{"id":4282,"date":"2024-08-04T09:05:16","date_gmt":"2024-08-04T09:05:16","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4282"},"modified":"2024-08-04T09:05:16","modified_gmt":"2024-08-04T09:05:16","slug":"plum-blossom","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/plum-blossom\/","title":{"rendered":"Rezene k\u00f6k\u00fc kabu\u011fundaki \u00e7oklu bile\u015fen i\u00e7eri\u011finin UPLC ile belirlenmesi ve erik \u00e7i\u00e7eklerinde farkl\u0131 \u00e7i\u00e7eklenme d\u00f6nemlerinde kalite analizi"},"content":{"rendered":"

Rezene k\u00f6k\u00fc kabu\u011fundaki \u00e7oklu bile\u015fen i\u00e7eri\u011finin UPLC ile belirlenmesi ve erik \u00e7i\u00e7eklerinde farkl\u0131 \u00e7i\u00e7eklenme d\u00f6nemlerinde kalite analizi
\nMei, \u00c7in'de \u00e7ok \u00e7e\u015fitli \u00e7e\u015fitleriyle uzun ve derin bir yeti\u015ftirme ge\u00e7mi\u015fine sahiptir. \u00c7ok y\u0131ll\u0131k k\u00fc\u00e7\u00fck bir a\u011fa\u00e7 veya \u00e7al\u0131 olup, \u00e7i\u00e7ekleri ve meyveleri t\u0131bbi ama\u00e7lar i\u00e7in kullan\u0131labilir. Erik \u00e7i\u00e7e\u011fi \u00c7in'deki geleneksel \u00e7i\u00e7ek \u015fifal\u0131 bitkilerden biridir. Compendium of Materia Medica'ya g\u00f6re, erik \u00e7i\u00e7e\u011fi d\u00fcz bir yap\u0131ya, hafif ek\u015fi bir tada sahiptir ve karaci\u011fer, mide ve akci\u011fer meridyenlerine aittir. \u00c7in Halk Cumhuriyeti Farmakopesi'nde (bundan sonra \"\u00c7in Farmakopesi\" olarak an\u0131lacakt\u0131r) yer al\u0131r ve Prunus mume (Sieb.) Sieb et Zucc'un kurutulmu\u015f \u00e7i\u00e7ek tomurcuklar\u0131 g\u00fcl bitkisinden elde edilir. Karaci\u011feri yat\u0131\u015ft\u0131rma, balgam\u0131 \u00e7\u00f6zme ve nod\u00fclleri da\u011f\u0131tma etkilerine sahiptir. Genellikle erik \u00e7i\u00e7e\u011fi qi, karaci\u011fer ve mide qi a\u011fr\u0131s\u0131, depresyon ve sinirlilik, i\u015ftahs\u0131zl\u0131k ve skrofula tedavisinde kullan\u0131l\u0131r. Erik, \u00c7in'in \u00e7e\u015fitli b\u00f6lgelerinde yeti\u015ftirilir ve erik \u00e7i\u00e7ekleri i\u00e7in ana t\u0131bbi alanlar Jiangsu, Zhejiang, Anhui ve di\u011fer b\u00f6lgelerdir.
\n\u015eu anda, erik \u00e7i\u00e7eklerinden izole edilebilen, esas olarak u\u00e7ucu bile\u015fenler, flavonoidler, fenolik asitler, asilasyon \u00fcr\u00fcnleri, fenolik glikozitler ve alkol glikozitler dahil olmak \u00fczere y\u00fczden fazla kimyasal bile\u015fen bulunmaktad\u0131r; Bunlar aras\u0131nda fenolik asitler ve flavonoidler, erik \u00e7i\u00e7e\u011finin farmakolojik aktivitesinin ana malzeme temeli olan antibakteriyel, anti-enflamatuar, antioksidan ve melanin \u00fcretiminin inhibisyonu gibi \u00e7e\u015fitli farmakolojik aktivitelere sahiptir. \u00c7in Farmakopesi'nin g\u00fcncel versiyonu \u00fc\u00e7 i\u00e7erik belirleme g\u00f6stergesi belirtir: klorojenik asit, hiperosid ve izoquercitrin. Zheng ve arkada\u015flar\u0131 erik \u00e7i\u00e7e\u011findeki rutin, hyperoside, isoquercitrin, quercetin, kaempferol ve isorhamnetin dahil olmak \u00fczere alt\u0131 bile\u015fenin i\u00e7eri\u011fine dayal\u0131 kalite kontrol\u00fc ger\u00e7ekle\u015ftirmi\u015ftir. Ancak, di\u011fer flavonoidlerin i\u00e7eri\u011fine ili\u015fkin herhangi bir rapor bulunmamaktad\u0131r ve erik \u00e7i\u00e7e\u011finin kalite kontrol\u00fcne ili\u015fkin ara\u015ft\u0131rmalar hala nispeten azd\u0131r.
\nFenolik asitler ve flavonoidlerin erik \u00e7i\u00e7eklerinin farmakolojik etkileri i\u00e7in temel maddeler oldu\u011fu d\u00fc\u015f\u00fcn\u00fcld\u00fc\u011f\u00fcnde, bu \u00e7al\u0131\u015fma bir literat\u00fcr ara\u015ft\u0131rmas\u0131na dayanmaktad\u0131r. Neoklorojenik asit, klorojenik asit ve kriptoklorojenik asit olmak \u00fczere \u00fc\u00e7 temsili fenolik asit ve hiperosid, izoquercitrin, rutin, quercetin-3-O-glukosid, naringenin ve kaempferol-3-O-rutinosid olmak \u00fczere alt\u0131 temsili flavonoid bile\u015fen kalite kontrol g\u00f6stergeleri olarak se\u00e7ilmi\u015ftir. Erik \u00e7i\u00e7e\u011fi t\u0131bbi malzemelerindeki dokuz indikat\u00f6r bile\u015fenin i\u00e7eri\u011fini e\u015f zamanl\u0131 olarak belirlemek i\u00e7in bir UPLC y\u00f6ntemi olu\u015fturulmu\u015ftur. 45 parti erik \u00e7i\u00e7e\u011fi t\u0131bbi materyali topland\u0131 ve \u00fc\u00e7 kategoriye ayr\u0131ld\u0131: tomurcuk a\u015famas\u0131, tepe \u00e7i\u00e7eklenme a\u015famas\u0131 ve ge\u00e7 \u00e7i\u00e7eklenme a\u015famas\u0131. Kimyasal bile\u015fim i\u00e7eriklerindeki farkl\u0131l\u0131klar kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131 ve analiz edildi.
\nErik \u00e7i\u00e7eklerinin karma\u015f\u0131k kimyasal bile\u015fimi nedeniyle, t\u0131bbi malzemelerin kalitesini tek bir bile\u015fendeki de\u011fi\u015fikliklerle de\u011ferlendirmek zordur. Bununla birlikte, bu \u00e7al\u0131\u015fmada, farkl\u0131 zamanlarda i\u00e7erikteki de\u011fi\u015fiklikleri yans\u0131tmak i\u00e7in birden fazla aktif bile\u015fen t\u00fcr\u00fcn\u00fcn e\u015fzamanl\u0131 olarak \u00f6l\u00e7\u00fclmesiyle kalite de\u011fi\u015fikliklerinin e\u011filimi \u00e7\u0131kar\u0131labilir. Geleneksel \u00c7in t\u0131bb\u0131ndaki tarihi kay\u0131tlara g\u00f6re, hen\u00fcz \u00e7i\u00e7ek a\u00e7mam\u0131\u015f olanlar ile \u00e7i\u00e7ek a\u00e7m\u0131\u015f olanlar aras\u0131nda erik \u00e7i\u00e7e\u011fi kalitesinde farkl\u0131l\u0131klar vard\u0131r. Ancak, \u015fu anda farkl\u0131 b\u00fcy\u00fcme a\u015famalar\u0131n\u0131n kalite ara\u015ft\u0131rmas\u0131 hakk\u0131nda derinlemesine bir rapor bulunmamaktad\u0131r. Bu nedenle, farkl\u0131 \u00e7i\u00e7eklenme d\u00f6nemlerinde erik \u00e7i\u00e7e\u011fi kalitesinin kar\u015f\u0131la\u015ft\u0131r\u0131lmas\u0131, erik \u00e7i\u00e7e\u011fi hasat d\u00f6neminin belirlenmesi a\u00e7\u0131s\u0131ndan b\u00fcy\u00fck \u00f6nem ta\u015f\u0131maktad\u0131r.<\/p>\n

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Bu \u00e7al\u0131\u015fman\u0131n i\u00e7erik belirleme sonu\u00e7lar\u0131, farkl\u0131 \u00e7i\u00e7eklenme d\u00f6nemlerinde erik \u00e7i\u00e7e\u011fi t\u0131bbi malzemelerindeki neoklorojenik asit ve klorojenik asit gibi ana fenolik asitlerin i\u00e7eri\u011finin tomurcuk a\u015famas\u0131nda en y\u00fcksek oldu\u011funu, hesperidin, isoquercitrin ve rutin gibi flavonoidlerin i\u00e7eri\u011finin ise en yo\u011fun \u00e7i\u00e7eklenme d\u00f6neminde en y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir. Fenolik asit bile\u015fenlerinin i\u00e7eri\u011findeki de\u011fi\u015fiklikler literat\u00fcrde bildirilen e\u011filimle tutarl\u0131d\u0131r, yani klorojenik asit i\u00e7eri\u011fi tomurcuk a\u015famas\u0131ndan son \u00e7i\u00e7eklenme a\u015famas\u0131na kadar \u00e7i\u00e7eklenme a\u015famas\u0131yla birlikte azalmaktad\u0131r. Bu nedenle, erik \u00e7i\u00e7eklerinin \u00e7i\u00e7eklenme d\u00f6nemlerindeki farkl\u0131l\u0131klar\u0131n ana nedeni fenolik asit bile\u015fimindeki de\u011fi\u015fimdir.
\nSon y\u0131llarda, geleneksel \u00c7in t\u0131bb\u0131 \u00f6rneklerindeki farkl\u0131l\u0131klar\u0131 analiz etmek i\u00e7in kimyasal \u00f6r\u00fcnt\u00fc tan\u0131ma ile birlikte \u00e7ok bile\u015fenli analizin kullan\u0131m\u0131, geleneksel \u00c7in t\u0131bb\u0131 kalite de\u011ferlendirme ara\u015ft\u0131rmalar\u0131nda yayg\u0131n olarak uygulanmaktad\u0131r. Bu \u00e7al\u0131\u015fmada, 45 parti erik \u00e7i\u00e7e\u011fi t\u0131bbi malzemesinde 9 bile\u015fenin i\u00e7eri\u011fini e\u015f zamanl\u0131 olarak \u00f6l\u00e7erek ve bunlar\u0131 kimyasal modeller kullanarak analiz ederek erik \u00e7i\u00e7e\u011fi t\u0131bbi malzemelerinin farkl\u0131 \u00e7i\u00e7eklenme d\u00f6nemlerini belirleme y\u00f6ntemi ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r. HCA analizi sonu\u00e7lar\u0131nda, \u00fc\u00e7 \u00e7i\u00e7eklenme d\u00f6neminden gelen erik \u00e7i\u00e7e\u011fi \u00f6rnekleri \u00fc\u00e7 kategoride k\u00fcmelenmi\u015ftir; tomurcuk a\u015famas\u0131ndan gelen t\u00fcm erik \u00e7i\u00e7e\u011fi \u00f6rnekleri bir kategoride, ge\u00e7 \u00e7i\u00e7eklenme d\u00f6neminden gelen \u00e7o\u011fu erik \u00e7i\u00e7e\u011fi \u00f6rne\u011fi bir kategoride ve en yo\u011fun \u00e7i\u00e7eklenme d\u00f6neminden gelen t\u00fcm \u00f6rnekler bir kategoride k\u00fcmelenmi\u015ftir. Sonu\u00e7lar, farkl\u0131 \u00e7i\u00e7eklenme d\u00f6nemlerinde erik \u00e7i\u00e7e\u011fi t\u0131bbi malzemelerinin bile\u015fiminde \u00f6nemli farkl\u0131l\u0131klar oldu\u011funu g\u00f6stermi\u015ftir. PCA ve PLS-DA birle\u015ftirilerek, farkl\u0131 \u00e7i\u00e7eklenme d\u00f6nemlerindeki erik \u00e7i\u00e7eklerinin kalite fark\u0131 belirte\u00e7leri \u00fczerinde daha fazla analiz yap\u0131lm\u0131\u015ft\u0131r. Sonu\u00e7lar, \u00fc\u00e7 \u00e7i\u00e7eklenme d\u00f6nemindeki erik \u00e7i\u00e7e\u011fi \u00f6rneklerinin, farkl\u0131 \u00e7i\u00e7eklenme d\u00f6nemlerinde erik \u00e7i\u00e7e\u011fi \u00f6rneklerindeki farkl\u0131l\u0131klar\u0131 yans\u0131tacak \u015fekilde, \u00f6nemli \u00f6l\u00e7\u00fcde farkl\u0131 mek\u00e2nsal konumlarda yer ald\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Ayn\u0131 zamanda, \u00fc\u00e7 fenolik asit bile\u015feninin, yani neoklorojenik asit, klorojenik asit ve kriptoklorojenik asidin, farkl\u0131 \u00e7i\u00e7eklenme d\u00f6nemlerinden \u00f6rneklerin farkl\u0131la\u015fmas\u0131na \u00f6nemli \u00f6l\u00e7\u00fcde katk\u0131da bulundu\u011fu bulunmu\u015ftur. Bu, erik \u00e7i\u00e7eklerinin farkl\u0131 \u00e7i\u00e7eklenme d\u00f6nemlerindeki ana fenolik asit bile\u015fenlerinin i\u00e7eri\u011finin de\u011fi\u015fti\u011fi sonucuyla tutarl\u0131d\u0131r.
\n\u00d6zet olarak, bu \u00e7al\u0131\u015fma erik \u00e7i\u00e7e\u011fi t\u0131bbi malzemelerindeki \u00e7oklu bile\u015fenlerin i\u00e7eri\u011fini belirlemek i\u00e7in bir y\u00f6ntem olu\u015fturmu\u015f ve erik \u00e7i\u00e7e\u011fi t\u0131bbi malzemelerinin kalite standartlar\u0131n\u0131 iyile\u015ftirmek i\u00e7in \u00f6nemli bir referans sa\u011flam\u0131\u015ft\u0131r. Ayn\u0131 zamanda, kemometrik analiz ile birlikte, erik \u00e7i\u00e7e\u011finin farkl\u0131 \u00e7i\u00e7eklenme d\u00f6nemlerinde fenolik asit bile\u015fenlerindeki farkl\u0131l\u0131klar ortaya \u00e7\u0131kar\u0131lm\u0131\u015f ve erik \u00e7i\u00e7e\u011finin kalite de\u011fi\u015fim \u00f6zelliklerini yans\u0131tmak i\u00e7in kalite kontrol\u00fc ger\u00e7ekle\u015ftirilmi\u015ftir.<\/p>","protected":false},"excerpt":{"rendered":"

Determination of multi-component content in fennel root bark based on UPLC and quality analysis at different flowering periods in plum blossoms Mei has a long and profound cultivation history in China, with a wide variety of varieties. It is a perennial small tree or shrub, and its flowers and fruits can be used for medicinal […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nDetermination of multi-component content in fennel root bark based on UPLC and quality analysis at different flowering periods in plum blossoms - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/plum-blossom\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Determination of multi-component content in fennel root bark based on UPLC and quality analysis at different flowering periods in plum blossoms - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Determination of multi-component content in fennel root bark based on UPLC and quality analysis at different flowering periods in plum blossoms Mei has a long and profound cultivation history in China, with a wide variety of varieties. 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