{"id":4231,"date":"2024-08-04T08:55:39","date_gmt":"2024-08-04T08:55:39","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4231"},"modified":"2024-08-16T03:12:02","modified_gmt":"2024-08-16T03:12:02","slug":"chrysanthemum-stems-and-leaves","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/krizantem-saplari-ve-yapraklari\/","title":{"rendered":"Krizantem sap ve yapraklar\u0131ndan elde edilen toplam flavonoidlerdeki antioksidan maddelerin spektral etki ili\u015fkisine g\u00f6re taranmas\u0131 ve mekanizmas\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"

Krizantem sap ve yapraklar\u0131ndan elde edilen toplam flavonoidlerdeki antioksidan maddelerin spektral etki ili\u015fkisine g\u00f6re taranmas\u0131 ve mekanizmas\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131<\/h1>\n

Krizantemlerin uzun bir klinik uygulama ge\u00e7mi\u015fi vard\u0131r. Krizantemlerdeki aktif bile\u015fenler \u00fczerine ara\u015ft\u0131rmalar\u0131n s\u00fcrekli derinle\u015fmesiyle birlikte, krizantemlerle ilgili giderek daha fazla i\u015flenmi\u015f \u00fcr\u00fcn ortaya \u00e7\u0131kmaktad\u0131r. Bununla birlikte, krizantem hasad\u0131n\u0131n yan \u00fcr\u00fcnleri olan krizantem saplar\u0131 ve yapraklar\u0131 genellikle hayvan yemi olarak kullan\u0131l\u0131r veya at\u0131l\u0131r. \u015eu anda, derinlemesine ve sistematik bir ara\u015ft\u0131rma eksikli\u011fi bulunmaktad\u0131r. \u00d6nceki \u00e7al\u0131\u015fmalar krizantem sap ve yapraklar\u0131n\u0131n krizantem bile\u015fenlerine benzer flavonoidler, fenolik asitler, polisakkaritler, u\u00e7ucu ya\u011flar, n\u00fckleozitler ve amino asitler gibi kaynak bazl\u0131 kimyasal bile\u015fenler i\u00e7erdi\u011fini g\u00f6stermi\u015ftir. Ayr\u0131ca antioksidan, anti-enflamatuar, lipid d\u00fc\u015f\u00fcr\u00fcc\u00fc ve ba\u011f\u0131rsak fonksiyon bozuklu\u011funu iyile\u015ftirme gibi farmakolojik etkileri de vard\u0131r. G\u00fcn\u00fcm\u00fczde yap\u0131lan \u00e7al\u0131\u015fmalar, Chrysanthemum morifolium'un (TFCSL) sap ve yapraklar\u0131ndan elde edilen toplam flavonoidlerin iyi antibakteriyel ve serbest radikal \u00f6nleyici etkilere sahip oldu\u011funu g\u00f6stermi\u015ftir. Buna ek olarak, krizantem g\u00f6vde ve yaprak ekstreleri, insan karaci\u011fer h\u00fccrelerinde tert b\u00fctanol peroksit taraf\u0131ndan ind\u00fcklenen oksidatif stres \u00fczerinde de belirli bir koruyucu etkiye sahiptir. Bu nedenle, krizantem saplar\u0131 ve yapraklar\u0131, kaynak israf\u0131n\u0131 azaltmak i\u00e7in b\u00fcy\u00fck \u00f6nem ta\u015f\u0131yan toplam flavonoid aktif bile\u015fenler i\u00e7in ekstraksiyon malzemeleri olarak da kullan\u0131labilir.
\nGeleneksel \u00c7in t\u0131bb\u0131 spektrumu ile etkinlik aras\u0131ndaki ili\u015fkinin incelenmesi, geleneksel \u00c7in t\u0131bb\u0131ndaki her bir bile\u015fenin parmak izi spektrumunu farmakolojik sonu\u00e7larla ili\u015fkilendirmek, \u00e7e\u015fitli veri i\u015fleme modelleri arac\u0131l\u0131\u011f\u0131yla her bir bile\u015fenin farmakolojik etkiye katk\u0131 oran\u0131n\u0131 netle\u015ftirmek ve b\u00f6ylece farmakolojik etkiyle ilgili bile\u015fik gruplar\u0131n\u0131 belirlemektir. A\u011f farmakolojisi, hedef tahmini, etki mekanizmas\u0131 ve fizyolojik ve patolojik s\u00fcre\u00e7 analizine \u00e7apraz olarak uygulanan, ila\u00e7la ilgili hedefleri \u00e7oklu perspektiflerden belirleyen ve karma\u015f\u0131k hastal\u0131k mekanizmalar\u0131n\u0131 ortaya \u00e7\u0131karan yeni bir ila\u00e7 ara\u015ft\u0131rma modelidir. Molek\u00fcler yerle\u015ftirme, geleneksel \u00c7in t\u0131bb\u0131ndaki etken maddeler ve hedefler aras\u0131ndaki etkile\u015fimi ve konumu molek\u00fcler d\u00fczeyde ayd\u0131nlatan bilgisayar destekli bir ila\u00e7 tasar\u0131m\u0131 y\u00f6ntemidir. Vask\u00fcler endotel h\u00fccreleri, vask\u00fcler i\u015flevi d\u00fczenleyen aktif maddeler salg\u0131layarak dinamik dengeyi korur. Y\u00fcksek glikoz, insan umbilikal ven endotel h\u00fccrelerinde (HUVEC'ler) reaktif oksijen t\u00fcrlerinin \u00fcretiminde art\u0131\u015fa neden olarak oksidatif strese ve fonksiyonel bozukluklara yol a\u00e7abilir. Malondialdehit (MDA) ve s\u00fcperoksit dismutaz (SOD) seviyelerinin e\u015f zamanl\u0131 olarak \u00f6l\u00e7\u00fclmesi, vask\u00fcler endotel h\u00fccrelerindeki oksidatif stres durumunu daha do\u011fru bir \u015fekilde yans\u0131tabilir. Bu \u00e7al\u0131\u015fma, malzeme temelini taramak i\u00e7in farkl\u0131 TFCSL partilerinin parmak izi spektrumlar\u0131n\u0131 olu\u015fturarak ortak pikler ve antioksidan stres aktivasyonu aras\u0131ndaki korelasyonu ara\u015ft\u0131rm\u0131\u015ft\u0131r; Hastal\u0131k hedeflerini taramak, geleneksel \u00c7in t\u0131bb\u0131 bile\u015fen hedef a\u011f\u0131 olu\u015fturmak ve temel antioksidan hedefleri ve mekanizmalar\u0131 tahmin etmek i\u00e7in Gen Kartlar\u0131 ve OMIM gibi veri tabanlar\u0131n\u0131 kullanmak; Krizantem hasad\u0131n\u0131n yan \u00fcr\u00fcnleri olarak krizantem sap\u0131 ve yapra\u011f\u0131n\u0131n kullan\u0131m de\u011ferini art\u0131rmak, sonraki a\u015famada krizantem kaynaklar\u0131n\u0131n kapsaml\u0131 geli\u015fimi ve kullan\u0131m\u0131 i\u00e7in teorik temel sa\u011flamak ve geleneksel \u00c7in t\u0131bb\u0131n\u0131n kaynak kullan\u0131m\u0131n\u0131 iyile\u015ftirmek amac\u0131yla k\u00fc\u00e7\u00fck molek\u00fcller ve proteinler aras\u0131ndaki etkile\u015fimleri ke\u015ffetmek i\u00e7in molek\u00fcler yerle\u015ftirmeyi birle\u015ftirmek.<\/p>\n

 <\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"Bu \u00e7al\u0131\u015fmada 12 parti TFCSL numunesi i\u00e7in HPLC parmak izi spektrumlar\u0131 olu\u015fturulmu\u015f, 12 ortak pik belirlenmi\u015f ve standart numuneler kullan\u0131larak 9 pik tan\u0131mlanm\u0131\u015ft\u0131r. Y\u00fcksek \u015feker ko\u015fullar\u0131 alt\u0131nda, HUVEC hasar g\u00f6rebilir ve fizyolojik fakt\u00f6r salg\u0131lanmas\u0131 bozulabilir, bu da h\u00fccre apoptozunu te\u015fvik ederek, s\u00fcpernatanttaki LDH ve MDA i\u00e7eri\u011fini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rarak ve SOD aktivitesini \u00f6nemli \u00f6l\u00e7\u00fcde azaltarak kendini g\u00f6sterir. TFCSL ile tedaviden sonra, h\u00fccre apoptozunu \u00f6nemli \u00f6l\u00e7\u00fcde inhibe etmenin yan\u0131 s\u0131ra, oksidatif stresle ilgili fakt\u00f6rlerin seviyelerini de iyile\u015ftirebilir ve HUVEC'in normal fizyolojik i\u015flevini koruyabilir. Her bir ortak pik ile antioksidan aktivite aras\u0131ndaki korelasyonu analiz etmek i\u00e7in gri ili\u015fkisel analiz ve k\u0131smi en k\u00fc\u00e7\u00fck kareler regresyonu kullan\u0131larak, pik 5 (apigenin 7-O - \u03b2 - D-glukozit), pik 6 (izoklorojenik asit C) ve pik 7'nin (vanilin 7-O - \u03b2 - D-glukozit) TFCSL antioksidan stresinin maddi temeli oldu\u011fu tahmin edilmektedir.
\nSpektrum etki korelasyon analizinden elde edilen \u00fc\u00e7 bile\u015fenin antioksidan stres etkileri \u00fczerinde a\u011f farmakolojisi analizi yap\u0131lm\u0131\u015f ve bir etken madde hedef a\u011f\u0131 olu\u015fturulmu\u015ftur. TNF ve CASP3 potansiyel anahtar hedefler olarak taranm\u0131\u015ft\u0131r. KEGG zenginle\u015ftirme analizi, krizantem sap ve yapraklar\u0131ndaki toplam flavonoidlerin antioksidan aktivitesinin TNF yolu, MPKA yolu, IL-17 sinyal yolu ve di\u011fer yollarla ili\u015fkili olabilece\u011fini g\u00f6stermi\u015ftir. GO zenginle\u015ftirme analizi, protein kinaz aktivitesi, ATP ba\u011flanmas\u0131, enzim ba\u011flanmas\u0131 gibi molek\u00fcler i\u015flevlerin yan\u0131 s\u0131ra sinyal iletimi ve h\u00fccresel biyolojik s\u00fcre\u00e7lerin d\u00fczenlenmesi yoluyla antioksidan stres etkileri g\u00f6sterebilir. TNF, TNF - \u03b1'n\u0131n vazodilatasyonu uyarabildi\u011fi ve endotel h\u00fccre ge\u00e7irgenli\u011fini art\u0131rabildi\u011fi \u00f6nemli pro-enflamatuar fakt\u00f6rlerden biridir. Apigenin 7-O - \u03b2 - D-glukozit, MAPK yolunu inhibe ederek ve TNF - \u03b1 ekspresyonunu d\u00fczenleyerek dekstran s\u00fclfat kaynakl\u0131 koliti hafifletebilir; Modern farmakolojik \u00e7al\u0131\u015fmalar, izoklorojenik asit C'nin makrofajlarda TNF - \u03b1 ekspresyonunu ve transkripsiyonunu azaltabilece\u011fini g\u00f6stermi\u015ftir; CASP, apoptozda \u00f6nemli bir rol oynaman\u0131n yan\u0131 s\u0131ra, pro-enflamatuar sitokinlerin \u00fcretimini de te\u015fvik eder. Vanilin 7-O - \u03b2 - D-glukozit, serum i\u00e7ermeyen ko\u015fullar alt\u0131nda vask\u00fcler endotel h\u00fccreleri \u00fczerinde koruyucu bir etkiye sahiptir, h\u00fccre i\u00e7i ROS seviyelerini azalt\u0131r ve CASP3 seviyelerini a\u015fa\u011f\u0131 do\u011fru d\u00fczenler.
\nDiscovery Studio yaz\u0131l\u0131m\u0131n\u0131n molek\u00fcler kenetlenme sonu\u00e7lar\u0131n\u0131n analiz edilmesi ve kar\u015f\u0131la\u015ft\u0131r\u0131lmas\u0131yla, TFCSL'deki \u00fc\u00e7 ana aktif bile\u015fenin TNF ve CASP3 ile nispeten kararl\u0131 ba\u011flanma aktivitesine sahip oldu\u011fu bulunmu\u015ftur. Daha ileri tarama ve docking sonu\u00e7lar\u0131 sayesinde, \u00fc\u00e7 bile\u015fen ile TNF ve CASP3 proteinleri aras\u0131ndaki etkile\u015fimde yer alan kal\u0131nt\u0131lar\u0131n \u00e7o\u011funun ayn\u0131 oldu\u011fu bulunmu\u015ftur. Bunlar aras\u0131nda, birden fazla resept\u00f6r etkile\u015fimi t\u00fcr\u00fc ve g\u00fc\u00e7l\u00fc etkileri olan ortak kal\u0131nt\u0131lar esas olarak SER9 LYS11\u3001PRO12\u3001ALA156\u3001ASP10\u3001LYS11\uff0c Resept\u00f6rlerin aktif b\u00f6lge kal\u0131nt\u0131lar\u0131 olabilece\u011fi sonucuna var\u0131lm\u0131\u015ft\u0131r.
\nKrizantem kaynaklar\u0131 \u00c7in'de yayg\u0131n olarak bulunmaktad\u0131r, ancak \u015fu anda krizantemlerin geli\u015ftirilmesi ve kullan\u0131m\u0131nda eksiklikler vard\u0131r. K\u00f6kler, g\u00f6vdeler, yapraklar vb. gibi t\u0131bbi olmayan di\u011fer k\u0131s\u0131mlar hakk\u0131nda nispeten az say\u0131da ara\u015ft\u0131rma raporu bulunmaktad\u0131r. Krizantemin t\u0131bbi olmayan k\u0131s\u0131mlar\u0131n\u0131n kimyasal bile\u015fimi, \u00f6nemli biyolojik aktiviteye sahip krizantem ile son derece benzerdir. Bununla birlikte, derinlemesine ara\u015ft\u0131rma eksikli\u011fi nedeniyle, bu etkili bile\u015fenler uygun \u015fekilde kullan\u0131lmam\u0131\u015f ve geli\u015ftirilmemi\u015ftir. Bu \u00e7al\u0131\u015fma, krizantem sap ve yapraklar\u0131n\u0131n geli\u015ftirilmesi, kullan\u0131m\u0131 ve sanayile\u015ftirilmesi i\u00e7in bilimsel temel ve referans sa\u011flamak amac\u0131yla, TFCSL'nin antioksidan aktivasyonu \u00fczerine \u00f6n ara\u015ft\u0131rma ve ke\u015fif yapm\u0131\u015f, ard\u0131ndan belirsiz ortak zirvelerin yap\u0131sal analizini yapm\u0131\u015f ve farmakolojik deneyler yoluyla i\u015flevlerini daha da geli\u015ftirmi\u015ftir.<\/p>","protected":false},"excerpt":{"rendered":"

Screening of antioxidant substances in total flavonoids from chrysanthemum stems and leaves based on spectral effect relationship and exploration of its mechanism Chrysanthemums have a long history of clinical application. With the continuous deepening of research on the active ingredients in chrysanthemums, there are more and more processed products related to chrysanthemums. However, chrysanthemum stems […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nScreening of antioxidant substances in total flavonoids from chrysanthemum stems and leaves based on spectral effect relationship and exploration of its mechanism - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/krizantem-saplari-ve-yapraklari\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Screening of antioxidant substances in total flavonoids from chrysanthemum stems and leaves based on spectral effect relationship and exploration of its mechanism - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Screening of antioxidant substances in total flavonoids from chrysanthemum stems and leaves based on spectral effect relationship and exploration of its mechanism Chrysanthemums have a long history of clinical application. 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However, chrysanthemum stems […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/tr\/krizantem-saplari-ve-yapraklari\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-04T08:55:39+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-08-16T03:12:02+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-41.png\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/chrysanthemum-stems-and-leaves\/\",\"url\":\"https:\/\/longchangextracts.com\/chrysanthemum-stems-and-leaves\/\",\"name\":\"Screening of antioxidant substances in total flavonoids from chrysanthemum stems and leaves based on spectral effect relationship and exploration of its mechanism - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangextracts.com\/chrysanthemum-stems-and-leaves\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangextracts.com\/chrysanthemum-stems-and-leaves\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-41.png\",\"datePublished\":\"2024-08-04T08:55:39+00:00\",\"dateModified\":\"2024-08-16T03:12:02+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/chrysanthemum-stems-and-leaves\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/chrysanthemum-stems-and-leaves\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/chrysanthemum-stems-and-leaves\/#primaryimage\",\"url\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-41.png\",\"contentUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-41.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/chrysanthemum-stems-and-leaves\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Screening of antioxidant substances in total flavonoids from chrysanthemum stems and leaves based on spectral effect relationship and exploration of its mechanism\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Krizantem sap ve yapraklar\u0131ndan elde edilen toplam flavonoidlerdeki antioksidan maddelerin spektral etki ili\u015fkisine dayal\u0131 olarak taranmas\u0131 ve mekanizmas\u0131n\u0131n ara\u015ft\u0131r\u0131lmas\u0131 - \u00c7in Kimya \u00dcreticisi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/tr\/krizantem-saplari-ve-yapraklari\/","og_locale":"tr_TR","og_type":"article","og_title":"Screening of antioxidant substances in total flavonoids from chrysanthemum stems and leaves based on spectral effect relationship and exploration of its mechanism - China Chemical Manufacturer","og_description":"Screening of antioxidant substances in total flavonoids from chrysanthemum stems and leaves based on spectral effect relationship and exploration of its mechanism Chrysanthemums have a long history of clinical application. With the continuous deepening of research on the active ingredients in chrysanthemums, there are more and more processed products related to chrysanthemums. 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