{"id":4007,"date":"2024-08-04T08:07:05","date_gmt":"2024-08-04T08:07:05","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=4007"},"modified":"2024-08-04T08:07:05","modified_gmt":"2024-08-04T08:07:05","slug":"crocin","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/crocin\/","title":{"rendered":"Diyabet nefropatisinin tedavisinde NLRP3 yola\u011f\u0131n\u0131 d\u00fczenleyen ve epitelyal mezenkimal ge\u00e7i\u015fi inhibe eden krosin mekanizmas\u0131"},"content":{"rendered":"

Diyabet nefropatisinin tedavisinde NLRP3 yola\u011f\u0131n\u0131 d\u00fczenleyen ve epitelyal mezenkimal ge\u00e7i\u015fi inhibe eden krosin mekanizmas\u0131
\nDiyabet b\u00f6brek hastal\u0131\u011f\u0131 (DKH), diyabetin yayg\u0131n bir komplikasyonudur ve esas olarak glomer\u00fcler mezangial dilatasyon, tubulointerstisyel fibrozis, glomer\u00fcler bazal membran kal\u0131nla\u015fmas\u0131 vb. \u015feklinde kendini g\u00f6steren b\u00f6bre\u011fin yap\u0131s\u0131na ve i\u015flevine zarar verir ve sonunda son d\u00f6nem b\u00f6brek hastal\u0131\u011f\u0131na d\u00f6n\u00fc\u015f\u00fcr. DKH'nin gizli bir ba\u015flang\u0131c\u0131, h\u0131zl\u0131 ilerlemesi, karma\u015f\u0131k mekanizmas\u0131 ve k\u00f6t\u00fc prognozu vard\u0131r. Bat\u0131 t\u0131bb\u0131 tedavisi esas olarak kan \u015fekeri, kan bas\u0131nc\u0131 ve kan lipitlerini kontrol etmeye odaklan\u0131r, ancak DKH'nin ilerlemesi yava\u015flamaz ve hastalar\u0131n ya\u015fam kalitesini ciddi \u015fekilde etkiler. Dahas\u0131, \u00c7in'de DKH g\u00f6r\u00fclme oran\u0131 her ge\u00e7en y\u0131l artarken, DKH b\u00fcy\u00fck ekonomik ve sosyal y\u00fckler getirmi\u015ftir ve DKH tedavisi i\u00e7in etkili ila\u00e7lar\u0131n acilen geli\u015ftirilmesi gerekmektedir.
\nGeleneksel \u00c7in t\u0131bb\u0131n\u0131n aktif bile\u015fenleri, DKD'nin ilerlemesini geciktirmede \u00f6nemli avantajlara sahiptir. Epimedium glikozit b\u00f6brek dokusundaki enflamasyonu hafifletebilir ve n\u00fckleer fakt\u00f6r kappaB (NF - \u03ba B) yolunu inhibe ederek diyabetik b\u00f6brek hastal\u0131\u011f\u0131n\u0131n (DKD) ilerlemesini geciktirebilir. Silymarin, DKD'yi iyile\u015ftirmek i\u00e7in protein kinaz B (Akt) yolunu aktive edebilir. Hiperisin, makrofajlar\u0131n M1'den M2 fenotipine polarizasyonunu ve CD4+T h\u00fccrelerinin yard\u0131mc\u0131 T h\u00fccresi 2 (Th2) ve d\u00fczenleyici T h\u00fccresi (Treg) pop\u00fclasyonlar\u0131na farkl\u0131la\u015fmas\u0131n\u0131 te\u015fvik ederek fare DKD'sini iyile\u015ftirebilir. Meyan k\u00f6k\u00fcn\u00fcn biyoaktif bile\u015feni olan meyan k\u00f6k\u00fc flavonoidleri, demir \u00f6l\u00fcm\u00fcn\u00fc ve vask\u00fcler endotelyal b\u00fcy\u00fcme fakt\u00f6r\u00fc (VEGF)\/Akt\/ h\u00fccre d\u0131\u015f\u0131 sinyalle d\u00fczenlenen kinaz (ERK) yolunu inhibe ederek diyabetik b\u00f6brek hastal\u0131\u011f\u0131n\u0131 (DKD) iyile\u015ftirebilir. Paeoniflorin, interl\u00f6kin-1 beta (IL-1 \u03b2) gibi \u00e7e\u015fitli enflamatuar fakt\u00f6rleri inhibe edebilir, b\u00f6brek h\u00fccrelerinde fosforile Janus kinaz 2 (p-JAK2) ve fosforile sinyal d\u00f6n\u00fc\u015ft\u00fcr\u00fcc\u00fc ve transkripsiyon aktivat\u00f6r\u00fc 3'\u00fcn (p-STAT3) protein ekspresyonunu a\u015fa\u011f\u0131 reg\u00fcle edebilir, b\u00f6brek dokusu enflamasyonunu ve otofaji yan\u0131t\u0131n\u0131 hafifletebilir ve b\u00f6brekleri koruyabilir.
\nKrosin (CRO), anti-enflamatuar ve antioksidan gibi \u00e7e\u015fitli etkileri olan geleneksel \u00c7in t\u0131bb\u0131 safran\u0131n ana aktif bile\u015fenidir. \u00c7al\u0131\u015fmalar, CRO'nun oksidatif stresi ve enflamatuar yan\u0131t\u0131 inhibe ederek DKD'yi hafifletebilece\u011fini bulmu\u015ftur. CRO'nun kardiyomiyositlerde NLRP3 yola\u011f\u0131n\u0131n aktivasyonunu inhibe edebilece\u011fini bulan \u00e7al\u0131\u015fmalar da vard\u0131r. Bununla birlikte, NOD benzeri resept\u00f6r termal protein alan\u0131 ili\u015fkili protein 3'\u00fcn (NLRP3) aktivasyonunu inhibe ederek ve epitelyal mezenkimal ge\u00e7i\u015fi (EMT) bask\u0131layarak DKD'yi tedavi edip edemeyece\u011fi belirsizdir. Bu nedenle, bu \u00e7al\u0131\u015fmada CRO'nun DKD fareleri \u00fczerindeki terap\u00f6tik etkisini ara\u015ft\u0131rmak i\u00e7in bir DKD fare modeli olu\u015fturulmu\u015f ve CRO'nun DKD tedavisindeki mekanizmas\u0131 EMT ve NLRP3 yolaklar\u0131 perspektiflerinden incelenmi\u015ftir.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"
\nDKH, glomer\u00fcloskleroz, bazal membran kal\u0131nla\u015fmas\u0131 ve renal interstisyumda fibrozise yol a\u00e7an diyabetin neden oldu\u011fu mikrovask\u00fcler bir hastal\u0131kt\u0131r. Son d\u00f6nem b\u00f6brek hastal\u0131\u011f\u0131n\u0131n \u00f6nemli bir nedenidir. Her ge\u00e7en y\u0131l artan insidans oran\u0131 ciddi bir t\u0131bbi y\u00fck haline gelmi\u015ftir. DKH'yi incelemek i\u00e7in hayvan modellerinin kullan\u0131lmas\u0131, yeni ila\u00e7lar\u0131n geli\u015ftirilmesine yard\u0131mc\u0131 olur, b\u00f6ylece hastalar\u0131n ya\u015fam kalitesini art\u0131r\u0131r ve sosyal y\u00fck\u00fc azalt\u0131r. HFD diyeti ve STZ enjeksiyonu ind\u00fcksiyonu kombinasyonu, DKD'yi modellemek i\u00e7in klasik bir y\u00f6ntemdir ve ba\u015far\u0131l\u0131 modellemeden sonra semptomlar DKD hastalar\u0131n\u0131nkine benzerdir. Prensip temel olarak farelerde HFD diyeti ile ins\u00fclin direncinin ind\u00fcklenmesi ve STZ enjeksiyonu ile pankreatik beta h\u00fccre nekrozu ve b\u00f6brek hasar\u0131n\u0131n ind\u00fcklenmesi ile ilgilidir. 24 saatlik UTP, Cr ve BUN glomer\u00fcler filtrasyon fonksiyonunu de\u011ferlendirmek i\u00e7in yayg\u0131n olarak kullan\u0131l\u0131r ve y\u00fcksek seviyeler b\u00f6brek fonksiyon bozuklu\u011funu g\u00f6sterir. Bu \u00e7al\u0131\u015fmada, DKD fareleri, artm\u0131\u015f glomer\u00fcller, fibrozun e\u015flik etti\u011fi renal t\u00fcb\u00fclointerstisyel dokunun enflamatuar infiltrasyonu dahil olmak \u00fczere ciddi b\u00f6brek lezyonlar\u0131 g\u00f6stermi\u015f ve ba\u015far\u0131l\u0131 modellemeye i\u015faret etmi\u015ftir. CRO m\u00fcdahalesinden sonra, yukar\u0131daki semptomlar iyile\u015fmi\u015f, y\u00fcksek doz CRO en \u00f6nemli iyile\u015fme etkisini g\u00f6stermi\u015f ve iyile\u015fme derecesi pozitif ila\u00e7 MCC950 ile benzer olmu\u015ftur. Di\u011fer \u00e7al\u0131\u015fmalar, 25 mg\/kg dozunda CRO m\u00fcdahalesinin bleomisin kaynakl\u0131 pulmoner fibrozu etkili bir \u015fekilde iyile\u015ftirebilece\u011fini g\u00f6stermi\u015ftir.
\nEMT, renal fibrozis ve protein\u00fcrinin do\u011frudan nedenidir ve DKD geli\u015fiminde \u00f6nemli bir rol oynar. \u00c7al\u0131\u015fmalar, CRO'nun karaci\u011fer fibrozunu iyile\u015ftirmek i\u00e7in karaci\u011ferde EMT'yi inhibe edebilece\u011fini g\u00f6stermi\u015ftir. Bu nedenle, bu \u00e7al\u0131\u015fma CRO'nun renal EMT'yi iyile\u015ftirip iyile\u015ftiremeyece\u011fini ara\u015ft\u0131rmaktad\u0131r. Bu \u00e7al\u0131\u015fmada, DKD farelerinin b\u00f6breklerinde E-cad ekspresyonu a\u015fa\u011f\u0131 do\u011fru d\u00fczenlenirken, VIM, \u03b1 - SMA ve TGF - \u03b2 1 ekspresyonu yukar\u0131 do\u011fru d\u00fczenlenerek DKD farelerinin b\u00f6breklerinde EMT'nin \u015fiddetlendi\u011fini g\u00f6stermi\u015ftir. E-cad, epitelyal h\u00fccre polaritesinin ve h\u00fccreler aras\u0131 yap\u0131\u015fman\u0131n korunmas\u0131nda rol oynayan epitelyal h\u00fccrelerin ana belirtecidir. \u0130nterstisyel h\u00fccreler esas olarak VIM, \u03b1 - SMA ve TGF - \u03b2 1'i eksprese eder, bunlar\u0131n aras\u0131nda TGF - \u03b2 1'in g\u00fc\u00e7l\u00fc bir pro fibrotik etkisi vard\u0131r. \u00c7ok say\u0131da \u00e7al\u0131\u015fma, TGF - \u03b2 1'in DKD b\u00f6brek dokusunda y\u00fcksek oranda eksprese edildi\u011fini do\u011frulam\u0131\u015ft\u0131r. EMT s\u00fcreci s\u0131ras\u0131nda, epitelyal h\u00fccre adezyon molek\u00fcllerinin ve h\u00fccre iskeleti bile\u015fenlerinin azalmas\u0131 veya kaybolmas\u0131, epitelyal h\u00fccrelerin fenotipik bir d\u00f6n\u00fc\u015f\u00fcm\u00fcne yol a\u00e7arak stromal h\u00fccrelerin belirte\u00e7lerini elde eder. \u00c7e\u015fitli hasar uyaranlar\u0131 alt\u0131nda, farkl\u0131la\u015fm\u0131\u015f epitel h\u00fccreleri \u00e7ok say\u0131da fibroblast ve miyofibroblast olu\u015fturmak \u00fczere fenotipik d\u00f6n\u00fc\u015f\u00fcme u\u011frayarak renal fibrozis geli\u015fimini te\u015fvik eder. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, CRO'nun E-cad ekspresyonunu yukar\u0131, VIM, \u03b1 - SMA ve TGF - \u03b2 1 ekspresyonunu a\u015fa\u011f\u0131 d\u00fczenleyebildi\u011fini ve renal EM geli\u015fiminde iyi bir inhibit\u00f6r rol oynad\u0131\u011f\u0131n\u0131 ortaya koymu\u015ftur. Ek olarak, CRO'nun MAPK\/ERK yola\u011f\u0131 arac\u0131l\u0131\u011f\u0131yla t\u00fcm\u00f6r h\u00fccrelerinde EMT'yi inhibe etti\u011fi g\u00f6sterilmi\u015ftir. MAPK\/ERK ayr\u0131ca diyabetik b\u00f6brek hastal\u0131\u011f\u0131nda renal fibrozise yol a\u00e7an \u00f6nemli bir fakt\u00f6rd\u00fcr. Gelecekte, CRO'nun EMT'yi inhibe etmesi i\u00e7in yeni hedefler bulmak amac\u0131yla, CRO'nun MAPK\/ERK kaynakl\u0131 renal fibrozis \u00fczerindeki inhibit\u00f6r etkisi \u00fczerine daha fazla ara\u015ft\u0131rma yap\u0131labilir.
\nEMT lezyonlar\u0131 dinamik ve geri d\u00f6n\u00fc\u015f\u00fcml\u00fcd\u00fcr ve \u00e7al\u0131\u015fmalar NLRP3 yola\u011f\u0131n\u0131n fenotip ge\u00e7i\u015finin d\u00fczenlenmesinde rol oynad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Bu \u00e7al\u0131\u015fmada, NLRP3 inflamazomu DKD farelerinin b\u00f6breklerinde y\u00fcksek oranda eksprese edilmi\u015f ve DKD farelerinin b\u00f6breklerindeki enflamatuar yan\u0131t\u0131 \u015fiddetlendirmi\u015ftir. NLRP3 inflamazomu NLRP3, ASC ve kaspaz-1'den olu\u015fan \u00e7oklu bir protein kompleksidir. Aktive NLRP3 inflamazomu, DKD'nin yukar\u0131 ak\u0131\u015f\u0131nda \u00f6nemli bir rol oynar. NLRP3 aktive edildi\u011finde, NLRP3 inflamazom bile\u015fenlerinin (NLRP3, ASC, kaspaz-1) toplanmas\u0131n\u0131 te\u015fvik eder, b\u00f6ylece inflamatuar fakt\u00f6rler IL-1 \u03b2 ve IL-18'i par\u00e7alayan ve olgunla\u015ft\u0131ran aktif temizlenmi\u015f-Kaspaz-1 olu\u015fturmak i\u00e7in proKaspaz-1'i aktive eder. Olgun-IL-1 \u03b2, EMT geli\u015fiminde kilit bir fakt\u00f6r olan TGF - \u03b2 1 sentezini uyarabilir. TGF - \u03b2 1, h\u00fccre d\u0131\u015f\u0131 matristeki \u00e7e\u015fitli protein bile\u015fenlerinin sentezini te\u015fvik edebilir ve bunlar\u0131n bozulmas\u0131n\u0131 \u00f6nleyebilir, b\u00f6ylece renal EMT s\u00fcrecini \u015fiddetlendirir ve renal fibrozis olu\u015fumunu h\u0131zland\u0131r\u0131r. Ek olarak, \u00e7al\u0131\u015fmalar NLRP3 nakavt farelerde \u03b1 - SMA ekspresyonunun \u00f6nemli \u00f6l\u00e7\u00fcde a\u015fa\u011f\u0131 reg\u00fcle oldu\u011funu g\u00f6stermi\u015ftir. NLRP3'\u00fcn a\u015f\u0131r\u0131 ekspresyonunun E-cad ekspresyonunu inhibe etti\u011fi ve \u03b1 - SMA ekspresyonunu destekledi\u011fi, VIM'in ise NLRP3'\u00fcn aktivasyonunu destekledi\u011fi g\u00f6sterilmi\u015ftir. T\u00fcm bunlar NLRP3 ve EMT aras\u0131nda kar\u015f\u0131l\u0131kl\u0131 bir d\u00fczenleyici etki oldu\u011funu ve NLRP3'\u00fcn inhibe edilmesinin renal EMT'yi \u00f6nemli \u00f6l\u00e7\u00fcde hafifletebilece\u011fini g\u00f6stermektedir. Ve bu \u00e7al\u0131\u015fma, CRO m\u00fcdahalesinin NLRP3 inflamazom ile ilgili fakt\u00f6rlerin ekspresyonunu etkili bir \u015fekilde inhibe etti\u011fini, iyi anti-enflamatuar etkiler g\u00f6sterirken ayn\u0131 zamanda anti EMT etkileri de g\u00f6sterdi\u011fini ortaya koymu\u015ftur. NLRP3'\u00fcn aktivasyonu ikili sinyallerin kat\u0131l\u0131m\u0131n\u0131 gerektirir. \u0130lk olarak, transkripsiyon fakt\u00f6r\u00fc NF - \u03ba B aktive olur ve \u00e7ekirde\u011fe girerek NLRP3 ve IL-1 \u03b2 gibi genlerin ekspresyonunu te\u015fvik eder (ilk sinyal); Daha sonra, K+ve ROS gibi fakt\u00f6rlerin uyar\u0131s\u0131 alt\u0131nda NLRP3 inflamazom d\u00fczene\u011fi (ikinci sinyal) ba\u015flat\u0131l\u0131r. \u0130lgin\u00e7 bir \u015fekilde, \u00f6nceki \u00e7al\u0131\u015fmalar CRO'nun NF - \u03ba B \u00fczerindeki inhibit\u00f6r etkisini g\u00f6stermi\u015ftir. Dolay\u0131s\u0131yla, CRO'nun NLRP3 kaynakl\u0131 EMT'yi bast\u0131r\u0131p bast\u0131ramayaca\u011f\u0131 ve NF - \u03ba B'yi (ilk sinyal) inhibe ederek DKD'yi iyile\u015ftirip iyile\u015ftiremeyece\u011fi gelecekteki bir ara\u015ft\u0131rma y\u00f6n\u00fc olabilir. CRO, NLRP3 aktivasyonunu inhibe edebilir ve mitokondriyal reaktif oksijen t\u00fcrleri \u00fcretimini azaltarak peritoniti iyile\u015ftirebilir. Bu arada, CRO'nun antioksidan ve mitokondriyal onar\u0131m i\u015flevleri \u00e7e\u015fitli modellerde rapor edilmi\u015ftir. Bu nedenle, CRO'nun mitokondriyal ROS \u00fcretimini azaltarak ve b\u00f6ylece NLRP3'\u00fcn ikinci sinyalinin aktivasyonunu engelleyerek ve aktivasyonunu inhibe ederek DKD modelinin EMT'sini iyile\u015ftirip iyile\u015ftiremeyece\u011fini do\u011frulamak i\u00e7in daha fazla ara\u015ft\u0131rmaya ihtiya\u00e7 vard\u0131r. Ayr\u0131ca, bu \u00e7al\u0131\u015fmada NLRP3 inhibit\u00f6r\u00fc MCC950 pozitif kontrol olarak se\u00e7ilmi\u015f ve CRO'nun MCC950'ye benzer anti-enflamatuar etkiler g\u00f6sterdi\u011fi bulunmu\u015ftur. \u00d6zetle, CRO, EMT'yi bast\u0131rmak i\u00e7in NLRP3 yolunu inhibe ederek sonu\u00e7ta DKD'yi hafifletebilir.<\/p>","protected":false},"excerpt":{"rendered":"

Mechanism of crocin regulating NLRP3 pathway and inhibiting epithelial mesenchymal transition in the treatment of diabetes nephropathy Diabetes kidney disease (DKD) is a common complication of diabetes, which will lead to damage to the structure and function of the kidney, mainly manifested as glomerular mesangial dilatation, tubulointerstitial fibrosis, glomerular basement membrane thickening, etc., and eventually […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nMechanism of crocin regulating NLRP3 pathway and inhibiting epithelial mesenchymal transition in the treatment of diabetes nephropathy - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/crocin\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mechanism of crocin regulating NLRP3 pathway and inhibiting epithelial mesenchymal transition in the treatment of diabetes nephropathy - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Mechanism of crocin regulating NLRP3 pathway and inhibiting epithelial mesenchymal transition in the treatment of diabetes nephropathy Diabetes kidney disease (DKD) is a common complication of diabetes, which will lead to damage to the structure and function of the kidney, mainly manifested as glomerular mesangial dilatation, tubulointerstitial fibrosis, glomerular basement membrane thickening, etc., and eventually […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/tr\/crocin\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-04T08:07:05+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-26.png\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/crocin\/\",\"url\":\"https:\/\/longchangextracts.com\/crocin\/\",\"name\":\"Mechanism of crocin regulating NLRP3 pathway and inhibiting epithelial mesenchymal transition in the treatment of diabetes nephropathy - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangextracts.com\/crocin\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangextracts.com\/crocin\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-26.png\",\"datePublished\":\"2024-08-04T08:07:05+00:00\",\"dateModified\":\"2024-08-04T08:07:05+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/crocin\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/crocin\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/crocin\/#primaryimage\",\"url\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-26.png\",\"contentUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-26.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/crocin\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Mechanism of crocin regulating NLRP3 pathway and inhibiting epithelial mesenchymal transition in the treatment of diabetes nephropathy\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Diyabet nefropatisinin tedavisinde NLRP3 yolunu d\u00fczenleyen ve epitelyal mezenkimal ge\u00e7i\u015fi inhibe eden krosin mekanizmas\u0131 - \u00c7in Kimya \u00dcreticisi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/tr\/crocin\/","og_locale":"tr_TR","og_type":"article","og_title":"Mechanism of crocin regulating NLRP3 pathway and inhibiting epithelial mesenchymal transition in the treatment of diabetes nephropathy - China Chemical Manufacturer","og_description":"Mechanism of crocin regulating NLRP3 pathway and inhibiting epithelial mesenchymal transition in the treatment of diabetes nephropathy Diabetes kidney disease (DKD) is a common complication of diabetes, which will lead to damage to the structure and function of the kidney, mainly manifested as glomerular mesangial dilatation, tubulointerstitial fibrosis, glomerular basement membrane thickening, etc., and eventually […]","og_url":"https:\/\/longchangextracts.com\/tr\/crocin\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-04T08:07:05+00:00","og_image":[{"url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-26.png"}],"author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"longcha9","Tahmini okuma s\u00fcresi":"8 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/crocin\/","url":"https:\/\/longchangextracts.com\/crocin\/","name":"Diyabet nefropatisinin tedavisinde NLRP3 yolunu d\u00fczenleyen ve epitelyal mezenkimal ge\u00e7i\u015fi inhibe eden krosin mekanizmas\u0131 - \u00c7in Kimya \u00dcreticisi","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangextracts.com\/crocin\/#primaryimage"},"image":{"@id":"https:\/\/longchangextracts.com\/crocin\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-26.png","datePublished":"2024-08-04T08:07:05+00:00","dateModified":"2024-08-04T08:07:05+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/crocin\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/crocin\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/crocin\/#primaryimage","url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-26.png","contentUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-26.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/crocin\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Mechanism of crocin regulating NLRP3 pathway and inhibiting epithelial mesenchymal transition in the treatment of diabetes nephropathy"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"\u00c7in Kimyasal \u00dcreticisi","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"tr"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/4007"}],"collection":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/comments?post=4007"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/4007\/revisions"}],"predecessor-version":[{"id":4014,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/4007\/revisions\/4014"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/media?parent=4007"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/categories?post=4007"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/tags?post=4007"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}