{"id":4819,"date":"2024-08-04T15:53:45","date_gmt":"2024-08-04T15:53:45","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4819"},"modified":"2024-08-04T15:53:45","modified_gmt":"2024-08-04T15:53:45","slug":"burdock-fruit","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/burdock-fruit\/","title":{"rendered":"Yan\u0131t y\u00fczey metodolojisi kullan\u0131larak dulavratotu k\u00f6k\u00fcnden polisakkarit ekstraksiyon i\u015fleminin optimizasyonu ve h\u00fccreler \u00fczerindeki anti-inflamatuar etkisi \u00fczerine \u00e7al\u0131\u015fma"},"content":{"rendered":"

Yan\u0131t y\u00fczey metodolojisi kullan\u0131larak dulavratotu k\u00f6k\u00fcnden polisakkarit ekstraksiyon i\u015fleminin optimizasyonu ve h\u00fccreler \u00fczerindeki anti-inflamatuar etkisi \u00fczerine \u00e7al\u0131\u015fma
\nAsteraceae bitkisinin olgun ve kurutulmu\u015f bir meyvesi olan Arctium lappa L., \u00c7in Farmakopesi'nin 2020 bask\u0131s\u0131na dahil edilmi\u015ftir. Modern ara\u015ft\u0131rmalar, Arctium lappa'n\u0131n anti-enflamatuar, anti-t\u00fcm\u00f6r, anti diyabet nefropatisi, ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenlemesi, anti-vir\u00fcs, hipoglisemik, di\u00fcretik ve m\u00fcshil etkileri gibi \u00e7e\u015fitli farmakolojik aktiviteleri nedeniyle yayg\u0131n olarak \u00e7al\u0131\u015f\u0131ld\u0131\u011f\u0131n\u0131 g\u00f6stermektedir. Bununla birlikte, dulavratotu tohumlar\u0131n\u0131n aktif bile\u015fenleri \u00fczerine yap\u0131lan mevcut ara\u015ft\u0131rmalar esas olarak lignanlara odaklan\u0131rken, meyve bazl\u0131 geleneksel \u00c7in t\u0131bb\u0131nda zengin ana bile\u015fenlerden biri olan polisakkaritler dulavratotu tohumlar\u0131nda daha az \u00e7al\u0131\u015f\u0131lm\u0131\u015ft\u0131r. Enflamasyon, v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k sisteminin ilk savunma hatt\u0131 ve v\u00fccudun do\u011fal bir koruyucu reaksiyonudur. Ancak uzun s\u00fcreli ve kronik iltihaplanma ate\u015f, ast\u0131m, ateroskleroz, artrit, n\u00f6rodejeneratif hastal\u0131klar ve hatta kanser gibi hastal\u0131klar\u0131n ortaya \u00e7\u0131kmas\u0131na neden olabilir. \u015eu anda, iltihap tedavisi esas olarak steroid ve nonsteroid anti-enflamatuar ila\u00e7lara odaklanmaktad\u0131r, ancak bunlar uzun s\u00fcre kullan\u0131lamaz \u00e7\u00fcnk\u00fc hipertansiyon, osteoporoz, imm\u00fcnosupresyon, hemorajik gastrit, \u00fcst gastrointestinal \u00fclserler, hepatotoksisite, alerji vb. gibi yan etkilere neden olabilirler. Bu nedenle, g\u00fcvenli ve etkili yeni bir ila\u00e7 kayna\u011f\u0131n\u0131n geli\u015ftirilmesi aciliyet arz etmektedir. Son y\u0131llarda, do\u011fal polisakkaritler g\u00fcvenlikleri, eri\u015filebilirlikleri ve iyi anti-enflamatuar aktiviteleri nedeniyle yayg\u0131n ilgi g\u00f6rm\u00fc\u015ft\u00fcr.
\nBu nedenle, tek fakt\u00f6rl\u00fc ko\u015fullar\u0131n incelenmesine dayanan bu \u00e7al\u0131\u015fma, \u00fc\u00e7 fakt\u00f6rl\u00fc \u00fc\u00e7 seviyeli bir deneysel tasar\u0131m y\u00fcr\u00fctmek i\u00e7in yan\u0131t y\u00fczeyinde Box Behnken y\u00f6ntemini benimsemi\u015ftir. Dulavratotu tohumu polisakkaritlerinin ekstraksiyon oran\u0131na dayanarak, dulavratotu tohumu polisakkarit ekstraksiyon i\u015flemi i\u00e7in en uygun bile\u015fim olu\u015fturulmu\u015ftur. Lipopolisakkarit (LPS) ile ind\u00fcklenen bir RAW 246.7 h\u00fccre inflamasyon modeli olu\u015fturularak, dulavratotu tohumu polisakkaritlerinin anti-inflamatuar mekanizmalar\u0131 \u00fczerine \u00f6n \u00e7al\u0131\u015fmalar yap\u0131lm\u0131\u015f, yeni anti-inflamatuar ila\u00e7lar\u0131n geli\u015ftirilmesi ve dulavratotu tohumu polisakkaritlerinin kapsaml\u0131 kullan\u0131m\u0131 i\u00e7in bilimsel temel sa\u011flanm\u0131\u015ft\u0131r.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"Bu makale, dulavratotu tohumu polisakkaritlerinin ekstraksiyon s\u00fcrecinde \u00fc\u00e7 fakt\u00f6r (kat\u0131-s\u0131v\u0131 oran\u0131, zaman ve s\u0131cakl\u0131k) \u00fczerinde bir aral\u0131k belirleme \u00e7al\u0131\u015fmas\u0131 y\u00fcr\u00fctmektedir. Buna dayanarak, Box Behnken kullan\u0131larak \u00fc\u00e7 fakt\u00f6r kombinasyonlu bir deneysel tasar\u0131m ger\u00e7ekle\u015ftirilmi\u015ftir. Dulavratotu tohumu polisakkaritlerinin ger\u00e7ek ekstraksiyon oran\u0131na g\u00f6re, dulavratotu tohumu polisakkaritleri i\u00e7in optimum ekstraksiyon i\u015flemi ko\u015fullar\u0131 elde edilmi\u015ftir (kat\u0131-s\u0131v\u0131 oran\u0131=1:15g\/mL, ekstraksiyon s\u00fcresi 3 saat, ekstraksiyon s\u0131cakl\u0131\u011f\u0131 80 \u2103). Farkl\u0131 konsantrasyonlardaki dulavratotu tohumu polisakkaritlerinin h\u00fccresel enflamasyondaki etki mekanizmas\u0131 incelenerek, dulavratotu tohumu polisakkaritlerinin LPS taraf\u0131ndan ind\u00fcklenen RAW 264.7 h\u00fccrelerinin s\u00fcpernatant\u0131nda TNF - \u03b1 ve IL-6 salg\u0131lanmas\u0131n\u0131 inhibe edebilece\u011fi ve TLR4\/MyD88\/NF - \u03ba B yola\u011f\u0131ndaki ilgili proteinleri d\u00fczenleyerek ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenleyici bir rol oynayabilece\u011fi bulunmu\u015ftur. Bu \u00e7al\u0131\u015fma, dulavratotu tohumu polisakkaritlerinin geli\u015ftirilmesi ve uygulanmas\u0131 i\u00e7in bilimsel bir temel olu\u015fturabilir ve anti-enflamatuar etkilerde dulavratotunun geli\u015ftirilmesi ve uygulanmas\u0131 i\u00e7in teknik referanslar sa\u011flayabilir.<\/p>","protected":false},"excerpt":{"rendered":"

Optimization of polysaccharide extraction process from burdock root using response surface methodology and study on its anti-inflammatory effect on cells Arctium lappa L., a mature and dried fruit of the Asteraceae plant, is included in the 2020 edition of the Chinese Pharmacopoeia. Modern research shows that Arctium lappa has been widely studied because of its […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nOptimization of polysaccharide extraction process from burdock root using response surface methodology and study on its anti-inflammatory effect on cells - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/burdock-fruit\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Optimization of polysaccharide extraction process from burdock root using response surface methodology and study on its anti-inflammatory effect on cells - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Optimization of polysaccharide extraction process from burdock root using response surface methodology and study on its anti-inflammatory effect on cells Arctium lappa L., a mature and dried fruit of the Asteraceae plant, is included in the 2020 edition of the Chinese Pharmacopoeia. Modern research shows that Arctium lappa has been widely studied because of its […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/tr\/burdock-fruit\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-04T15:53:45+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-96.png\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/burdock-fruit\/\",\"url\":\"https:\/\/longchangextracts.com\/burdock-fruit\/\",\"name\":\"Optimization of polysaccharide extraction process from burdock root using response surface methodology and study on its anti-inflammatory effect on cells - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangextracts.com\/burdock-fruit\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangextracts.com\/burdock-fruit\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-96.png\",\"datePublished\":\"2024-08-04T15:53:45+00:00\",\"dateModified\":\"2024-08-04T15:53:45+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/burdock-fruit\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/burdock-fruit\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/burdock-fruit\/#primaryimage\",\"url\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-96.png\",\"contentUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-96.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/burdock-fruit\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Optimization of polysaccharide extraction process from burdock root using response surface methodology and study on its anti-inflammatory effect on cells\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Yan\u0131t y\u00fczey metodolojisi kullan\u0131larak dulavratotu k\u00f6k\u00fcnden polisakkarit ekstraksiyon i\u015fleminin optimizasyonu ve h\u00fccreler \u00fczerindeki anti-enflamatuar etkisi \u00fczerine \u00e7al\u0131\u015fma - China Chemical Manufacturer","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/tr\/burdock-fruit\/","og_locale":"tr_TR","og_type":"article","og_title":"Optimization of polysaccharide extraction process from burdock root using response surface methodology and study on its anti-inflammatory effect on cells - China Chemical Manufacturer","og_description":"Optimization of polysaccharide extraction process from burdock root using response surface methodology and study on its anti-inflammatory effect on cells Arctium lappa L., a mature and dried fruit of the Asteraceae plant, is included in the 2020 edition of the Chinese Pharmacopoeia. Modern research shows that Arctium lappa has been widely studied because of its […]","og_url":"https:\/\/longchangextracts.com\/tr\/burdock-fruit\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-04T15:53:45+00:00","og_image":[{"url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-96.png"}],"author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"longcha9","Tahmini okuma s\u00fcresi":"4 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/burdock-fruit\/","url":"https:\/\/longchangextracts.com\/burdock-fruit\/","name":"Yan\u0131t y\u00fczey metodolojisi kullan\u0131larak dulavratotu k\u00f6k\u00fcnden polisakkarit ekstraksiyon i\u015fleminin optimizasyonu ve h\u00fccreler \u00fczerindeki anti-enflamatuar etkisi \u00fczerine \u00e7al\u0131\u015fma - China Chemical Manufacturer","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangextracts.com\/burdock-fruit\/#primaryimage"},"image":{"@id":"https:\/\/longchangextracts.com\/burdock-fruit\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-96.png","datePublished":"2024-08-04T15:53:45+00:00","dateModified":"2024-08-04T15:53:45+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/burdock-fruit\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/burdock-fruit\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/burdock-fruit\/#primaryimage","url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-96.png","contentUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-96.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/burdock-fruit\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Optimization of polysaccharide extraction process from burdock root using response surface methodology and study on its anti-inflammatory effect on cells"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"\u00c7in Kimyasal \u00dcreticisi","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"tr"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/4819"}],"collection":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/comments?post=4819"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/4819\/revisions"}],"predecessor-version":[{"id":4827,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/4819\/revisions\/4827"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/media?parent=4819"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/categories?post=4819"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/tags?post=4819"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}