{"id":4840,"date":"2024-08-04T16:03:22","date_gmt":"2024-08-04T16:03:22","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4840"},"modified":"2024-08-04T16:03:22","modified_gmt":"2024-08-04T16:03:22","slug":"allergic-rhinitis","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/alerjik-rinit\/","title":{"rendered":"Veri madencili\u011fi, a\u011f farmakolojisi ve deneysel do\u011frulamaya dayal\u0131 olarak alerjik rinit tedavisinde geleneksel \u00c7in t\u0131bb\u0131n\u0131n ila\u00e7 kurallar\u0131n\u0131n ve ilgili farmakolojik analizinin ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"

Veri madencili\u011fi, a\u011f farmakolojisi ve deneysel do\u011frulamaya dayal\u0131 olarak alerjik rinit tedavisinde geleneksel \u00c7in t\u0131bb\u0131n\u0131n ila\u00e7 kurallar\u0131n\u0131n ve ilgili farmakolojik analizinin ara\u015ft\u0131r\u0131lmas\u0131
\nAlerjik rinit olarak da bilinen alerjik rinit (AR), atopik bireylerde alerjenlere maruz kald\u0131ktan sonra imm\u00fcnoglobulin E (IgE) arac\u0131l\u0131\u011f\u0131 ile inflamatuar fakt\u00f6rlerin (histamin, l\u00f6kotrienler, prostaglandinler, trombosit aktive edici fakt\u00f6rler, vb) sal\u0131n\u0131m\u0131n\u0131n neden oldu\u011fu ve birden fazla imm\u00fcn aktif h\u00fccre ve imm\u00fcn fakt\u00f6r\u00fcn dahil oldu\u011fu nazal mukozan\u0131n kronik enfeksiy\u00f6z olmayan inflamasyonudur. Enflamatuar fakt\u00f6rler lokal burun mukozas\u0131nda \u00f6dem ve eks\u00fcdasyona neden olarak burun duyu sinirlerini uyar\u0131r ve paroksismal ve tekrarlayan burun ka\u015f\u0131nt\u0131s\u0131, hap\u015f\u0131rma ve sulu burun ak\u0131nt\u0131s\u0131 gibi tipik semptomlarla sonu\u00e7lan\u0131r. Burun t\u0131kan\u0131kl\u0131\u011f\u0131, koku alma duyusunda azalma, ast\u0131m ve di\u011fer semptomlar da e\u015flik edebilir. AR, alerjenlerin yan\u0131 s\u0131ra genetik fakt\u00f6rler, b\u00f6lgesel iklim, hava kirlili\u011fi, n\u00f6rolojik ve psikolojik fakt\u00f6rler ve sosyo-ekonomik fakt\u00f6rlerle de yak\u0131ndan ili\u015fkilidir. AR, geleneksel \u00c7in t\u0131bb\u0131nda \"burun t\u0131kan\u0131kl\u0131\u011f\u0131\" kategorisine girmektedir. Geleneksel \u00c7in t\u0131bb\u0131, bu hastal\u0131\u011f\u0131n i\u00e7 ve d\u0131\u015f fakt\u00f6rlerin birle\u015fik etkisinin sonucu oldu\u011funa inanmaktad\u0131r. \u0130\u00e7 fakt\u00f6rler \u00e7o\u011funlukla organ eksikli\u011fi ve yetersiz pozitif qi iken, d\u0131\u015f fakt\u00f6rler \u00e7o\u011funlukla r\u00fczgar, so\u011fuk veya yabanc\u0131 qi istilas\u0131, k\u00f6t\u00fc ve pozitif qi'nin \u00e7at\u0131\u015fmas\u0131 ve akci\u011fer qi'sinin serbest b\u0131rak\u0131lamamas\u0131d\u0131r ve burun t\u0131kan\u0131kl\u0131\u011f\u0131na neden olur. Klinik uygulamada, AR'yi tedavi etmek i\u00e7in \u00e7o\u011funlukla antihistaminikler ve nazal kortikosteroidler kullan\u0131l\u0131r, ancak uzun s\u00fcreli kullan\u0131m\u0131n etkinli\u011fi zay\u0131ft\u0131r ve n\u00fcksetmeye e\u011filimlidir. Geleneksel \u00c7in t\u0131bb\u0131, AR'yi oral uygulama, \u00c7in bitkisel kaynatmalar\u0131n\u0131n nazal y\u0131kanmas\u0131 veya akupunktur noktas\u0131 uygulamas\u0131, \u00c7in bitkisel f\u00fcmigasyonu, neb\u00fclizasyon ve di\u011fer y\u00f6ntemlerle tedavi eder. Bu makale, AR tedavisinde geleneksel \u00c7in t\u0131bb\u0131n\u0131n ila\u00e7 modellerini analiz etmek i\u00e7in veri madencili\u011fi y\u00f6ntemlerini kullanmakta ve AR tedavisinde y\u00fcksek frekansl\u0131 geleneksel \u00c7in t\u0131bb\u0131n\u0131n potansiyel etki mekanizmas\u0131n\u0131 tahmin etmek ve do\u011frulamak i\u00e7in a\u011f farmakolojisi ve in vivo farmakoloji do\u011frulama y\u00f6ntemlerini kullanarak AR'nin klinik tedavisi i\u00e7in rasyonel referans ve bilimsel teorik temel sa\u011flamaktad\u0131r.<\/p>\n

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\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"AR tedavisinde kullan\u0131lan geleneksel \u00c7in t\u0131bb\u0131n\u0131n s\u0131kl\u0131k analizinde, en s\u0131k kullan\u0131lan ilk be\u015f bitki Xinyi, Huangqi, Fangfeng, Meyan k\u00f6k\u00fc ve Cang'er Zi'dir. En s\u0131k kullan\u0131lan geleneksel \u00c7in ilac\u0131 olan Xinyi, s\u0131cak bir do\u011faya sahiptir, r\u00fczgar\u0131 ve so\u011fu\u011fu giderebilir ve burun a\u00e7\u0131lmas\u0131n\u0131 te\u015fvik edebilir. Ana bile\u015fenleri, mukoza zarlar\u0131n\u0131 koruma, yerel kan dola\u015f\u0131m\u0131n\u0131 iyile\u015ftirme, anti-enflamatuar, antibakteriyel, anti alerjik, antioksidan ve d\u00fcz kaslar\u0131 gev\u015fetme gibi \u00e7ok \u00e7e\u015fitli farmakolojik etkilere sahip olan u\u00e7ucu ya\u011flar, lignanlar ve alkaloidlerdir. Xinyi genellikle Xinyi Rinit Haplar\u0131, Biyan Kang Tabletleri, Biyuan Haplar\u0131, Tongqiao Rinit Gran\u00fclleri, Xinfang Rinit Kaps\u00fclleri, Xinyi Tozu, Xinyi Haplar\u0131, Xinyi Merhemi, Sin\u00fcs \u0130nf\u00fczyon S\u0131v\u0131s\u0131 gibi \u00e7e\u015fitli rinit ve burun hastal\u0131klar\u0131n\u0131n tedavisinde kraliyet ilac\u0131 olarak kullan\u0131l\u0131r. Li Shizhen ayr\u0131ca Compendium of Materia Medica'da \"Xinyi ortay\u0131 \u0131s\u0131tabilir ve ba\u015f, y\u00fcz, burun ve dokuz delikteki hastal\u0131klar\u0131 tedavi edebilir\" diye kaydetmi\u015ftir.
\nAra\u015ft\u0131rmalar sonucunda, 252 geleneksel \u00c7in t\u0131bb\u0131 re\u00e7etesi aras\u0131nda ila\u00e7 s\u0131n\u0131fland\u0131rmas\u0131n\u0131n esas olarak y\u00fczey temizleyici ila\u00e7lar (Xinyi, Fangfeng, Xixin, Baizhi, Guizhi, vb.) ve eksiklik giderici ila\u00e7lar (Huangqi, Meyan k\u00f6k\u00fc, Atractylodes macrocephala, vb.) temelinde yap\u0131ld\u0131\u011f\u0131 tespit edilmi\u015ftir. T\u0131bbi \u00f6zellikler \u00e7o\u011funlukla \u0131s\u0131tmaya odaklan\u0131r ve t\u0131bbi tatlar \u00e7o\u011funlukla baharatl\u0131 ve tatl\u0131d\u0131r. S\u0131cak bitkilerin ortay\u0131 \u0131s\u0131tma ve so\u011fu\u011fu giderme, ate\u015fi tonifiye etme ve yang'a yard\u0131mc\u0131 olma etkileri vard\u0131r. Baharatl\u0131 bitkiler r\u00fczgar\u0131 ve so\u011fu\u011fu giderebilir, qi ve kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik edebilir. Tatl\u0131 bitkilerin t\u0131bbi \u00f6zellikleri uyumla\u015ft\u0131rma, orta b\u00f6lgeyi besleme ve akci\u011fer, dalak ve karaci\u011fer meridyenlerini d\u00fczenleme etkileri vard\u0131r. Kapsaml\u0131 analize dayanarak, AR tedavisinde kullan\u0131lan tek geleneksel \u00c7in ilac\u0131 \u00e7o\u011funlukla titreme, ate\u015f, ba\u015f a\u011fr\u0131s\u0131, terleme, uzuv a\u011fr\u0131s\u0131, burun ak\u0131nt\u0131s\u0131, burun t\u0131kan\u0131kl\u0131\u011f\u0131, ince ve beyaz k\u00fcrk, bo\u011faz ka\u015f\u0131nt\u0131s\u0131 ve \u00f6ks\u00fcr\u00fck ve de\u011fi\u015fken nab\u0131z gibi r\u00fczgar ve so\u011fuk belirtileri i\u00e7in kullan\u0131lan Xinyi, Fangfeng, Cang'er Zi, Xixin, Baizhi, Guizhi vb.
\nBirliktelik kurallar\u0131n\u0131n analizinde, y\u00fcksek deste\u011fe sahip \u00e7ekirdek ila\u00e7 kombinasyonlar\u0131 Huangqi Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes macrocephala Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylodes Radix Atractylo. Schisandra chinensis, Cicada molt ve nane d\u0131\u015f\u0131nda, di\u011fer y\u00fcksek frekansl\u0131 ila\u00e7lar\u0131n yayg\u0131n olarak kullan\u0131lan dozlar\u0131 \u00c7in Farmakopesi'nde belirtilen doz aral\u0131\u011f\u0131ndad\u0131r.
\nK\u00fcme analizinde, bir grup geleneksel \u00c7in ilac\u0131 temel olarak eksikli\u011fin giderilmesine ve d\u0131\u015f semptomlar\u0131n hafifletilmesine odaklanmaktad\u0131r. Bunlar aras\u0131nda, Astragalus membranaceus'un ana aktif bile\u015feni olan Astragalus polisakkaritleri, AR s\u0131\u00e7anlar\u0131nda hap\u015f\u0131rma, burun ka\u015f\u0131ma ve burun ak\u0131nt\u0131s\u0131 gibi semptomlar\u0131 hafifletebilir. T-bet ve IFN - \u03b3 mRNA ekspresyonunu yukar\u0131 d\u00fczenleyerek, GATA-3 ve IL-4 mRNA ekspresyonunu a\u015fa\u011f\u0131 d\u00fczenleyerek AR s\u0131\u00e7an burun mukozal dokusunun enflamasyonunu azaltabilir ve serum IL-4, IL-6, IL1 \u03b2, IgE, TNF - \u03b1 gibi enflamatuar fakt\u00f6rlerin seviyelerini azaltarak AR'nin iyile\u015fmesini te\u015fvik edebilir. Windproof, r\u00fczgar\u0131 uzakla\u015ft\u0131rma, y\u00fczey nemini giderme ve ka\u015f\u0131nt\u0131y\u0131 hafifletme etkilerine sahiptir. R\u00fczgar ge\u00e7irmez polisakkaritlerin in vitro deneylerle iyi anti alerjik etkilere sahip oldu\u011fu kan\u0131tlanm\u0131\u015ft\u0131r. R\u00fczgar ge\u00e7irmez alkol \u00f6zleri, in vitro h\u00fccrelerde PAR-2 ekspresyonunu azaltarak anti alerjik etkiler g\u00f6sterebilir. Guizhi terleme ve kaslar\u0131 rahatlatma, meridyenleri \u0131s\u0131tma ve destekleme, yang'\u0131n qi'yi d\u00f6n\u00fc\u015ft\u00fcrmesine yard\u0131mc\u0131 olma ve d\u0131\u015f r\u00fczgar patojenlerini da\u011f\u0131tma etkilerine sahiptir. Ju Er Cang Er Zi'nin r\u00fczgar ve so\u011fu\u011fu da\u011f\u0131tma, burun a\u00e7\u0131lmas\u0131n\u0131 te\u015fvik etme ve r\u00fczgar ve rutubeti giderme etkileri vard\u0131r. R\u00fczgar ve so\u011fuk ba\u015f a\u011fr\u0131lar\u0131, burun t\u0131kan\u0131kl\u0131\u011f\u0131 ve burun ak\u0131nt\u0131s\u0131, burun t\u0131kan\u0131kl\u0131\u011f\u0131, burun sin\u00fcsleri, romatizma ve ka\u015f\u0131nt\u0131 ve nemli durgunluk ve spazmlar\u0131n tedavisinde kullan\u0131l\u0131r; Fructus Xanthii'nin n-butanol ekstresi, AR kobaylar\u0131nda nazal mukozal inflamasyonu hafifletebilir, beyaz kan h\u00fccresi say\u0131s\u0131n\u0131, eozinofil y\u00fczdesini ve serum SIgE seviyelerini azaltabilir; Atractylodes macrocephala'n\u0131n su ekstresi, AR kobaylar\u0131nda nazal mukozal ayr\u0131lma, doku \u00f6demi ve inflamatuar h\u00fccre infiltrasyonu gibi semptomlar\u0131 hafifletebilir ve serumda inflamatuar sitokin IgE, IL-4 ve IFN - \u03b3 ekspresyon seviyelerini azaltabilir.
\nBu makale TCMSP veri taban\u0131n\u0131 taram\u0131\u015f ve literat\u00fcr\u00fc desteklemi\u015f ve Huangqi Xinyi ila\u00e7 \u00e7iftinde 306 hedef noktaya kar\u015f\u0131l\u0131k gelen toplam 48 aktif bile\u015fen bulmu\u015ftur. Her bir bile\u015fen birden fazla hedef i\u00e7in kullan\u0131lm\u0131\u015ft\u0131r. Hedef noktalar ve bile\u015fenler aras\u0131ndaki ili\u015fkiyi daha iyi g\u00f6stermek i\u00e7in, bile\u015fen hedefleri ve hastal\u0131k hedeflerinin kesi\u015fimi al\u0131narak bir \"bile\u015fen hedef hastal\u0131k\" a\u011f\u0131 olu\u015fturulmu\u015ftur. Ana bile\u015fenler olan kaempferol ve kuersetinin hedeflerle en y\u00fcksek korelasyona sahip oldu\u011fu ve Huangqi Xinyi'nin AR tedavisinde \u00f6nemli farmakolojik roller oynayan anahtar bile\u015fenler olabilece\u011fi bulunmu\u015ftur. \u00c7al\u0131\u015fmalar, kaempferol\u00fcn ba\u011f\u0131rsak bariyerinin b\u00fct\u00fcnl\u00fc\u011f\u00fcn\u00fc iyile\u015ftirerek ba\u011f\u0131rsak iltihab\u0131n\u0131n olu\u015fumunu azaltabilece\u011fini ve \u00f6nemli anti hiperglisemik ve antioksidan etkilere sahip oldu\u011funu g\u00f6stermi\u015ftir; Quercetin, galektin-3 ve NLRP3'\u00fcn ba\u011flanmas\u0131n\u0131 inhibe ederek aterosklerotik iltihab\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azaltabilir. KEGG yolunun daha ileri analizi, n\u00f6roaktif ligand resept\u00f6r etkile\u015fim yolunun, kalsiyum iyon sinyal yolunun, steroid hormon biyosentez yolunun ve kanser yolunun, Huangqi Xinyi'nin 34 aktif bile\u015fen ve 39 \u00e7ekirdek hedefi i\u00e7eren anti AR etkilerini uygulad\u0131\u011f\u0131 ana yollar oldu\u011funu ortaya koymu\u015ftur. \"Bile\u015fen hedef yolak hastal\u0131\u011f\u0131\" ili\u015fkisini analiz ederek, PTGS2, HSP90, NOS2, CALM1, CHRM1, CYP1B1 ve di\u011fer hedef proteinlerin yolakta \u00f6nemli bir rol oynad\u0131\u011f\u0131n\u0131 bulduk. PTGS2, inflamasyon veya t\u00fcm\u00f6rler gibi patolojik reaksiyonlarda yer al\u0131r ve nonsteroid antiinflamatuar ila\u00e7lar\u0131n hedefidir. Pro-inflamatuar sitokinler ve b\u00fcy\u00fcme fakt\u00f6rleri taraf\u0131ndan y\u00fcksek oranda ind\u00fcklenerek inflamatuar fakt\u00f6rler salg\u0131layabilir ve inflamatuar bir yan\u0131t\u0131 tetikleyebilir. HSP90, m\u00fc\u015fteri proteinlerinin do\u011fru uzaysal katlanmay\u0131 tamamlamas\u0131na ve h\u00fccre d\u00f6ng\u00fcs\u00fc d\u00fczenlemesine kat\u0131lmas\u0131na yard\u0131mc\u0131 olabilen ATP ba\u011f\u0131ml\u0131 bir molek\u00fcler \u015faperondur. \u00c7al\u0131\u015fmalar HSP90'\u0131n lenfosit aktivasyonunu d\u00fczenleyebildi\u011fini, enfeksiyon b\u00f6lgelerine lenfosit g\u00f6\u00e7\u00fcn\u00fc te\u015fvik edebildi\u011fini ve v\u00fccutta fizyolojik stres alt\u0131nda lokal enflamatuar yan\u0131tlar\u0131 kolayla\u015ft\u0131rabildi\u011fini g\u00f6stermi\u015ftir. NOS2, v\u00fccutta yaralanmadan sonra eksprese edilen ind\u00fcklenebilir bir nitrik oksit sentazd\u0131r ve v\u00fccutta ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenlemesine ve enflamatuar yan\u0131ta kat\u0131lmak i\u00e7in nitrik oksidin oksidatif stresini kullanabilir. CALM1 bir kalmodulin proteinidir ve CALM1'in a\u015f\u0131r\u0131 ekspresyonu h\u00fccresel kalsiyum iyonu sinyal kanallar\u0131n\u0131 anormal \u015fekilde aktive edebilir, sonu\u00e7ta v\u00fccutta enflamatuar reaksiyonlara ve belirli bir derecede karaci\u011fer hasar\u0131na yol a\u00e7abilir. CHRM1 parasempatik bir resept\u00f6rd\u00fcr ve \u00e7al\u0131\u015fmalar CHRM1 agonistlerinin h\u00fccresel kalsiyum iyonu aktivitesini art\u0131rarak n\u00f6ronal farkl\u0131la\u015fmay\u0131 d\u00fczenleyebilece\u011fini g\u00f6stermi\u015ftir. Molek\u00fcler yerle\u015ftirme do\u011frulamas\u0131nda, kaempferole d\u00fc\u015f\u00fck ba\u011flanma enerjisine sahiptirler ve kalsiyum iyon kanallar\u0131n\u0131n aktivasyonunu d\u00fczenleyerek inflamatuar sitokinlerin sal\u0131n\u0131m\u0131n\u0131 tetikleyebilirler. CYP1B1, steroid hormon sentez yolunda yer alan \u00f6nemli bir proteindir. Steroidler \u00f6nemli anti-enflamatuar ve anti alerjik ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenleyici etkilere sahiptir ve molek\u00fcler yerle\u015ftirme do\u011frulamas\u0131nda quercetin ve kaempferol'e iyi ve kararl\u0131 ba\u011flanma yetene\u011fi g\u00f6stermi\u015ftir. Yukar\u0131daki analizden, Huangqi Xinyi'deki ana bile\u015fenlerin AR \u00fczerinde terap\u00f6tik etkiler g\u00f6stermek i\u00e7in PTGS2, HSP90, NOS2, CALM1, CHRM1, CYP1B1 gibi hedefler arac\u0131l\u0131\u011f\u0131yla n\u00f6roaktif ligand resept\u00f6r etkile\u015fim yolu, kalsiyum iyon sinyal yolu, steroid hormon biyosentez yolu ve kanser yolu \u00fczerinde etkili olabilece\u011fi g\u00f6r\u00fclebilir. Yukar\u0131daki tahmin sonu\u00e7lar\u0131n\u0131n g\u00fcvenilirli\u011fini daha fazla do\u011frulamak amac\u0131yla, in vivo deneysel do\u011frulama i\u00e7in ragweed poleni taraf\u0131ndan ind\u00fcklenen bir AR fare modeli olu\u015fturulmu\u015ftur. Ara\u015ft\u0131rma sonu\u00e7lar\u0131 Huangqi Xinyi ilac\u0131n\u0131n AR farelerinde PTGS2, HSP90 ve NOS2 protein ekspresyonunu azaltabildi\u011fini, AR fare serumu, nazal lavaj s\u0131v\u0131s\u0131 ve bronkoalveolar lavaj s\u0131v\u0131s\u0131nda inflamatuar fakt\u00f6rler histamin, IgE, TNF - \u03b1 ve IL-6 ekspresyon seviyelerini inhibe edebildi\u011fini g\u00f6stermi\u015ftir, anti-enflamatuar fakt\u00f6r IL-10'un ekspresyonunu art\u0131rd\u0131\u011f\u0131n\u0131, AR fare ka\u015f\u0131ma ve hap\u015f\u0131rma semptomlar\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde hafifletti\u011fini ve Huangqi Xinyi ilac\u0131n\u0131n HSP90\/PTGS2\/NOS2 yolunu inhibe ederek enflamatuar reaksiyonlar\u0131n olu\u015fumunu ve geli\u015fimini engelleyebilece\u011fini ve b\u00f6ylece AR'ye m\u00fcdahale etme etkisini elde edebilece\u011fini ortaya koymaktad\u0131r.
\n\u00d6zetle, AR'nin klinik tedavisi i\u00e7in ila\u00e7 kurallar\u0131 veri madencili\u011fi istatistiksel analizi ve a\u011f farmakolojisi teknikleri ile \u00f6zetlenmi\u015f ve AR tedavisinde y\u00fcksek frekansl\u0131 ila\u00e7 kombinasyonu Huangqi Xinyi'nin molek\u00fcler mekanizmas\u0131 derinlemesine incelenmi\u015ftir. Molek\u00fcler yerle\u015ftirme sim\u00fclasyonu, Huangqi Xinyi'nin \u00e7ok bile\u015fenli, \u00e7ok hedefli ve \u00e7ok yollu \u00f6zelliklerini do\u011frulad\u0131 ve in vivo deneyler, Huangqi Xinyi ila\u00e7lar\u0131n\u0131n enflamatuar reaksiyonlar\u0131n olu\u015fumunu engelleyebilece\u011fini, farelerde AR semptomlar\u0131n\u0131 hafifletebilece\u011fini ve sonu\u00e7ta HSP90\/PTGS2\/NOS2 yolunu inhibe ederek AR tedavisinin etkisini elde edebilece\u011fini do\u011frulad\u0131. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, Xinyi Huangqi ilac\u0131n\u0131n klinik uygulamada rasyonel kullan\u0131m\u0131 i\u00e7in bilimsel bir teorik temel sa\u011flayabilir ve alerjik rinit tedavisinde geleneksel \u00c7in t\u0131bb\u0131n\u0131n uygulanmas\u0131n\u0131 daha da te\u015fvik edebilir.<\/p>","protected":false},"excerpt":{"rendered":"

Exploring the medication rules and related pharmacological analysis of traditional Chinese medicine in the treatment of allergic rhinitis based on data mining, network pharmacology, and experimental verification Allergic rhinitis (AR), also known as allergic rhinitis, is a chronic non infectious inflammation of the nasal mucosa caused by the release of inflammatory factors (histamine, leukotrienes, prostaglandins, […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExploring the medication rules and related pharmacological analysis of traditional Chinese medicine in the treatment of allergic rhinitis based on data mining, network pharmacology, and experimental verification - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/alerjik-rinit\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the medication rules and related pharmacological analysis of traditional Chinese medicine in the treatment of allergic rhinitis based on data mining, network pharmacology, and experimental verification - 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