{"id":4431,"date":"2024-08-04T14:11:47","date_gmt":"2024-08-04T14:11:47","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4431"},"modified":"2024-08-04T14:11:47","modified_gmt":"2024-08-04T14:11:47","slug":"vitamin-b12","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/vitamin-b12\/","title":{"rendered":"Besinsel Zenginle\u015ftirme i\u00e7in B12 Vitamini Nedir?"},"content":{"rendered":"

B12 Vitamini Nedir<\/strong><\/p>\n

B12 Vitamini (Siyanokobalamin), hayvansal protein fakt\u00f6r\u00fc olarak da bilinen siyanokobalamin olarak da bilinen suda \u00e7\u00f6z\u00fcnen bir vitamindir, siyanokobalamine benzer aktif maddeler i\u00e7eren bir grup vitamin i\u00e7in kullan\u0131lan genel bir terimdir. Metal iyonlar\u0131 i\u00e7eren suda \u00e7\u00f6z\u00fcnen tek vitamindir ve temel vitaminlerden biridir. B12 vitamininin sentetik \u00fcr\u00fcn\u00fc, kobalaminin ayr\u0131\u015fmas\u0131 s\u0131ras\u0131nda olu\u015fan siyanokobalamindir. \u00c7ok stabil olan k\u0131rm\u0131z\u0131 bir kristaldir ve g\u0131da takviyesi ve besin takviyesi i\u00e7in kullan\u0131l\u0131r. Bitki h\u00fccreleri B12 vitamini sentezleyemez, bu nedenle \u00e7o\u011fu bitkisel g\u0131da, hayvansal dokularda yo\u011funla\u015fan B12 vitamini i\u00e7ermez.<\/p>\n

B12 vitamininin fizyolojik i\u015flevleri<\/strong><\/p>\n

1. Folik asit kullan\u0131m oran\u0131n\u0131 art\u0131r\u0131n<\/strong>
\nFolik asit ile birlikte metiyonin (homosisteinden sentezlenir) ve kolin sentezler, metilkobalamin ve koenzim B12 gibi siyanokobalamin Schengen \u00f6nc\u00fcllerinin sentezlenmesi s\u00fcrecinde p\u00fcrin ve pirimidin \u00fcretir ve bir\u00e7ok \u00f6nemli bile\u015fi\u011fin metilasyon s\u00fcrecine kat\u0131l\u0131r. B12 vitamini eksikli\u011finde, metiltetrahidrofolattan metil gruplar\u0131n\u0131n transferi azal\u0131r, folik asidi kullan\u0131lamayan bir forma d\u00f6n\u00fc\u015ft\u00fcr\u00fcr ve folat eksikli\u011fine yol a\u00e7ar.<\/p>\n

2. Sinir miyelin metabolizmas\u0131n\u0131n ve fonksiyonunun s\u00fcrd\u00fcr\u00fclmesi<\/strong>
\nB12 Vitamini eksikli\u011fi sinir bozukluklar\u0131na, omurilik dejenerasyonuna ve ciddi psikiyatrik semptomlara neden olabilir. B12 vitamini eksikli\u011fi periferik n\u00f6rite yol a\u00e7abilir. \u00c7ocuklarda B12 vitamini eksikli\u011finin erken belirtileri anormal ruh hali, donuk ifade, yava\u015f tepki ve son olarak anemidir.<\/p>\n

3. K\u0131rm\u0131z\u0131 kan h\u00fccrelerinin geli\u015fimini ve olgunla\u015fmas\u0131n\u0131 destekler<\/strong>
\nMetilmalonil koenzim A'y\u0131 s\u00fcksinil koenzim A'ya d\u00f6n\u00fc\u015ft\u00fcr\u00fcr ve s\u00fcksinil koenzim A'n\u0131n hemoglobin sentezi ile ili\u015fkili oldu\u011fu trikarboksilik asit d\u00f6ng\u00fcs\u00fcne kat\u0131l\u0131r.<\/p>\n

4.<\/strong> B12 vitamini deoksiribon\u00fckleik asit (DNA) sentezinde rol oynar<\/strong>ya\u011flar\u0131n, karbonhidratlar\u0131n ve proteinlerin metabolizmas\u0131n\u0131 ve n\u00fckleik asitlerin ve proteinlerin sentezini art\u0131r\u0131r.<\/p>\n

B12 vitamini eksikli\u011fi hastal\u0131klar\u0131<\/strong><\/p>\n

1. B12 vitamini eksikli\u011finin yayg\u0131n nedenleri<\/strong><\/p>\n

(1) Kronik vejetaryenler gibi yetersiz al\u0131m;<\/p>\n

(2) Pankreatikojenik, gastrik, hepatik veya enterojenik hastal\u0131klar gibi edinilmi\u015f malabsorpsiyon;<\/p>\n

(3) B12 vitamini i\u00e7in artan gereksinim, \u00f6rne\u011fin hamilelik, do\u011fum sonras\u0131, tenyalar vb;<\/p>\n

(4) Endojen fakt\u00f6rlerin do\u011fu\u015ftan eksikli\u011fi gibi do\u011fu\u015ftan gelen B12 vitamini metabolik basamak bozukluklar\u0131.<\/p>\n

(5) Farmakogenetik: \u00e7al\u0131\u015fmalar oral metforminin serum B12 vitamini d\u00fczeylerini d\u00fc\u015f\u00fcrd\u00fc\u011f\u00fcn\u00fc ortaya koymu\u015ftur.<\/p>\n

2. B12 vitamini eksikli\u011finin yayg\u0131n hastal\u0131klar\u0131<\/strong>
\nB12 vitamini eksikli\u011fi temel olarak kan, metabolizma ve sinir sistemine yans\u0131r ve hiperhomosisteinemi (Hhcy), pernisiy\u00f6z anemi, subakut kombine dejenerasyon, zihinsel depresyon, metilmalonik asidemi, vask\u00fcler demans ve Alzheimer hastal\u0131\u011f\u0131na yol a\u00e7abilir.<\/p>\n

3. B12 vitamini nispeten d\u00fc\u015f\u00fck toksisiteye sahiptir.<\/strong>
\nG\u00fcnl\u00fck 100\u03bcg'a kadar oral kullan\u0131m raporuna g\u00f6re, \u00f6nemli bir yan etki g\u00f6r\u00fclmemi\u015ftir.
\nNot: B12 vitamininin beslenme durumu serum B12 vitamini konsantrasyonu, serum holotranskobalamin II (holo Tc II), serum holobinding cochineal, serum homosistein ve metilmalonik asit \u00f6l\u00e7\u00fclerek belirlenebilir.<\/p>\n

Referans Al\u0131m Miktar\u0131 ve G\u0131da Kaynaklar\u0131<\/strong><\/p>\n

\u0130nsan v\u00fccudu \u00e7ok az B12 vitaminine ihtiya\u00e7 duyar. B12 vitamini i\u00e7in \u00d6nerilen Diyet \u00d6dene\u011fi (RDA), erken \u00e7ocukluk d\u00f6neminde g\u00fcnde 0,9 \u03bcg ile yeti\u015fkinlikte g\u00fcnde 2,4 \u03bcg aras\u0131nda de\u011fi\u015fmektedir ve bu da n\u00fcfusun 97,5%'sinin ihtiya\u00e7lar\u0131n\u0131 kar\u015f\u0131lamak i\u00e7in yeterlidir. Hamile kad\u0131nlar i\u00e7in RDA g\u00fcnde 6 \u03bcg'd\u0131r ve ya\u015fl\u0131lar i\u00e7in RDA art\u0131r\u0131lmam\u0131\u015f olsa da, B12 vitamini malabsorpsiyonuna yatk\u0131nd\u0131rlar ve B12 vitamini ile g\u00fc\u00e7lendirilmi\u015f g\u0131dalar veya takviyeler al\u0131mlar\u0131n\u0131 art\u0131rmalar\u0131 tavsiye edilir. B12 vitamini i\u00e7in \u00f6nerdi\u011fimiz AI yeti\u015fkinler i\u00e7in 2,4 \u03bcg\/g\u00fcn'd\u00fcr.<\/p>\n

Diyetle al\u0131nan B12 vitamini hayvansal g\u0131dalardan elde edilir; ana besin kaynaklar\u0131 et, sakatat, bal\u0131k, k\u00fcmes hayvanlar\u0131, kabuklu deniz \u00fcr\u00fcnleri ve yumurta olup, s\u00fct ve s\u00fct \u00fcr\u00fcnlerinde daha az miktarda bulunur (Tablo 1). Bitkisel g\u0131dalar esasen B12 vitamini i\u00e7ermez.<\/p>\n

Tablo 1 Se\u00e7ilmi\u015f g\u0131dalar\u0131n B12 vitamini i\u00e7eri\u011fi (\u03bcg\/100g)<\/strong><\/p>\n

Not: Ensminger AH et al. 1989.American Encyclopedia of Food and Nutrition Selected (5) Food Composition'da al\u0131nt\u0131lanm\u0131\u015ft\u0131r.<\/p>\n

Besin takviyesi olarak B12 vitamini hangi g\u0131dalarda kullan\u0131labilir<\/strong><\/p>\n

\"\"<\/p>\n

 <\/p>\n

 <\/p>","protected":false},"excerpt":{"rendered":"

What is Vitamin B12 Vitamin B12 (Cyanocobalamin) is a water-soluble vitamin also known as cyanocobalamin, also known as animal protein factor, is a general term for a group of vitamins containing active substances similar to cyanocobalamin. It is the only water-soluble vitamin that contains metal ions and is one of the essential vitamins. The synthetic […]<\/p>","protected":false},"author":4,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[46],"tags":[],"yoast_head":"\nWhat is Vitamin B12 for Nutritional Enrichment? - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/vitamin-b12\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"What is Vitamin B12 for Nutritional Enrichment? - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"What is Vitamin B12 Vitamin B12 (Cyanocobalamin) is a water-soluble vitamin also known as cyanocobalamin, also known as animal protein factor, is a general term for a group of vitamins containing active substances similar to cyanocobalamin. 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