{"id":4220,"date":"2024-08-04T08:53:16","date_gmt":"2024-08-04T08:53:16","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4220"},"modified":"2024-08-04T08:53:16","modified_gmt":"2024-08-04T08:53:16","slug":"astragalus-membranaceus","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/astragalus-membranaceus\/","title":{"rendered":"A\u011f farmakolojisi, molek\u00fcler yerle\u015ftirme teknolojisi ve deneysel do\u011frulamaya dayal\u0131 olarak iskemik hipoksik ensefalopatinin tedavisinde Huangqi ekstrakt\u0131n\u0131n mekanizmas\u0131 \u00fczerine \u00e7al\u0131\u015fma"},"content":{"rendered":"

A\u011f farmakolojisi, molek\u00fcler yerle\u015ftirme teknolojisi ve deneysel do\u011frulamaya dayal\u0131 olarak iskemik hipoksik ensefalopatinin tedavisinde Huangqi ekstrakt\u0131n\u0131n mekanizmas\u0131 \u00fczerine \u00e7al\u0131\u015fma
\nNeonatal iskemik ensefalopati (HIE), yenido\u011fan ve bebeklerin sinir b\u00fcy\u00fcmesini ve geli\u015fimini etkileyen bir hastal\u0131k t\u00fcr\u00fcd\u00fcr. Hayatta kalanlar genellikle geride \u00e7e\u015fitli n\u00f6rolojik sekeller b\u0131rak\u0131r ve bu da etkilenen \u00e7ocuklar ve aileleri \u00fczerinde a\u011f\u0131r bir y\u00fck olu\u015fturur. \u015eu anda klinik uygulamada HIE'yi tedavi etmek i\u00e7in \u00f6zel bir ila\u00e7 bulunmamaktad\u0131r ve HIE'nin patofizyolojik mekanizmalar\u0131n\u0131 incelemek, daha etkili tedavi planlar\u0131 bulmak i\u00e7in b\u00fcy\u00fck \u00f6nem ta\u015f\u0131maktad\u0131r. Ara\u015ft\u0131rmalar oksidatif stres, kalsiyum ak\u0131\u015f\u0131, serbest radikal \u00fcretimi, asidoz, iyon dengesizli\u011fi, enflamasyon, apoptoz, otofaji, nekroz ve di\u011fer fakt\u00f6rlerin hepsinin HIE patogenezinde \u00f6nemli rol oynad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Geleneksel \u00c7in t\u0131bb\u0131 alan\u0131nda, Huangqi ve preparatlar\u0131n\u0131n HIE tedavisinde iyi etkiler g\u00f6sterdi\u011fi bildirilmi\u015ftir. Modern farmakoloji, Huangqi \u00f6z\u00fct\u00fcn\u00fcn serbest oksijen radikallerini temizleme, enfeksiyonu \u00f6nleme ve vask\u00fcler endoteli koruma etkilerine sahip oldu\u011funu do\u011frulam\u0131\u015ft\u0131r. Klinik uygulamada kardiyovask\u00fcler ve serebrovask\u00fcler hastal\u0131klar\u0131 tedavi etmek i\u00e7in yayg\u0131n olarak kullan\u0131lmaktad\u0131r. Bu \u00e7al\u0131\u015fma, Huangqi ekstresinin HIE tedavisindeki etki mekanizmas\u0131n\u0131 a\u011f farmakolojisi ve molek\u00fcler yerle\u015ftirme teknikleri arac\u0131l\u0131\u011f\u0131yla analiz etmeyi ve klinik uygulamay\u0131 te\u015fvik etmek i\u00e7in referans sa\u011flamay\u0131 ama\u00e7lamaktad\u0131r.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"<\/p>\n

H\u0130E'nin ana patofizyolojik mekanizmas\u0131 beyin dokusunun iskemi ve hipoksisidir. Beyin dokusu iskemisi ve hipoksisi, temel olarak h\u00fccre apoptozu, enflamatuar yan\u0131t ve oksidatif stres yan\u0131t\u0131 dahil olmak \u00fczere bir dizi patolojik ve fizyolojik de\u011fi\u015fikli\u011fe neden olabilir. \u0130skemik ve hipoksik sinir hasar\u0131n\u0131n farkl\u0131 a\u015famalar\u0131, yukar\u0131da bahsedilen \u00fc\u00e7 fizyolojik de\u011fi\u015fiklik aras\u0131ndaki etkile\u015fimden kaynaklan\u0131r. Neonatal H\u0130E'nin tedavisi klinik ara\u015ft\u0131rmalarda her zaman s\u0131cak ve zor bir konu olmu\u015ftur. Geleneksel \"\u00fc\u00e7 destek\" ve \"\u00fc\u00e7 semptomatik\" tedavi, gebelik ya\u015f\u0131, zaman ve t\u0131bbi olanaklar gibi \u00e7e\u015fitli fakt\u00f6rlerle s\u0131n\u0131rl\u0131d\u0131r ve H\u0130E i\u00e7in s\u0131n\u0131rl\u0131 terap\u00f6tik etkilerle sonu\u00e7lan\u0131r. Klinik olarak, HIE tedavisi i\u00e7in tamamlay\u0131c\u0131 veya alternatif tedaviler i\u00e7in acil bir aray\u0131\u015f olmu\u015ftur. Geleneksel bir \u00c7in ilac\u0131 olan Huangqi, son y\u0131llarda Huangqi'deki aktif bile\u015fenlerin etkileri \u00fczerine yap\u0131lan modern farmakolojik ara\u015ft\u0131rmalar sayesinde \u00f6nemli ilerlemeler kaydetmi\u015ftir. Ara\u015ft\u0131rmalar, Astragalus membranaceus'un v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131n\u0131 art\u0131rma, hipoksi ve oksidatif strese direnme ve vask\u00fcler endotel fonksiyonunu iyile\u015ftirme etkilerine sahip oldu\u011funu g\u00f6stermi\u015ftir. Hayvan deneyleri, Astragalus membranaceus'un s\u0131\u00e7an beyin dokusunda B-lenfot\u00fcm\u00f6r-2 proteininin ekspresyon seviyesini y\u00fckseltebildi\u011fini, n\u00f6ronal apoptozu inhibe edebildi\u011fini ve iskemi ve hipoksinin neden oldu\u011fu beyin hasar\u0131n\u0131 hafifletebildi\u011fini g\u00f6stermi\u015ftir. Bununla birlikte, Astragalus membranaceus'un klinik uygulamadaki ana aktif bile\u015fenleri ve etki mekanizmalar\u0131 hen\u00fcz net de\u011fildir. A\u011f farmakolojisi ve molek\u00fcler yerle\u015ftirme, b\u00fcy\u00fck veri tabanlar\u0131na dayal\u0131 farmakolojik ara\u015ft\u0131rmalar i\u00e7in son y\u0131llarda ortaya \u00e7\u0131kan teknolojilerdir. B\u00fcy\u00fck veri sayesinde, ilgili ila\u00e7lar\u0131n ana etken maddeleri ve hedefleri elde edilir ve ila\u00e7lar\u0131n spesifik etki mekanizmas\u0131n\u0131 analiz etmek i\u00e7in hastal\u0131k hedefleriyle molek\u00fcler yerle\u015ftirme yap\u0131l\u0131r. TCMSP veri taban\u0131na g\u00f6re, Huangqi \u00f6z\u00fct\u00fcn\u00fcn toplam 70 aktif bile\u015feni elde edilmi\u015ftir. Toplam 350 ilgili hedef elde edildi ve yinelenen hedefler ve gen ek a\u00e7\u0131klamalar\u0131 \u00e7\u0131kar\u0131ld\u0131ktan sonra, \"Huangqi Ekstresi\" i\u00e7indeki aktif bile\u015fenlerin 120 hedefi nihayet elde edildi.
\nTopolojik analiz yoluyla elde edilen bile\u015fik a\u011f\u0131 hedef haritas\u0131, Astragalus membranaceus'un HIE tedavisindeki ana aktif bile\u015fenlerinin 4-hidroksisinnamik asit, cis aviyonik asit, astragalosid, hederagenin ve galangin oldu\u011funu g\u00f6stermektedir. 4-hidroksisinnamik asidin serbest oksijen radikallerini temizleme yetene\u011fine sahip oldu\u011fu kan\u0131tlanm\u0131\u015ft\u0131r. Hayvan deneyleri, 4-hidroksisinnamik asidin s\u0131\u00e7anlarda n\u00f6ropatik a\u011fr\u0131y\u0131 hafifletebildi\u011fini g\u00f6stermi\u015ftir. Xizang'da yap\u0131lan bir \u00e7al\u0131\u015fma, cis asitretinin v\u00fccudun oksijen doygunlu\u011funu etkili bir \u015fekilde art\u0131rabildi\u011fini ve hipoksinin neden oldu\u011fu olumsuz semptomlar\u0131 hafifletebildi\u011fini g\u00f6stermi\u015ftir; Ve aktif bile\u015fen v\u00fccutta astragaloside IV'\u00fcn emilimini te\u015fvik edebilir. Astragaloside IV kapsaml\u0131 bir \u015fekilde incelenmi\u015f ve anti-enflamatuar, anti apoptotik ve imm\u00fcnomod\u00fclat\u00f6r biyolojik aktivitelere sahip oldu\u011fu kan\u0131tlanm\u0131\u015ft\u0131r, bu da onu \u00f6nemli bir n\u00f6roprotektif ajan haline getirmektedir. Astragaloside g\u00fcl a\u011fac\u0131 glikozidi, Astragalus membranaceus'tan izole edilen ve insan trombosit kaynakl\u0131 b\u00fcy\u00fcme fakt\u00f6r\u00fc BB (PDGF-BB) stim\u00fclasyonu ile ind\u00fcklenen h\u00fccre d\u0131\u015f\u0131 d\u00fczenlenmi\u015f protein kinazlar\u0131n 1\/2 (ERK1\/2) aktivasyonunu inhibe edebilen ve mitojen aktive edici protein (MAP) kinaz\u0131n fosforilasyonunu inhibe edebilen bir bile\u015fiktir; Ayr\u0131ca ERK1\/2MAP kinaz kaskad yolunu bask\u0131layarak vask\u00fcler d\u00fcz kas h\u00fccrelerinin PDGF-BB ile ind\u00fcklenen proliferasyonunu inhibe edebilir. A\u011f farmakolojisi \u00e7al\u0131\u015fmalar\u0131, Huangqi'nin aktif bile\u015feni olan Hualiangjiangsu'nun PDK Akt sinyal yolu, t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc ve MAPK sinyal yolu arac\u0131l\u0131\u011f\u0131yla diz osteoartriti \u00fczerinde terap\u00f6tik etkiler g\u00f6sterebilece\u011fini g\u00f6stermi\u015ftir.
\nHIE'nin 242 hedefi ile 120 hedefin e\u015fle\u015ftirilmesinden sonra 18 potansiyel hedef elde edilmi\u015ftir. Daha ileri PPI a\u011f analizi, NOS2, PTGS2, SOD1, MAPK4 ve CASP8'in HIE tedavisinde Huangqi'nin temel hedefleri oldu\u011funu ortaya koymu\u015ftur. Enflamasyon, HIE'nin \u00f6nemli bir patojenik fakt\u00f6r\u00fc olarak kabul edilir ve b\u00fcy\u00fck miktarda enflamatuar fakt\u00f6r, n\u00f6ronal h\u00fccrelerin apoptozunu ve nekrozunu h\u0131zland\u0131rabilir. NOS2, merkezi ve periferik sinir sistemlerinin n\u00f6ral dokular\u0131nda nitrik oksit \u00fcretimini te\u015fvik edebilir ve inflamasyon ve oksidatif stres yan\u0131tlar\u0131na kat\u0131labilir. Hayvan deneyleri, s\u0131\u00e7an NOS2 geninin devre d\u0131\u015f\u0131 b\u0131rak\u0131lmas\u0131n\u0131n Rac1 sentezini inhibe edebilece\u011fini ve b\u00f6ylece t\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc alfan\u0131n pro-inflamatuar etkisini bask\u0131layabilece\u011fini g\u00f6stermi\u015ftir. SOD1'in ana i\u015flevi v\u00fccutta antioksidan etkiler g\u00f6stermektir. SOD1, h\u00fccrelerde hidrojen peroksitin par\u00e7alanmas\u0131n\u0131 te\u015fvik edebildi\u011fi, serbest oksijen radikallerinin \u00fcretimini azaltabildi\u011fi ve v\u00fccudun oksidatif antioksidan sisteminin dengesini koruyabildi\u011fi i\u00e7in v\u00fccudun oksidatif stres tepkisinde \u00f6nemli bir rol oynar. \u0130n vitro h\u00fccre deneyleri, PTGS2'nin a\u015f\u0131r\u0131 ekspresyonunun glikoz yoksunlu\u011fu modeli alt\u0131nda PC12 h\u00fccrelerinde h\u00fccre hasar\u0131n\u0131 \u015fiddetlendirebilece\u011fini g\u00f6stermi\u015ftir. Lokal iskemi ve hipoksi meydana geldi\u011finde ve sitokinleri serbest b\u0131rakt\u0131\u011f\u0131nda, MAPK4 yolunu aktive edebilir, ba\u011f\u0131\u015f\u0131kl\u0131k h\u00fccrelerini pro-enflamatuar sitokinleri serbest b\u0131rakmak ve lokal enflamatuar reaksiyonlar\u0131 \u015fiddetlendirmek i\u00e7in daha fazla uyarabilir. CASP8, h\u00fccre apoptozu ve nekrotik apoptoz i\u00e7in kilit bir d\u00fczenleyici fakt\u00f6r olmas\u0131n\u0131n yan\u0131 s\u0131ra dimerizasyonu ve enzim aktivitesi yoluyla enflamatuar yan\u0131t\u0131n d\u00fczenlenmesinde kilit bir fakt\u00f6rd\u00fcr. \u0130\u00e7eri\u011findeki bir art\u0131\u015f, yerel enflamatuar yan\u0131t\u0131n artt\u0131\u011f\u0131n\u0131 g\u00f6sterir. Yukar\u0131daki analizden, Astragalus membranaceus'un ana aktif bile\u015fenlerinin yukar\u0131da belirtilen hedeflere etki ederek HIE \u00fczerindeki terap\u00f6tik etkilerini g\u00f6sterdi\u011fini ve biyolojik s\u00fcre\u00e7lerinin enflamatuar reaksiyonlar\u0131, oksidatif stres h\u00fccrelerini, hasar onar\u0131m\u0131n\u0131 vb. i\u00e7erebilece\u011fini g\u00f6rebiliriz.
\nMolek\u00fcler yerle\u015ftirme sonu\u00e7lar\u0131, Astragalus membranaceus'taki \u00fc\u00e7 aktif bile\u015fenin, 4-hidroksisinnamik asit, cis aviyonik asit ve astragalosidin, HIE \u00fczerinde terap\u00f6tik etkiler g\u00f6stermek i\u00e7in esas olarak hidrofobik veya hidrojen ba\u011f\u0131na dayanan temel hedeflerle iyi ba\u011flanma aktivitesine sahip oldu\u011funu g\u00f6stermi\u015ftir. Ba\u011flanma enerjisi a\u00e7\u0131s\u0131ndan, SOD1 ile Astragalus membranaceus g\u00fcl a\u011fac\u0131 glikozidi aras\u0131ndaki en d\u00fc\u015f\u00fck ba\u011flanma enerjisi -8,9 kcal\/mol'd\u00fcr. Hayvan deneyi do\u011frulama sonu\u00e7lar\u0131, tedavi grubu s\u0131\u00e7anlar\u0131n hipokamp\u00fcs\u00fcndeki NOS2 ve PTGS2 proteinlerinin ekspresyon seviyelerinin model grubundakilerden daha d\u00fc\u015f\u00fck oldu\u011funu ve SOD1 proteininin ekspresyon seviyesinin model grubundakinden daha y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir. Sham cerrahi grubu s\u0131\u00e7anlar\u0131n hipokamp\u00fcs\u00fcndeki NOS2 ve PTGS2 proteinlerinin ekspresyon seviyeleri tedavi grubu ve model grubundakilerden daha d\u00fc\u015f\u00fckt\u00fc ve SOD1'in ekspresyon seviyesi tedavi grubu ve model grubundakinden daha y\u00fcksekti, bu da Huangqi ekstrakt\u0131n\u0131n HIE tedavisindeki g\u00fcvenilir rol\u00fcn\u00fc do\u011frulamaktad\u0131r. \u0130lgili \u00e7al\u0131\u015fmalar astragalus saponinlerinin Nrf2\/HO sinyal yolunu aktive edebildi\u011fini, a\u015fa\u011f\u0131 y\u00f6nl\u00fc antioksidan gen HO-1'in ekspresyonunu yukar\u0131 y\u00f6nl\u00fc d\u00fczenleyebildi\u011fini, nitrik oksit \u00fcretimini inhibe edebildi\u011fini, SOD aktivitesini art\u0131rabildi\u011fini ve beyin dokusunun antioksidan kapasitesini geli\u015ftirebildi\u011fini g\u00f6stermi\u015ftir. Modern farmakoloji, Huangqi'nin serbest radikalleri temizlemedeki g\u00fc\u00e7l\u00fc yetene\u011finin yan\u0131 s\u0131ra, serebral iskemi-reperf\u00fczyon s\u0131ras\u0131nda trombosit aktivitesini azaltabilen, siklooksijenaz-2 ekspresyonunu inhibe edebilen ve serebral iskemi-reperf\u00fczyon hasar\u0131n\u0131 hafifletebilen flavonoidler i\u00e7erdi\u011fini de do\u011frulam\u0131\u015ft\u0131r.
\n\u00d6zetle, bu makalede HIE tedavisinde Astragalus membranaceus ekstrakt\u0131ndaki ana aktif bile\u015fenlerin mekanizmas\u0131n\u0131 analiz etmek i\u00e7in a\u011f farmakolojisi ve molek\u00fcler yerle\u015ftirme teknolojisi kullan\u0131lm\u0131\u015ft\u0131r. Astragalus membranaceus ekstrakt\u0131n\u0131n HIE tedavisindeki \u00fc\u00e7 ana bile\u015feninin, HIE \u00fczerindeki terap\u00f6tik etkilerini g\u00f6stermek i\u00e7in NOS2, PTGS2, SOD1, MAPK4 ve CASP8 gibi kilit hedefler \u00fczerinde etkili olan 4-hidroksisinnamik asit, cis aviyonik asit ve Astragalus membranaceus g\u00fcl a\u011fac\u0131 glikozidi oldu\u011fu sonucuna var\u0131lm\u0131\u015ft\u0131r. A\u011f farmakolojisi analizi de bu s\u00fcrecin birden fazla bile\u015fen, hedef ve yolun sinerjik etkisinin bir sonucu oldu\u011funu do\u011frulam\u0131\u015ft\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the mechanism of Huangqi extract in treating ischemic hypoxic encephalopathy based on network pharmacology, molecular docking technology, and experimental verification Neonatal ischemic encephalopathy (HIE) is a type of disease that affects the nerve growth and development of newborns and infants. Survivors often leave behind various neurological sequelae, which impose a heavy burden on […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the mechanism of Huangqi extract in treating ischemic hypoxic encephalopathy based on network pharmacology, molecular docking technology, and experimental verification - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/astragalus-membranaceus\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the mechanism of Huangqi extract in treating ischemic hypoxic encephalopathy based on network pharmacology, molecular docking technology, and experimental verification - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the mechanism of Huangqi extract in treating ischemic hypoxic encephalopathy based on network pharmacology, molecular docking technology, and experimental verification Neonatal ischemic encephalopathy (HIE) is a type of disease that affects the nerve growth and development of newborns and infants. Survivors often leave behind various neurological sequelae, which impose a heavy burden on […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/tr\/astragalus-membranaceus\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-04T08:53:16+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-40.png\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/astragalus-membranaceus\/\",\"url\":\"https:\/\/longchangextracts.com\/astragalus-membranaceus\/\",\"name\":\"Study on the mechanism of Huangqi extract in treating ischemic hypoxic encephalopathy based on network pharmacology, molecular docking technology, and experimental verification - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangextracts.com\/astragalus-membranaceus\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangextracts.com\/astragalus-membranaceus\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-40.png\",\"datePublished\":\"2024-08-04T08:53:16+00:00\",\"dateModified\":\"2024-08-04T08:53:16+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/astragalus-membranaceus\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/astragalus-membranaceus\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/astragalus-membranaceus\/#primaryimage\",\"url\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-40.png\",\"contentUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-40.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/astragalus-membranaceus\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Study on the mechanism of Huangqi extract in treating ischemic hypoxic encephalopathy based on network pharmacology, molecular docking technology, and experimental verification\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"A\u011f farmakolojisi, molek\u00fcler yerle\u015ftirme teknolojisi ve deneysel do\u011frulamaya dayal\u0131 olarak iskemik hipoksik ensefalopatinin tedavisinde Huangqi ekstrakt\u0131n\u0131n mekanizmas\u0131 \u00fczerine \u00e7al\u0131\u015fma - China Chemical Manufacturer","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/tr\/astragalus-membranaceus\/","og_locale":"tr_TR","og_type":"article","og_title":"Study on the mechanism of Huangqi extract in treating ischemic hypoxic encephalopathy based on network pharmacology, molecular docking technology, and experimental verification - China Chemical Manufacturer","og_description":"Study on the mechanism of Huangqi extract in treating ischemic hypoxic encephalopathy based on network pharmacology, molecular docking technology, and experimental verification Neonatal ischemic encephalopathy (HIE) is a type of disease that affects the nerve growth and development of newborns and infants. Survivors often leave behind various neurological sequelae, which impose a heavy burden on […]","og_url":"https:\/\/longchangextracts.com\/tr\/astragalus-membranaceus\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-04T08:53:16+00:00","og_image":[{"url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-40.png"}],"author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"longcha9","Tahmini okuma s\u00fcresi":"8 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/astragalus-membranaceus\/","url":"https:\/\/longchangextracts.com\/astragalus-membranaceus\/","name":"A\u011f farmakolojisi, molek\u00fcler yerle\u015ftirme teknolojisi ve deneysel do\u011frulamaya dayal\u0131 olarak iskemik hipoksik ensefalopatinin tedavisinde Huangqi ekstrakt\u0131n\u0131n mekanizmas\u0131 \u00fczerine \u00e7al\u0131\u015fma - China Chemical Manufacturer","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangextracts.com\/astragalus-membranaceus\/#primaryimage"},"image":{"@id":"https:\/\/longchangextracts.com\/astragalus-membranaceus\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-40.png","datePublished":"2024-08-04T08:53:16+00:00","dateModified":"2024-08-04T08:53:16+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/astragalus-membranaceus\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/astragalus-membranaceus\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/astragalus-membranaceus\/#primaryimage","url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-40.png","contentUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-40.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/astragalus-membranaceus\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Study on the mechanism of Huangqi extract in treating ischemic hypoxic encephalopathy based on network pharmacology, molecular docking technology, and experimental verification"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"\u00c7in Kimyasal \u00dcreticisi","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"tr"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/4220"}],"collection":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/comments?post=4220"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/4220\/revisions"}],"predecessor-version":[{"id":4230,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/4220\/revisions\/4230"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/media?parent=4220"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/categories?post=4220"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/tags?post=4220"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}