{"id":4588,"date":"2024-08-04T14:55:47","date_gmt":"2024-08-04T14:55:47","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4588"},"modified":"2024-08-04T14:55:47","modified_gmt":"2024-08-04T14:55:47","slug":"bairui-granules","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/bairui-granules\/","title":{"rendered":"UHPLC-Q-TOF-MS\/MS Teknolojisine Dayal\u0131 Bai Rui Gran\u00fcllerinin Kan Bile\u015fenleri \u00dczerine \u00c7al\u0131\u015fma"},"content":{"rendered":"<p>UHPLC-Q-TOF-MS\/MS Teknolojisine Dayal\u0131 Bai Rui Gran\u00fcllerinin Kan Bile\u015fenleri \u00dczerine \u00c7al\u0131\u015fma<\/p>\n<p>UHPLC-Q-TOF-MS\/MS Teknolojisine Dayal\u0131 Bai Rui Gran\u00fcllerinin Kan Bile\u015fenleri \u00dczerine \u00c7al\u0131\u015fma<br \/>\nBairui gran\u00fclleri, antibakteriyel ve anti-enflamatuar, \u0131s\u0131y\u0131 temizleme ve detoksifiye etme ve \u00f6ks\u00fcr\u00fc\u011f\u00fc hafifletme etkilerine sahip tek bitki Bairui otundan olu\u015fan gran\u00fcler bir preparatt\u0131r. Modern klinik uygulamada pediatrik tonsillit, bron\u015fit ve \u00e7e\u015fitli solunum yolu enfeksiyonlar\u0131n\u0131 tedavi etmek i\u00e7in yayg\u0131n olarak kullan\u0131l\u0131rlar. Geleneksel \u00c7in t\u0131bb\u0131n\u0131n aktif bile\u015fenleri, etkilerini g\u00f6stermek i\u00e7in \u00e7o\u011funlukla bir ara\u00e7 olarak kan yoluyla hedefe ta\u015f\u0131n\u0131r (ba\u011f\u0131rsakta do\u011frudan etki ve harici ila\u00e7 hari\u00e7). Bu nedenle, geleneksel \u00c7in t\u0131bb\u0131n\u0131n a\u011f\u0131z yoluyla uygulanmas\u0131ndan sonra v\u00fccuttaki aktif bile\u015fenlerin analiz edilmesi, geleneksel \u00c7in t\u0131bb\u0131 etkinli\u011finin maddi temelinin incelenmesi i\u00e7in \u00e7ok \u00f6nemlidir. Ara\u015ft\u0131rma grubumuz daha \u00f6nce Atractylodes macrocephala'n\u0131n alkol \u00f6z\u00fct\u00fcn\u00fcn kimyasal bile\u015fimini sistematik olarak analiz etmek i\u00e7in s\u0131v\u0131 kromatografi-k\u00fctle spektrometresi teknolojisini kullanm\u0131\u015f ve Atractylodes macrocephala'da flavonoidler, alkaloidler ve di\u011fer bile\u015fikler gibi bir\u00e7ok etkili bile\u015fen oldu\u011funu tespit etmi\u015ftir. \u00d6nceki literat\u00fcr \u00e7al\u0131\u015fmalar\u0131 \u00e7o\u011funlukla tek bitkilerin kimyasal bile\u015fimi ve kalite kontrol\u00fcne odaklanm\u0131\u015ft\u0131r, Atractylodes macrocephala gran\u00fcllerinin in vivo kan bile\u015fenleri ve metabolik s\u00fcre\u00e7leri \u00fczerine ara\u015ft\u0131rma yap\u0131lmam\u0131\u015ft\u0131r ve farmakolojik madde temeli hen\u00fcz net de\u011fildir.<\/p>\n<p>D\u00f6rt kutuplu u\u00e7u\u015f zaman\u0131 k\u00fctle spektrometresi teknolojisi, y\u00fcksek hassasiyeti ve \u00e7\u00f6z\u00fcn\u00fcrl\u00fc\u011f\u00fc sayesinde geleneksel \u00c7in t\u0131bb\u0131ndaki kimyasal bile\u015fenleri h\u0131zl\u0131 ve verimli bir \u015fekilde analiz edebilir ve geleneksel \u00c7in t\u0131bb\u0131n\u0131n etkinli\u011finin madde temelinin ara\u015ft\u0131r\u0131lmas\u0131nda yayg\u0131n olarak kullan\u0131lmaktad\u0131r. Bu nedenle, \u00f6nceki ara\u015ft\u0131rmalara dayanarak, ara\u015ft\u0131rma grubumuz, etkili maddelerin temel ara\u015ft\u0131rmas\u0131 i\u00e7in bir referans temeli sa\u011flayan ve geleneksel \u00c7in patentli ila\u00e7lar\u0131n ve basit preparatlar\u0131n kalite kontrol\u00fc ve geli\u015ftirilmesi ve kullan\u0131m\u0131 i\u00e7in b\u00fcy\u00fck \u00f6nem ta\u015f\u0131yan Baisui Gran\u00fcl\u00fcn\u00fcn kana giren bile\u015fenlerini ve metabolik s\u00fcrecini analiz etmek i\u00e7in ultra y\u00fcksek performansl\u0131 s\u0131v\u0131 kromatografi d\u00f6rt kutuplu u\u00e7u\u015f s\u00fcresi k\u00fctle spektrometresi (UHPLC-Q-TOF-MS\/MS) teknolojisini kullanmaya devam etmektedir.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4589\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-74.png\" alt=\"\" width=\"604\" height=\"791\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-74.png 604w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-74-550x720.png 550w\" sizes=\"(max-width: 604px) 100vw, 604px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4590\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-64.png\" alt=\"\" width=\"601\" height=\"515\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4591\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-2.jpg\" alt=\"\" width=\"601\" height=\"286\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4592\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-6.jpg\" alt=\"\" width=\"601\" height=\"281\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4593\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-49.png\" alt=\"\" width=\"601\" height=\"462\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4594\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-45.png\" alt=\"\" width=\"601\" height=\"661\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4595\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-2.jpg\" alt=\"\" width=\"600\" height=\"651\" \/><br \/>\nBu \u00e7al\u0131\u015fmada, Bairui gran\u00fcllerinin emilen kan bile\u015fenlerini analiz etmek i\u00e7in UHPLC-Q-TOF-MS\/MS teknolojisi kullan\u0131lm\u0131\u015ft\u0131r. S\u0131\u00e7an serumundan toplam 20 prototip bile\u015fen ve 10 metabolit tespit edilmi\u015ftir. V\u00fccutta analiz edilen ana bile\u015fenler kuersetin ve sofokarpin gibi alkaloidlerin yan\u0131 s\u0131ra kaempferol ve resveratrol I gibi flavonoidlerdir; V\u00fccuttaki ana metabolik \u00fcr\u00fcnler kaempferol\u00fcn oksidasyonu ve glukuronidasyonu ve sofokarpinin oksidasyonu ve hidrolizidir, bu da alkaloidlerin ve flavonoidlerin v\u00fccuda giren ana bile\u015fenler oldu\u011funu ve ayr\u0131ca ila\u00e7 etkinli\u011fi i\u00e7in potansiyel aktif bile\u015fenler olabilece\u011fini g\u00f6sterir.<\/p>\n<p>Modern farmakolojik ara\u015ft\u0131rmalar, flavonoidlerin ve alkaloidlerin anti-enflamatuar, antibakteriyel, antiviral ve antioksidan gibi farmakolojik i\u015flevlere sahip oldu\u011funu g\u00f6stermi\u015ftir. \u00d6nceki \u00e7al\u0131\u015fmalar, Bai Rui Cao'daki resveratrol t\u00fcrevlerinin anti-enflamatuar etkisinin, h\u00fccre i\u00e7i reaktif oksijen t\u00fcrleri \u00fcretiminin ve p38 MAPK ve aktivat\u00f6r protein 1'in aktivasyonunun etkili bir \u015fekilde inhibe edilmesiyle ili\u015fkili oldu\u011funu bildirmi\u015ftir. Do\u011fal bir flavonol olarak resveratrol, enflamatuar h\u00fccre fonksiyonunu inhibe etmede ve pro-enflamatuar sitokinlerin ve kemokinlerin ekspresyonunu bast\u0131rmada g\u00fc\u00e7l\u00fc bir etkiye sahiptir. Bairuicao I, NF - \u03ba B ve MAPK yolaklar\u0131na etki ederek TNF - \u03b1, IL-6, IL-1 \u03b2 vb. enflamatuar sitokinlerin ekspresyonunu inhibe edebilir ve b\u00f6ylece pn\u00f6moni ile enfekte farelerde pulmoner \u00f6demi iyile\u015ftirebilir. Alkaloidler, Escherichia coli ve Staphylococcus aureus gibi mikroorganizmalar\u0131n b\u00fcy\u00fcmesini \u00f6nemli \u00f6l\u00e7\u00fcde engelleyebilir. Sophocarpine g\u00fc\u00e7l\u00fc anti-enflamatuar ve analjezik etkilere sahiptir ve NF - \u03ba B sinyal yolunu inhibe ederek enflamasyonu azaltabilir. Oxymatrine, NF - \u03ba B sinyal yolunu inhibe ederek ve inflamatuar fakt\u00f6rler IL-6 ve IL-8'in ekspresyonunu azaltarak anti-inflamatuar etkiler g\u00f6sterebilir.<\/p>\n<p>\u00d6zetle, bu \u00e7al\u0131\u015fmada UHPLC-Q-TOFMS\/MS teknolojisi kullan\u0131larak Bairui gran\u00fcllerinin kan bile\u015fenleri ve metabolitleri ayd\u0131nlat\u0131lm\u0131\u015ft\u0131r. Bu bile\u015fikler, Bairui gran\u00fcllerinin anti-enflamatuar ve antibakteriyel etkileriyle yak\u0131ndan ili\u015fkili olabilir; bu da geleneksel \u00c7in t\u0131bb\u0131 etkinli\u011finin maddi temelini a\u00e7\u0131kl\u0131\u011fa kavu\u015fturmak ve geleneksel \u00c7in t\u0131bb\u0131n\u0131n kalite standartlar\u0131n\u0131 iyile\u015ftirmek i\u00e7in b\u00fcy\u00fck \u00f6nem ta\u015f\u0131maktad\u0131r. Etki mekanizmas\u0131n\u0131n ve klinik uygulamas\u0131n\u0131n daha iyi anla\u015f\u0131lmas\u0131 i\u00e7in bir referans temeli sa\u011flar.<\/p>","protected":false},"excerpt":{"rendered":"<p>Study on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology Study on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology Bairui granules are a granular preparation composed of single herb Bairui grass, which has the effects of antibacterial and anti-inflammatory, clearing heat and detoxifying, and relieving cough. They are [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Study on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/bairui-granules\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology Study on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology Bairui granules are a granular preparation composed of single herb Bairui grass, which has the effects of antibacterial and anti-inflammatory, clearing heat and detoxifying, and relieving cough. 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They are [&hellip;]","og_url":"https:\/\/longchangextracts.com\/tr\/bairui-granules\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-04T14:55:47+00:00","og_image":[{"url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-74.png"}],"author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"longcha9","Tahmini okuma s\u00fcresi":"5 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/bairui-granules\/","url":"https:\/\/longchangextracts.com\/bairui-granules\/","name":"UHPLC-Q-TOF-MS\/MS Teknolojisine Dayal\u0131 Bai Rui Gran\u00fcllerinin Kan Bile\u015fenleri \u00dczerine \u00c7al\u0131\u015fma - \u00c7in Kimya \u00dcreticisi","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangextracts.com\/bairui-granules\/#primaryimage"},"image":{"@id":"https:\/\/longchangextracts.com\/bairui-granules\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-74.png","datePublished":"2024-08-04T14:55:47+00:00","dateModified":"2024-08-04T14:55:47+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/bairui-granules\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/bairui-granules\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/bairui-granules\/#primaryimage","url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-74.png","contentUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-74.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/bairui-granules\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Study on the Blood Components of Bai Rui Granules Based on UHPLC-Q-TOF-MS\/MS Technology"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"\u00c7in Kimyasal \u00dcreticisi","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"tr"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/4588"}],"collection":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/comments?post=4588"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/4588\/revisions"}],"predecessor-version":[{"id":4596,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/4588\/revisions\/4596"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/media?parent=4588"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/categories?post=4588"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/tags?post=4588"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}