{"id":4663,"date":"2024-08-04T15:08:10","date_gmt":"2024-08-04T15:08:10","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4663"},"modified":"2024-08-04T15:08:10","modified_gmt":"2024-08-04T15:08:10","slug":"ombu","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/ombu\/","title":{"rendered":"Tibet ilac\u0131 Weng Bu'nun \u00fclseratif kolit \u00fczerindeki etki mekanizmas\u0131 \u00fczerine \u00e7al\u0131\u015fma"},"content":{"rendered":"<p>Tibet ilac\u0131 Weng Bu'nun \u00fclseratif kolit \u00fczerindeki etki mekanizmas\u0131 \u00fczerine \u00e7al\u0131\u015fma<br \/>\nWengbu, Myricaria, Tamaricaceae'nin \u00e7e\u015fitli bitkilerinin yumu\u015fak yapraklar\u0131ndan elde edilen ve Xizang, Qinghai, Yunnan ve di\u011fer yerlerde yayg\u0131n olarak da\u011f\u0131t\u0131lan geleneksel bir Tibet ilac\u0131d\u0131r. Modern ara\u015ft\u0131rmalar, Wenbu'nun ana kimyasal bile\u015fenlerinin flavonoidler ve polifenolik bile\u015fikler oldu\u011funu g\u00f6stermi\u015ftir. T\u0131bbi k\u0131s\u0131mlar\u0131, d\u00fcz bir yap\u0131ya ve hafif ac\u0131 bir tada sahip, ye\u015fil renkli, yumu\u015fak dallard\u0131r. Sar\u0131 su hastal\u0131\u011f\u0131, i\u00e7 bo\u015fluk toksik \u0131s\u0131s\u0131 ve da\u011f\u0131n\u0131k d\u00f6k\u00fcnt\u00fcleri tedavi etmek i\u00e7in kullan\u0131l\u0131r. Ayr\u0131ca veba, kan \u0131s\u0131s\u0131, toksik \u0131s\u0131 sendromu, k\u0131zam\u0131k opasitesi ve bo\u011faz a\u011fr\u0131s\u0131 gibi hastal\u0131klar i\u00e7in de kullan\u0131l\u0131r. \"Kronik ishal \"in temel patogenezi dalak eksikli\u011fi, nemli \u0131s\u0131 ve qi ile kan aras\u0131ndaki uyumsuzlu\u011fun birikmesi iken, \"kan \u0131s\u0131s\u0131\" \u00fclseratif kolitin aktif a\u015famas\u0131nda \u00f6nemli bir patojenik fakt\u00f6rd\u00fcr. Modern farmakolojik ara\u015ft\u0131rmalar Onbu'nun ayr\u0131ca antibakteriyel, anti-enflamatuar, analjezik, anti romatizmal, anti yorgunluk ve antioksidan etkilere sahip oldu\u011funu g\u00f6stermi\u015ftir.<br \/>\n\u00dclseratif kolit (\u00dcK), etiyolojisi belirsiz, kolonun kronik inflamatuar bir hastal\u0131\u011f\u0131d\u0131r. Lezyonlar kal\u0131n ba\u011f\u0131rsa\u011f\u0131n mukoza ve submukozas\u0131 ile s\u0131n\u0131rl\u0131d\u0131r ve ana semptomlar kar\u0131n a\u011fr\u0131s\u0131, ishal, mukuslu p\u00fcr\u00fclan kanl\u0131 d\u0131\u015fk\u0131 vb.dir. Durum n\u00fcksetmeye e\u011filimlidir ve tedavisi zordur. \u0130mm\u00fcnosupresanlar, kortikosteroidler ve sodyum aminosalisilat preparatlar\u0131 \u015fu anda UC tedavisinin ana ara\u00e7lar\u0131d\u0131r ve \u00f6nemli k\u0131sa vadeli tedavi etkileri vard\u0131r, ancak b\u00fcy\u00fck yan etkiler ve s\u00fcrd\u00fcr\u00fclememe gibi sorunlar vard\u0131r. Onbu'nun \u00dcK \u00fczerinde terap\u00f6tik bir etkisi olup olmad\u0131\u011f\u0131 hen\u00fcz net de\u011fildir. Bu \u00e7al\u0131\u015fma, UHPLC-Q-Exactive-Orbitrap-MS teknolojisi, a\u011f farmakolojisi, molek\u00fcler yerle\u015ftirme ve hayvan deneyleri yoluyla UC tedavisinde Tibet ilac\u0131 Ongbu'nun etkisini ve mekanizmas\u0131n\u0131 ara\u015ft\u0131rmay\u0131 ve Ongbu'nun rasyonel geli\u015fimi ve kullan\u0131m\u0131 i\u00e7in referans sa\u011flamay\u0131 ama\u00e7lamaktad\u0131r.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4666\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-80.png\" alt=\"\" width=\"455\" height=\"199\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4667\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-70.png\" alt=\"\" width=\"816\" height=\"791\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-70.png 816w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-70-768x744.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-70-743x720.png 743w\" sizes=\"(max-width: 816px) 100vw, 816px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4668\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-66.png\" alt=\"\" width=\"809\" height=\"630\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-66.png 809w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-66-768x598.png 768w\" sizes=\"(max-width: 809px) 100vw, 809px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4669\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-55.png\" alt=\"\" width=\"809\" height=\"256\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-55.png 809w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-55-768x243.png 768w\" sizes=\"(max-width: 809px) 100vw, 809px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4670\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-54.png\" alt=\"\" width=\"807\" height=\"312\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-54.png 807w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-54-768x297.png 768w\" sizes=\"(max-width: 807px) 100vw, 807px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4671\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-50.png\" alt=\"\" width=\"807\" height=\"330\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-50.png 807w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-50-768x314.png 768w\" sizes=\"(max-width: 807px) 100vw, 807px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4672\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-47.png\" alt=\"\" width=\"807\" height=\"389\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-47.png 807w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-47-768x370.png 768w\" sizes=\"(max-width: 807px) 100vw, 807px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4673\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-42.png\" alt=\"\" width=\"807\" height=\"420\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-42.png 807w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-42-768x400.png 768w\" sizes=\"(max-width: 807px) 100vw, 807px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4674\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-36.png\" alt=\"\" width=\"809\" height=\"495\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-36.png 809w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-36-768x470.png 768w\" sizes=\"(max-width: 809px) 100vw, 809px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4675\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-32.png\" alt=\"\" width=\"806\" height=\"264\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-32.png 806w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-32-768x252.png 768w\" sizes=\"(max-width: 806px) 100vw, 806px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4676\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-1.jpg\" alt=\"\" width=\"810\" height=\"372\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-1.jpg 810w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-1-768x353.jpg 768w\" sizes=\"(max-width: 810px) 100vw, 810px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4677\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-25.png\" alt=\"\" width=\"809\" height=\"294\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-25.png 809w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-25-768x279.png 768w\" sizes=\"(max-width: 809px) 100vw, 809px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4678\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-21.png\" alt=\"\" width=\"809\" height=\"315\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-21.png 809w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-21-768x299.png 768w\" sizes=\"(max-width: 809px) 100vw, 809px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4679\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-18.png\" alt=\"\" width=\"806\" height=\"214\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-18.png 806w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-18-768x204.png 768w\" sizes=\"(max-width: 806px) 100vw, 806px\" \/>Bu \u00e7al\u0131\u015fmada, Wenbu'nun 171 bile\u015fenini analiz etmek i\u00e7in UHPLC-Q-Exactive-Orbitrap-MS teknolojisi kullan\u0131lm\u0131\u015f ve TCMSP platformu arac\u0131l\u0131\u011f\u0131yla Wenbu'nun 23 aktif bile\u015feni taranm\u0131\u015ft\u0131r. \"Weng Bu Active Ingredient UC\" a\u011f diyagram\u0131na g\u00f6re, en \u00e7ok e\u015fle\u015fen hedeflere sahip ilk 5 bile\u015fen piretroid, demetile piretroid, rhein, isorhamnetin ve tannik asittir. He ve arkada\u015flar\u0131n\u0131n ara\u015ft\u0131rmas\u0131, tanik asidin antioksidan ve anti-inflamatuar \u00f6zellikler gibi farmakolojik etkilere sahip oldu\u011funu g\u00f6stermektedir. Zheng ve arkada\u015flar\u0131, tanik asidin MAPK\/I \u03ba B - \u03b1\/NF - \u03ba B\/COX gibi yollar\u0131 inhibe ederek TNF - \u03b1, IL-1 \u03b2 ve NO sal\u0131n\u0131m\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde azaltt\u0131\u011f\u0131n\u0131 ve b\u00f6ylece UC'yi iyile\u015ftirdi\u011fini bulmu\u015flard\u0131r. Rhein anti-t\u00fcm\u00f6r, antibakteriyel ve anti-enflamatuar aktivitelere sahiptir ve \u00e7al\u0131\u015fmalar JAK2 gibi hedef proteinleri inhibe ederek enflamatuar sinyallerin iletimini engelleyebildi\u011fini, enflamatuar fakt\u00f6rlerin sal\u0131n\u0131m\u0131n\u0131 azaltabildi\u011fini ve UC'de anormal ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonunun neden oldu\u011fu enflamatuar yan\u0131t\u0131 hafifletebildi\u011fini g\u00f6stermi\u015ftir. \u0130zorhamnetin (ISO), \u00e7e\u015fitli bitkilerde yayg\u0131n olarak bulunan, anti-enflamatuar ve antiviral etkiler gibi \u00e7oklu biyolojik i\u015flevlere sahip do\u011fal bir k\u00fc\u00e7\u00fck molek\u00fcll\u00fc flavonoid bile\u015fi\u011fidir. ISO, MPO aktivitesini inhibe ederek, pro-enflamatuar mediat\u00f6rlerin (TNF - \u03b1, IL-2, IL-6) sal\u0131n\u0131m\u0131n\u0131 inhibe ederek ve NF - \u03ba B sinyal yolunu a\u015fa\u011f\u0131 do\u011fru d\u00fczenleyerek enflamatuar enterit \u00fczerinde anti-enflamatuar ve terap\u00f6tik etkiler g\u00f6sterebilir. Scutellaria lakton NLRP3 inflamazom ve h\u00fccre piroptozunun aktivasyonunu inhibe edebilir, b\u00f6ylece in vivo anti-inflamatuar etkiler g\u00f6sterir.<br \/>\nA\u011f farmakolojisi teknoloji taramas\u0131 yoluyla, \u00fclseratif kolit hastal\u0131\u011f\u0131 i\u00e7in 285 hedef dahil olmak \u00fczere Onbu'nun 2415 hedefi belirlendi. Kesi\u015fimden sonra, \u00fclseratif kolit tedavisi i\u00e7in 111 potansiyel hedef elde edildi. \"Onbu Aktif Bile\u015fen UC\" a\u011f\u0131 olu\u015fturularak, Onbu'nun \u00fclseratif kolit tedavisindeki molek\u00fcler mekanizmas\u0131 ortaya \u00e7\u0131kar\u0131ld\u0131; Onbu'nun \u00fclseratif kolit tedavisindeki temel hedeflerini protein etkile\u015fim a\u011flar\u0131 arac\u0131l\u0131\u011f\u0131yla tahmin ederek, PPI a\u011f analizi, Onbu'nun TNF, CASP3, EGFR, PTGS2 ve HSP90AA1 gibi hedef proteinleri d\u00fczenleyerek \u00fclseratif kolit \u00fczerinde terap\u00f6tik etkiler g\u00f6sterebilece\u011fini ortaya koydu. Bu genler do\u011frudan veya dolayl\u0131 olarak h\u00fccresel inflamasyon, apoptoz ve oksidatif stres gibi s\u00fcre\u00e7lere kat\u0131lmaktad\u0131r. TNF - \u03b1 \u00fclseratif kolit tedavisi i\u00e7in \u00f6nemli bir hedeftir. \u00c7al\u0131\u015fmalar, \u00fclseratif kolitli hastalar\u0131n d\u0131\u015fk\u0131 \u00f6rneklerinde ve kolon mukozal biyopsi \u00f6rneklerinde TNF - \u03b1 seviyelerinin y\u00fckseldi\u011fini g\u00f6stermi\u015ftir. Anti TNF - \u03b1 monoklonal antikorlar, biyolojik aktivitelerini bloke ederek anti-enflamatuar etkiler elde edebilir. Anti TNF - \u03b1 monoklonal antikorlar \u00fclseratif kolit tedavisinde iyi terap\u00f6tik etkilere sahiptir. Kaspazlar h\u00fccre apoptozunda yer al\u0131r ve kaspaz 3 (CASP3) h\u00fccre apoptozu s\u00fcrecinde \u00f6nemli bir rol oynar. \u00dclseratif kolit olu\u015fumu h\u00fccre apoptozu ile yak\u0131ndan ili\u015fkilidir. Hayvan \u00e7al\u0131\u015fmalar\u0131, \u00fclseratif kolit model grubunun ba\u011f\u0131rsak mukozas\u0131ndaki CASP3 i\u00e7eri\u011finin \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131n\u0131 ve etkili ila\u00e7 tedavisinden sonra ekspresyon seviyesinin a\u015fa\u011f\u0131 do\u011fru d\u00fczenlendi\u011fini ve kolon h\u00fccrelerinin apoptoz oran\u0131n\u0131n \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Prostasiklin endoperoksit sentaz (PTGS2) proteini \u00e7oklu inflamatuar sinyal yolaklar\u0131nda yer al\u0131r ve bu proteinin inhibe edilmesi inflamatuar arac\u0131lar\u0131n \u00fcretimini azaltabilir. \u0130nsan v\u00fccudunda \u00f6nemli bir sinyal yolu olan EGFR sinyal yolu, h\u00fccre apoptozuna ve proliferasyonuna arac\u0131l\u0131k eder ve kolonik mukozal hasar\u0131n olu\u015fumu ile ili\u015fkilidir. Bu nedenle, EGFR sinyal yoluna m\u00fcdahale etmek \u00dcK tedavisine olanak sa\u011flamaktad\u0131r. \u00dclseratif kolitin ba\u011f\u0131rsak mukozas\u0131ndaki hasar\u0131n EGFR ekspresyonunu etkileyebilece\u011fini, b\u00f6ylece kolon mukozas\u0131 \u00fczerindeki koruyucu ve onar\u0131c\u0131 etkilerini azaltabilece\u011fini g\u00f6steren \u00e7al\u0131\u015fmalar vard\u0131r ve EGFR seviyelerinin UC n\u00fcks\u00fc ile yak\u0131ndan ili\u015fkili oldu\u011fu bulunmu\u015ftur. HSP90AA1 inflamasyonla yak\u0131ndan ili\u015fkilidir ve h\u00fccre proliferasyonu ile apoptozu d\u00fczenleyebilir. HSP90AA1'in inhibe edilmesi otofajiyi ind\u00fckleyebilir ve \u00fclseratif koliti iyile\u015ftirebilir.<br \/>\nWeng Bu'nun, anti-enflamatuar, antioksidan ve h\u00fccre apoptozunu azaltmak i\u00e7in yukar\u0131da belirtilen be\u015f hedef proteini d\u00fczenleyerek UC \u00fczerinde terap\u00f6tik etkiler g\u00f6sterebilece\u011fi tahmin edilmektedir. Molek\u00fcler yerle\u015ftirme sonu\u00e7lar\u0131 da Weng Bu'nun yukar\u0131da belirtilen be\u015f \u00e7ekirdek gen ile iyi bir ba\u011flanma aktivitesine sahip oldu\u011funu g\u00f6stermi\u015ftir.<br \/>\nKEGG sonu\u00e7lar\u0131, \u00fclseratif kolit i\u00e7in Onbu tedavisinin ana yollar\u0131n\u0131n, T h\u00fccre resept\u00f6r\u00fc sinyal yolu, MAPK sinyal yolu ve TNF - \u03b1 sinyal yolu gibi h\u00fccresel ba\u011f\u0131\u015f\u0131kl\u0131k ara\u015ft\u0131rmas\u0131n\u0131n \u00e7ekirdek yollar\u0131n\u0131 i\u00e7erdi\u011fini g\u00f6stermi\u015ftir. IL-6, t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc alfa ve interl\u00f6kin-1 beta, enflamatuar yan\u0131tta yayg\u0131n olarak g\u00f6r\u00fclen \u00fc\u00e7 enflamatuar fakt\u00f6rd\u00fcr. TNF - \u03b1 ve IL-1 \u03b2 akut \u00dcK'nin erken evresinde \u00f6nemli pro-inflamatuar fakt\u00f6rlerdir. Pro-inflamatuar fakt\u00f6rlerin T h\u00fccre apoptozisi \u00fczerindeki inhibit\u00f6r etkisi, s\u00fcrekli bir pro-inflamatuar rol oynar ve b\u00f6ylece \u00dcK'nin olu\u015fumuna ve geli\u015fimine kat\u0131l\u0131r. Akci\u011fer ve ba\u011f\u0131rsak dokular\u0131n\u0131n patolojik hasar\u0131n\u0131n TNF - \u03b1\/NF - \u03ba B sinyal yolu arac\u0131l\u0131\u011f\u0131yla iyile\u015ftirilebilece\u011fini ve hem akci\u011ferleri hem de ba\u011f\u0131rsaklar\u0131 birlikte tedavi etme etkisine ula\u015f\u0131labilece\u011fini g\u00f6steren \u00e7al\u0131\u015fmalar vard\u0131r. Mitojen aktive protein kinaz sinyal yolu, inflamasyon, oksidatif stres, h\u00fccre farkl\u0131la\u015fmas\u0131 ve apoptoz gibi \u00e7e\u015fitli fizyolojik ve patolojik s\u00fcre\u00e7lerin d\u00fczenlenmesine kat\u0131labilen ERK ve p38 MAPK sinyal yollar\u0131n\u0131 i\u00e7erir. MAPK sinyal iletimi, UC'nin enflamatuar yan\u0131t\u0131 ile yak\u0131ndan ili\u015fkilidir.<br \/>\nTNF - \u03b1 v\u00fccuttaki zararl\u0131 uyaranlar taraf\u0131ndan sal\u0131nan ilk sitokindir ve IL-1 \u03b2 TNF - \u03b1 taraf\u0131ndan ind\u00fcklenebilir. IL-1 \u03b2 art\u0131\u015f\u0131 TNF - \u03b1 ile IL-6 \u00fcretimini sinerjik olarak uyarabilir. Bu nedenle, bu \u00e7al\u0131\u015fmada Onbu'nun \u00fclseratif kolit \u00fczerindeki potansiyel terap\u00f6tik hedeflerini ve sinyal yollar\u0131n\u0131 tahmin etmek i\u00e7in a\u011f farmakolojisi ve molek\u00fcler yerle\u015ftirme teknikleri kullan\u0131lm\u0131\u015ft\u0131r. Bir fare \u00fclseratif kolit modeli, farmakolojik de\u011ferlendirme i\u00e7in serbest DSS t\u00fcketimi ile \u00e7o\u011falt\u0131lm\u0131\u015ft\u0131r. Onbu, UC farelerinde DSS taraf\u0131ndan ind\u00fcklenen kolon uzunlu\u011funu ve kolon mukozal hasar\u0131n\u0131 iyile\u015ftirebilir, kolon ve serumdaki TNF - \u03b1 ve IL-6 seviyelerini azaltabilir ve \u00fclseratif kolonun enflamatuar tepkisini hafifletebilir.<br \/>\n\u00d6zetle, bu \u00e7al\u0131\u015fma Onbu'nun \u00dcK tedavisindeki etki mekanizmas\u0131n\u0131 a\u011f farmakolojisi y\u00f6ntemleriyle sistematik olarak analiz etmi\u015f ve molek\u00fcler yerle\u015ftirme teknolojisini kullanarak hedefini \u00f6nceden do\u011frulam\u0131\u015ft\u0131r. Ayn\u0131 zamanda, Onbu'nun \u00dcK tedavisindeki etkinli\u011fi C57BL-6 farelerinde in vivo deneylerle test edilmi\u015ftir. \u00d6n ara\u015ft\u0131rma sonu\u00e7lar\u0131, Onbu'nun \"\u00e7ok hedefli, \u00e7ok yollu\" terapi yoluyla UC'yi tedavi edebilece\u011fini ve DSS kaynakl\u0131 enflamatuar yan\u0131t\u0131 hafifletebilece\u011fini g\u00f6stermektedir, ancak mekanizmas\u0131 hala belirsizdir. \u00dclseratif kolit tedavisinde Onbu'nun etki mekanizmas\u0131 i\u00e7in referans sa\u011flamak amac\u0131yla daha sonraki ara\u015ft\u0131rmalar yap\u0131lacakt\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"<p>Study on the mechanism of action of Tibetan medicine Weng Bu on ulcerative colitis Wengbu is a traditional Tibetan medicine, which originates from the tender leaves of various plants of Myricaria, Tamaricaceae, and is widely distributed in Xizang, Qinghai, Yunnan and other places. Modern research has shown that the main chemical components of Wenbu are [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Study on the mechanism of action of Tibetan medicine Weng Bu on ulcerative colitis - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/ombu\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the mechanism of action of Tibetan medicine Weng Bu on ulcerative colitis - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the mechanism of action of Tibetan medicine Weng Bu on ulcerative colitis Wengbu is a traditional Tibetan medicine, which originates from the tender leaves of various plants of Myricaria, Tamaricaceae, and is widely distributed in Xizang, Qinghai, Yunnan and other places. Modern research has shown that the main chemical components of Wenbu are [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/tr\/ombu\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-04T15:08:10+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-80.png\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"9 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/ombu\/\",\"url\":\"https:\/\/longchangextracts.com\/ombu\/\",\"name\":\"Study on the mechanism of action of Tibetan medicine Weng Bu on ulcerative colitis - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangextracts.com\/ombu\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangextracts.com\/ombu\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-80.png\",\"datePublished\":\"2024-08-04T15:08:10+00:00\",\"dateModified\":\"2024-08-04T15:08:10+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/ombu\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/ombu\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/ombu\/#primaryimage\",\"url\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-80.png\",\"contentUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-80.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/ombu\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Study on the mechanism of action of Tibetan medicine Weng Bu on ulcerative colitis\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Tibet ilac\u0131 Weng Bu'nun \u00fclseratif kolit \u00fczerindeki etki mekanizmas\u0131 \u00fczerine \u00e7al\u0131\u015fma - \u00c7in Kimya \u00dcreticisi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/tr\/ombu\/","og_locale":"tr_TR","og_type":"article","og_title":"Study on the mechanism of action of Tibetan medicine Weng Bu on ulcerative colitis - China Chemical Manufacturer","og_description":"Study on the mechanism of action of Tibetan medicine Weng Bu on ulcerative colitis Wengbu is a traditional Tibetan medicine, which originates from the tender leaves of various plants of Myricaria, Tamaricaceae, and is widely distributed in Xizang, Qinghai, Yunnan and other places. 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