{"id":4718,"date":"2024-08-04T15:16:25","date_gmt":"2024-08-04T15:16:25","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4718"},"modified":"2024-08-04T15:16:25","modified_gmt":"2024-08-04T15:16:25","slug":"icariin","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/icariin\/","title":{"rendered":"Depresyon modelinde mikroglia fenotip d\u00f6n\u00fc\u015f\u00fcm\u00fc \u00fczerinde icariinin d\u00fczenleyici etkisi"},"content":{"rendered":"

Depresyon modelinde mikroglia fenotip d\u00f6n\u00fc\u015f\u00fcm\u00fc \u00fczerinde icariinin d\u00fczenleyici etkisi
\nDepresyon, g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131 y\u00fcksek, tekrarlamas\u0131 kolay, hatta ciddi vakalarda ya\u015fam\u0131 tehdit eden bir t\u00fcr duygusal ruhsal bozukluktur. K\u00fcresel bir halk sa\u011fl\u0131\u011f\u0131 sorunu haline gelmi\u015ftir. Depresyon hastalar\u0131n\u0131n klinik belirtileri temel olarak depresif duygular, zevk almada azalma, de\u011fersizlik veya su\u00e7luluk duygular\u0131 ve intihar d\u00fc\u015f\u00fcncesini i\u00e7erir. Karma\u015f\u0131k biyolojik mekanizmalar ve \u00e7ok say\u0131da sistemin kat\u0131l\u0131m\u0131 nedeniyle, depresyonun patogenezi tam olarak anla\u015f\u0131lamam\u0131\u015ft\u0131r ve antidepresanlar \u00fczerine ara\u015ft\u0131rmalar k\u00fcresel bir odak noktas\u0131d\u0131r, ancak ilerleme yava\u015ft\u0131r. Depresyon tedavisi i\u00e7in yeni yakla\u015f\u0131mlar ve ila\u00e7 hedefleri bulmak acil bir konu haline gelmi\u015ftir.
\nStresin neden oldu\u011fu n\u00f6roinflamatuar yan\u0131t, depresyon patogenezinde giderek daha fazla kabul g\u00f6rmektedir. Mikroglia, merkezi sinir sisteminde bulunan, beyindeki n\u00f6roinflamatuar yan\u0131tlarla yak\u0131ndan ili\u015fkili bir t\u00fcr do\u011fu\u015ftan gelen ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccresidir ve yeni bir terap\u00f6tik hedef olma potansiyeline sahiptir. Klasik M1 polarizasyonu, interl\u00f6kin-6 (IL6), interl\u00f6kin-1 (IL-1), t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc alfa (TNF - \u03b1) vb. gibi inflamatuar fakt\u00f6rleri salg\u0131layarak n\u00f6roinflamatuar reaksiyonlara neden olur; Aktive edilmi\u015f M2 polarizasyonunu de\u011fi\u015ftirin, interl\u00f6kin-10 (interle, ukin-10, IL-10), d\u00f6n\u00fc\u015ft\u00fcr\u00fcc\u00fc b\u00fcy\u00fcme fakt\u00f6r\u00fc beta (TGF - \u03b2) vb. salg\u0131lay\u0131n, doku onar\u0131m\u0131n\u0131 ind\u00fckleyin ve n\u00f6roprotektif etkiler g\u00f6sterin. Mikroglialar\u0131n fenotip d\u00f6n\u00fc\u015f\u00fcm\u00fcn\u00fc d\u00fczenlemek, depresyonun olu\u015fumuna ve geli\u015fimine m\u00fcdahale etmenin \u00f6nemli yollar\u0131ndan biridir. Geleneksel \u00c7in t\u0131bb\u0131 depresyonun \u00f6nlenmesi ve tedavisinde her zaman \u00f6nemli avantajlara sahip olmu\u015ftur. Geleneksel \u00c7in t\u0131bb\u0131nda, b\u00f6brek yang eksikli\u011fi depresyonun \u00f6nemli mekanizmalar\u0131ndan biridir ve depresyonun b\u00f6brek teorisi perspektifinden tedavisi fikir vermektedir. Klinik uygulamada, b\u00f6brek yang\u0131n\u0131 tonifiye etmek i\u00e7in geleneksel bir \u00c7in ilac\u0131 olan Epimedium, b\u00f6brek yang eksikli\u011fi tipindeki depresyonu tedavi etmek i\u00e7in genellikle Xianmao, Morinda officinalis ve Yejiaoteng gibi di\u011fer \u00c7in ila\u00e7lar\u0131yla birle\u015ftirilir. \u00d6nceki \u00e7al\u0131\u015fmalarda, b\u00f6brek yang\u0131n\u0131 tonifiye etmek i\u00e7in geleneksel bir \u00c7in ilac\u0131 olan Epimedium brevicomu Maxim'in aktif bile\u015feni olan icariin'in iyi antidepresan etkilere sahip oldu\u011fu g\u00f6zlenmi\u015ftir, ancak mekanizmas\u0131 hala belirsizdir. Bu \u00e7al\u0131\u015fma, icariinin antidepresan etkisinin mekanizmas\u0131n\u0131 ke\u015ffetmek i\u00e7in lipopolisakkarit (LPS) ile ind\u00fcklenen BV-2 h\u00fccre polarizasyon modeli ile birlikte kronik \u00f6ng\u00f6r\u00fclemeyen hafif stres kaynakl\u0131 depresyon modelini kullanmay\u0131 ama\u00e7lamaktad\u0131r.<\/p>\n

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\nDepresyon, karma\u015f\u0131k patogenezi nedeniyle ideal tedavi y\u00f6ntemlerinden yoksun ciddi bir ruhsal hastal\u0131kt\u0131r. Geleneksel \u00c7in t\u0131bb\u0131n\u0131n depresyon tedavisinde kendine has \u00f6zellikleri ve avantajlar\u0131 vard\u0131r. G\u00fcn\u00fcm\u00fczde depresyonun patogenezi tam olarak anla\u015f\u0131lamam\u0131\u015ft\u0131r. \u015eu anda olu\u015fturulan hipotezler ba\u015fl\u0131ca \u015funlard\u0131r: enflamatuar ba\u011f\u0131\u015f\u0131kl\u0131k hipotezi, hipotalamik hipofiz adrenal (HPA) eksen disfonksiyonu hipotezi, monoamin n\u00f6rotransmitter hipotezi, n\u00f6rotrofik fakt\u00f6r hipotezi vb. Ara\u015ft\u0131rmalar\u0131n derinle\u015fmesiyle birlikte, enflamatuar ba\u011f\u0131\u015f\u0131kl\u0131k hipotezi hem yurt i\u00e7inde hem de yurt d\u0131\u015f\u0131nda yayg\u0131n bir ilgi g\u00f6rm\u00fc\u015ft\u00fcr. Ara\u015ft\u0131rmalar, depresyon hastalar\u0131n\u0131n sadece periferik inflamatuar reaksiyonlar ya\u015famad\u0131\u011f\u0131n\u0131, ayn\u0131 zamanda merkezi sinir sisteminde de imm\u00fcn aktivasyon oldu\u011funu g\u00f6stermi\u015ftir. Mikroglia, merkezi sinir sisteminde \u00f6nemli bir ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccresi t\u00fcr\u00fcd\u00fcr ve merkezi sinir sisteminin enflamatuar tepkisiyle yak\u0131ndan ili\u015fkilidir. Uzun s\u00fcreli stres alt\u0131nda, yap\u0131lar\u0131 ve i\u015flevleri anormalle\u015fir ve depresyonun ortaya \u00e7\u0131kmas\u0131nda ve geli\u015fmesinde \u00f6nemli fakt\u00f6rler olan duygularda ve zihinsel durumlarda de\u011fi\u015fikliklere yol a\u00e7ar.
\nKlasik aktivasyon tipi (M1 tipi) ve alternatif aktivasyon tipi (M2 tipi) mikroglialar\u0131n iki ana polarizasyon fenotipidir. M1 tipi aktive olmu\u015f h\u00fccrelerin b\u00fcy\u00fck \u00e7o\u011funlu\u011funu olu\u015fturur ve TNF - \u03b1, IL-1, IL-6 ve nitrik oksit sentaz iNOS gibi pro-enflamatuar arac\u0131lar\u0131 sentezleyip salg\u0131layarak bir imm\u00fcn enflamatuar kaskad reaksiyonunu tetikleyebilir; M2 tipi (\u00fc\u00e7 alt tip M2a, M2b imm\u00fcnofenotipi, M2c inaktif fenotipi) interl\u00f6kin-4 (IL-4), interl\u00f6kin-13 (IL-13) ve di\u011fer fakt\u00f6rler taraf\u0131ndan uyar\u0131labilir, IL-10 ve CD206 gibi anti-enflamatuar fakt\u00f6rleri serbest b\u0131rakabilir, anti-enflamatuar ve n\u00f6roprotektif i\u015flevler uygulayabilir ve beyin sinir onar\u0131m\u0131 ve plastisitesinde \u00f6nemli bir rol oynayabilir. Hayvan deneyleri, CUMS'a maruz kalan fare ve s\u0131\u00e7anlar\u0131n prefrontal korteksindeki mikroglialar\u0131n y\u00fcksek oranda aktive oldu\u011funu ve depresyonla ili\u015fkili inflamasyonla ili\u015fkili n\u00f6ronal dejenerasyona yol a\u00e7abilecek ilgili inflamatuar arac\u0131lar\u0131n y\u00fcksek ekspresyonunun e\u015flik etti\u011fini g\u00f6stermi\u015ftir. Bir post-mortem inceleme, \u015fiddetli depresyonu olan hastalarda, anterior singulat korteks ve ventral prefrontal lobun beyaz madde alan\u0131ndaki mikroglia yo\u011funlu\u011funun \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131n\u0131 ve aktif bir durum g\u00f6sterdi\u011fini, ancak M2 mikroglia'n\u0131n tipik belirteci olan CD206'n\u0131n \u00f6nemli \u00f6l\u00e7\u00fcde a\u015fa\u011f\u0131 reg\u00fcle oldu\u011funu g\u00f6stermi\u015ftir. Yukar\u0131daki ara\u015ft\u0131rma, mikroglialar\u0131n a\u015f\u0131r\u0131 aktivasyonunun ve M1 ve M2 mikroglialar\u0131n polarizasyonunun depresyonun ortaya \u00e7\u0131kmas\u0131nda ve geli\u015fmesinde \u00f6nemli bir rol oynad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir.<\/p>\n

Bu \u00e7al\u0131\u015fma, CUMS ile ind\u00fcklenen depresyon farelerinin hipokamp\u00fcs\u00fcnde, pro-enflamatuar sitokin IL-6 seviyelerinin y\u00fckseldi\u011fini ve IL-6 mRNA, iNOS mRNA ve iNOS proteininin a\u015f\u0131r\u0131 eksprese edildi\u011fini, depresif benzeri davran\u0131\u015flarda art\u0131\u015f (artan zorunlu y\u00fczme hareketsizli\u011fi s\u00fcresi, azalt\u0131lm\u0131\u015f \u015fekerli su t\u00fcketimi ve egzersiz mesafesi) ile birlikte depresyon farelerinin hipokamp\u00fcs\u00fcnde klasik aktive M1 mikroglia'da \u00f6nemli bir art\u0131\u015f oldu\u011funu g\u00f6stermi\u015ftir. Epimedium glikozit, mikroglialar\u0131n M1 tipi aktivasyonunu inhibe edebilir, pro-inflamatuar sitokin IL-6 seviyelerini azaltabilir, IL-6 mRNA, iNOS mRNA ve iNOS proteininin a\u015f\u0131r\u0131 ekspresyonunu azaltabilir ve model farelerde beyin inflamasyonunu bask\u0131layabilir; \u00d6te yandan, icariin mikroglialar\u0131n M2 aktivasyonunu te\u015fvik edebilir, CUMS'a maruz kalan farelerin hipokamp\u00fcs\u00fcnde IL-10 seviyelerini art\u0131rabilir, IL-10 mRNA, CD206 mRNA ve CD206 protein ekspresyonunu te\u015fvik edebilir, b\u00f6ylece model farelerde depresyon benzeri davran\u0131\u015f\u0131 engelleyebilir. \u0130n vitro deneyler ayr\u0131ca LPS uyar\u0131m\u0131 alt\u0131nda mikroglialar\u0131n M1 polarizasyonunun artt\u0131\u011f\u0131n\u0131 ve icariinin mikroglialar\u0131n M1 polarizasyonunu inhibe edip M2 polarizasyonunu te\u015fvik edebildi\u011fini g\u00f6stermi\u015ftir. Bu, icariinin mikroglialar\u0131n fenotipik d\u00f6n\u00fc\u015f\u00fcm\u00fcn\u00fc d\u00fczenleyerek a\u015f\u0131r\u0131 n\u00f6roinflamasyonu hafifletti\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir.<\/p>\n

Monoamin n\u00f6rotransmitterleri 5-HT, DA ve NE'nin metabolik bozukluklar\u0131 depresyon gibi n\u00f6rolojik ve psikiyatrik bozukluklar\u0131n olu\u015fumu ve geli\u015fimi ile yak\u0131ndan ili\u015fkilidir. CUMS ile ind\u00fcklenen depresyon modeli s\u0131\u00e7anlar\u0131n beynindeki monoamin n\u00f6rotransmitterleri 5-HT, DA ve NE seviyeleri \u00f6nemli \u00f6l\u00e7\u00fcde azalm\u0131\u015ft\u0131r. Rehmannia glutinosa, model s\u0131\u00e7anlar\u0131n hipokamp\u00fcs\u00fcndeki 5-HT, DA ve NE seviyelerini d\u00fc\u015f\u00fcrebilir ve depresif benzeri davran\u0131\u015flar\u0131 iyile\u015ftirebilir. Danshen polifenolik asidi, muhtemelen resept\u00f6r olmayan tirozin kinaz 2 (Janus kinaz 2)\/sinyal d\u00f6n\u00fc\u015ft\u00fcr\u00fcc\u00fc ve transkripsiyon aktivat\u00f6r\u00fc 3 (STAT3) sinyal yolunu inhibe ederek, n\u00f6roinflamasyonu hafifleterek ve monoamin n\u00f6rotransmitter seviyelerini d\u00fczenleyerek s\u0131\u00e7anlarda depresyon benzeri davran\u0131\u015f\u0131 etkili bir \u015fekilde iyile\u015ftirebilir. Giderek daha fazla ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccresi - mikroglia. Aktive olmu\u015f mikroglia, interl\u00f6kin-1 \u03b2 (IL-1 \u03b2), TNF - \u03b1, TGF - \u03b2, vb. gibi bir\u00e7ok enflamatuar fakt\u00f6r\u00fcn sal\u0131nmas\u0131na neden olur. Bu enflamatuar fakt\u00f6rler monoamin n\u00f6ronlar\u0131n\u0131n i\u015flevini etkileyebilir ve depresyonda \u00f6nemli bir fakt\u00f6r olarak kabul edilen oksidatif stres yoluyla monoamin n\u00f6rotransmisyonunda bir azalmaya neden olabilir. Monoamin ila\u00e7lar\u0131n\u0131n mikroglia aktivasyonunu engelleyebildi\u011fi ve depresyonu bir \u015fekilde tersine \u00e7evirebildi\u011fi do\u011frulanm\u0131\u015ft\u0131r. Ara\u015ft\u0131rmalar, depresyonun tan\u0131nm\u0131\u015f bir biyobelirteci olan tetrahidrobiopterinin (BH4) 5-HT, DA ve NE sentezi i\u00e7in gerekli anahtar bir enzimatik kofakt\u00f6r oldu\u011funu bulmu\u015ftur. BH4 eksikli\u011fi depresyona yol a\u00e7abilir. M1 tipi mikroglia BH4 katabolizmas\u0131na yol a\u00e7abilir. Mikroglialarda M1 polarizasyonunun engellenmesi BH4 katabolizmas\u0131n\u0131 s\u0131n\u0131rlayabilir ve monoamin n\u00f6rotransmitterlerinin sentezini ve salg\u0131lanmas\u0131n\u0131 te\u015fvik edebilir. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, CUMS ile ind\u00fcklenen fare depresyon modelinin hipokamp\u00fcs\u00fcnde monoamin n\u00f6rotransmitterlerindeki azalmaya depresif benzeri davran\u0131\u015flarda art\u0131\u015f\u0131n e\u015flik etti\u011fini g\u00f6stermi\u015ftir. Epimedium glikozit, model farelerin hipokamp\u00fcs\u00fcndeki monoamin n\u00f6rotransmitterlerinin seviyesini art\u0131rabilir, bu da \u00f6nceki raporlarla tutarl\u0131 olarak antidepresan etkisinin mekanizmalar\u0131ndan biri olabilir. Bununla birlikte, icariinin mikroglia fenotip d\u00f6n\u00fc\u015f\u00fcm\u00fcn\u00fc d\u00fczenleyerek depresyon modeli farelerin hipokamp\u00fcs\u00fcnde monoamin n\u00f6rotransmitterlerinin sentezini ve salg\u0131lanmas\u0131n\u0131 destekleyip desteklemedi\u011fi daha fazla ara\u015ft\u0131r\u0131lmaya devam etmektedir.<\/p>\n

\u00d6zetle, bu \u00e7al\u0131\u015fmada bir fare depresyon modeli ve LPS ile ind\u00fcklenmi\u015f bir mikroglia polarizasyon modeli olu\u015fturmak i\u00e7in CUMS kullan\u0131lm\u0131\u015ft\u0131r. Geleneksel \u00c7in t\u0131bb\u0131 Epimedium'da b\u00f6brek yang\u0131n\u0131 tonland\u0131rmak i\u00e7in kullan\u0131lan aktif bir bile\u015fen olan icariin'in M1 polarizasyonunu inhibe etti\u011fi ve mikroglialar\u0131n M2 polarizasyonunu destekledi\u011fi, depresif farelerin hipokamp\u00fcs\u00fcnde inflamasyonu azaltt\u0131\u011f\u0131 ve antidepresan etki mekanizmalar\u0131ndan biri olan monoamin n\u00f6rotransmitterlerinin \u00fcretimini destekledi\u011fi bulunmu\u015ftur.<\/p>","protected":false},"excerpt":{"rendered":"

Depresyon modelinde mikroglia fenotip d\u00f6n\u00fc\u015f\u00fcm\u00fc \u00fczerinde icariinin d\u00fczenleyici etkisi Depresyon, g\u00f6r\u00fclme s\u0131kl\u0131\u011f\u0131 y\u00fcksek, tekrarlamas\u0131 kolay ve hatta ciddi vakalarda hayat\u0131 tehdit eden bir t\u00fcr duygusal ruhsal bozukluktur. K\u00fcresel bir halk sa\u011fl\u0131\u011f\u0131 sorunu haline gelmi\u015ftir. Depresyon hastalar\u0131n\u0131n klinik belirtileri temel olarak depresif [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"video","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nRegulatory effect of icariin on phenotype transformation of microglia in depression model - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/icariin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Regulatory effect of icariin on phenotype transformation of microglia in depression model - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Regulatory effect of icariin on phenotype transformation of microglia in depression model Depression is a kind of emotional mental disorder, with a high incidence of incidence rate, which is easy to recur, and even life-threatening in serious cases. 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