{"id":3990,"date":"2024-08-04T08:05:15","date_gmt":"2024-08-04T08:05:15","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3990"},"modified":"2024-08-04T08:05:15","modified_gmt":"2024-08-04T08:05:15","slug":"ginger","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/zencefil\/","title":{"rendered":"Yunnan'da \u00fcretilen zencefilin d\u00f6rt bile\u015feninin UHPLC parmak izi ve kantitatif analizi \u00fczerine ara\u015ft\u0131rma"},"content":{"rendered":"<p>Yunnan'da \u00fcretilen zencefilin d\u00f6rt bile\u015feninin UHPLC parmak izi ve kantitatif analizi \u00fczerine ara\u015ft\u0131rma<br \/>\nZencefil, zencefilgiller familyas\u0131ndan bir bitki olan Zingiber officinale Rosc. bitkisinin taze k\u00f6k\u00fc ve rizomudur. \u00c7in'de uzun bir t\u00fcketim ge\u00e7mi\u015fine sahip \u00f6nemli t\u0131bbi ve yenilebilir \u00c7in t\u0131bbi malzemelerinden biridir. T\u0131bbi kullan\u0131m\u0131 ilk olarak \"Shennong Bencao Jing \"de kaydedilmi\u015ftir ve \"y\u00fczey so\u011fuklu\u011funu giderme, ortay\u0131 \u0131s\u0131tma ve kusmay\u0131 durdurma, balgam ve \u00f6ks\u00fcr\u00fc\u011f\u00fc giderme ve bal\u0131k ve yenge\u00e7 toksinlerini giderme\" etkilerine sahiptir. Modern farmakolojik ara\u015ft\u0131rmalar zencefilin anti-enflamatuar, antioksidan, antibakteriyel, anti-t\u00fcm\u00f6r, n\u00f6roprotektif vb. gibi \u00e7e\u015fitli etkilere sahip oldu\u011funu g\u00f6stermi\u015ftir.<br \/>\nZencefil, gingerol, u\u00e7ucu ya\u011f vb. gibi \u00e7e\u015fitli bile\u015fenler i\u00e7erir. Bunlar aras\u0131nda gingerol, 6-gingerol, 8-gingerol, 10 gingerol, 6-gingerol ve di\u011fer bile\u015fenler dahil olmak \u00fczere zencefilde \u00f6nemli bir fonksiyonel bile\u015fen ve aroma maddesidir. \u015eu anda, zencefil bile\u015fenleri \u00fczerine yap\u0131lan nicel ara\u015ft\u0131rmalar da gingerol ve u\u00e7ucu ya\u011fa odaklanm\u0131\u015ft\u0131r; bunlar\u0131n aras\u0131nda 6-gingerol, 8-gingerol ve 10 gingerol, \u00c7in Farmakopesinde (2020 bask\u0131s\u0131) zencefilin g\u00f6sterge bile\u015fenleridir; Ayn\u0131 zamanda, baz\u0131 bilim adamlar\u0131 zencefilin kalitesini incelemek i\u00e7in HPLC ve UPLC parmak izi spektrumlar\u0131n\u0131 kullanm\u0131\u015flard\u0131r, ancak zencefilin parmak izi spektrumlar\u0131n\u0131 e\u015fzamanl\u0131 olarak analiz etmek ve UHPLC y\u00f6ntemine dayal\u0131 gingerol bile\u015fenlerinin i\u00e7eri\u011fini belirlemek i\u00e7in daha fazla ara\u015ft\u0131rmaya ihtiya\u00e7 vard\u0131r.<br \/>\n\u00c7in, zencefil yeti\u015ftiricili\u011finde uzun bir ge\u00e7mi\u015fe ve bol miktarda germplazm kayna\u011f\u0131na sahiptir. \u00c7e\u015fitli b\u00f6lgelerde belirli b\u00f6lgesel avantajl\u0131 \u00e7e\u015fitler vard\u0131r. Dikim \u00e7e\u015fitleri ve dikim ortamlar\u0131ndaki farkl\u0131l\u0131klar nedeniyle, zencefilin bile\u015fiminde de \u00f6nemli farkl\u0131l\u0131klar vard\u0131r. Yunnan ve di\u011fer yerlerden gelen k\u00fc\u00e7\u00fck sar\u0131 zencefil, t\u0131bbi se\u00e7im i\u00e7in bir kaynak ve \u00e7e\u015fittir. Bu \u00e7al\u0131\u015fma, Yunnan Eyaletindeki Honghe, Wenshan ve Qujing'den 20 parti zencefil \u00fczerine odaklanmaktad\u0131r. UHPLC parmak izi spektrumlar\u0131 olu\u015fturulmu\u015f ve farkl\u0131 k\u00f6kenler ve partiler aras\u0131ndaki kompozisyon farkl\u0131l\u0131klar\u0131n\u0131 kar\u015f\u0131la\u015ft\u0131rmak i\u00e7in kemometrik analiz yap\u0131lm\u0131\u015ft\u0131r. Zencefil hammaddelerinin sonraki kalite de\u011ferlendirmesi ve men\u015fe se\u00e7imi i\u00e7in referans sa\u011flamak amac\u0131yla kantitatif belirleme ve analiz i\u00e7in d\u00f6rt gingerol bile\u015feni se\u00e7ilmi\u015ftir.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3991\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-25.png\" alt=\"\" width=\"805\" height=\"352\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-25.png 805w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-25-768x336.png 768w\" sizes=\"(max-width: 805px) 100vw, 805px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3992\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-23.png\" alt=\"\" width=\"805\" height=\"427\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-23.png 805w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-23-768x407.png 768w\" sizes=\"(max-width: 805px) 100vw, 805px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3993\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-22.png\" alt=\"\" width=\"805\" height=\"401\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-22.png 805w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-22-768x383.png 768w\" sizes=\"(max-width: 805px) 100vw, 805px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3994\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-21.png\" alt=\"\" width=\"805\" height=\"517\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-21.png 805w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-21-768x493.png 768w\" sizes=\"(max-width: 805px) 100vw, 805px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3995\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-18.png\" alt=\"\" width=\"805\" height=\"409\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-18.png 805w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-18-768x390.png 768w\" sizes=\"(max-width: 805px) 100vw, 805px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3996\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-18.png\" alt=\"\" width=\"805\" height=\"350\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-18.png 805w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-18-768x334.png 768w\" sizes=\"(max-width: 805px) 100vw, 805px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3997\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-17.png\" alt=\"\" width=\"805\" height=\"331\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-17.png 805w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-17-768x316.png 768w\" sizes=\"(max-width: 805px) 100vw, 805px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3998\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-13.png\" alt=\"\" width=\"805\" height=\"335\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-13.png 805w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-13-768x320.png 768w\" sizes=\"(max-width: 805px) 100vw, 805px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3999\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-10.png\" alt=\"\" width=\"805\" height=\"207\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-10.png 805w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-10-768x197.png 768w\" sizes=\"(max-width: 805px) 100vw, 805px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4000\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-6.png\" alt=\"\" width=\"805\" height=\"251\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-6.png 805w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-6-768x239.png 768w\" sizes=\"(max-width: 805px) 100vw, 805px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4001\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-6.png\" alt=\"\" width=\"805\" height=\"486\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-6.png 805w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-6-768x464.png 768w\" sizes=\"(max-width: 805px) 100vw, 805px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4002\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-6.png\" alt=\"\" width=\"805\" height=\"336\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-6.png 805w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-6-768x321.png 768w\" sizes=\"(max-width: 805px) 100vw, 805px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4003\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-6.png\" alt=\"\" width=\"805\" height=\"657\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-6.png 805w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-6-768x627.png 768w\" sizes=\"(max-width: 805px) 100vw, 805px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4004\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-1.jpg\" alt=\"\" width=\"805\" height=\"418\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-1.jpg 805w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-1-768x399.jpg 768w\" sizes=\"(max-width: 805px) 100vw, 805px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-4005\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-4.png\" alt=\"\" width=\"805\" height=\"485\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-4.png 805w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-4-768x463.png 768w\" sizes=\"(max-width: 805px) 100vw, 805px\" \/><br \/>\nBu \u00e7al\u0131\u015fma, kromatografik ko\u015fullar\u0131 optimize ederek ve test numunelerinin haz\u0131rlanma y\u00f6ntemini ara\u015ft\u0131rarak bir zencefil UHPLC parmak izi olu\u015fturmu\u015f ve parmak izi ile ayn\u0131 kromatografik ko\u015fullar alt\u0131nda bile\u015fenler i\u00e7in nicel bir analiz y\u00f6ntemi belirlemi\u015ftir. Ayn\u0131 zamanda, parmak izi spektrumlar\u0131ndaki karma\u015f\u0131k bile\u015fenlerin da\u011f\u0131l\u0131m modellerini ve etkile\u015fim ili\u015fkilerini daha iyi analiz etmek i\u00e7in parmak izi spektrumlar\u0131n\u0131 incelemek i\u00e7in kemometrik y\u00f6ntemler kullan\u0131lm\u0131\u015ft\u0131r. De\u011fi\u015fken olarak 18 zencefil parmak izi spektrumunun ortak pik alan\u0131 kullan\u0131larak, k\u00fcme analizi ve temel bile\u015fen analizi i\u00e7in Origin Pro 2023 yaz\u0131l\u0131m\u0131 kullan\u0131lm\u0131\u015ft\u0131r. Sonu\u00e7lar, her bir partideki numuneler aras\u0131nda baz\u0131 farkl\u0131l\u0131klar olmas\u0131na ra\u011fmen, hem k\u00fcme analizinin hem de temel bile\u015fen analizinin numuneleri iki ana kategoriye (g\u00fcneydo\u011fu Yunnan ve do\u011fu Yunnan) ay\u0131rabildi\u011fini g\u00f6stermi\u015ftir. Honghe ve Wenshan co\u011frafi olarak do\u011fu ve bat\u0131da birbirine biti\u015fiktir ve iki \u00f6rnek aras\u0131ndaki farklar nispeten k\u00fc\u00e7\u00fckt\u00fcr; kuzey ve g\u00fcneye biti\u015fik olan Qujing \u00f6rne\u011fi ise iki yerden nispeten b\u00fcy\u00fck farklara sahiptir (ve toplama yeri nispeten uzakt\u0131r). Bu nedenle, \u00fc\u00e7 \u00fcretim alan\u0131 ve b\u00f6lgesinin da\u011f\u0131l\u0131m\u0131na dayanarak, zencefili g\u00fcneydo\u011fu ve do\u011fu Yunnan'dan etkili bir \u015fekilde ay\u0131rt edebilen SIMCA14.1 yaz\u0131l\u0131m\u0131 kullan\u0131larak OPLS-DA analizi yap\u0131lm\u0131\u015ft\u0131r. Y\u00fcksek katk\u0131 de\u011ferlerine sahip se\u00e7ilen diferansiyel kromatografik pikler, k\u00fcme analizi ve temel bile\u015fen analizindeki s\u0131n\u0131fland\u0131rma gruplar\u0131na benzerdir (4-gingerol, pik 1, 6-gingerol, pik 6, pik 5, pik 13, pik 15 ve pik 11). \u00dc\u00e7 kemometrik analizin sonu\u00e7lar\u0131 aras\u0131nda belirli bir korelasyon vard\u0131r; bile\u015fimdeki farkl\u0131l\u0131klar iki b\u00f6lgenin kuzey ve g\u00fcneyindeki farkl\u0131 ekim ortamlar\u0131 ve yerel iklimlerle ilgili olabilir.<br \/>\nZencefil i\u00e7in t\u0131bbi bile\u015fenlerin se\u00e7iminde \u00e7e\u015fit ve men\u015fe yerinin se\u00e7imi \u00f6nemlidir. Zencefil \u00c7in'in bir\u00e7ok yerinde yeti\u015ftirilmektedir, ancak farkl\u0131 b\u00f6lgelerden gelen zencefillerde 8-gingerol ve 10 gingerol i\u00e7eri\u011finde \u00f6nemli farkl\u0131l\u0131klar vard\u0131r. Yunnan Xiaohuang zencefili daha y\u00fcksek bir yeterlilik oran\u0131na sahiptir. Yunnan zencefil \u00f6rneklerinin 20 partisinin kantitatif analiz sonu\u00e7lar\u0131, \u00c7in Farmakopesi'ndeki (2020 bask\u0131s\u0131) zencefil maddesi alt\u0131ndaki 6-gingerol, 8-gingerol ve 10 gingerol i\u00e7in i\u00e7erik belirleme y\u00f6ntemlerinin farkl\u0131 olmas\u0131na ra\u011fmen, Yunnan'daki \u00fc\u00e7 men\u015fe yerinden gelen zencefil \u00f6rneklerinin i\u00e7erik belirleme de\u011ferlerinin nispeten y\u00fcksek oldu\u011funu ve bunlar\u0131 t\u0131bbi hammadde olarak uygun hale getirdi\u011fini g\u00f6stermektedir; Ayn\u0131 zamanda, d\u00f6rt i\u00e7erik belirleme sonucu, Honghe ve Wenshan zencefil \u00f6rneklerinin i\u00e7eri\u011finin nispeten benzer oldu\u011funu, ancak Qujing zencefil \u00f6rnekleriyle kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, \u00f6zellikle 6-gingerol, 8-gingerol ve 6-gingerol i\u00e7eri\u011finde baz\u0131 farkl\u0131l\u0131klar oldu\u011funu g\u00f6stermi\u015ftir.<br \/>\nBu \u00e7al\u0131\u015fma, bir zencefil UHPLC parmak izi y\u00f6ntemi olu\u015fturmu\u015f ve daha sonraki a\u015famada t\u0131bbi zencefil \u00fcretim alanlar\u0131n\u0131n se\u00e7imi, kalite ara\u015ft\u0131rmas\u0131 ve end\u00fcstriyel uygulama i\u00e7in referans sa\u011flayabilecek d\u00f6rt gingerol bile\u015feninin i\u00e7eri\u011fini e\u015fzamanl\u0131 olarak belirleyebilmi\u015ftir.<\/p>","protected":false},"excerpt":{"rendered":"<p>Research on UHPLC fingerprint and quantitative analysis of four components of ginger produced in Yunnan Ginger is the fresh root and rhizome of Zingiber officinale Rosc., a plant in the ginger family. It is one of the important medicinal and edible Chinese medicinal materials with a long history of consumption in China. Its medicinal use [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Research on UHPLC fingerprint and quantitative analysis of four components of ginger produced in Yunnan - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/zencefil\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Research on UHPLC fingerprint and quantitative analysis of four components of ginger produced in Yunnan - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Research on UHPLC fingerprint and quantitative analysis of four components of ginger produced in Yunnan Ginger is the fresh root and rhizome of Zingiber officinale Rosc., a plant in the ginger family. It is one of the important medicinal and edible Chinese medicinal materials with a long history of consumption in China. 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