yam ve aktif bile\u015feni ALL'nin kad\u0131n \u00fcreme korumas\u0131nda geli\u015ftirilmesi ve kullan\u0131lmas\u0131 i\u00e7in referans sa\u011flam\u0131\u015ft\u0131r.<\/p>\n

 <\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"Siklofosfamid (CP), k\u00f6t\u00fc huylu t\u00fcm\u00f6rleri ve otoimm\u00fcn hastal\u0131klar\u0131 tedavi etmek i\u00e7in yayg\u0131n olarak kullan\u0131lan bir kemoterapi ilac\u0131d\u0131r, ancak toksik yan etkileri g\u00fc\u00e7l\u00fcd\u00fcr ve yumurtal\u0131klarda kal\u0131c\u0131 hasara neden olabilir. Ge\u00e7ti\u011fimiz birka\u00e7 on y\u0131lda, \u00fcreme yetene\u011finin korunmas\u0131 ve yumurtal\u0131k fonksiyonunun geri kazan\u0131lmas\u0131 kanser tedavisinde \u00e7ok \u00f6nemli hale gelmi\u015ftir, \u00e7\u00fcnk\u00fc bu tedavi rejimi kad\u0131n kanser hastalar\u0131n\u0131n ya\u015fam kalitesini art\u0131rabilir. Ayr\u0131ca CP, oksidatif stres belirte\u00e7lerini ve antioksidan savunma mekanizmalar\u0131n\u0131n a\u015f\u0131r\u0131 t\u00fcketimini aktive ederek kalp ve b\u00f6brekler gibi ana organlar\u0131 da etkileyebilir. Bu nedenle, oksidatif stresi d\u00fczenleyerek CP'nin organlara verdi\u011fi zarar\u0131 iyile\u015ftirmek bu \u00e7al\u0131\u015fman\u0131n odak noktalar\u0131ndan biridir.<\/p>\n

CP'nin toksisitesi, metabolitlerinden biri olan akrolein \u00fcretimiyle ili\u015fkilidir. CP tedavisinden sonra, kanser hastalar\u0131 glutatyonda (GSH) \u00f6nemli bir d\u00fc\u015f\u00fc\u015f g\u00f6sterir, bu da akroleinin ba\u011flanmas\u0131n\u0131n bir sonucu olabilir. GSH bir tripeptittir ve v\u00fccutta \u00f6nemli bir antioksidan ve serbest radikal temizleyicidir. Ayn\u0131 zamanda CP, sa\u011fl\u0131kl\u0131 yumurtal\u0131k dokusunda SOD gibi di\u011fer endojen antioksidanlar\u0131n aktivitesini de de\u011fi\u015ftirerek yumurtal\u0131k h\u00fccrelerinde h\u00fccre i\u00e7i serbest radikal hasar\u0131n\u0131 te\u015fvik eder. Bu \u00e7al\u0131\u015fmada ALL, s\u0131\u00e7an yumurtal\u0131klar\u0131n\u0131 CP'nin neden oldu\u011fu oksidatif stresten \u00f6nemli \u00f6l\u00e7\u00fcde korumu\u015ftur. ALL, hayvanlar\u0131n ve bitkilerin v\u00fccutlar\u0131nda bulunan p\u00fcrin bozunmas\u0131 ile \u00fcretilen bir metabolittir. Cilt h\u00fccresi b\u00fcy\u00fcmesini ve yara iyile\u015fmesini destekleyebilir, fibroblast b\u00fcy\u00fcmesini uyarabilir ve \u00f6strojen benzeri etkilere sahiptir. Bu nedenle, organ hasar\u0131na kar\u015f\u0131 koruyucu etkilerini ara\u015ft\u0131r\u0131rken, bu \u00e7al\u0131\u015fma ayn\u0131 zamanda antioksidan etkilerine ve etki yollar\u0131na da odaklanmaktad\u0131r. Bu \u00e7al\u0131\u015fmada, 70mg\/kg ve 140mg\/kg allantoinin yumurtal\u0131k GSH Px ve SOD aktivitesini korudu\u011fu ve MDA'y\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde inhibe etti\u011fi ve s\u0131\u00e7an yumurtal\u0131klar\u0131n\u0131 CP kaynakl\u0131 oksidatif stres kaynakl\u0131 yumurtal\u0131k hasar\u0131ndan korudu\u011fu bulunmu\u015ftur.<\/p>\n

N\u00fckleer transkripsiyon fakt\u00f6r\u00fc Nrf2, antioksidan aktiviteyi ind\u00fckleyerek protein kodlayan genleri koruyan ve h\u00fccre i\u00e7i ortamda oksidatif deoksijenasyon reaksiyonlar\u0131n\u0131 d\u00fczenleyen CNC l\u00f6sin fermuar transkripsiyon aktivat\u00f6r ailesine aittir. Nrf2, antioksidan yan\u0131t elementlerine (ARE) ba\u011flanarak a\u015fa\u011f\u0131 ak\u0131m antioksidan proteinleri ve enzimleri aktive eder ve oksidatif strese kar\u015f\u0131 koruma sa\u011flar. Bu \u00e7al\u0131\u015fmada, POF s\u0131\u00e7anlar\u0131n\u0131n yumurtal\u0131klar\u0131nda Nrf2 ekspresyonunda bir azalma ve oksidatif streste bir art\u0131\u015f bulduk; ALL, Nrf2 seviyesini belirli bir dozda d\u00fczenler. Ara\u015ft\u0131rmalar, a\u015fa\u011f\u0131 ak\u0131\u015f hedef genlerinin (HO-1, NQO1, vb.) ifadesinin Nrf2 n\u00fckleer translokasyonu ile tutarl\u0131 oldu\u011funu g\u00f6stermi\u015ftir; bu sadece Kelch like as social protein 1 (Keap1) - Nrf2 ARE yola\u011f\u0131n\u0131n kat\u0131l\u0131m\u0131n\u0131 do\u011frulamakla kalmaz, ayn\u0131 zamanda HO-1 ve NQO1'in redoks homeostaz\u0131n\u0131n korunmas\u0131nda kritik bir rol oynad\u0131\u011f\u0131n\u0131 da g\u00f6sterir. HO-1, kolayca uyar\u0131lan ve ind\u00fcklenen, dolayl\u0131 bir antioksidan rol oynayan bir hem oksijenaz alt tipidir. NQO1, s\u00fcperoksit anyon radikallerini temizleyebilir ve oksidatif stres taraf\u0131ndan d\u00fczenlenen reaktif oksijen t\u00fcrlerinin (ROS) a\u015f\u0131r\u0131 birikimini hafifletebilir. \u00c7al\u0131\u015fmam\u0131zda, POF s\u0131\u00e7an modeli, yumurtal\u0131klar\u0131nda anlaml\u0131 NQO1 ekspresyonu g\u00f6stermemi\u015ftir. Bununla birlikte, 14 g\u00fcn boyunca s\u00fcrekli uygulamadan sonra, pozitif ila\u00e7 EV ve ALL, 70 mg \/ kg'l\u0131k bir dozda NQO1'in ekspresyon seviyesini \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131rm\u0131\u015ft\u0131r, bu da yumurtal\u0131k hasar\u0131 stresinde de olumlu bir rol oynayabileceklerini d\u00fc\u015f\u00fcnd\u00fcrmektedir. Bu sonu\u00e7 NQO1'in stabilitesi, \u00e7ift aktif b\u00f6lgesi ve enzimatik olmayan aktivitesi ile ili\u015fkili olabilir. CP stim\u00fclasyonunun NQO1'i aktive etmemesi, ALL'nin ise belirli bir dozda aktif b\u00f6lgeye ba\u011flanabilmesi m\u00fcmk\u00fcnd\u00fcr. Bu nedenle, daha fazla ara\u015ft\u0131rma ve ke\u015ffe ihtiya\u00e7 vard\u0131r. POF s\u0131\u00e7an modeli yumurtal\u0131klarda HO-1 ekspresyonunu \u00f6nemli \u00f6l\u00e7\u00fcde azalt\u0131rken, pozitif ila\u00e7 EV ve ALL 140mg\/kg dozunda HO-1 ekspresyonunda \u00f6nemli bir iyile\u015fme g\u00f6stermi\u015ftir. HO-1, hem proteinlerinin par\u00e7alanmas\u0131n\u0131 ve bilirubine d\u00f6n\u00fc\u015ft\u00fcr\u00fclmesini katalize eden strese duyarl\u0131 bir proteindir. Par\u00e7alanma metabolizmas\u0131n\u0131n \u00fcr\u00fcnleri antioksidan, anti apoptotik ve imm\u00fcnomod\u00fclat\u00f6r etkilere sahiptir. Bu nedenle, HO-1 stres alt\u0131nda koruyucu bir rol oynayabilir, bu da ALL'nin antioksidan stres etkileri uygulamak i\u00e7in HO-1'i d\u00fczenleyerek POF s\u0131\u00e7anlar\u0131nda yumurtal\u0131k hasar\u0131n\u0131 iyile\u015ftirebilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir. Bu \u00e7al\u0131\u015fmada oksidatif stresin NQO1 yola\u011f\u0131 \u00fczerindeki etkisini ara\u015ft\u0131rmak i\u00e7in daha fazla ara\u015ft\u0131rmaya ihtiya\u00e7 vard\u0131r.<\/p>\n

ALL, POF s\u0131\u00e7anlar\u0131n\u0131n yumurtal\u0131k dokusunda HO-1 ve Nrf2 ekspresyonunu art\u0131rm\u0131\u015f, oksidatif stresi hafifletmi\u015f, hormon seviyelerini d\u00fczenlemi\u015f ve POF s\u0131\u00e7anlar\u0131nda yumurtal\u0131k disfonksiyonunu iyile\u015ftirmi\u015ftir. Bu \u00e7al\u0131\u015fma, yer elmas\u0131 ve aktif bile\u015feni ALL'nin geli\u015ftirilmesi ve kullan\u0131m\u0131 i\u00e7in bir referans sa\u011flamaktad\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

The protective effect of allantoin in yam on cyclophosphamide induced premature ovarian failure Premature ovarian failure (POF) is a common disease of the gynecological endocrine system. In recent years, the incidence rate of POF in women of childbearing age has increased, and the decline of ovarian function has seriously affected the quality of life of […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nThe protective effect of allantoin in yam on cyclophosphamide induced premature ovarian failure - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/yam\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The protective effect of allantoin in yam on cyclophosphamide induced premature ovarian failure - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"The protective effect of allantoin in yam on cyclophosphamide induced premature ovarian failure Premature ovarian failure (POF) is a common disease of the gynecological endocrine system. 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