{"id":4263,"date":"2024-08-04T09:03:00","date_gmt":"2024-08-04T09:03:00","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4263"},"modified":"2024-08-04T09:03:00","modified_gmt":"2024-08-04T09:03:00","slug":"fennel-root-bark","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/fennel-root-bark\/","title":{"rendered":"Rezene k\u00f6k\u00fc kabu\u011fundaki etkili bile\u015fenlerin spektral etki ili\u015fkisine dayal\u0131 olarak karaci\u011fer fibrozuna kar\u015f\u0131 taranmas\u0131 ve mekanizmas\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"

Rezene k\u00f6k\u00fc kabu\u011fundaki etkili bile\u015fenlerin spektral etki ili\u015fkisine dayal\u0131 olarak karaci\u011fer fibrozuna kar\u015f\u0131 taranmas\u0131 ve mekanizmas\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131
\nKaraci\u011fer fibrozu, karaci\u011fer sirozunun ve hatta karaci\u011fer kanserinin ana nedenidir ve karaci\u011fer kanserinin yakla\u015f\u0131k 90%'si karaci\u011fer fibrozu veya sirozu temelinde geli\u015fir. Bu nedenle, karaci\u011fer fibrozunun tedavisi \u00f6zellikle \u00f6nemlidir. Karaci\u011fer fibrozunun klinik insidans\u0131 her ge\u00e7en y\u0131l artmakta ve bu da insanlar\u0131n ya\u015fam g\u00fcvenli\u011fini ciddi \u015fekilde tehlikeye atmaktad\u0131r. Karaci\u011fer fibrozunun ba\u015fl\u0131ca nedenleri aras\u0131nda kronik hepatit vir\u00fcs\u00fc enfeksiyonu, alkol kullan\u0131m\u0131 ve alkolik olmayan ya\u011fl\u0131 karaci\u011fer hastal\u0131\u011f\u0131 yer almaktad\u0131r. Karaci\u011fer fibrozunun \u00f6zelli\u011fi, ekstrasel\u00fcler matriksin sentezinin ve birikiminin artmas\u0131n\u0131n yan\u0131 s\u0131ra ekstrasel\u00fcler matriksin degradasyonunun azalmas\u0131 veya hi\u00e7 olmamas\u0131ndan kaynaklanan a\u015f\u0131r\u0131 ekstrasel\u00fcler matriks birikimidir. Hepatik stellat h\u00fccrelerin aktivasyonu karaci\u011fer fibrozunda anahtar bir ba\u011flant\u0131 olarak kabul edilir ve karaci\u011ferde h\u00fccre d\u0131\u015f\u0131 matriks proteinlerinin a\u015f\u0131r\u0131 birikiminin ana nedenidir.
\nRezene k\u00f6k\u00fc kabu\u011fu, Umbelliferae bitkisi Foeniculum vulgare Mill'in kurutulmu\u015f k\u00f6k kabu\u011fudur. Standart Uygur t\u0131p kitab\u0131nda yer al\u0131r ve \u0131slak so\u011fuktan kaynaklanan \u00e7e\u015fitli iltihaplar ve \u015fi\u015flikler, iki tarafl\u0131 so\u011fuk a\u011fr\u0131s\u0131, bel a\u011fr\u0131s\u0131, amenore, idrar t\u0131kan\u0131kl\u0131\u011f\u0131 ve eski ba\u011f\u0131rsak t\u0131kan\u0131kl\u0131\u011f\u0131 gibi \u0131slak so\u011fuk veya m\u00fcsinli hastal\u0131klar\u0131 tedavi etmek i\u00e7in kullan\u0131l\u0131r. Hugan Buzu Re Gran\u00fclleri, geleneksel \u00c7in t\u0131bb\u0131nda karaci\u011feri korumak i\u00e7in kullan\u0131lan klasik bir form\u00fcld\u00fcr. Kereviz tohumu, kereviz k\u00f6k\u00fc, krizantem tohumu, dodder tohumu, hindiba k\u00f6k\u00fc, rezene k\u00f6k\u00fc kabu\u011fu ve rezeneden olu\u015fur ve karaci\u011feri besleyici ve safra ak\u0131\u015f\u0131n\u0131 te\u015fvik edici etkilere sahiptir. Ara\u015ft\u0131rma grubunun \u00f6n ara\u015ft\u0131rmas\u0131, Hugan BuZuRe gran\u00fcllerinin s\u0131\u00e7anlarda CCI4 kaynakl\u0131 karaci\u011fer fibrozuna kar\u015f\u0131 koruma sa\u011flayabilece\u011fini ortaya koymu\u015ftur. Medina Saifudin ve arkada\u015flar\u0131, geleneksel \u00c7in t\u0131bb\u0131 rezene k\u00f6k\u00fc kabu\u011funun karaci\u011fer dokusu onar\u0131m\u0131n\u0131 te\u015fvik etme ve karaci\u011fer h\u00fccre zarlar\u0131n\u0131 koruma konusunda belirli bir dereceye sahip oldu\u011funu bulmu\u015ftur. Bu nedenle, rezene k\u00f6k\u00fc kabu\u011fu karaci\u011fer fibrozunu \u00f6nleyici etkilere sahip olabilir.
\n\u0130la\u00e7 spektrum etkisi ili\u015fkisi \u00e7al\u0131\u015fmas\u0131, etkili kimyasal bile\u015fenleri analiz etmek i\u00e7in kimyasal bile\u015fimi ve farmakolojik ara\u015ft\u0131rmay\u0131 birle\u015ftiren bir y\u00f6ntemdir. Spektrum \u00e7al\u0131\u015fmas\u0131na dayanarak, yararl\u0131 kimyasal bilgilerin elde edilmesini en \u00fcst d\u00fczeye \u00e7\u0131kar\u0131r, spektrumlar\u0131 farmakolojik sonu\u00e7larla ili\u015fkilendirir, do\u011frusal veya do\u011frusal olmayan matematiksel i\u015fleme yoluyla bir \"spektrum etkisi\" matematiksel modeli olu\u015fturur ve farmakolojik etkilerle ilgili bile\u015fik gruplar\u0131n\u0131 belirler. Bilinen ve bilinmeyen bile\u015fenleri analiz ederek, geleneksel \u00c7in t\u0131bb\u0131n\u0131n karma\u015f\u0131k karma sistemlerinde bulunan kimyasal bile\u015fenlerin t\u00fcrleri ve i\u00e7erikleri en \u00fcst d\u00fczeyde yans\u0131t\u0131labilir, b\u00f6ylece geleneksel \u00c7in t\u0131bb\u0131n\u0131n kalitesinin genel bir tan\u0131m\u0131 ve de\u011ferlendirilmesi sa\u011flanabilir. Bu nedenle, bu \u00e7al\u0131\u015fmada, \u00c7in \u015fifal\u0131 bitkisi rezenenin k\u00f6k kabu\u011funun kimyasal bile\u015fenlerini ara\u015ft\u0131rmak i\u00e7in ultra y\u00fcksek performansl\u0131 s\u0131v\u0131 kromatografi-k\u00fctle spektrometresi kullan\u0131lm\u0131\u015ft\u0131r. Etanol ekstraksiyonu, petrol eteri ekstraksiyonu, etil asetat ekstraksiyonu, n-b\u00fctanol ekstraksiyonu ve su ekstraksiyonunun HSC-T6 h\u00fccre proliferasyonu \u00fczerindeki etkileri, k\u0131smi en k\u00fc\u00e7\u00fck kareler ve gri ili\u015fkisel analiz kullan\u0131larak rezene k\u00f6k kabu\u011funun kimyasal bile\u015fenlerini taramak i\u00e7in UPLC-Orbitrap-MS\/MS ile birle\u015ftirildi. Rezene k\u00f6k\u00fc kabu\u011funun etkili bile\u015fenlerinin anti karaci\u011fer fibrozis etkisini ve mekanizmas\u0131n\u0131 do\u011frulamak i\u00e7in in vitro deneyler yap\u0131lm\u0131\u015f ve etnik t\u0131bb\u0131n ara\u015ft\u0131r\u0131lmas\u0131 ve geli\u015ftirilmesi i\u00e7in bilimsel temel sa\u011flanm\u0131\u015ft\u0131r.<\/p>\n

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Geleneksel \u00c7in t\u0131bb\u0131ndaki \u00e7oklu hedeflerin ve bile\u015fenlerin sinerjik etkileri ara\u015ft\u0131rmalarda s\u0131cak bir konu haline gelmi\u015ftir. Aktif bile\u015fenlerin incelenmesi ila\u00e7 ara\u015ft\u0131rmalar\u0131n\u0131n temelidir ve aktif bile\u015fenleri ve etki \u015fekilleri karma\u015f\u0131kl\u0131k ile karakterize edilir. 2002 y\u0131l\u0131nda Li Rong, geleneksel \u00c7in t\u0131bb\u0131 etkinli\u011finin incelenmesi i\u00e7in yeni bir ara\u015ft\u0131rma y\u00f6n\u00fcne i\u015faret eden spektral etki ili\u015fkisi teorisini \u00f6nermi\u015ftir. Rezene k\u00f6k\u00fc kabu\u011funun alkol ekstrakt\u0131n\u0131n ve farkl\u0131 ekstraktlar\u0131n\u0131n UPLC-Orbitrap-MS\/MS spektrumlar\u0131ndaki ortak piklerin ve bunlar\u0131n karaci\u011fer fibrozu kar\u015f\u0131t\u0131 etkilerinin \u00f6l\u00e7\u00fclmesine dayanan bu \u00e7al\u0131\u015fmada, rezene k\u00f6k\u00fc kabu\u011funun toplam iyon ak\u0131\u015f spektrumlar\u0131ndaki ortak pikler ile bunlar\u0131n karaci\u011fer fibrozu kar\u015f\u0131t\u0131 etkileri aras\u0131ndaki korelasyonu ara\u015ft\u0131rmak i\u00e7in k\u0131smi en k\u00fc\u00e7\u00fck kareler ve gri korelasyon analizi kullan\u0131lm\u0131\u015ft\u0131r. Bu, bile\u015fenlerin farmakolojik etkiye katk\u0131s\u0131n\u0131 b\u00fcy\u00fck \u00f6l\u00e7\u00fcde yans\u0131tabilir.
\nBu \u00e7al\u0131\u015fma rezene k\u00f6k\u00fc kabu\u011funun alkol ekstrakt\u0131, petrol eteri, etil asetat, n-b\u00fctanol ve su k\u0131s\u0131mlar\u0131na odaklanmaktad\u0131r. Rezene k\u00f6k\u00fc kabu\u011funun s\u0131v\u0131 kromatografi-k\u00fctle spektrometresi (LC-MS) spektrumunu olu\u015fturmak i\u00e7in y\u00fcksek performansl\u0131 s\u0131v\u0131 kromatografi-k\u00fctle spektrometresi analizi yap\u0131lm\u0131\u015ft\u0131r. Toplam 58 ortak pik pozitif ve negatif iyon modlar\u0131nda kalibre edilmi\u015f ve spektrumlar analiz edilmi\u015ftir. Her numunenin ortak pik alanlar\u0131n\u0131n farkl\u0131 oldu\u011fu g\u00f6r\u00fclebilir, bu da spektral verimlilik ili\u015fkisi ara\u015ft\u0131rmas\u0131 i\u00e7in kullan\u0131labilir. Spektral etki ili\u015fkisi analizi, 11 bile\u015fenin anti karaci\u011fer fibrozis etkisine \u00f6nemli \u00f6l\u00e7\u00fcde katk\u0131da bulundu\u011funu g\u00f6stermi\u015ftir (VIP>1 ve regresyon katsay\u0131s\u0131>0). Bunlar aras\u0131nda, literat\u00fcrde karaci\u011fer fibrozu kar\u015f\u0131t\u0131 etkileri oldu\u011fu bildirilen bile\u015fikler aras\u0131nda gallik asit, apigenin, kaempferol, kuersetin, skopoletin ve rhein bulunmaktad\u0131r ve rezene k\u00f6k\u00fc kabu\u011funun \u00e7ok bile\u015fenli ve \u00e7ok hedefli karaci\u011fer fibrozu kar\u015f\u0131t\u0131 etkilerinin \u00f6zelliklerini yans\u0131tmaktad\u0131r. Dihidrokamptotesin, dihidrokapsaisin ve skopolamin, rezene k\u00f6k\u00fc kabu\u011funda ilk kez bulunan nispeten y\u00fcksek i\u00e7erikli ve iyi anti karaci\u011fer fibrozis aktivitesine sahip bile\u015fiklerdir ve potansiyel kalite belirte\u00e7leri olabilirler. Bunlar aras\u0131nda dehidrokamelbin, akci\u011fer dokusunda TGF - \u03b2 1, Smad3 ve NF kB p65 ekspresyonunu azaltarak Echinococcus granulosus'un ikincil enfeksiyonunun neden oldu\u011fu fare akci\u011fer dokusu fibrozunu iyile\u015ftirebilir. Dihidrokapsaisin ve skopolaminin karaci\u011fer fibrozisini \u00f6nleyici etkileri hakk\u0131nda herhangi bir rapor bulunmamaktad\u0131r.
\nBcl-2 anti apoptotik gene aittir ve h\u00fccre ya\u015fam\u0131 ile \u00f6l\u00fcm\u00fcn\u00fcn koordine edilmesinde kilit bir fakt\u00f6rd\u00fcr, Bax ise pro apoptotik gene aittir ve Bcl-2 ailesinin pro apoptotik bir proteinidir. H\u00fccre apoptozunun \u00f6nemli bir efekt\u00f6r fakt\u00f6r\u00fc olan kaspaz3, apoptotik proteazlar\u0131n kaskad reaksiyonu i\u00e7in gerekli bir yoldur. Aktivasyonu, apoptozun geri d\u00f6n\u00fc\u015f\u00fc olmayan bir a\u015famaya girdi\u011fini g\u00f6sterir. Apoptozda Bax\/Bcl-2 oran\u0131, mitokondriyal yolla h\u00fccre apoptozunu \u00f6l\u00e7mek i\u00e7in \u00f6nemli bir g\u00f6stergedir. Bax\/Bcl-2 oran\u0131 artt\u0131\u011f\u0131nda apoptoz artar; tersi durumda ise apoptoz azal\u0131r. H\u00fccreler apoptotik sinyalleri alg\u0131lad\u0131klar\u0131nda, Bcl-2 ve Bax gibi apoptotik fakt\u00f6rlerin ekspresyonunu d\u00fczenleyerek Kaspaz-9'u (Caspase9) aktive edebilir, b\u00f6ylece Kaspaz3'\u00fc aktive edebilir ve Kaspaz ailesinin bir kaskad reaksiyonunu tetikleyerek h\u00fccre apoptozunu ind\u00fckleyebilirler. Bu \u00e7al\u0131\u015fma, dehidrokamptotesin ve dihidrokapsaisinin mitokondriyal fonksiyonu azaltabildi\u011fini ve aktive edilmi\u015f hepatik stellat h\u00fccrelerinde mitokondriyal membran potansiyeli dengesini bozabildi\u011fini, pro apoptotik fakt\u00f6r\u00fcn (Bax) b\u00fcy\u00fck \u00f6l\u00e7\u00fcde sal\u0131nmas\u0131na yol a\u00e7t\u0131\u011f\u0131n\u0131 ve sonu\u00e7ta h\u00fccre apoptozuna neden oldu\u011funu, hepatik stellat h\u00fccrelerinin \u00e7o\u011falmas\u0131n\u0131 azaltt\u0131\u011f\u0131n\u0131, h\u00fccre d\u0131\u015f\u0131 matris ve \u03b1 - d\u00fcz kas aktivat\u00f6r proteininin ekspresyonunu inhibe etti\u011fini ve b\u00f6ylece karaci\u011fer fibrozunu hafifletti\u011fini deneyler yoluyla do\u011frulam\u0131\u015ft\u0131r. Sonraki deneylerde, se\u00e7ilen monomerik bile\u015fikleri do\u011frulamak ve rezene k\u00f6k\u00fc kabu\u011fu monomerik bile\u015fiklerinin anti karaci\u011fer fibrozis mekanizmas\u0131n\u0131 mRNA ve protein seviyelerinde daha fazla ara\u015ft\u0131rmak i\u00e7in in vivo deneylerin yap\u0131lmas\u0131 gerekmektedir.
\n\u00d6zetle, bu \u00e7al\u0131\u015fmada rezene k\u00f6k\u00fc kabu\u011funun \u00e7ok bile\u015fenli ve \u00e7ok hedefli anti karaci\u011fer fibrozu etkilerinin \u00f6zelliklerini yans\u0131tan, anti karaci\u011fer fibrozunda rezene k\u00f6k\u00fc kabu\u011funun olas\u0131 bile\u015fenlerini ayd\u0131nlatmak i\u00e7in k\u0131smi en k\u00fc\u00e7\u00fck kareler ve gri korelasyon analizi ile birlikte UPLC Orbitrap MS\/MS teknolojisi kullan\u0131lm\u0131\u015ft\u0131r. Bu, geleneksel \u00c7in t\u0131bb\u0131 etkinli\u011finin maddi temelini a\u00e7\u0131kl\u0131\u011fa kavu\u015fturmak ve geleneksel \u00c7in t\u0131bb\u0131n\u0131n kalite standartlar\u0131n\u0131 iyile\u015ftirmek, etki mekanizmas\u0131n\u0131 ve klinik uygulamas\u0131n\u0131 daha iyi anlamak i\u00e7in referans sa\u011flamak a\u00e7\u0131s\u0131ndan b\u00fcy\u00fck \u00f6nem ta\u015f\u0131maktad\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

Screening of effective ingredients in fennel root bark for anti liver fibrosis based on spectral effect relationship and exploration of its mechanism Liver fibrosis is the main cause of liver cirrhosis and even liver cancer, and about 90% of liver cancer develops on the basis of liver fibrosis or cirrhosis. Therefore, the treatment of liver […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nScreening of effective ingredients in fennel root bark for anti liver fibrosis based on spectral effect relationship and exploration of its mechanism - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/fennel-root-bark\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Screening of effective ingredients in fennel root bark for anti liver fibrosis based on spectral effect relationship and exploration of its mechanism - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Screening of effective ingredients in fennel root bark for anti liver fibrosis based on spectral effect relationship and exploration of its mechanism Liver fibrosis is the main cause of liver cirrhosis and even liver cancer, and about 90% of liver cancer develops on the basis of liver fibrosis or cirrhosis. 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