{"id":4806,"date":"2024-08-04T15:51:27","date_gmt":"2024-08-04T15:51:27","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4806"},"modified":"2024-08-04T15:51:27","modified_gmt":"2024-08-04T15:51:27","slug":"wild-silkworm-bean-root","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/yabani-ipekbocegi-fasulyesi-koku\/","title":{"rendered":"A\u011f farmakolojisi ve in vitro deneylere dayal\u0131 olarak yabani ipekb\u00f6ce\u011fi soya fasulyesi k\u00f6k\u00fcn\u00fcn antioksidan aktivitesinin ve mekanizmas\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"

A\u011f farmakolojisi ve in vitro deneylere dayal\u0131 olarak yabani ipekb\u00f6ce\u011fi soya fasulyesi k\u00f6k\u00fcn\u00fcn antioksidan aktivitesinin ve mekanizmas\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131
\nYabani ipekb\u00f6ce\u011fi fasulyesi k\u00f6k\u00fc, Scrophulariaceae familyas\u0131ndan bir bitki olan Centrantheragrandiflora Benth'nin k\u00f6k\u00fcd\u00fcr ve \u00e7o\u011funlukla Yunnan, Guizhou, Guangxi ve di\u011fer yerlerde da\u011f\u0131t\u0131l\u0131r. Yabani ipekb\u00f6ce\u011fi fasulyesi k\u00f6kleri, sikloheksen eter terpenler, feniletanolik glikozitler, iyononlar, karotenoidler, monoterpenler ve di\u011fer bile\u015fikler gibi \u00e7e\u015fitli aktif maddeler bak\u0131m\u0131ndan zengin t\u0131bbi ve yenilebilir bitkilerdir. Antioksidan, anti-enflamatuar, antikoag\u00fclan ve miyokardiyal iskemi gibi fizyolojik aktivitelere sahiptirler ve ayr\u0131ca yara iyile\u015fmesini te\u015fvik ederler. Eski kitaplar, serebral tromboz ve inme gibi hastal\u0131klar\u0131 \u00f6nlemek ve tedavi etmek i\u00e7in \u015farap yap\u0131m\u0131nda kullan\u0131ld\u0131\u011f\u0131n\u0131 kaydeder. Yunnan'da Yi etnik \u015fifal\u0131 bitkileri olarak ekilir ve etnik t\u0131pta yayg\u0131n olarak kullan\u0131l\u0131r. \u015eu anda, ara\u015ft\u0131rmalar esas olarak yabani ipekb\u00f6ce\u011fi fasulyesi k\u00f6klerinin \u00e7\u0131kar\u0131lmas\u0131 ve ayr\u0131lmas\u0131n\u0131n yan\u0131 s\u0131ra aktivite \u00e7al\u0131\u015fmalar\u0131na odaklanmaktad\u0131r. Yabani ipekb\u00f6ce\u011fi fasulyesi k\u00f6kleri, antioksidan, lipit d\u00fc\u015f\u00fcr\u00fcc\u00fc, hepatoprotektif ve kardiyovask\u00fcler ve serebrovask\u00fcler hastal\u0131klara kar\u015f\u0131 \u00f6nleyici etkileri olan iridoid glikozitler a\u00e7\u0131s\u0131ndan zengindir ve geli\u015fim i\u00e7in b\u00fcy\u00fck bir potansiyele sahiptir.<\/p>\n

Oksidatif stres, v\u00fccudun a\u015f\u0131r\u0131 reaktif oksijen t\u00fcrleri (ROS) \u00fcretmesi i\u00e7in uyar\u0131ld\u0131\u011f\u0131, antioksidanlarla dengesizli\u011fe yol a\u00e7an ve kardiyovask\u00fcler hastal\u0131klara, n\u00f6rolojik bozukluklara ve kansere neden olan bir stres durumunu ifade eder. \u0130\u015flenmi\u015f ve sentezlenmi\u015f antioksidanlar\u0131n sa\u011fl\u0131\u011fa potansiyel zararlar\u0131 nedeniyle, insanlar do\u011fal antioksidanlar\u0131 aramaya daha kararl\u0131d\u0131r. Do\u011fal antioksidanlar, \u00f6nemli terap\u00f6tik etkileri ve d\u00fc\u015f\u00fck toksisite ve yan etkileri nedeniyle giderek daha fazla dikkat \u00e7ekmektedir. Do\u011fal bir ila\u00e7 olarak yabani ipekb\u00f6ce\u011fi \u00e7ekirde\u011fi k\u00f6k\u00fc iyi bir antioksidan aktiviteye sahiptir, ancak spesifik aktif bile\u015fenleri ve etki mekanizmas\u0131 hakk\u0131nda s\u0131n\u0131rl\u0131 ara\u015ft\u0131rma vard\u0131r.<\/p>\n

A\u011f farmakolojisi, ila\u00e7lar\u0131n v\u00fccuttaki d\u00fczenleyici a\u011f\u0131n\u0131 sistemik d\u00fczeyde ortaya \u00e7\u0131karan geli\u015fmekte olan bir disiplindir. \u0130la\u00e7lar, etken maddeler, hedefler ve hastal\u0131klar aras\u0131nda karma\u015f\u0131k bir a\u011f ili\u015fkisi kurarak, \u00f6zellikle geleneksel \u00c7in t\u0131bb\u0131 geli\u015ftirmede \u00e7ok hedefli ila\u00e7lar\u0131n etki mekanizmas\u0131n\u0131n tahmini i\u00e7in ila\u00e7lar\u0131n etki mekanizmas\u0131 tahmin edilebilir. Bu makale, yabani ipekb\u00f6ce\u011fi soya fasulyesi k\u00f6k\u00fcn\u00fcn ana etken maddelerini ve hedef bile\u015fenlerini analiz etmek i\u00e7in a\u011f farmakolojisini kullanmakta ve antioksidan etkisinin molek\u00fcler mekanizmas\u0131n\u0131 derinlemesine ara\u015ft\u0131rmaktad\u0131r. \u0130n vitro antioksidan deneyler ve biyolojik y\u00f6ntemlerle do\u011frulanarak yabani ipekb\u00f6ce\u011fi soya fasulyesi k\u00f6k\u00fc \u00fczerine daha fazla temel deneysel ara\u015ft\u0131rma i\u00e7in teorik bir temel sa\u011flar.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"Yabani ipekb\u00f6ce\u011fi fasulyesi k\u00f6k\u00fc\"\"\"\"
\nYabani ipekb\u00f6ce\u011fi fasulyesi k\u00f6k\u00fc, \u00c7in'de sikloheksen eter terpenler, feniletanol, karotenoidler gibi \u00e7e\u015fitli aktif maddeler i\u00e7eren geleneksel bir \u00c7in ilac\u0131d\u0131r. Antioksidan, hipoglisemik, antikoag\u00fclan ve miyokardiyal iskemi gibi \u00e7e\u015fitli farmakolojik aktivitelere sahiptir. \u015eu anda, yabani ipekb\u00f6ce\u011fi fasulyesi k\u00f6klerinin antioksidan aktivitesi \u00fczerine yap\u0131lan ara\u015ft\u0131rmalar giderek derinle\u015fmektedir, ancak spesifik aktif bile\u015fenler ve mekanizmalar hen\u00fcz ke\u015ffedilmemi\u015ftir. Yabani ipekb\u00f6ce\u011fi soya fasulyesi k\u00f6k\u00fcn\u00fcn antioksidan stres mekanizmas\u0131n\u0131 daha fazla ara\u015ft\u0131rmak i\u00e7in bu \u00e7al\u0131\u015fmada in vitro antioksidan deneyler, a\u011f farmakolojisi, molek\u00fcler yerle\u015ftirme teknolojisi ve Western blot tespiti yap\u0131lm\u0131\u015ft\u0131r.
\n\u0130n vitro antioksidan deneyler sayesinde, yabani ipekb\u00f6ce\u011fi fasulyesi k\u00f6k\u00fc ekstresinin DPPH serbest radikallerini, ABTS serbest radikallerini ve hidroksil serbest radikallerini temizleme yetene\u011fine sahip oldu\u011fu ve belirli bir konsantrasyon aral\u0131\u011f\u0131nda, yabani ipekb\u00f6ce\u011fi fasulyesi k\u00f6k\u00fc ekstresinin \u00fc\u00e7 serbest radikal temizleme oran\u0131n\u0131n belirli bir do\u011frusal ili\u015fkiye sahip oldu\u011fu bulunmu\u015ftur. 320 \u03bcg\/mL konsantrasyonda, \u00fc\u00e7 serbest radikalin temizleme oranlar\u0131 s\u0131ras\u0131yla 3.86%, 83.89% ve 59.15%'dir. IC50 de\u011ferleri s\u0131ras\u0131yla 0.166mg\/mL, 0.054mg\/mL ve 0.180mg\/mL olup iyi antioksidan kapasiteye i\u015faret etmektedir.
\nLiterat\u00fcr taramas\u0131 ve ilgili veri taban\u0131 taramas\u0131 yoluyla, yabani ipekb\u00f6ce\u011fi soya fasulyesi k\u00f6klerinden aucubin, rhodopsin, \u03b2 - sitosterol, geniposide metil ester, catalpol vb. dahil olmak \u00fczere 22 aktif bile\u015fen elde edilmi\u015ftir. Bunlar aras\u0131nda \u015feftali yapraklar\u0131ndaki aucubin, yabani ipekb\u00f6ce\u011fi fasulyesi k\u00f6klerinde en y\u00fcksek i\u00e7eri\u011fe sahiptir ve antioksidan, antibakteriyel ve antikanser gibi \u00e7ok \u00e7e\u015fitli aktivitelere sahiptir. Nrf2, antioksidan stres i\u00e7in temel bir transkripsiyon fakt\u00f6r\u00fcd\u00fcr, a\u015fa\u011f\u0131 ak\u0131\u015f antioksidan fakt\u00f6rlerinin aktivasyonunu ve ekspresyonunu d\u00fczenler ve h\u00fccresel homeostaz\u0131 korur. \u00c7al\u0131\u015fmalar, aucubin'in Nrf2 arac\u0131l\u0131 antioksidan yollar yoluyla fare osteoklastlar\u0131n\u0131n farkl\u0131la\u015fmas\u0131n\u0131 engelleyebildi\u011fini ve b\u00f6ylece osteoporoz geli\u015fimini yava\u015flatt\u0131\u011f\u0131n\u0131 bulmu\u015ftur. Rhododendron k\u0131rm\u0131z\u0131 pigmenti do\u011fal bir karotenoiddir ve yabani ipekb\u00f6ce\u011fi fasulyesi k\u00f6klerinde \u00f6nemli bir aktif bile\u015fendir. Ara\u015ft\u0131rmalar, yabani ipekb\u00f6ce\u011fi fasulyesi k\u00f6klerindeki rodopsinin, s\u00fcperoksit dismutaz (SOD) aktivitesini art\u0131rarak h\u00fccresel oksidatif stres hasar\u0131na kar\u015f\u0131 koruyucu bir etki g\u00f6sterebilece\u011fini bulmu\u015ftur. Bu arada, Nrf2 ARE yolunu uyararak miyokardiyal hasara kar\u015f\u0131 koruyucu aktivite de g\u00f6sterebilir. Zichun ayr\u0131ca anti-enflamatuar ve antioksidan \u00f6zellikler gibi \u00e7ok \u00e7e\u015fitli farmakolojik aktivitelere sahip bir t\u00fcr iridoid glikozit bile\u015fi\u011fidir. Ara\u015ft\u0131rmalar, Zichun'un ayr\u0131ca Nrf2 ve HO-1 ekspresyonunu d\u00fczenleyebilece\u011fini, SOD aktivitesini art\u0131rabilece\u011fini, MDA aktivitesini azaltabilece\u011fini, beyin h\u00fccresi apoptozunu azaltabilece\u011fini, Bcl-2 protein ekspresyonunu te\u015fvik edebilece\u011fini, Bax protein ekspresyonunu inhibe edebilece\u011fini ve oksidatif stres hasar\u0131n\u0131 hafifletebilece\u011fini bulmu\u015ftur.
\nProtein etkile\u015fim a\u011f\u0131 analizinde, yabani ipekb\u00f6ce\u011fi soya fasulyesi k\u00f6klerinden elde edilen aktif bile\u015fenlerin 82 antioksidan stres hedefi tespit edilmi\u015ftir. Bu hedefler temel olarak STAT3, HSP90AA1, HDAC1, PPARG, HSPAB1 gibi 23 \u00e7ekirdek hedefi i\u00e7ermektedir. Is\u0131 \u015foku proteinleri (HSP'ler), di\u011fer proteinlerin yap\u0131s\u0131n\u0131 ve etkile\u015fimlerini de\u011fi\u015ftirebilen ve \u0131s\u0131 \u015foku ve di\u011fer kimyasal ve fiziksel stresler taraf\u0131ndan ind\u00fcklenen molek\u00fcler \u015faperon proteinlerdir. HSP90AA1 ve HSP90AB1, HSP90 HSP ailesine aittir. Oksidatif stres olu\u015ftu\u011funda, h\u00fccre i\u00e7i \u0131s\u0131 \u015foku proteinlerinin ekspresyonunu aktive eder. Ara\u015ft\u0131rmalar, HSP90'\u0131n Keap1 (INrf2) - Nrf2 sinyal yolunu mod\u00fcle ederek v\u00fccuttaki oksidatif hasar\u0131 d\u00fczenleyebilece\u011fini bulmu\u015ftur. Oksidatif stres alt\u0131nda HSP90, Keap1 ile reaksiyona girerek Keap1 Nrf2 kompleksinin ayr\u0131\u015fmas\u0131n\u0131 te\u015fvik eder ve Nrf2'yi serbest b\u0131rak\u0131r. Nrf2 ve a\u015fa\u011f\u0131 ak\u0131\u015f proteinlerinin transkripsiyonel aktivasyonu yoluyla h\u00fccreleri oksidatif stresten korur. STAT3, g\u00fc\u00e7l\u00fc proliferatif ve apoptotik diren\u00e7 etkileri ile oksidatif stres sonras\u0131 h\u00fccre sa\u011fkal\u0131m\u0131n\u0131n \u00f6nemli bir arac\u0131s\u0131d\u0131r. Ara\u015ft\u0131rmalar, STATA3'\u00fcn h\u00fccresel koruyucu etkisini anti apoptotik protein Bcl XL ekspresyonunu yukar\u0131 do\u011fru d\u00fczenleyerek ve kaspazlar\u0131n inaktivasyonunu te\u015fvik ederek g\u00f6sterebilece\u011fini g\u00f6stermi\u015ftir. HDAC1, histonlar\u0131n ve histon olmayan maddelerin deasetilasyonunu katalize eden bir enzim t\u00fcr\u00fcd\u00fcr ve histonlar\u0131n ve transkripsiyon fakt\u00f6rlerinin deasetilasyonu yoluyla antioksidan enzimlerin ekspresyonunu azaltabilir. Bu arada, \u00e7al\u0131\u015fmalar HDAC1 ifadesinin inhibe edilmesinin, h\u00fccre canl\u0131l\u0131\u011f\u0131n\u0131 iyile\u015ftirerek ve SOD aktivitesini art\u0131rarak H9c2 h\u00fccrelerinde kimyasal hipoksinin neden oldu\u011fu oksidatif stres dengesizli\u011fini \u00f6nleyebilece\u011fini bulmu\u015ftur.
\nKEGG zenginle\u015ftirme analizi, yabani ipekb\u00f6ce\u011fi soya fasulyesi k\u00f6klerinin antioksidan kapasitesinin esas olarak PI3K\/Akt sinyal yolu, n\u00fckleotid metabolizmas\u0131 yolu, \u00f6strojen sinyal yolu vb. ile ili\u015fkili oldu\u011funu g\u00f6stermi\u015ftir. PI3K\/Akt sinyal yolu antioksidan streste \u00f6nemli bir rol oynar ve iyi n\u00f6roprotektif \u00f6zelliklere sahip memeli h\u00fccrelerinde yayg\u0131n olarak bulunur. PI3K\/Akt sinyal yolunun aktivasyonu, Akt kaskad\u0131n\u0131n fosforilasyonunu te\u015fvik edecek ve oksidatif hasar\u0131 \u00f6nleyecektir. Ara\u015ft\u0131rmalar, PI3K\/Akt sinyal yolunun d\u00fczenlenmesinin kondrositlerde ve H9c2 kardiyomiyositlerde apoptozu ve oksidatif stresi iyile\u015ftirebilece\u011fini g\u00f6stermi\u015ftir.
\nMolek\u00fcler yerle\u015ftirme sonu\u00e7lar\u0131, yabani ipekb\u00f6ce\u011fi fasulyesi k\u00f6k\u00fc aktif bile\u015fenleri ile \u00e7ekirdek hedef aras\u0131nda g\u00fc\u00e7l\u00fc kar\u015f\u0131l\u0131kl\u0131 ba\u011flanma yetene\u011fi ve yak\u0131n etkile\u015fim ile iyi bir ba\u011flanma etkisi oldu\u011funu g\u00f6stermi\u015ftir.
\nPI3K sitoplazmik lipid kinazlara aittir. PI3K fosforile edildi\u011finde, Akt fosforilasyonunu i\u015fe al\u0131r ve ind\u00fckler, b\u00f6ylece oksidatif stres ve apoptoz gibi fizyolojik aktiviteleri d\u00fczenler. Western blot analizi, yabani ipekb\u00f6ce\u011fi soya fasulyesi k\u00f6k\u00fcn\u00fcn n-butanol \u00f6z\u00fct\u00fcn\u00fcn protein PI3K ve Akt fosforilasyonunu te\u015fvik edebilece\u011fini, b\u00f6ylece PI3K\/Akt sinyal yolunu aktive edebilece\u011fini ve oksidatif stresi iyile\u015ftirebilece\u011fini g\u00f6stermi\u015ftir.
\n\u00d6zetle, bu makalede yabani ipekb\u00f6ce\u011fi soya fasulyesi k\u00f6klerinin antioksidan aktivitesi in vitro antioksidan deneyler kullan\u0131larak de\u011ferlendirilmi\u015ftir. Yabani ipekb\u00f6ce\u011fi soya fasulyesi k\u00f6klerindeki antioksidan stresin aktif bile\u015fenleri, hedefleri ve sinyal yollar\u0131, a\u011f farmakolojisi ve molek\u00fcler yerle\u015ftirme teknikleri kullan\u0131larak tahmin edilmi\u015ftir. Son olarak, etki mekanizmas\u0131n\u0131 do\u011frulamak i\u00e7in Western blot analizi kullan\u0131lm\u0131\u015ft\u0131r. Sonu\u00e7lar, yabani ipekb\u00f6ce\u011fi fasulyesi k\u00f6k ekstrakt\u0131n\u0131n DPPH serbest radikallerini, ABTS serbest radikallerini ve hidroksil serbest radikallerini temizlemek i\u00e7in IC50 de\u011ferlerinin s\u0131ras\u0131yla 0.166, 0.054 ve 0.180 mg \/ mL oldu\u011funu ve iyi antioksidan aktivitesini do\u011frulad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. A\u011f farmakolojisinin sonu\u00e7lar\u0131, yabani ipekb\u00f6ce\u011fi fasulyesi k\u00f6klerinin, aralar\u0131nda PI3K\/Akt sinyal yolunun antioksidan etkisi i\u00e7in anahtar yol olabilece\u011fi birden fazla bile\u015fen, hedef ve yol arac\u0131l\u0131\u011f\u0131yla oksidatif stresi iyile\u015ftirebilece\u011fini g\u00f6stermektedir. Western blot analizi ayr\u0131ca yabani soya fasulyesi k\u00f6k\u00fc ekstrakt\u0131n\u0131n, ilgili proteinlerin fosforilasyonunu te\u015fvik ederek PI3K\/Akt sinyal yolunu aktive edebilece\u011fini ve b\u00f6ylece antioksidan aktivite uygulayabilece\u011fini ortaya koymu\u015ftur. Bu, yabani soya fasulyesi k\u00f6k\u00fcn\u00fcn oksidatif strese kar\u015f\u0131 etki mekanizmas\u0131n\u0131 do\u011frulayarak, yabani soya fasulyesi k\u00f6k\u00fcn\u00fcn antioksidan stres etkisi \u00fczerine daha fazla ara\u015ft\u0131rma i\u00e7in bir temel olu\u015fturmakta ve y\u00f6n sa\u011flamaktad\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

Exploring the antioxidant activity and mechanism of wild silkworm soybean root based on network pharmacology and in vitro experiments Wild silkworm bean root is the root of Centrantheragrandiflora Benth, a plant in the Scrophulariaceae family, mainly distributed in Yunnan, Guizhou, Guangxi and other places. Wild silkworm bean roots are medicinal and edible plants, rich in […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nExploring the antioxidant activity and mechanism of wild silkworm soybean root based on network pharmacology and in vitro experiments - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/yabani-ipekbocegi-fasulyesi-koku\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the antioxidant activity and mechanism of wild silkworm soybean root based on network pharmacology and in vitro experiments - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the antioxidant activity and mechanism of wild silkworm soybean root based on network pharmacology and in vitro experiments Wild silkworm bean root is the root of Centrantheragrandiflora Benth, a plant in the Scrophulariaceae family, mainly distributed in Yunnan, Guizhou, Guangxi and other places. 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