{"id":3943,"date":"2024-08-03T14:20:47","date_gmt":"2024-08-03T14:20:47","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3943"},"modified":"2024-08-03T14:20:47","modified_gmt":"2024-08-03T14:20:47","slug":"uplc-q-tof-ms-ms-and-network-pharmacology","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/uplc-q-tof-ms-ms-and-network-pharmacology\/","title":{"rendered":"UPLC-Q-TOF-MS\/MS ve A\u011f Farmakolojisine Dayal\u0131 Olarak Taro acuminata'n\u0131n Meme Kanseri Kar\u015f\u0131t\u0131 Mekanizmas\u0131n\u0131n Ara\u015ft\u0131r\u0131lmas\u0131"},"content":{"rendered":"<p>UPLC-Q-TOF-MS\/MS ve A\u011f Farmakolojisine Dayal\u0131 Olarak Taro acuminata'n\u0131n Meme Kanseri Kar\u015f\u0131t\u0131 Mekanizmas\u0131n\u0131n Ara\u015ft\u0131r\u0131lmas\u0131<br \/>\nK\u00fcresel olarak meme kanseri, t\u00fcm kanserlerin g\u00f6r\u00fclme oran\u0131n\u0131n 10%'sini ve kad\u0131nlarda t\u00fcm\u00f6re ba\u011fl\u0131 \u00f6l\u00fcmlerin 15%'sini olu\u015fturmaktad\u0131r. D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc taraf\u0131ndan yay\u0131nlanan en son K\u00fcresel Kanser Raporu 2020, 2018 y\u0131l\u0131nda 2,1 milyon yeni meme kanseri vakas\u0131 ve 27000 ki\u015finin meme kanserinden \u00f6ld\u00fc\u011f\u00fcn\u00fc ve insan sa\u011fl\u0131\u011f\u0131 i\u00e7in ciddi bir tehdit olu\u015fturdu\u011funu g\u00f6stermektedir. Bu nedenle, meme kanserinin etkili tedavisi \u00f6zellikle \u00f6nemlidir. Sendrom farkl\u0131la\u015fmas\u0131 ve tedavisi teorisine g\u00f6re, geleneksel \u00c7in t\u0131bb\u0131, yin, yang, qi, kan, i\u00e7 organlar ve meridyenler gibi v\u00fccudun i\u015flevlerini ayarlayarak meme kanseri \u00fczerinde belirgin iyile\u015ftirici etkiye sahiptir. Geleneksel \u00c7in t\u0131bb\u0131 v\u00fccudun metabolizmas\u0131n\u0131 iyile\u015ftirebilir, hastan\u0131n v\u00fccudunun genel i\u015flevini d\u00fczenleyebilir ve klinik etkinli\u011fi art\u0131rmak i\u00e7in meme kanserinin n\u00fcks\u00fcn\u00fc ve metastaz\u0131n\u0131 azaltabilir.<br \/>\nAraceae familyas\u0131ndan bir bitki olan Alocassia cuculata (Lour.) Schott'un k\u00f6k ve g\u00f6vdesi, \u0131s\u0131y\u0131 temizleme, detoksifiye etme, \u015fi\u015fli\u011fi azaltma, a\u011fr\u0131y\u0131 hafifletme etkilerine sahip geleneksel bir halk ilac\u0131d\u0131r. Modern farmakolojik \u00e7al\u0131\u015fmalar, taronun melanom gibi \u00e7e\u015fitli t\u00fcm\u00f6r h\u00fccrelerinin aktivitesini inhibe etmek, v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k yetene\u011fini geli\u015ftirmek, kanser h\u00fccrelerinin apoptozunu ind\u00fcklemek ve anti-t\u00fcm\u00f6r etkileri uygulamak i\u00e7in ba\u011f\u0131\u015f\u0131kl\u0131k fakt\u00f6rlerini aktive edebilece\u011fini g\u00f6stermi\u015ftir. \u0130lgili molek\u00fcler mekanizmalar\u0131 MAPK ve PI3K Akt gibi sinyal yolaklar\u0131n\u0131 i\u00e7erir. Literat\u00fcrde Alocasia cucullata'n\u0131n (EAC) petrol eteri fraksiyonunun in vitro h\u00fccre deneylerinde meme kanseri MDA-MB-231 h\u00fccrelerinin proliferasyonunu inhibe edebildi\u011fi bildirilmektedir. Mekanizma, MAPK yola\u011f\u0131ndaki p-ERK\/ERK ekspresyonunun inhibisyonu ile ilgilidir. Ayn\u0131 zamanda, Alocasia cucullata'n\u0131n petrol eteri fraksiyonu, GC-MS analizi yoluyla linoleik asit gibi \u00e7e\u015fitli doymam\u0131\u015f ya\u011f asitleri ve \u03b3 - sitosterol gibi \u00e7e\u015fitli fitosteroller bak\u0131m\u0131ndan zengindir. Modern ara\u015ft\u0131rmalar, linoleik asit ve fitosteroller gibi doymam\u0131\u015f ya\u011f asitlerinin Bax\/Bcl-2 seviyesini d\u00fczenleyerek meme kanseri h\u00fccrelerinin apoptozunu ind\u00fckleyebildi\u011fini g\u00f6stermektedir. Bu durum, Taro'nun petrol eteri fraksiyonunun meme kanseri kar\u015f\u0131t\u0131 mekanizmas\u0131n\u0131n da Bax\/Bcl-2 seviyesinin d\u00fczenlenmesiyle ilgili olabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir. Bununla birlikte, \u015fu anda, Taro acuminata'n\u0131n petrol eteri k\u0131sm\u0131n\u0131n kimyasal bile\u015fimi \u00fczerine yap\u0131lan ara\u015ft\u0131rmalar sadece GC-MS analizi ile s\u0131n\u0131rl\u0131d\u0131r ve Taro acuminata'n\u0131n petrol eteri k\u0131sm\u0131n\u0131n in vivo meme kanseri kar\u015f\u0131t\u0131 etki mekanizmas\u0131 hakk\u0131nda ilgili bir rapor bulunmamaktad\u0131r. Etkinli\u011finin maddi temeli ve in vivo meme kanseri kar\u015f\u0131t\u0131 etki mekanizmas\u0131 \u00fczerine yap\u0131lan ara\u015ft\u0131rmalar nispeten zay\u0131ft\u0131r. 4T1 h\u00fccre transplantasyonu t\u00fcm\u00f6r modelinin b\u00fcy\u00fcme durumu ve metastaz b\u00f6lgesi, insan ileri meme kanserini iyi bir \u015fekilde sim\u00fcle edebilir ve ileri meme kanserine y\u00f6nelik ila\u00e7lar\u0131 de\u011ferlendirmek i\u00e7in iyi bir model haline gelebilir. Bu nedenle, bu makalede, Taro acuminata'n\u0131n petrol eteri k\u0131sm\u0131 ara\u015ft\u0131rma nesnesi olarak al\u0131nm\u0131\u015f ve Taro acuminata'n\u0131n petrol eteri k\u0131sm\u0131n\u0131n kimyasal bile\u015fimi UPLC-Q-TOF-MS\/MS arac\u0131l\u0131\u011f\u0131yla belirlenirken, Taro acuminata'n\u0131n petrol eteri k\u0131sm\u0131n\u0131n anti meme kanseri mekanizmas\u0131n\u0131n molek\u00fcler seviyesini a\u00e7\u0131kl\u0131\u011fa kavu\u015fturmak i\u00e7in molek\u00fcler yerle\u015ftirme teknolojisi ile birle\u015ftirilmi\u015f a\u011f farmakolojisi stratejisi kullan\u0131lm\u0131\u015ft\u0131r. Son olarak, Taro acuminata acuminata'n\u0131n petrol eteri k\u0131sm\u0131n\u0131n in vivo meme kanseri kar\u015f\u0131t\u0131 etkisi, 4T1 meme kanseri t\u00fcm\u00f6r\u00fc ta\u015f\u0131yan fare modeli arac\u0131l\u0131\u011f\u0131yla de\u011ferlendirilmi\u015f ve meme kanseri kar\u015f\u0131t\u0131 mekanizmas\u0131 do\u011frulanm\u0131\u015ft\u0131r. Sivri kuyruklu taronun derinlemesine ara\u015ft\u0131r\u0131lmas\u0131 ve geli\u015ftirilmesi i\u00e7in deneysel referanslar sa\u011flamak amac\u0131yla.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3948\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-23.png\" alt=\"\" width=\"1178\" height=\"350\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-23.png 1178w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-23-768x228.png 768w\" sizes=\"(max-width: 1178px) 100vw, 1178px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3949\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-21.png\" alt=\"\" width=\"1096\" height=\"518\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-21.png 1096w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-21-768x363.png 768w\" sizes=\"(max-width: 1096px) 100vw, 1096px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3950\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-20.png\" alt=\"\" width=\"914\" height=\"1150\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-20.png 914w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-20-768x966.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-20-572x720.png 572w\" sizes=\"(max-width: 914px) 100vw, 914px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3951\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-19.png\" alt=\"\" width=\"928\" height=\"898\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-19.png 928w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-19-768x743.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-19-744x720.png 744w\" sizes=\"(max-width: 928px) 100vw, 928px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3952\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-17.png\" alt=\"\" width=\"770\" height=\"436\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-17.png 770w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-17-768x435.png 768w\" sizes=\"(max-width: 770px) 100vw, 770px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3953\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-16.png\" alt=\"\" width=\"748\" height=\"422\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3954\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-15.png\" alt=\"\" width=\"770\" height=\"450\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-15.png 770w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-15-768x449.png 768w\" sizes=\"(max-width: 770px) 100vw, 770px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3955\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-11.png\" alt=\"\" width=\"768\" height=\"460\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3956\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-8.png\" alt=\"\" width=\"824\" height=\"460\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-8.png 824w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-8-768x429.png 768w\" sizes=\"(max-width: 824px) 100vw, 824px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3957\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-5.png\" alt=\"\" width=\"768\" height=\"448\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3958\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-4.png\" alt=\"\" width=\"794\" height=\"312\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-4.png 794w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/11-4-768x302.png 768w\" sizes=\"(max-width: 794px) 100vw, 794px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3959\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-4.png\" alt=\"\" width=\"814\" height=\"468\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-4.png 814w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/12-4-768x442.png 768w\" sizes=\"(max-width: 814px) 100vw, 814px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3960\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-4.png\" alt=\"\" width=\"824\" height=\"468\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-4.png 824w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/13-4-768x436.png 768w\" sizes=\"(max-width: 824px) 100vw, 824px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3961\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-4.png\" alt=\"\" width=\"798\" height=\"470\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-4.png 798w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/14-4-768x452.png 768w\" sizes=\"(max-width: 798px) 100vw, 798px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3962\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-3.png\" alt=\"\" width=\"900\" height=\"400\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-3.png 900w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/15-3-768x341.png 768w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3963\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-3.png\" alt=\"\" width=\"924\" height=\"208\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-3.png 924w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/16-3-768x173.png 768w\" sizes=\"(max-width: 924px) 100vw, 924px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3964\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/17-3.png\" alt=\"\" width=\"766\" height=\"526\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3965\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/18-3.png\" alt=\"\" width=\"934\" height=\"594\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/18-3.png 934w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/18-3-768x488.png 768w\" sizes=\"(max-width: 934px) 100vw, 934px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3966\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/19-3.png\" alt=\"\" width=\"745\" height=\"631\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3967\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/20-3.png\" alt=\"\" width=\"924\" height=\"456\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/20-3.png 924w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/20-3-768x379.png 768w\" sizes=\"(max-width: 924px) 100vw, 924px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3968\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/21-2.png\" alt=\"\" width=\"940\" height=\"342\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/21-2.png 940w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/21-2-768x279.png 768w\" sizes=\"(max-width: 940px) 100vw, 940px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3969\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/22-1.png\" alt=\"\" width=\"956\" height=\"620\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/22-1.png 956w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/22-1-768x498.png 768w\" sizes=\"(max-width: 956px) 100vw, 956px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3970\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/23-1.png\" alt=\"\" width=\"944\" height=\"544\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/23-1.png 944w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/23-1-768x443.png 768w\" sizes=\"(max-width: 944px) 100vw, 944px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3971\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/24-1.png\" alt=\"\" width=\"776\" height=\"357\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/24-1.png 776w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/24-1-768x353.png 768w\" sizes=\"(max-width: 776px) 100vw, 776px\" \/><\/p>\n<p>&nbsp;<\/p>\n<p>Bu \u00e7al\u0131\u015fmada, taro'nun petrol eteri fraksiyonunun 41 kimyasal bile\u015fenini analiz etmek i\u00e7in UPLC-Q-TOF-MS\/MS teknolojisi kullan\u0131lm\u0131\u015ft\u0131r. Ayn\u0131 zamanda, a\u011f farmakolojisi stratejisi ile Tara acuminata'n\u0131n petrol eteri fraksiyonundan 32 anti meme kanseri aktif bile\u015feni ve 556 anti meme kanseri ile ilgili hedef analiz edilmi\u015ftir. MAPK1 ve Bcl-2 gibi 40 \u00e7ekirdek hedef PPI a\u011f\u0131 taraf\u0131ndan tahmin edildi ve bu hedefler esas olarak MAPK protein ailesi ve PI3K protein ailesinde yo\u011funla\u015ft\u0131. Ayr\u0131ca, GO biyolojik s\u00fcre\u00e7 zenginle\u015ftirme analizi, Tara acuminata'n\u0131n petrol eteri fraksiyonunun meme kanseri kar\u015f\u0131t\u0131 biyolojik s\u00fcrecinin esas olarak h\u00fccre apoptozunun ve di\u011fer biyolojik s\u00fcre\u00e7lerin negatif d\u00fczenlenmesinde yer ald\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. KEGG sinyal yolunun zenginle\u015ftirme analizi, Tara acuminata'n\u0131n petrol eteri fraksiyonunun anti meme kanseri hedef zenginle\u015ftirmesinin \u00e7o\u011funlukla PI3K-Akt ve MAPK sinyal yollar\u0131nda oldu\u011funu ve her ikisinin de h\u00fccre apoptozu ile ilgili oldu\u011funu g\u00f6stermi\u015ftir. PPI a\u011f\u0131, MAPK1, Bcl-2 ve di\u011fer apoptozla ilgili \u00e7ekirdek hedeflerin elde edildi\u011fini \u00f6ng\u00f6rm\u00fc\u015f ve sterol bile\u015feni digitalis glikozit ligand\u0131n\u0131n, ya\u011f asidi bile\u015feni linolenik asidin ve kumarin bile\u015feni 7-hidroksikumarinin, Amorphophallus senticosus'un petrol eteri k\u0131sm\u0131n\u0131n meme kanseri i\u00e7in ilgili \u00e7ekirdek hedefleriyle (p-ERK, Bcl-2, Bax) serbest\u00e7e ba\u011flanabildi\u011fi (ba\u011flanma enerjisi &lt;0 kcal \/ mol) molek\u00fcler yerle\u015ftirme teknolojisi ile do\u011frulanm\u0131\u015ft\u0131r. Yukar\u0131daki sonu\u00e7lar, taro&#039;nun petrol eteri fraksiyonunun meme kanseri kar\u015f\u0131t\u0131 etkisinin \u00e7ok bile\u015fenli ve \u00e7ok hedefli \u00f6zellikleriyle ili\u015fkili oldu\u011funu ve meme kanseri kar\u015f\u0131t\u0131 mekanizmas\u0131n\u0131n PI3K Akt ve MAPK gibi apoptozla ilgili sinyal yollar\u0131yla ili\u015fkili oldu\u011funu g\u00f6stermektedir.<\/p>\n<p>Jianwei tarosu halk t\u0131bb\u0131nda \u00e7e\u015fitli kanserleri tedavi etmek i\u00e7in yayg\u0131n olarak kullan\u0131lmaktad\u0131r ve yumrular\u0131ndaki bile\u015fikler \u00e7e\u015fitli kanser h\u00fccrelerinin b\u00fcy\u00fcmesini engelleyebilmektedir. Ara\u015ft\u0131rma grubumuzun \u00f6nceki ara\u015ft\u0131rmas\u0131, taro su \u00f6z\u00fct\u00fcn\u00fcn meme kanserinin b\u00fcy\u00fcmesini engelleyebilece\u011fini ve fare dalak h\u00fccrelerinin aktivitesini art\u0131rarak meme kanseri farelerinin hayatta kalma s\u00fcresini uzatabilece\u011fini buldu. H\u00fccre deneyi, taronun ba\u011f\u0131\u015f\u0131kl\u0131k monositlerinin makrofajlara farkl\u0131la\u015fmas\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde katalize edebilece\u011fini, megafagositlerin i\u015flevini uyarabilece\u011fini ve anti-t\u00fcm\u00f6r etki elde etmek i\u00e7in ba\u011f\u0131\u015f\u0131kl\u0131k sistemini aktive edebilece\u011fini buldu. Taro'nun petrol eteri fraksiyonu, insan MDA-MB-231 meme kanseri h\u00fccrelerinin b\u00fcy\u00fcmesini engelleyebilir ve kanser h\u00fccrelerinin apoptozunu te\u015fvik edebilir. Bu deneyin sonu\u00e7lar\u0131, taronun petrol eteri fraksiyonunun t\u00fcm\u00f6r ta\u015f\u0131yan farelerde meme kanserinin b\u00fcy\u00fcme oran\u0131n\u0131 engelleyebildi\u011fini, t\u00fcm\u00f6r a\u011f\u0131rl\u0131\u011f\u0131n\u0131 azaltabildi\u011fini ve t\u00fcm\u00f6r inhibisyon oran\u0131n\u0131n konsantrasyona ba\u011fl\u0131 bir e\u011filim g\u00f6sterdi\u011fini ortaya koymu\u015ftur. Dalak, hayvanlarda ila\u00e7lar\u0131n ba\u011f\u0131\u015f\u0131kl\u0131k sistemi \u00fczerindeki etkisini yans\u0131tabilen \u00f6nemli bir ba\u011f\u0131\u015f\u0131kl\u0131k organ\u0131d\u0131r. A\u011f\u0131z yoluyla uygulanan EAC'nin orta ve y\u00fcksek doz gruplar\u0131ndaki farelerin dalak indeksi daha y\u00fcksekti ve model grup farelere k\u0131yasla \u00f6nemli farkl\u0131l\u0131klar vard\u0131, bu da taro'nun petrol eteri fraksiyonunun t\u00fcm\u00f6r ta\u015f\u0131yan farelerin ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonunu iyile\u015ftirebilece\u011fini g\u00f6stermektedir. T\u00fcm\u00f6r dokusunun HE boyama sonu\u00e7lar\u0131, model fare grubundaki t\u00fcm\u00f6r h\u00fccrelerinin yo\u011fun bir \u015fekilde b\u00fcy\u00fcd\u00fc\u011f\u00fcn\u00fc g\u00f6sterirken, 5-florourasil grubu ve taro ile tedavi edilen grupta gev\u015fek h\u00fccre d\u00fczeni, bulan\u0131k h\u00fccre konturlar\u0131 ve t\u00fcm\u00f6r h\u00fccrelerinin membran r\u00fcpt\u00fcr\u00fcn\u00fc g\u00f6steren t\u00fcm\u00f6r h\u00fccrelerinin belirgin nekrotik alanlar\u0131 vard\u0131. Taro'nun petrol eteri b\u00f6lgesi t\u00fcm\u00f6r h\u00fccrelerinin apoptozunu ind\u00fckleyebilmi\u015ftir.<\/p>\n<p>\u00c7ok say\u0131da \u00e7al\u0131\u015fma, enflamasyonun kardiyovask\u00fcler hastal\u0131k, kanser, diyabet, artrit, Alzheimer hastal\u0131\u011f\u0131 vb. dahil olmak \u00fczere \u00e7e\u015fitli hastal\u0131klara arac\u0131l\u0131k edebilece\u011fini g\u00f6stermi\u015ftir. Etken fakt\u00f6rlerin s\u00fcrekli varl\u0131\u011f\u0131, ortadan kald\u0131r\u0131lamayan iltihaplanmaya yol a\u00e7abilir ve iltihaplanma kronikle\u015febilir, bu da kanserin olu\u015fmas\u0131na ve geli\u015fmesine daha elveri\u015fli olan h\u00fccre mutasyonlar\u0131 ve \u00e7o\u011falmas\u0131yla sonu\u00e7lanabilir. T\u00fcm\u00f6r nekroz fakt\u00f6r\u00fc (TNF) \u00f6nemli proinflamatuar sitokinlerden biridir. Meme kanseri ile ilgili mikro \u00e7evre kronik inflamasyon ile karakterizedir. TNF - \u03b1, t\u00fcm\u00f6r h\u00fccrelerinde ve \u00e7evresindeki stromal h\u00fccrelerde \u00f6strojen metabolizmas\u0131n\u0131 uyararak ve \u00f6strojen biriktirerek t\u00fcm\u00f6rlerin olu\u015fumunu ve geli\u015fimini te\u015fvik edebilir. \u00c7al\u0131\u015fmalar, eksojen TNF - \u03b1'n\u0131n MDAMB-468, SK-BR3 ve MDA-MB-231 h\u00fccrelerinde t\u00fcm\u00f6r h\u00fccresi apoptozunu ind\u00fckleyemedi\u011fini, endojen TNF - \u03b1'n\u0131n ise HS578T h\u00fccrelerinde koruyucu anti apoptotik aktiviteye sahip oldu\u011funu bulmu\u015ftur. Pro-enflamatuar sitokin interl\u00f6kin-1 \u03b2'n\u0131n (IL-1 \u03b2) ana kaynaklar\u0131, t\u00fcm\u00f6r b\u00fcy\u00fcmesini te\u015fvik etmede veya t\u00fcm\u00f6r mikro\u00e7evresinde anti-t\u00fcm\u00f6r imm\u00fcn tespitini art\u0131rmada rol oynayan MDSC'ler, makrofajlar ve DC'ler gibi miyeloid h\u00fccreleri i\u00e7erir. IL-1 \u03b2'n\u0131n t\u00fcm\u00f6r mikro\u00e7evresindeki olgunla\u015fmam\u0131\u015f miyeloid h\u00fccrelerde MDSC'lerin birikimini te\u015fvik etti\u011fi ve b\u00f6ylece t\u00fcm\u00f6r ilerlemesini destekledi\u011fi g\u00f6sterilmi\u015ftir. Bu \u00e7al\u0131\u015fmada, ELISA kiti tespiti yoluyla, model grupla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, pozitif ila\u00e7 grubunun ve farkl\u0131 konsantrasyonlarda taro ile tedavi edilen gruplar\u0131n serumundaki TNF - \u03b1 ve IL-1 \u03b2 seviyelerinin azald\u0131\u011f\u0131 ve y\u00fcksek doz grubunun en d\u00fc\u015f\u00fck seviyelere sahip oldu\u011fu bulunmu\u015ftur. Bu nedenle, farelerde t\u00fcm\u00f6r a\u015f\u0131lamas\u0131ndan sonra, taro'nun petrol eteri fraksiyonunun pro-enflamatuar sitokin seviyelerini azaltarak t\u00fcm\u00f6r geli\u015fimini engelleyebilece\u011fi tahmin edilmektedir. Sonu\u00e7 olarak, Taro acuminata'n\u0131n petrol eteri fraksiyonu in vivo meme kanseri kar\u015f\u0131t\u0131 \u00f6nemli bir etkiye sahiptir.<\/p>\n<p>MAPK, endojen apoptotik yola\u011fa ait bir serin protein kinazd\u0131r. ERK, JNK ve p38, memelilerde ke\u015ffedilen ve farkl\u0131 aktivasyon durumlar\u0131na sahip en \u00f6nemli \u00fc\u00e7 sinyal yoludur. Aktivasyondan sonra \u00e7e\u015fitli b\u00fcy\u00fcme fakt\u00f6rleri, sitokinler ve hormon resept\u00f6rlerinin sinyal etkilerine kat\u0131larak h\u00fccre b\u00fcy\u00fcmesini ve farkl\u0131la\u015fmas\u0131n\u0131 d\u00fczenlerler. Bu deneysel \u00e7al\u0131\u015fmada, MAPKs sinyal yolu ile ilgili proteinler, ERK, JNK, p38, p-JNK ve p-p38 proteinlerinin seviyelerinde \u00f6nemli bir fark yoktu ve p-ERK proteininin ekspresyonu azald\u0131, bu da Taro'nun petrol eteri k\u0131sm\u0131n\u0131n p-ERK \/ ERK ekspresyonunu inhibe ederek meme kanseri kar\u015f\u0131t\u0131 bir rol oynayabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir, bu da \u00f6nceki \u00e7al\u0131\u015fmalar\u0131n in vitro sonu\u00e7lar\u0131 ve ilgili yollar\u0131n a\u011f farmakolojisi tahmini ile tutarl\u0131d\u0131r. Buna ek olarak, EAC, Bax\/Bcl-2 proteininin ekspresyonunu ve apoptoz geni Bax\/Bcl-2 mRNA seviyesini art\u0131rabilir, bu da EAC'nin t\u00fcm\u00f6r h\u00fccrelerinin apoptozunu te\u015fvik ederek meme kanseri kar\u015f\u0131t\u0131 bir rol oynad\u0131\u011f\u0131n\u0131 d\u00fc\u015f\u00fcnd\u00fcrmektedir.<br \/>\n\u00d6zetle, taro'nun petrol eteri fraksiyonu 4T1 meme kanseri ta\u015f\u0131yan farelerin t\u00fcm\u00f6r b\u00fcy\u00fcmesini engelleyebilir. Meme kanseri kar\u015f\u0131t\u0131 etkisi, \u00e7ok bile\u015fenli ve \u00e7ok hedefli \u00f6zellikleriyle ili\u015fkilidir. Mekanizmas\u0131, p-ERK\/ERK ekspresyonunun a\u015fa\u011f\u0131 reg\u00fclasyonu, Bax\/Bcl-2 ekspresyonunun art\u0131\u015f\u0131, Bax\/Bcl-2 mRNA seviyesinin art\u0131\u015f\u0131 ve t\u00fcm\u00f6r h\u00fccresi apoptozunun te\u015fvik edilmesi ile ilgili olabilir. Bu \u00e7al\u0131\u015fma, Taro acuminata'n\u0131n meme kanseri tedavisinde klinik uygulamas\u0131 i\u00e7in teorik bir referans sa\u011flamaktad\u0131r, ancak etkinli\u011fin, hedefin ve mekanizman\u0131n daha derinlemesine maddi temelinin daha fazla ara\u015ft\u0131r\u0131lmas\u0131 gerekmektedir.<\/p>","protected":false},"excerpt":{"rendered":"<p>Exploring the Anti breast cancer Mechanism of Taro acuminata Based on UPLC-Q-TOF-MS\/MS and Network Pharmacology Globally, breast cancer accounts for 10% of the incidence rate of all cancers and 15% of female tumor related mortality. The latest Global Cancer Report 2020 published by the World Health Organization shows that 2.1 million new breast cancer cases [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Exploring the Anti breast cancer Mechanism of Taro acuminata Based on UPLC-Q-TOF-MS\/MS and Network Pharmacology - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/uplc-q-tof-ms-ms-and-network-pharmacology\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Exploring the Anti breast cancer Mechanism of Taro acuminata Based on UPLC-Q-TOF-MS\/MS and Network Pharmacology - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Exploring the Anti breast cancer Mechanism of Taro acuminata Based on UPLC-Q-TOF-MS\/MS and Network Pharmacology Globally, breast cancer accounts for 10% of the incidence rate of all cancers and 15% of female tumor related mortality. 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