{"id":4790,"date":"2024-08-04T15:31:10","date_gmt":"2024-08-04T15:31:10","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4790"},"modified":"2024-08-04T15:31:10","modified_gmt":"2024-08-04T15:31:10","slug":"alocasia-cucullata","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/alocasia-cucullata\/","title":{"rendered":"Taro acuminata'n\u0131n Petrol Eter Fraksiyonunun Kimyasal Bile\u015fenleri ve Meme Kanserindeki Sitotoksik Aktivitesi \u00dczerine \u00c7al\u0131\u015fmalar"},"content":{"rendered":"

Taro acuminata'n\u0131n Petrol Eter Fraksiyonunun Kimyasal Bile\u015fenleri ve Meme Kanserindeki Sitotoksik Aktivitesi \u00dczerine \u00c7al\u0131\u015fmalar
\nAraceae familyas\u0131na ait bir bitki olan Alocasia cuculata (Lour.) Schott, kurutulmu\u015f k\u00f6kleri ve saplar\u0131 ile ila\u00e7 olarak kullan\u0131lmaktad\u0131r. \u0130lk olarak \"Guangxi'deki Pratik \u00c7in Bitkisel \u0130la\u00e7lar\u0131n\u0131n Yeni Se\u00e7imi \"nde kaydedilmi\u015ftir. Keskin ve hafif ac\u0131 bir tada, so\u011fuk bir yap\u0131ya sahiptir ve toksiktir. Akci\u011fer meridyenine aittir ve \u0131s\u0131y\u0131 temizleme, detoksifiye etme, \u015fi\u015fli\u011fi azaltma ve a\u011fr\u0131y\u0131 hafifletme etkilerine sahiptir. Taro k\u00f6k\u00fc ve g\u00f6vdesi halk t\u0131bb\u0131nda y\u00fcksek ate\u015f, grip, leptospiroz, tifo, skrofula ve t\u00fcberk\u00fcloz i\u00e7in yayg\u0131n olarak kullan\u0131l\u0131r; yaralar, yan\u0131klar, zehirli y\u0131lan \u0131s\u0131r\u0131klar\u0131 ve e\u015fek ar\u0131s\u0131 sokmalar\u0131 i\u00e7in topikal tedavi. Jianwei taro toksiktir ve a\u011f\u0131zdan al\u0131nmadan \u00f6nce en az 6 saat kaynat\u0131lmas\u0131 gerekir. Yanl\u0131\u015fl\u0131kla t\u00fcketildi\u011finde, genellikle sirke ve az miktarda zencefil suyu ile kaynat\u0131l\u0131r, a\u011f\u0131zdan al\u0131n\u0131r veya detoksifiye etmek i\u00e7in durulan\u0131r. Klinik uygulamada, intram\u00fcsk\u00fcler difenhidramin enjeksiyonu ve intraven\u00f6z glikoz salin sol\u00fcsyonu enjeksiyonu ile detoksifiye edilir. Modern ara\u015ft\u0131rmalar, taronun su ve alkol ekstrelerinin anti-enflamatuar, anti-t\u00fcm\u00f6r ve dalak koruyucu etkileri gibi \u00f6nemli farmakolojik aktivitelere sahip oldu\u011funu g\u00f6stermi\u015ftir. Bununla birlikte, taronun farmakolojik madde temeli \u00fczerine yap\u0131lan ara\u015ft\u0131rmalar, \u00f6zellikle GC-MS analizi ile s\u0131n\u0131rl\u0131 olan petrol eteri fraksiyonunun kimyasal bile\u015fimi nispeten zay\u0131ft\u0131r. Bu nedenle, bu makalede, Tara acuminata'n\u0131n petrol eteri k\u0131sm\u0131 ara\u015ft\u0131rma nesnesi olarak al\u0131nm\u0131\u015f ve Tara acuminata'n\u0131n petrol eteri k\u0131sm\u0131n\u0131 ay\u0131rmak ve safla\u015ft\u0131rmak i\u00e7in silika jel, Sephadex LH-20 ve di\u011fer kromatografik y\u00f6ntemler kullan\u0131lm\u0131\u015f ve Tara acuminata'n\u0131n petrol eteri k\u0131sm\u0131n\u0131n kimyasal bile\u015fenleri, petrol eteri k\u0131sm\u0131n\u0131n etkinli\u011finin maddi temelini ara\u015ft\u0131rmak i\u00e7in UV spektrumu, tek boyutlu n\u00fckleer manyetik rezonans spektrumu ve di\u011fer spektral tekniklerle tan\u0131mlanm\u0131\u015ft\u0131r. Ayn\u0131 zamanda, insan meme kanseri MDA-MB-231, MCF-7 h\u00fccreleri ve fare meme kanseri 4T1 h\u00fccreleri tarama modelleri olarak kullan\u0131larak, izole edilen monomer bile\u015fiklerinin meme kanserindeki sitotoksisitesi incelenmi\u015ftir. Sivri kuyruk tarosunun derinlemesine ara\u015ft\u0131r\u0131lmas\u0131 ve geli\u015ftirilmesi i\u00e7in bir temel sa\u011flamak amac\u0131yla.<\/p>\n

\u00d6nceki \u00e7al\u0131\u015fmalarda, ara\u015ft\u0131rma ekibimiz Taro acuminata'n\u0131n alkol \u00f6z\u00fct\u00fcn\u00fcn petrol eteri k\u0131sm\u0131n\u0131n iyi bir anti meme kanseri aktivitesine sahip oldu\u011funu ve mekanizmas\u0131n\u0131n MAPKs yola\u011f\u0131ndaki p-ERK\/ERK ekspresyonunu inhibe etmekle ili\u015fkili oldu\u011funu bulmu\u015ftur. Bununla birlikte, Taro acuminata'n\u0131n alkol ekstrakt\u0131n\u0131n petrol eteri k\u0131sm\u0131n\u0131n anti meme kanseri etkisi i\u00e7in maddi temeli hala belirsizdir. Bu nedenle, bu \u00e7al\u0131\u015fmada, taro rizomunun petrol eteri fraksiyonundan esterler (metil miristat, etil vanilik asit), terpenler (skualen, oleanolik asit, ursolik asit, perilla alkol\u00fc dahil olmak \u00fczere 16 bile\u015fik izole edilmi\u015ftir, perilla lakton), fenilpropanoidler (p-hidroksibenzaldehit, 7-hidroksikumarin), polifenoller (etil gallat, protokatekualdehit, protokatekuik asit), aromatik asitler (benzoik asit), ya\u011f alkolleri (oktakosanol) ve fenolik asitler (gallik asit). Bile\u015fik 2-15 taro cinsinde ilk kez izole edilmi\u015ftir ve t\u00fcm bile\u015fikler taroda ilk kez izole edilmi\u015ftir. \u0130n vitro meme kanseri h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 engelleme sonu\u00e7lar\u0131, bile\u015fik 4, 8 ve 9'un insan meme kanseri MDA-MB-231, MCF-7 h\u00fccreleri ve fare meme kanseri 4T1 h\u00fccrelerinin \u00e7o\u011falmas\u0131 \u00fczerinde belirli inhibit\u00f6r etkilere sahip oldu\u011funu g\u00f6stermi\u015ftir. Oleanolik asit, ursolik asit ve etil gallat\u0131n \u00e7e\u015fitli t\u00fcm\u00f6r h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 ve proliferasyonunu inhibe edebildi\u011fi ve t\u00fcm\u00f6r h\u00fccrelerinin apoptozunu ind\u00fckleyebildi\u011fi bulunmu\u015ftur. Anti-t\u00fcm\u00f6r etkileri PI3K\/Akt, MAPK, Wnt\/\u03b2 - catenin ve di\u011fer sinyal yolaklar\u0131n\u0131n d\u00fczenlenmesi ile ilgili olabilir, bu da meme kanseri \u00fczerine yapt\u0131\u011f\u0131m\u0131z \u00f6nceki ara\u015ft\u0131rmam\u0131zda taro'nun petrol eteri fraksiyonunun mekanizmas\u0131 ile tutarl\u0131d\u0131r. \u00d6zetle, bu \u00e7al\u0131\u015fma Tara acuminata'n\u0131n petrol eteri k\u0131sm\u0131n\u0131n kimyasal bile\u015fimini daha da zenginle\u015ftirmi\u015f ve meme kanseri h\u00fccrelerinin in vitro \u00e7o\u011falmas\u0131n\u0131 engelleyen aktif bile\u015fenlerini tarayarak Tara acuminata'n\u0131n petrol eteri k\u0131sm\u0131n\u0131n meme kanserine kar\u015f\u0131 maddi temelini incelemek i\u00e7in belirli bir deneysel temel sa\u011flam\u0131\u015ft\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

Studies on the Chemical Constituents of Petroleum Ether Fraction of Taro acuminata and Its Cytotoxic Activity in breast cancer Alocasia cuculata (Lour.) Schott, a plant belonging to the Araceae family, is used as medicine with its dried roots and stems. It was first recorded in the “New Selection of Practical Chinese Herbal Medicines in Guangxi”. […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudies on the Chemical Constituents of Petroleum Ether Fraction of Taro acuminata and Its Cytotoxic Activity in breast cancer - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/alocasia-cucullata\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Studies on the Chemical Constituents of Petroleum Ether Fraction of Taro acuminata and Its Cytotoxic Activity in breast cancer - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Studies on the Chemical Constituents of Petroleum Ether Fraction of Taro acuminata and Its Cytotoxic Activity in breast cancer Alocasia cuculata (Lour.) Schott, a plant belonging to the Araceae family, is used as medicine with its dried roots and stems. It was first recorded in the “New Selection of Practical Chinese Herbal Medicines in Guangxi”. 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Schott, a plant belonging to the Araceae family, is used as medicine with its dried roots and stems. It was first recorded in the “New Selection of Practical Chinese Herbal Medicines in Guangxi”. 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