{"id":4983,"date":"2024-08-04T16:44:55","date_gmt":"2024-08-04T16:44:55","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4983"},"modified":"2024-08-04T16:44:55","modified_gmt":"2024-08-04T16:44:55","slug":"turtle-shell-glue","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/kaplumbaga-kabugu-tutkali\/","title":{"rendered":"Farkl\u0131 \u00dcreticilerin Kaplumba\u011fa Kabu\u011fu Yap\u0131\u015ft\u0131r\u0131c\u0131lar\u0131ndaki Amino Asit \u0130\u00e7eri\u011findeki Farkl\u0131l\u0131klar\u0131n ve Anti Osteoporozun Potansiyel Mekanizmalar\u0131n\u0131n A\u011f Farmakolojisi ile Birle\u015ftirilmi\u015f UHPLC-QTRAP-MS\/MS'ye Dayal\u0131 Olarak Ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"<p>Farkl\u0131 \u00dcreticilerin Kaplumba\u011fa Kabu\u011fu Yap\u0131\u015ft\u0131r\u0131c\u0131lar\u0131ndaki Amino Asit \u0130\u00e7eri\u011findeki Farkl\u0131l\u0131klar\u0131n ve Anti Osteoporozun Potansiyel Mekanizmalar\u0131n\u0131n A\u011f Farmakolojisi ile Birle\u015ftirilmi\u015f UHPLC-QTRAP-MS\/MS'ye Dayal\u0131 Olarak Ara\u015ft\u0131r\u0131lmas\u0131<br \/>\nTestudinis Carapacis et Plasti Colla (TCPC), kaplumba\u011fa ailesinden Chinemys reevesii (Gray) adl\u0131 hayvan\u0131n kaplumba\u011fa kabu\u011funun suda kaynat\u0131l\u0131p konsantre edilmesiyle elde edilen kat\u0131 bir jel olan geleneksel bir \u00c7in besleyici ilac\u0131d\u0131r. \u0130lk olarak \"Compendium of Materia Medica \"da kaydedilmi\u015ftir. Serin bir do\u011fas\u0131, tuzlu ve tatl\u0131 bir tad\u0131 vard\u0131r ve karaci\u011fer, b\u00f6brek ve kalp meridyenleri i\u00e7in uygundur. Klinik uygulamada osteoporoz tedavisinde yayg\u0131n olarak kullan\u0131l\u0131r. Guilu Erxian serisi form\u00fcl\u00fc, Zuogui Wan, Huqian Wan, vb. gibi esas olarak kaplumba\u011fa kabu\u011fu tutkal\u0131ndan olu\u015fan klasik form\u00fcller, \u00f6z\u00fc beslemede, ili\u011fi doldurmada, tendonlar\u0131 ve kemikleri g\u00fc\u00e7lendirmede \u00f6nemli etkilere sahiptir. Kaplumba\u011fa kabu\u011fu tutkal\u0131 kolajen, keratin ve serbest amino asitler bak\u0131m\u0131ndan zengindir. Protein hidrolizinden elde edilen amino asitler, kaplumba\u011fa kabu\u011fu tutkal\u0131ndaki ana aktif bile\u015fenlerdir ve sonu\u00e7ta insan v\u00fccudu taraf\u0131ndan emilir ve kullan\u0131l\u0131r. Geleneksel \u00c7in t\u0131bb\u0131 te\u015fhis ve tedavisinde osteoporoz \u00e7o\u011funlukla \"kemik t\u0131kan\u0131kl\u0131\u011f\u0131\", \"kemik nekrozu\" ve \"kemik fist\u00fcl\u00fc\" olarak s\u0131n\u0131fland\u0131r\u0131l\u0131r. \"Acil Bak\u0131m i\u00e7in Temel Re\u00e7eteler\" \u015funlar\u0131 belirtmektedir: \"A\u015f\u0131r\u0131 kemik rahats\u0131zl\u0131\u011f\u0131 olanlar... el ve ayaklar\u0131nda a\u011fr\u0131, uzun s\u00fcre ayakta duramama, e\u011filme ve esnemede zorluk ya\u015fayabilir, bu da v\u00fccut t\u0131kan\u0131kl\u0131\u011f\u0131na, beyin ve omurilik i\u015flev bozuklu\u011funa yol a\u00e7abilir. B\u00f6brek \u00f6z depolar ve kemik ili\u011fi \u00fcretimini kontrol eder. Yetersiz olmas\u0131 durumunda ilik azal\u0131r ve kemik k\u00f6relir. Kemik ili\u011fi kayb\u0131 kemik k\u0131r\u0131lganl\u0131\u011f\u0131n\u0131n artmas\u0131na ve osteoporoza yol a\u00e7acakt\u0131r. Modern ara\u015ft\u0131rmalar, kaplumba\u011fa kabu\u011fu tutkal\u0131 ve klasik form\u00fcllerinin kemik sa\u011fl\u0131\u011f\u0131, ba\u011f\u0131\u015f\u0131kl\u0131k geli\u015ftirme, anti-t\u00fcm\u00f6r ve di\u011fer y\u00f6nlerden iyi aktivitelere sahip oldu\u011funu g\u00f6stermi\u015ftir. Kaplumba\u011fa kabu\u011fu yap\u0131\u015ft\u0131r\u0131c\u0131s\u0131ndaki glisin ve prolin, menopoz sonras\u0131 osteoporozun te\u015fhisi i\u00e7in potansiyel biyobelirte\u00e7ler olarak hizmet edebilir. Amino asitlerin kendileri de sinyal molek\u00fclleridir ve kalsiyum iyonlar\u0131 ile kalsiyuma duyarl\u0131 resept\u00f6rleri sinerjik olarak aktive edebilir, kemik yo\u011funlu\u011funu art\u0131rabilir, osteoblast farkl\u0131la\u015fmas\u0131n\u0131 te\u015fvik edebilir ve kemik kalsifikasyonunu geli\u015ftirebilir. Farkl\u0131 \u00fcreticilerin kaplumba\u011fa kabu\u011fu yap\u0131\u015ft\u0131r\u0131c\u0131s\u0131n\u0131n amino asit i\u00e7eri\u011findeki farkl\u0131l\u0131klar\u0131 ara\u015ft\u0131rmak i\u00e7in bu \u00e7al\u0131\u015fmada 4 farkl\u0131 \u00fcreticiden 15 parti kaplumba\u011fa kabu\u011fu yap\u0131\u015ft\u0131r\u0131c\u0131s\u0131 \u00f6rne\u011fi se\u00e7ilmi\u015ftir. Kaplumba\u011fa kabu\u011fu tutkal\u0131n\u0131n asit hidrolizinden sonra 17 amino asidi belirlemek i\u00e7in s\u0131v\u0131 kromatografi-k\u00fctle spektrometresi kullan\u0131lm\u0131\u015ft\u0131r. Farkl\u0131 \u00fcreticilerin kaplumba\u011fa kabu\u011fu tutkal\u0131ndaki hidrolize amino asit bile\u015fenlerinin kompozisyon farkl\u0131l\u0131klar\u0131n\u0131 kar\u015f\u0131la\u015ft\u0131rmak i\u00e7in \u00e7ok de\u011fi\u015fkenli istatistikler kullan\u0131ld\u0131 ve kaplumba\u011fa kabu\u011fu tutkal\u0131n\u0131n kalite kontrol\u00fc i\u00e7in referans sa\u011fland\u0131. Ve kaplumba\u011fa kabu\u011fu tutkal\u0131ndaki amino asit bile\u015fenlerini analiz etmek i\u00e7in a\u011f farmakolojisi ile birle\u015ftirilerek, osteoporoz kar\u015f\u0131t\u0131 kaplumba\u011fa kabu\u011fu tutkal\u0131n\u0131n ana aktif bile\u015fenlerini ve hedeflerini daha fazla tahmin etmek i\u00e7in bir temel sa\u011flanm\u0131\u015ft\u0131r.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4984\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-108.png\" alt=\"\" width=\"782\" height=\"418\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-108.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-108-768x411.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4985\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-94.png\" alt=\"\" width=\"778\" height=\"320\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-94.png 778w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-94-768x316.png 768w\" sizes=\"(max-width: 778px) 100vw, 778px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4986\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-90.png\" alt=\"\" width=\"781\" height=\"482\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-90.png 781w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-90-768x474.png 768w\" sizes=\"(max-width: 781px) 100vw, 781px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4987\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-79.png\" alt=\"\" width=\"776\" height=\"249\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-79.png 776w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-79-768x246.png 768w\" sizes=\"(max-width: 776px) 100vw, 776px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4988\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-73.png\" alt=\"\" width=\"778\" height=\"498\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-73.png 778w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-73-768x492.png 768w\" sizes=\"(max-width: 778px) 100vw, 778px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4989\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-65.png\" alt=\"\" width=\"776\" height=\"275\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-65.png 776w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-65-768x272.png 768w\" sizes=\"(max-width: 776px) 100vw, 776px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4990\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-61.png\" alt=\"\" width=\"779\" height=\"285\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-61.png 779w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-61-768x281.png 768w\" sizes=\"(max-width: 779px) 100vw, 779px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4991\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-55.png\" alt=\"\" width=\"780\" height=\"425\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-55.png 780w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-55-768x418.png 768w\" sizes=\"(max-width: 780px) 100vw, 780px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4992\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-49.png\" alt=\"\" width=\"766\" height=\"241\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4993\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-42.png\" alt=\"\" width=\"779\" height=\"453\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-42.png 779w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-42-768x447.png 768w\" sizes=\"(max-width: 779px) 100vw, 779px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4994\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-36.png\" alt=\"\" width=\"776\" height=\"748\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-36.png 776w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-36-768x740.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-36-747x720.png 747w\" sizes=\"(max-width: 776px) 100vw, 776px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4995\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-32.png\" alt=\"\" width=\"779\" height=\"838\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-32.png 779w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-32-768x826.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-32-669x720.png 669w\" sizes=\"(max-width: 779px) 100vw, 779px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4996\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-27.png\" alt=\"\" width=\"780\" height=\"311\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-27.png 780w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-27-768x306.png 768w\" sizes=\"(max-width: 780px) 100vw, 780px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4997\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-23.png\" alt=\"\" width=\"780\" height=\"146\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-23.png 780w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-23-768x144.png 768w\" sizes=\"(max-width: 780px) 100vw, 780px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4998\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-17.png\" alt=\"\" width=\"777\" height=\"330\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-17.png 777w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-17-768x326.png 768w\" sizes=\"(max-width: 777px) 100vw, 777px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4999\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-14.png\" alt=\"\" width=\"779\" height=\"308\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-14.png 779w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-14-768x304.png 768w\" sizes=\"(max-width: 779px) 100vw, 779px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5000\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/17-12.png\" alt=\"\" width=\"778\" height=\"300\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/17-12.png 778w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/17-12-768x296.png 768w\" sizes=\"(max-width: 778px) 100vw, 778px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-5001\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/18-10.png\" alt=\"\" width=\"782\" height=\"303\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/18-10.png 782w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/18-10-768x298.png 768w\" sizes=\"(max-width: 782px) 100vw, 782px\" \/>Bu makalede \u00e7e\u015fitli \u00fcreticilerden ve partilerden elde edilen hidrolize kaplumba\u011fa kabu\u011fu tutkal\u0131n\u0131n genel amino asit i\u00e7eri\u011fi farmakope seviyesinden daha d\u00fc\u015f\u00fckt\u00fcr. Bunun nedeni sadece numunenin kalitesiyle de\u011fil, ayn\u0131 zamanda test y\u00f6ntemiyle de ilgili olabilir. Hidrolize amino asitlerin karakteristik iyon \u00e7iftlerini tespit etmek i\u00e7in y\u00fcksek hassasiyet ve \u00f6zg\u00fcll\u00fc\u011fe sahip s\u0131v\u0131 kromatografi-k\u00fctle spektrometresi kullan\u0131yoruz; Farmakopede kullan\u0131lan HPLC y\u00f6ntemi, bile\u015fiklerin karakteristik fonksiyonel gruplar\u0131n\u0131n absorbans sinyallerini tespit ederek benzer yap\u0131lara sahip bile\u015fiklerin ay\u0131rt edilmesini zorla\u015ft\u0131r\u0131r. S\u0131v\u0131 kromatografi-k\u00fctle spektrometresi (LC-MS) y\u00f6ntemi daha do\u011frudur ve spesifik olmayan bile\u015fenlerin giri\u015fimini ortadan kald\u0131rabilir, bu nedenle hidrolize amino asitlerin i\u00e7eri\u011fi farmakopedekinden daha d\u00fc\u015f\u00fck olabilir. A\u011f farmakolojisinin sonu\u00e7lar\u0131, osteoporoz tedavisinde kaplumba\u011fa kabu\u011fu yap\u0131\u015ft\u0131r\u0131c\u0131s\u0131n\u0131n temel bile\u015fenlerinin Ala ve Gly oldu\u011funu g\u00f6stermektedir. Ala, \u015fekerlerin ve organik asitlerin metabolizmas\u0131na yard\u0131mc\u0131 olabilir ve menopoz sonras\u0131 osteoporozu iyile\u015ftirebilir. Gly, erkeklerde k\u0131r\u0131k riskiyle do\u011frudan ili\u015fkilidir ve kolajendeki mutasyonlar osteogenezis imperfekta'ya neden olabilir. Osteoporozun kaplumba\u011fa kabu\u011fu tutkal\u0131 ile tedavisi i\u00e7in temel hedefler CAT, NOS1, NOS3, F2 vb. i\u00e7erir. Katalaz (CAT), oksidatif stresi inhibe ederek farelerde kemik yo\u011funlu\u011funu ve kemik mineral i\u00e7eri\u011fini art\u0131rabilir; N\u00f6ronal nitrik oksit sentaz (NOS1) kemik iyile\u015fmesi ile ili\u015fkilidir ve esas olarak fibr\u00f6z doku ile kallus aras\u0131ndaki fibrokartilaj b\u00f6lgesinde ifade edilir; Endotelyal nitrik oksit sentaz (NOS3) da kemik iyile\u015fmesi ile ili\u015fkilidir ve esas olarak kondrositlerde ve perivask\u00fcler h\u00fccrelerde ifade edilir; Protrombin, organ k\u00fclt\u00fcr\u00fcnde kemik rezorpsiyonunu uyarabilen osteoblastlarda spesifik bir agonisttir. KEGG ve GO zenginle\u015ftirme analizi sonu\u00e7lar\u0131, kaplumba\u011fa kabu\u011fu sak\u0131z\u0131n\u0131n kemik h\u00fccrelerinde vitamin ba\u011flama, piridoksal fosfat ba\u011flama, organik asit ba\u011flama ve amino asit sentezi metabolizmas\u0131 gibi bir dizi biyolojik fonksiyonda yer alabilece\u011fini g\u00f6stermektedir; ins\u00fclin sinyali, kalsiyum sinyali, siklik guanozin monofosfat protein kinaz G (cGMP PKG) sinyali, karbon metabolizmas\u0131 ve amino asit sentezi gibi sinyal yollar\u0131n\u0131 etkileyerek \u00e7al\u0131\u015f\u0131r. \u0130ns\u00fclin sinyal yolu, iskelet kaslar\u0131n\u0131 v\u00fccudun glikozunun 80%'sini almas\u0131 i\u00e7in uyarabilir; cGMP PKG sinyal yolu kemik olu\u015fumunu d\u00fczenleyebilir ve osteoblast mineralizasyonunu ve olgunla\u015fmas\u0131n\u0131 te\u015fvik ederek osteogenezin \u00e7ift y\u00f6nl\u00fc ve karma\u015f\u0131k d\u00fczenlemesini sergileyebilir.<br \/>\n\u00d6zetle, bu makalede UHPLC-QTRAP-MS\/MS \u00e7ok de\u011fi\u015fkenli istatistiksel analiz ile birlikte kullan\u0131larak d\u00f6rt \u00fcretici aras\u0131nda A \u00fcreticisinin kaplumba\u011fa kabu\u011fu yap\u0131\u015ft\u0131r\u0131c\u0131s\u0131n\u0131n istikrarl\u0131 kalitesine ve y\u00fcksek hidrolize amino asit i\u00e7eri\u011fine sahip oldu\u011fu; Kaplumba\u011fa kabu\u011fu yap\u0131\u015ft\u0131r\u0131c\u0131s\u0131n\u0131n CAT, NOS1, NOS3, vb. dahil olmak \u00fczere osteoporozun 68 temel hedefini d\u00fczenleyebilece\u011fi Alanin ve glisin gibi bile\u015fenler arac\u0131l\u0131\u011f\u0131yla, b\u00f6ylece amino asit sentezi, arginin ve prolin metabolizmas\u0131 ve osteoporoz \u00fczerinde terap\u00f6tik etkiler uygulamak i\u00e7in karbon metabolizmas\u0131 gibi 212 sinyal yolunu etkiler.<\/p>","protected":false},"excerpt":{"rendered":"<p>Exploring the Differences in Amino Acid Content and Potential Mechanisms of Anti Osteoporosis in Turtle Shell Adhesive from Different Manufacturers Based on UHPLC-QTRAP-MS\/MS Combined with Network Pharmacology Testudinis Carapacis et Plasti Colla (TCPC) is a traditional Chinese nourishing medicine, which is a solid gel made by boiling and concentrating the turtle shell of the turtle [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - 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