{"id":4171,"date":"2024-08-04T08:45:01","date_gmt":"2024-08-04T08:45:01","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4171"},"modified":"2024-08-04T08:45:01","modified_gmt":"2024-08-04T08:45:01","slug":"18-%ce%b2-glycyrrhetinic-acid","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/18-%ce%b2-glycyrrhetinic-acid\/","title":{"rendered":"18 \u03b2 - glisiretinik asit, PGK1 glikoliz yolu arac\u0131l\u0131\u011f\u0131yla oxLDL kaynakl\u0131 endotel h\u00fccre apoptozunu inhibe eder"},"content":{"rendered":"

18 \u03b2 - glisiretinik asit, PGK1 glikoliz yolu arac\u0131l\u0131\u011f\u0131yla oxLDL kaynakl\u0131 endotel h\u00fccre apoptozunu inhibe eder
\nAteroskleroz (AS), kardiyovask\u00fcler hastal\u0131klar\u0131n (KVH) ba\u015fl\u0131ca risk fakt\u00f6rlerinden biridir. \u0130nsan aortik endotel h\u00fccreleri (HAEC'ler) aterosklerotik lezyonlar\u0131n geli\u015fimi ile ili\u015fkilidir. Ayr\u0131ca, \u00f6nceki \u00e7al\u0131\u015fmalar HAEC'lerin anormal g\u00f6\u00e7\u00fc, proliferasyonu ve apoptozunun AS'nin ilerlemesiyle yak\u0131ndan ili\u015fkili oldu\u011funu g\u00f6stermi\u015ftir. Oksitlenmi\u015f d\u00fc\u015f\u00fck yo\u011funluklu lipoprotein (ox LDL) insan aort endotel h\u00fccrelerinin i\u015flevini bozabilir ve aterosklerozun ilerlemesini te\u015fvik etmek i\u00e7in \u00f6nemli bir risk fakt\u00f6r\u00fcd\u00fcr. Glikolizin ateroskleroz olu\u015fumunda rol oynayan en \u00f6nemli metabolik yollardan biri oldu\u011fu bulunmu\u015ftur. Sarrazy ve arkada\u015flar\u0131, aterosklerotik farelerde glukoz ta\u015f\u0131y\u0131c\u0131 1'in ekspresyon seviyesinin d\u00fc\u015f\u00fcr\u00fclmesinin farelerin glukoz al\u0131m\u0131n\u0131 iyile\u015ftirebilece\u011fini ve aterosklerotik bir rol oynayabilece\u011fini bulmu\u015ftur. Matsui ve arkada\u015flar\u0131, glikoz-6-fosfat dehidrojenaz aktivitesini inhibe ederek glikolizi azaltman\u0131n kan damarlar\u0131ndaki s\u00fcperoksit seviyesini azaltabilece\u011fini ve b\u00f6ylece ateroskleroz farelerinin hasar\u0131n\u0131 hafifletebilece\u011fini bulmu\u015ftur. Bir ba\u015fka \u00e7al\u0131\u015fmada, glikoliz yolunun anahtar geni olan PGK1'in, insan aktif ven endotel h\u00fccrelerinin ox LDL kaynakl\u0131 apoptozuna kat\u0131ld\u0131\u011f\u0131 bulunmu\u015ftur. Yukar\u0131daki sonu\u00e7lar, glikoliz yolunun aterosklerozun patolojik s\u00fcrecinde \u00f6nemli bir rol oynad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir.
\n18 \u03b2 - glisiretinik asit (GA) meyan k\u00f6k\u00fcnde bulunan ve anti-enflamatuar, antioksidan, antiviral ve antikanser etkiler gibi \u00e7e\u015fitli farmakolojik etkileri olan \u00f6nemli bir biyoaktif bile\u015fendir. Bunlar aras\u0131nda antioksidan etkisi \u00f6zellikle \u00f6nemlidir ve ayr\u0131ca biyolojik d\u00f6n\u00fc\u015f\u00fcm ve di\u011fer s\u00fcre\u00e7ler yoluyla daha b\u00fcy\u00fck \u00f6l\u00e7\u00fcde olumlu etkiler g\u00f6sterebilir. Wang ve arkada\u015flar\u0131, GA'n\u0131n interl\u00f6kin-6 (IL-6) gibi enflamatuar sitokinlerin salg\u0131lanmas\u0131n\u0131 ve lipopolisakkarit (LPS) taraf\u0131ndan ind\u00fcklenen umbilikal ven endotel h\u00fccrelerinin apoptozunu inhibe edebilece\u011fini bulmu\u015flard\u0131r, bu da GA'n\u0131n endotel h\u00fccrelerinin enflamasyonunu ve apoptozunu inhibe edebilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir. Dolay\u0131s\u0131yla, GA'n\u0131n endotel h\u00fccrelerinin apoptozunu inhibe edip edemeyece\u011fi ve glikoliz yoluyla aterosklerozu \u00f6nleyip \u00f6nleyemeyece\u011fi hen\u00fcz bildirilmemi\u015ftir. Bu nedenle, bu \u00e7al\u0131\u015fma, endotel h\u00fccre apoptozunu inhibe etmede GA'n\u0131n molek\u00fcler mekanizmas\u0131n\u0131 ara\u015ft\u0131rmak i\u00e7in PGK1 arac\u0131l\u0131 glikoliz yoluna dayanmakta ve AS'nin \u00f6nlenmesi ve tedavisi i\u00e7in yeni fikirler ve bilimsel temel sa\u011flamaktad\u0131r.<\/p>\n

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Son y\u0131llarda yap\u0131lan ara\u015ft\u0131rmalar, meyan k\u00f6k\u00fcn\u00fcn \u00f6nemli bir biyoaktif bile\u015feni olan GA'n\u0131n \u00e7e\u015fitli kardiyovask\u00fcler hastal\u0131klar \u00fczerinde belirli \u00f6nleyici ve tedavi edici etkilere sahip oldu\u011funu ortaya koymu\u015ftur. GA, RhoA\/Rho kinaz yolunu d\u00fczenleyerek pulmoner arterlerdeki d\u00fcz kas h\u00fccrelerinin proliferasyonunu inhibe eder, b\u00f6ylece pulmoner arteriyel hipertansiyonu \u00f6nler ve tedavi eder. Yang ve arkada\u015flar\u0131, metabolomik analiz yoluyla GA'n\u0131n antioksidan ve anti-enflamatuar etkiler yoluyla pulmoner hipertansiyon s\u0131\u00e7anlar\u0131nda metabolik bozukluklar\u0131 hafifletebilece\u011fini, v\u00fccudun hipoksiye direnme yetene\u011fini geli\u015ftirebilece\u011fini ve \u00e7e\u015fitli metabolik yollar\u0131 (enerji metabolizmas\u0131, amino asit metabolizmas\u0131, lipid metabolizmas\u0131) geri y\u00fckleyebilece\u011fini bulmu\u015flard\u0131r. Ek olarak GA, endotel h\u00fccrelerinde IP3 arac\u0131l\u0131 kalsiyum sinyal yolunu inhibe ederek \u00e7e\u015fitli kardiyovask\u00fcler fonksiyonlar\u0131 d\u00fczenleyebilir. \u00d6rne\u011fin, h\u00fccre i\u00e7i kalsiyum a\u015f\u0131r\u0131 y\u00fcklenmesini azaltarak kardiyak diyastolik fonksiyonu iyile\u015ftirebilir ve kalsiyum ak\u0131\u015f\u0131n\u0131n arac\u0131l\u0131k etti\u011fi p38 MAPK yolunu d\u00fczenleyerek iskemik miyokardiyal h\u00fccre apoptozunu inhibe edebilir. Bununla birlikte, GA'n\u0131n AS'yi \u00f6nleme ve tedavi etme mekanizmas\u0131 \u015fu anda belirsizdir.
\nBu \u00e7al\u0131\u015fmada, aterosklerozun in vitro h\u00fccre modelini sim\u00fcle etmek amac\u0131yla insan aortik endotel h\u00fccrelerini tedavi etmek i\u00e7in oxLDL kullan\u0131lm\u0131\u015ft\u0131r. OxLDL ile ind\u00fcklenen endotel h\u00fccre hasar\u0131 modelinde, pro apoptotik belirte\u00e7ler olan b\u00f6l\u00fcnm\u00fc\u015f Kaspaz-3, b\u00f6l\u00fcnm\u00fc\u015f Kaspaz-9, Bax ve TUNEL seviyelerinin \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131, anti apoptotik fakt\u00f6r Bcl2 seviyelerinin ise \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131 bulunmu\u015ftur. D\u00fc\u015f\u00fck, orta ve y\u00fcksek dozlarda GA ilavesi, pro apoptotik belirte\u00e7ler Caspase-3, Caspase-9, Bax ve TUNEL seviyelerini etkili bir \u015fekilde inhibe etmi\u015f ve anti apoptotik fakt\u00f6r Bcl2'nin ekspresyonunu te\u015fvik ederek GA'n\u0131n oxLDL kaynakl\u0131 endotelyal h\u00fccre apoptozunu inhibe edebilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrm\u00fc\u015ft\u00fcr. Daha ileri ara\u015ft\u0131rmalar, oxLDL ile ind\u00fcklenen endotel h\u00fccre apoptoz modelinde, anahtar glikolitik genler PGK1, GLUT1, HK2 ve PKM'nin ekspresyon seviyelerinin \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131n\u0131, bu da h\u00fccrelerin glikolitik metabolizmas\u0131n\u0131n oxLDL ile ind\u00fcklenen endotel h\u00fccre apoptoz s\u00fcreci s\u0131ras\u0131nda aktive oldu\u011funu g\u00f6sterdi\u011fini bulmu\u015ftur. D\u00fc\u015f\u00fck, orta ve y\u00fcksek dozlarda GA ilavesi, glikolizde rol oynayan kilit genlerin ekspresyon seviyelerini etkili bir \u015fekilde bask\u0131layabilir, bu da GA'n\u0131n endotel h\u00fccrelerinde oxLDL taraf\u0131ndan ind\u00fcklenen glikoliz yolunu inhibe edebilece\u011fini g\u00f6sterir. \u00c7e\u015fitli \u00e7al\u0131\u015fmalar, glikolizin ateroskleroz olu\u015fumunda rol oynayan en \u00f6nemli metabolik yollardan biri oldu\u011funu do\u011frulam\u0131\u015ft\u0131r ve bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131 da glikolizin oxLDL ile ind\u00fcklenen endotel h\u00fccre apoptozu s\u00fcrecine dahil oldu\u011funu ve GA'n\u0131n oxLDL ile ind\u00fcklenen endotel h\u00fccrelerinin glikoliz yolunu inhibe edebilece\u011fini do\u011frulam\u0131\u015ft\u0131r. Bu \u00e7al\u0131\u015fma ayr\u0131ca PGK1 agonisti Terazosin ilavesinin GA'n\u0131n oxLDL ile ind\u00fcklenen endotel h\u00fccre apoptozu \u00fczerindeki inhibit\u00f6r etkisini \u00f6nemli \u00f6l\u00e7\u00fcde tersine \u00e7evirebilece\u011fini bulmu\u015ftur. Yukar\u0131daki \u00e7al\u0131\u015fma, GA'n\u0131n PGK1 arac\u0131l\u0131 glikoliz yolu arac\u0131l\u0131\u011f\u0131yla endotel h\u00fccre apoptozunu inhibe etti\u011fini g\u00f6stermektedir. PGK1, glikoliz yolunda ATP \u00fcretimini katalize eden ilk enzimdir ve glikoliz yoluna arac\u0131l\u0131k eden anahtar bir gendir. Zhang ve arkada\u015flar\u0131, oxLDL ile tedavi edilen insan aortik endotel h\u00fccre modelinde PGK1 proteininin ekspresyonunun \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131n\u0131 ve bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131n\u0131n yukar\u0131dakilerle tutarl\u0131 oldu\u011funu ve PGK1 arac\u0131l\u0131 glikoliz yolunun aterosklerozun \u00f6nemli bir patolojik mekanizmas\u0131 oldu\u011funu g\u00f6sterdi\u011fini bulmu\u015flard\u0131r.
\nSonu\u00e7 olarak, bu \u00e7al\u0131\u015fma GA'n\u0131n PGK1 arac\u0131l\u0131 glikoliz yolunu inhibe ederek oxLDL taraf\u0131ndan ind\u00fcklenen endotelyal h\u00fccre apoptozunu inhibe etti\u011fini ve ateroskleroz tedavisi i\u00e7in yeni fikirler ve hedefler sa\u011flad\u0131\u011f\u0131n\u0131 bulmu\u015ftur.<\/p>","protected":false},"excerpt":{"rendered":"

18 \u03b2 – glycyrrhetinic acid inhibits oxLDL induced endothelial cell apoptosis through PGK1 glycolysis pathway Atherosclerosis (AS) is one of the major risk factors of cardiovascular disease (CVD). Human aortic endothelial cells (HAECs) are associated with the development of atherosclerotic lesions. In addition, previous studies have shown that abnormal migration, proliferation, and apoptosis of HAECs […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\n18 \u03b2 - glycyrrhetinic acid inhibits oxLDL induced endothelial cell apoptosis through PGK1 glycolysis pathway - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/18-\u03b2-glycyrrhetinic-acid\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"18 \u03b2 - glycyrrhetinic acid inhibits oxLDL induced endothelial cell apoptosis through PGK1 glycolysis pathway - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"18 \u03b2 – glycyrrhetinic acid inhibits oxLDL induced endothelial cell apoptosis through PGK1 glycolysis pathway Atherosclerosis (AS) is one of the major risk factors of cardiovascular disease (CVD). 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