{"id":4523,"date":"2024-08-04T14:39:26","date_gmt":"2024-08-04T14:39:26","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4523"},"modified":"2024-08-04T14:39:26","modified_gmt":"2024-08-04T14:39:26","slug":"corydalis-fangshanensis","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/corydalis-fangshanensis\/","title":{"rendered":"Corydalis Fangshanensis'in Toprak \u00dcst\u00fc K\u0131sm\u0131n\u0131n Kimyasal Bile\u015fenleri ve Meme Kanseri H\u00fccreleri \u00dczerindeki Anti Proliferasyon Etkisi \u00dczerine \u00c7al\u0131\u015fmalar"},"content":{"rendered":"<p>Corydalis Fangshanensis'in Toprak \u00dcst\u00fc K\u0131sm\u0131n\u0131n Kimyasal Bile\u015fenleri ve Meme Kanseri H\u00fccreleri \u00dczerindeki Anti Proliferasyon Etkisi \u00dczerine \u00c7al\u0131\u015fmalar<br \/>\nCorydalis fangshanensis, Papaveraceae familyas\u0131ndan Corydalis cinsine ait tek y\u0131ll\u0131k otsu bir bitkidir. \u00c7o\u011funlukla Fangshan, Pekin, Shanxi, Henan, Hebei ve di\u011fer yerlerde da\u011f\u0131l\u0131m g\u00f6sterir ve 500-1600 m y\u00fckseklikte kire\u00e7ta\u015f\u0131 ve kayal\u0131k yama\u00e7larda yeti\u015fir. Mor menek\u015fe \u015fifal\u0131 otlar \u00e7o\u011funlukla b\u00fct\u00fcn otlar olarak kullan\u0131l\u0131r ve ana bile\u015fenleri tatl\u0131 ve so\u011fuk bir tada sahiptir. Is\u0131y\u0131 temizleme ve detoksifiye etme etkisine sahiptirler ve genellikle so\u011fuk alg\u0131nl\u0131\u011f\u0131, ate\u015f, \u00fclser ve \u00fclser gibi hastal\u0131klar\u0131 tedavi etmek i\u00e7in kullan\u0131l\u0131rlar. \u00d6nceki \u00e7al\u0131\u015fmalar, bu bitki cinsinin alkaloidler, flavonoidler, kumarinler ve organik asitler gibi kimyasal bile\u015fenler i\u00e7erdi\u011fini ve bunlar\u0131n aras\u0131nda alkaloidlerin ana farmakolojik aktif bile\u015fenler oldu\u011funu bulmu\u015ftur. Modern farmakolojik ara\u015ft\u0131rmalar, bu cinsteki alkaloidlerin anti-t\u00fcm\u00f6r, anti-inflamatuar, anti miyokardiyal iskemi, antibakteriyel ve hepatoprotektif etkiler gibi \u00e7e\u015fitli aktivitelere sahip oldu\u011funu bulmu\u015ftur. \u00c7in Halk Cumhuriyeti Farmakopesi'nin 2020 bask\u0131s\u0131, Corydalis yanhusuo cinsinde C. yanhusuo'yu i\u00e7erir\u3001 C decumbens olmadan yaz\u3001 Kudi Ding C Bungeana, bile\u015fik Corydalis yanhusuo tabletleri ve yaz enjeksiyonu gibi t\u0131bbi bitkiler klinik uygulamada kullan\u0131lm\u0131\u015ft\u0131r. \u015eu anda, b\u00fcy\u00fcme ortam\u0131 ve verim gibi fakt\u00f6rler nedeniyle, Fangshan mor menek\u015fesinin kimyasal bile\u015fimi veya farmakolojik aktivitesi hakk\u0131nda \u00e7ok az rapor vard\u0131r, bu da t\u0131bbi bile\u015fenlerinin ara\u015ft\u0131r\u0131lmas\u0131n\u0131 engellemektedir. Bu nedenle, bu \u00e7al\u0131\u015fmada Shanxi Eyaleti, Zuoquan \u0130l\u00e7esinden toplanan Corydalis fangshan'\u0131n kimyasal bile\u015fimi ve in vitro sitotoksisitesi sistematik olarak incelenmi\u015ftir. 80% etanol\u00fcn ham ekstrakt\u0131n\u0131 sistematik olarak ay\u0131rmak i\u00e7in \u00e7e\u015fitli kromatografik ay\u0131rma teknikleri kullan\u0131lm\u0131\u015f ve ayr\u0131lan bile\u015fikler, bu ilac\u0131n meme kanserine kar\u015f\u0131 uygulanmas\u0131na ve daha sonraki kalite kontrol ara\u015ft\u0131rmalar\u0131na bir temel sa\u011flamak amac\u0131yla meme t\u00fcm\u00f6r h\u00fccresi inhibisyonu a\u00e7\u0131s\u0131ndan test edilmi\u015ftir.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4526\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-69.png\" alt=\"\" width=\"700\" height=\"560\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4527\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-59.png\" alt=\"\" width=\"802\" height=\"564\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-59.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-59-768x540.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4528\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-56.png\" alt=\"\" width=\"802\" height=\"334\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-56.png 802w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-56-768x320.png 768w\" sizes=\"(max-width: 802px) 100vw, 802px\" \/>Bu deneyde, Fangshan mor menek\u015fesinin 80% etanol ekstrakt\u0131ndan (etil asetat ve n-b\u00fctanol) toplam 17 monomerik bile\u015fik izole edilmi\u015ftir. Bile\u015fik 1-10 izokinolin alkaloidler, 11 ve 12 di\u011fer alkaloidler, 13 ve 14 fenilpropanoidler, 15 flavonlar ve 16 ve 17 lignanlard\u0131r. Bunlar aras\u0131nda, bile\u015fik 1 ilk kez do\u011fal bir \u00fcr\u00fcn olarak rapor edilmi\u015f ve 2-17 ilk kez Fangshan mor menek\u015fesinden izole edilmi\u015ftir. Yukar\u0131da izole edilen bile\u015fikler temel olarak literat\u00fcrde Corydalis cinsinin bildirilen bile\u015fim t\u00fcrleri ile tutarl\u0131d\u0131r. Meme kanseri h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 in vitro inhibe eden aktivite testi sonu\u00e7lar\u0131, 3, 4, 7 ve 10 numaral\u0131 bile\u015fiklerin MDA-MB-231'e kar\u015f\u0131 belirgin inhibit\u00f6r aktiviteye sahip oldu\u011funu, 4 ve 17 numaral\u0131 bile\u015fiklerin MCF-7 h\u00fccrelerine kar\u015f\u0131 belirgin inhibit\u00f6r aktiviteye sahip oldu\u011funu ve di\u011fer bile\u015fiklerin yukar\u0131daki meme kanseri t\u00fcm\u00f6r h\u00fccreleri \u00fczerinde inhibit\u00f6r etkisi olmad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Aktivite testi sonu\u00e7lar\u0131na g\u00f6re, benzilizokinolin alkaloid bile\u015fenlerinin \u00e7o\u011fu belirli bir inhibit\u00f6r etkiye sahiptir, ancak izole edilen alkaloid bile\u015fikleri genellikle azd\u0131r, bu da yap\u0131-aktivite ili\u015fkilerini etkili bir \u015fekilde \u00f6zetlemeyi zorla\u015ft\u0131r\u0131r. Sonraki \u00e7al\u0131\u015fmalar, y\u00fcksek i\u00e7erikli baz\u0131 benzilizokinolin alkaloid bile\u015fenlerinin yap\u0131lar\u0131n\u0131 de\u011fi\u015ftirebilir ve yap\u0131-aktivite ili\u015fkilerini \u00f6zetleyebilir. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, farmakolojik madde temelinin ayd\u0131nlat\u0131lmas\u0131, kalite kontrol\u00fc ve Fangshan Mor Osmanthus'un farmakolojik etkileri \u00fczerine daha derinlemesine ara\u015ft\u0131rmalar i\u00e7in belirli bir referans de\u011ferine sahiptir.<\/p>","protected":false},"excerpt":{"rendered":"<p>Studies on the Chemical Constituents of the Aboveground Part of Corydalis Fangshanensis and Its Anti proliferation Effect on breast cancer Cells Corydalis fangshanensis is an annual herbaceous plant of the genus Corydalis in the Papaveraceae family. It is mainly distributed in Fangshan, Beijing, Shanxi, Henan, Hebei and other places, and grows on limestone and rocky [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Studies on the Chemical Constituents of the Aboveground Part of Corydalis Fangshanensis and Its Anti proliferation Effect on breast cancer Cells - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/corydalis-fangshanensis\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Studies on the Chemical Constituents of the Aboveground Part of Corydalis Fangshanensis and Its Anti proliferation Effect on breast cancer Cells - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Studies on the Chemical Constituents of the Aboveground Part of Corydalis Fangshanensis and Its Anti proliferation Effect on breast cancer Cells Corydalis fangshanensis is an annual herbaceous plant of the genus Corydalis in the Papaveraceae family. 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