{"id":4704,"date":"2024-08-04T15:14:34","date_gmt":"2024-08-04T15:14:34","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4704"},"modified":"2024-08-04T15:14:34","modified_gmt":"2024-08-04T15:14:34","slug":"rose-root","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/gul-koku\/","title":{"rendered":"Rosa rugosa k\u00f6k\u00fcnden elde edilen polisakkaritlerin farelerde siklofosfamid ile ind\u00fcklenen imm\u00fcnosupresyon \u00fczerindeki imm\u00fcn d\u00fczenleyici etkileri"},"content":{"rendered":"

Rosa davurica Pall. polisakkaritlerinin farelerde siklofosfamid ile ind\u00fcklenen imm\u00fcnosupresyon \u00fczerindeki imm\u00fcnomod\u00fclat\u00f6r etkisi. Rosa davurica Pall., Rosa davurica k\u00f6k\u00fc, yabani g\u00fcl k\u00f6k\u00fc ve ahududu meyve k\u00f6k\u00fc olarak da bilinen Rosa davurica Pall. kurutulmu\u015f k\u00f6k\u00fcd\u00fcr. Shan Ci Mei Kuzeydo\u011fu \u00c7in'de yayg\u0131n olarak yeti\u015ftirilir ve \u00e7i\u00e7ekleri, meyveleri ve k\u00f6kleri ila\u00e7 olarak kullan\u0131l\u0131r. Rosa rugosa \u015fifal\u0131 bitkisinin standard\u0131 Jilin Eyaleti ila\u00e7 standartlar\u0131nda yer almaktad\u0131r. Ac\u0131 ve buruk bir tada, hafif bir yap\u0131ya ve hemostatik ve antibakteriyel etkilere sahiptir. Adet kanamas\u0131, fonksiyonel uterus kanamas\u0131, kronik bron\u015fit, enterit, bakteriyel dizanteri, sistit ve nefrit tedavisinde kullan\u0131l\u0131r. Mo\u011fol t\u0131bb\u0131nda, dikenli armut k\u00f6k\u00fc i\u00e7in Mo\u011fol ilac\u0131n\u0131n ad\u0131 \"Zherelige - Zamuer Yin Wen Du Su\" dur. Etkisi Xie Ri'yi gidermek, He Yi'yi kontrol etmek ve yiyecekleri sindirmektir. He Yi Xie Ri sendromu, Badagan Xie Ri sendromu, mide Xie Ri sendromu, nab\u0131z hastal\u0131\u011f\u0131, \u00f6ks\u00fcr\u00fck ve karaci\u011fer toksisitesini temizlemek i\u00e7in kullan\u0131l\u0131r. Ara\u015ft\u0131rma raporlar\u0131na g\u00f6re, Rosa rugosa k\u00f6k\u00fc laktonlar, tanenler, polisakkaritler, toplam glikozitler, flavonoidler, fenoller, alkaloidler, proteinler, antrakinonlar ve antioksidan, hipoglisemik, antibakteriyel ve vazodilat\u00f6r gibi farmakolojik etkileri olan di\u011fer bile\u015fenleri i\u00e7erir. Han ve arkada\u015flar\u0131 Rosa rugosa k\u00f6k\u00fcnden elde edilen polisakkaritlerin ya\u015flanma modeli farelerin ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonu \u00fczerinde iyile\u015ftirici bir etkiye sahip oldu\u011funu bildirmi\u015ftir, ancak Rosa rugosa k\u00f6k\u00fcnden elde edilen polisakkaritler hakk\u0131nda \u00e7ok az ara\u015ft\u0131rma vard\u0131r.
\nSon y\u0131llarda, polisakkaritler \u00e7oklu biyolojik aktivitelere sahip do\u011fal \u00fcr\u00fcnler olarak artan bir ilgi g\u00f6rmektedir. \u00c7ok say\u0131da \u00e7al\u0131\u015fma, polisakkaritlerin ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenleme, anti-t\u00fcm\u00f6r, antiviral, antioksidan ve kan glikozunu d\u00fc\u015f\u00fcrme gibi \u00e7e\u015fitli aktivitelere sahip oldu\u011funu g\u00f6stermi\u015ftir. Do\u011fal ba\u011f\u0131\u015f\u0131kl\u0131k mod\u00fclat\u00f6rleri olarak \u00c7in bitkisel polisakkaritleri, net bir etkinli\u011fe ve az say\u0131da yan etkiye sahiptir ve ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccreleri, ba\u011f\u0131\u015f\u0131kl\u0131k organlar\u0131 ve ba\u011f\u0131rsak mikrobiyotas\u0131 \u00fczerinde d\u00fczenleyici etkilere sahiptir. \u00c7in'in Kuzeydo\u011fu b\u00f6lgesi bol miktarda yabani da\u011f dikeni kayna\u011f\u0131na sahiptir ve t\u0131p ve fonksiyonel g\u0131da alan\u0131ndaki ara\u015ft\u0131rma ve geli\u015ftirme \u00e7al\u0131\u015fmalar\u0131 yerel ekonomik kalk\u0131nmay\u0131 destekleyecektir. G\u00fcl k\u00f6k\u00fc t\u0131pta yayg\u0131n olarak kullan\u0131lmaktad\u0131r, ancak ilgili sa\u011fl\u0131k \u00fcr\u00fcnleri veya g\u0131dalardaki uygulamas\u0131 nispeten s\u0131n\u0131rl\u0131d\u0131r. Bu makale Rosa rugosa k\u00f6klerinden polisakkaritlerin yap\u0131s\u0131n\u0131 \u00e7\u0131karmakta, safla\u015ft\u0131rmakta ve analiz etmektedir. Ayn\u0131 zamanda, siklofosfamidin (CTX) ba\u011f\u0131\u015f\u0131kl\u0131k sistemi bask\u0131lanm\u0131\u015f farelerde ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonu \u00fczerindeki d\u00fczenleyici etkisini de\u011ferlendirmekte ve etki mekanizmas\u0131n\u0131 ara\u015ft\u0131rarak gelecekte Rosa rugosa k\u00f6kleri polisakkaritlerinin geli\u015ftirilmesi i\u00e7in deneysel veriler sa\u011flamaktad\u0131r.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nBitki polisakkaritleri \u00e7e\u015fitli biyolojik aktivitelere sahiptir ve do\u011fal \u00fcr\u00fcn ara\u015ft\u0131rmac\u0131lar\u0131n\u0131n ilgisini giderek daha fazla \u00e7ekmektedir. Biyoaktif bitki polisakkaritleri ila\u00e7, g\u0131da, sa\u011fl\u0131k \u00fcr\u00fcnleri ve ye\u015fil \u00fcr\u00fcnler gibi alanlarda \u00f6nemli bir rol oynamaktad\u0131r. Bilim ve teknolojinin s\u00fcrekli ilerlemesiyle birlikte, bitki polisakkaritlerinin ekstraksiyonu, safla\u015ft\u0131r\u0131lmas\u0131 ve yap\u0131sal tan\u0131mlama teknikleri, s\u0131cak su ekstraksiyonu, alkali ekstraksiyonu, etanol fermantasyon \u00e7\u00f6keltmesi, enzim destekli ekstraksiyon, mikrodalga destekli ekstraksiyon, ultrasonik ekstraksiyon, ultrasonik destekli enzim ekstraksiyonu, kritik alt\u0131 su ekstraksiyonu, ultra y\u00fcksek bas\u0131n\u00e7 ekstraksiyonu ve vakum ekstraksiyonu gibi giderek daha \u00e7e\u015fitli hale gelmektedir. Bu y\u00f6ntemlerin hepsinin avantajlar\u0131 ve dezavantajlar\u0131 vard\u0131r, bunlar\u0131n aras\u0131nda s\u0131cak su ekstraksiyon y\u00f6ntemi, ekstraksiyon oran\u0131 \u00e7ok y\u00fcksek olmasa da, ekonomiklik, toksik olmama, g\u00fcvenlik ve h\u00fccre duvarlar\u0131na zarar vermeme avantajlar\u0131na sahiptir ve polisakkarit ekstraksiyonunda yayg\u0131n olarak kullan\u0131lmaktad\u0131r. Bu \u00e7al\u0131\u015fmada, Rosa rugosa k\u00f6klerinden polisakkaritleri \u00e7\u0131karmak i\u00e7in s\u0131cak su ekstraksiyonu\/etanol \u00e7\u00f6keltme y\u00f6ntemi kullan\u0131lm\u0131\u015f ve deproteinizasyon i\u00e7in iki y\u00f6ntem kullan\u0131lm\u0131\u015ft\u0131r. Sonu\u00e7lar, TCA y\u00f6nteminin deproteinizasyon \u00fczerinde \u00f6nemli bir etkiye sahip oldu\u011funu, ancak daha fazla \u015feker kayb\u0131 oldu\u011funu g\u00f6stermi\u015ftir. Bu nedenle, Sevage y\u00f6ntemi, TCA y\u00f6ntemine k\u0131yasla Rosa rugosa k\u00f6klerinden polisakkaritlerin deproteinizasyonu i\u00e7in daha uygundur. Etanol \u00e7\u00f6keltmesinden sonra, 60% alkol \u00e7\u00f6keltmesi ile 94.1% \u015feker i\u00e7eri\u011fine sahip nispeten d\u00fc\u015f\u00fck polidispersiteye sahip bir polisakkarit RDRP elde edilmi\u015ftir. Bitki polisakkaritlerinin yap\u0131s\u0131 biyolojik aktivitelerini do\u011frudan etkiler ve polisakkaritlerin temel yap\u0131s\u0131 molek\u00fcler a\u011f\u0131rl\u0131k da\u011f\u0131l\u0131m\u0131, k\u0131z\u0131l\u00f6tesi karakteristik absorpsiyon pikleri, monosakkarit bile\u015fimi vb. ile tan\u0131mlanabilir. Bu \u00e7al\u0131\u015fmada, Rosa rugosa k\u00f6klerinden elde edilen polisakkaritlerin molek\u00fcler a\u011f\u0131rl\u0131\u011f\u0131n\u0131 belirlemek i\u00e7in GPC y\u00f6ntemi kullan\u0131lm\u0131\u015f ve RDRP'nin ortalama molek\u00fcler a\u011f\u0131rl\u0131\u011f\u0131 13,1 kDa ve d\u00fc\u015f\u00fck molek\u00fcler a\u011f\u0131rl\u0131\u011fa (66,7 kDa) sahip polisakkaritlerin bir kar\u0131\u015f\u0131m\u0131 oldu\u011fu bulunmu\u015ftur. K\u0131z\u0131l\u00f6tesi tespit sonu\u00e7lar\u0131 Rosa rugosa k\u00f6k\u00fcnden elde edilen polisakkaritin alfa konfig\u00fcrasyonu i\u00e7eren n\u00f6tr bir piran polisakkarit oldu\u011funu g\u00f6stermektedir. Monosakkarit bile\u015fiminin analizi, esas olarak glikoz, arabinoz, galaktoz, mannoz ve ksilozdan olu\u015ftu\u011funu g\u00f6stermektedir. Ancak monosakkarit dall\u0131 zincir ba\u011flant\u0131 y\u00f6nteminin daha derinlemesine ara\u015ft\u0131r\u0131lmas\u0131 gerekmektedir.
\nBa\u011f\u0131\u015f\u0131kl\u0131k sistemi, v\u00fccudu patojenlerden korumak i\u00e7in birlikte \u00e7al\u0131\u015fan ba\u011f\u0131\u015f\u0131kl\u0131k organlar\u0131n\u0131, ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerini ve ba\u011f\u0131\u015f\u0131kl\u0131k molek\u00fcllerini i\u00e7erir. Timus ve dalak, ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerinin \u00fcretilmesinde ve korunmas\u0131nda \u00f6nemli rol oynayan ana ba\u011f\u0131\u015f\u0131kl\u0131k organlar\u0131d\u0131r. H\u00fcmoral ve h\u00fccresel ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131n merkezi olan dalak, T ve B lenfositlerinin yerle\u015fti\u011fi ana b\u00f6lgedir, bu nedenle dalak indeksi v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k seviyesini yans\u0131tabilir. Siklofosfamid, kanser tedavisinde yayg\u0131n olarak kullan\u0131lan bir t\u00fcr alkilleyici ajand\u0131r. Ancak sadece kanser h\u00fccreleri i\u00e7in de\u011fil, ayn\u0131 zamanda ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccreleri ve epitel h\u00fccreleri gibi h\u0131zla b\u00f6l\u00fcnen h\u00fccreler i\u00e7in de \u00e7e\u015fitli toksisitelere sahiptir ve genellikle imm\u00fcnosupresif modeller olu\u015fturmak i\u00e7in kullan\u0131l\u0131r. Bu \u00e7al\u0131\u015fmada, farelere intraperitoneal siklofosfamid enjeksiyonundan sonra, v\u00fccut k\u00fctlesi, dalak indeksi, timus indeksi ve imm\u00fcnoglobulin konsantrasyon seviyeleri bo\u015f kontrol grubununkinden \u00f6nemli \u00f6l\u00e7\u00fcde d\u00fc\u015f\u00fckt\u00fc (P<0.01), bu da imm\u00fcnosupresif model farelerin ba\u015far\u0131l\u0131 bir \u015fekilde haz\u0131rland\u0131\u011f\u0131n\u0131 g\u00f6stermektedir. Rosa rugosa k\u00f6k\u00fc polisakkaritlerinden elde edilen RDRP ile 2 hafta boyunca s\u00fcrekli m\u00fcdahaleden sonra, model kontrol grubuyla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, RDRP grubundaki farelerin periferik kan l\u00f6kosit, lenfosit, trombosit say\u0131s\u0131, dalak indeksi ve timus indeksi \u00f6nemli \u00f6l\u00e7\u00fcde artm\u0131\u015ft\u0131r (P<0.05 veya P<0.01), bu da imm\u00fcn sistemi bask\u0131lanm\u0131\u015f farelerde imm\u00fcn organlar\u0131n geli\u015fimini destekleyebilece\u011fini g\u00f6stermektedir. Timus ve dala\u011f\u0131n patolojik de\u011fi\u015fiklikleri biyolojik optik mikroskop alt\u0131nda g\u00f6zlemlenmi\u015f ve sonu\u00e7lar Rosa rugosa polisakkaritlerinin RDRP grubunun farelerde dalak ve timusun patolojik de\u011fi\u015fikliklerini iyile\u015ftirdi\u011fini g\u00f6stererek ba\u011f\u0131\u015f\u0131kl\u0131k organlar\u0131n\u0131n ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonunu art\u0131rabilece\u011fini g\u00f6stermi\u015ftir. ELISA tespiti, Rosa rugosa k\u00f6k\u00fc polisakkaritlerinin RDRP gruplar\u0131nda ve shiitake mantar\u0131 polisakkaritleri grubunda imm\u00fcnoglobulin IgA, IgG ve IgM seviyelerinin \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131n\u0131 (P<0.01) ve Rosa rugosa k\u00f6k\u00fc polisakkaritlerinin v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonunu geli\u015ftirmeye yard\u0131mc\u0131 oldu\u011funu g\u00f6stermi\u015ftir. Buna ek olarak, bitki polisakkaritleri T lenfositleri, B lenfositleri, makrofajlar\u0131 vb. aktive edebilir, ilgili sitokinleri te\u015fvik edebilir ve v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonunu iyile\u015ftirebilir. Bu \u00e7al\u0131\u015fmada, hem Rosa rugosa k\u00f6k\u00fc polisakkaritlerinin RDRP dozaj gruplar\u0131 hem de shiitake mantar\u0131 polisakkaritleri grubu, ba\u011f\u0131\u015f\u0131kl\u0131k sistemi bask\u0131lanm\u0131\u015f farelerin serumundaki IL-2, IFN - \u03b3, TNF - \u03b1 ve IL-6 seviyelerini \u00f6nemli \u00f6l\u00e7\u00fcde y\u00fckseltmi\u015ftir (P<0.01), Rosa rugosa k\u00f6k\u00fc polisakkaritlerinin ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonunu d\u00fczenleyebilece\u011fini ve ba\u011f\u0131\u015f\u0131kl\u0131k sistemi bask\u0131lanm\u0131\u015f farelerin serumundaki sitokin seviyelerini y\u00fckselterek siklofosfamid kaynakl\u0131 imm\u00fcnosupresyonu hafifletebilece\u011fini g\u00f6stermektedir.
\nG\u00fcn\u00fcm\u00fczde, polisakkaritlerin imm\u00fcnomod\u00fclat\u00f6r mekanizmas\u0131 \u00fczerine yap\u0131lan \u00e7al\u0131\u015fmalar da dikkat \u00e7ekmektedir. Bunlar aras\u0131nda, TLR'nin a\u015fa\u011f\u0131 ak\u0131\u015f yolu olan NF - \u03ba B en \u00e7ok rapor edilen yol olmu\u015ftur. Bu \u00e7al\u0131\u015fmada, her grupta TLR4, MyD88, TRAF-6 ve NF - \u03ba B p65 proteinlerinin ifade d\u00fczeylerini \u00f6l\u00e7mek i\u00e7in Western blot kullan\u0131lm\u0131\u015ft\u0131r. Sonu\u00e7lar, model grupla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, Rosa rugosa k\u00f6k\u00fcnden elde edilen RDRP'nin y\u00fcksek doz grubundaki TLR4, MyD88 ve TRAF-6 proteinlerinin \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131n\u0131 (P<0.01) ve Rosa rugosa k\u00f6k\u00fcnden elde edilen RDRP'nin her doz grubundaki NF - \u03ba B p65 proteininin y\u00fckselme e\u011filimi g\u00f6sterdi\u011fini ortaya koymu\u015ftur. Bu sonu\u00e7, Rosa rugosa k\u00f6k\u00fcnden elde edilen polisakkaritlerin TLR4 resept\u00f6rlerini aktive edebilece\u011fini ve bunun da TRAF-6 (TNF resept\u00f6r ili\u015fkili fakt\u00f6r 6) ve I \u03ba B kinaz kompleksini devre d\u0131\u015f\u0131 b\u0131rakmak \u00fczere IRAK (IL resept\u00f6r ili\u015fkili kinaz) ile ba\u011flanmak \u00fczere MyD88'i (miyeloid farkl\u0131la\u015fma fakt\u00f6r\u00fc 88) aktive edebilece\u011fini g\u00f6stermektedir, protein kinaz I \u03ba B fosforilasyonunun NF - \u03ba B inhibisyonunu ind\u00fckler, TNF - \u03b1 ve IL-6 gibi sitokinlerin salg\u0131lanmas\u0131n\u0131 art\u0131r\u0131r ve b\u00f6ylece imm\u00fcnomod\u00fclat\u00f6r etkiler g\u00f6sterir.
\n\u00d6zetle, Rosa rugosa'dan elde edilen ve a\u011f\u0131rl\u0131kl\u0131 olarak ortalama molek\u00fcler a\u011f\u0131rl\u0131\u011f\u0131 13,1 kDa olan polisakkaritlerden olu\u015fan polisakkaritler, ba\u011f\u0131\u015f\u0131kl\u0131k organlar\u0131n\u0131n indeksini ve periferik kan beyaz kan h\u00fccrelerinin, lenfositlerin ve trombositlerin say\u0131s\u0131n\u0131 art\u0131rabilir, ba\u011f\u0131\u015f\u0131kl\u0131k organlar\u0131n\u0131n patolojik de\u011fi\u015fikliklerini iyile\u015ftirebilir, ba\u011f\u0131\u015f\u0131kl\u0131k ile ilgili proteinlerin ve sitokinlerin ekspresyon seviyelerini yukar\u0131 do\u011fru d\u00fczenleyebilir, CTX'in neden oldu\u011fu ba\u011f\u0131\u015f\u0131kl\u0131k eksikli\u011fini hafifletebilir ve belirli ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenleyici aktivite g\u00f6sterebilir. Etki mekanizmas\u0131 TLR\/NF - \u03ba B kanallar\u0131 ile ili\u015fkilidir. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131 Rosa rugosa k\u00f6klerinden elde edilen polisakkaritlerin geli\u015ftirilmesi ve uygulanmas\u0131 i\u00e7in de\u011ferli deneysel kan\u0131tlar sa\u011flamaktad\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

The immunomodulatory effect of polysaccharides from Rosa davurica Pall. on cyclophosphamide induced immunosuppression in mice. Rosa davurica Pall. is the dried root of Rosa davurica Pall., also known as Rosa davurica root, wild rose root, and raspberry fruit root. Shan Ci Mei is widely grown in Northeast China, and its flowers, fruits, and roots are […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nImmune regulatory effects of polysaccharides from Rosa rugosa root on cyclophosphamide induced immunosuppression in mice - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/gul-koku\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Immune regulatory effects of polysaccharides from Rosa rugosa root on cyclophosphamide induced immunosuppression in mice - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"The immunomodulatory effect of polysaccharides from Rosa davurica Pall. on cyclophosphamide induced immunosuppression in mice. Rosa davurica Pall. is the dried root of Rosa davurica Pall., also known as Rosa davurica root, wild rose root, and raspberry fruit root. Shan Ci Mei is widely grown in Northeast China, and its flowers, fruits, and roots are […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/tr\/gul-koku\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-04T15:14:34+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-84.png\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"7 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/rose-root\/\",\"url\":\"https:\/\/longchangextracts.com\/rose-root\/\",\"name\":\"Immune regulatory effects of polysaccharides from Rosa rugosa root on cyclophosphamide induced immunosuppression in mice - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangextracts.com\/rose-root\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangextracts.com\/rose-root\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-84.png\",\"datePublished\":\"2024-08-04T15:14:34+00:00\",\"dateModified\":\"2024-08-04T15:14:34+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/rose-root\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/rose-root\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/rose-root\/#primaryimage\",\"url\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-84.png\",\"contentUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-84.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/rose-root\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Immune regulatory effects of polysaccharides from Rosa rugosa root on cyclophosphamide induced immunosuppression in mice\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Rosa rugosa k\u00f6k\u00fcnden elde edilen polisakkaritlerin farelerde siklofosfamid kaynakl\u0131 imm\u00fcnosupresyon \u00fczerindeki imm\u00fcn d\u00fczenleyici etkileri - \u00c7in Kimya \u00dcreticisi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/tr\/gul-koku\/","og_locale":"tr_TR","og_type":"article","og_title":"Immune regulatory effects of polysaccharides from Rosa rugosa root on cyclophosphamide induced immunosuppression in mice - China Chemical Manufacturer","og_description":"The immunomodulatory effect of polysaccharides from Rosa davurica Pall. on cyclophosphamide induced immunosuppression in mice. Rosa davurica Pall. is the dried root of Rosa davurica Pall., also known as Rosa davurica root, wild rose root, and raspberry fruit root. Shan Ci Mei is widely grown in Northeast China, and its flowers, fruits, and roots are […]","og_url":"https:\/\/longchangextracts.com\/tr\/gul-koku\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-04T15:14:34+00:00","og_image":[{"url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-84.png"}],"author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"longcha9","Tahmini okuma s\u00fcresi":"7 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/rose-root\/","url":"https:\/\/longchangextracts.com\/rose-root\/","name":"Rosa rugosa k\u00f6k\u00fcnden elde edilen polisakkaritlerin farelerde siklofosfamid kaynakl\u0131 imm\u00fcnosupresyon \u00fczerindeki imm\u00fcn d\u00fczenleyici etkileri - \u00c7in Kimya \u00dcreticisi","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangextracts.com\/rose-root\/#primaryimage"},"image":{"@id":"https:\/\/longchangextracts.com\/rose-root\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-84.png","datePublished":"2024-08-04T15:14:34+00:00","dateModified":"2024-08-04T15:14:34+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/rose-root\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/rose-root\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/rose-root\/#primaryimage","url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-84.png","contentUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-84.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/rose-root\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Immune regulatory effects of polysaccharides from Rosa rugosa root on cyclophosphamide induced immunosuppression in mice"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"\u00c7in Kimyasal \u00dcreticisi","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"tr"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/4704"}],"collection":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/comments?post=4704"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/4704\/revisions"}],"predecessor-version":[{"id":4717,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/4704\/revisions\/4717"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/media?parent=4704"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/categories?post=4704"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/tags?post=4704"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}