{"id":3898,"date":"2024-08-03T08:34:30","date_gmt":"2024-08-03T08:34:30","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3898"},"modified":"2024-08-03T08:34:30","modified_gmt":"2024-08-03T08:34:30","slug":"prevention-and-treatment-of-atherosclerosis","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/prevention-and-treatment-of-atherosclerosis\/","title":{"rendered":"Buyang Huanwu Dekoksiyonunun Nrf2\/ARE Sinyal Yolu ile Aterosklerozu \u00d6nleme ve Tedavi Etme Mekanizmas\u0131 \u00dczerine \u00c7al\u0131\u015fma"},"content":{"rendered":"

Buyang Huanwu Dekoksiyonunun Nrf2\/ARE Sinyal Yolu ile Aterosklerozu \u00d6nleme ve Tedavi Etme Mekanizmas\u0131 \u00dczerine \u00c7al\u0131\u015fma
\nAteroskleroz (AS) kronik inflamatuar bir hastal\u0131kt\u0131r. AS hastalar\u0131nda erken ba\u015flang\u0131\u00e7 sinsidir ve belirgin klinik bulgular yoktur, ancak hastal\u0131k ilerledik\u00e7e kalp ve beyin gibi hedef organlar ilerleyen a\u015famalarda etkilenebilir. D\u00fcnya Sa\u011fl\u0131k \u00d6rg\u00fct\u00fc (WHO) taraf\u0131ndan yap\u0131lan bir ara\u015ft\u0131rmaya g\u00f6re, orta ya\u015fl\u0131 ve ya\u015fl\u0131 insanlar hala kardiyovask\u00fcler advers olaylar i\u00e7in ana gruptur ve kardiyovask\u00fcler hastal\u0131k hastalar\u0131n\u0131n yakla\u015f\u0131k 81%'si 65 ya\u015f ve \u00fczerinde \u00f6lmektedir. Bununla birlikte, son y\u0131llarda AS hastalar\u0131n\u0131n n\u00fcfusu da daha gen\u00e7 olma e\u011filimindedir. \u00c7in'de kardiyovask\u00fcler ve serebrovask\u00fcler hastal\u0131klardan muzdarip yakla\u015f\u0131k 300 milyon insan bulunmaktad\u0131r. AS'nin modern t\u0131bbi tedavisi belirli bir etkinli\u011fe sahip olsa da, AS'nin y\u00fcksek insidans oran\u0131n\u0131 hala azaltamamaktad\u0131r ve uzun s\u00fcreli uygulamadan sonra bir\u00e7ok yan etki ortaya \u00e7\u0131kmaktad\u0131r. Bu nedenle, AS insidans\u0131n\u0131n azalt\u0131lmas\u0131 en \u00f6nemli \u00f6ncelik ve ana ak\u0131m ara\u015ft\u0131rma y\u00f6n\u00fcd\u00fcr. Oksidatif stres, ateroskleroz geli\u015fimine yol a\u00e7an \u00f6nemli fakt\u00f6rlerden biridir. \u0130leri oksidatif protein \u00fcr\u00fcnleri (AOPP) erken biyobelirte\u00e7ler ve aterosklerozun ba\u011f\u0131ms\u0131z g\u00fc\u00e7l\u00fc belirleyicileri olarak hizmet edebilirken, reaktif oksijen t\u00fcrleri (ROS) beyaz proteinlerin AOPP'ye oksidasyonunu te\u015fvik ederek oksidatif stresin patlak vermesine yol a\u00e7abilir; Malondialdehit (MDA), s\u00fcperoksit dismutaz (SOD) ve glutatyon peroksidaz (GSH Px), temel olarak v\u00fccudun oksidatif stres durumunu yans\u0131tabilen oksidatif stres yan\u0131t\u0131n\u0131n \u00f6nemli biyobelirte\u00e7leridir. Bu \u00fc\u00e7\u00fc s\u0131kl\u0131kla birbirleriyle etkile\u015fime girerek vask\u00fcler endotel ve doku h\u00fccrelerinde oksidatif hasara yol a\u00e7arak ateroskleroz olu\u015fumuna neden olur. Ara\u015ft\u0131rmalar, n\u00fckleer fakt\u00f6r E2 ile ili\u015fkili fakt\u00f6r 2 (Nrf2)\/antioksidan yan\u0131t eleman\u0131 (ARE) sinyal yolunun oksidatif stresi d\u00fczenleyen \u00f6nemli bir n\u00fckleer transkripsiyon fakt\u00f6r\u00fc oldu\u011funu bulmu\u015ftur. \u00c7oklu antioksidan proteinleri aktive edebilir ve h\u00fccre ya\u015flanmas\u0131, apoptoz ve proliferasyon gibi \u00e7e\u015fitli biyolojik s\u00fcre\u00e7lere kat\u0131labilir.
\nGeleneksel \u00c7in T\u0131bb\u0131 genellikle AS'nin ana patogenezinin, hastal\u0131\u011f\u0131n temel nedeni olan pozitif qi eksikli\u011finde yatt\u0131\u011f\u0131na inanmaktad\u0131r; Balgam, kan staz\u0131 ve di\u011fer patojenik fakt\u00f6rler \u00f6nemli patojenik fakt\u00f6rler ve hastal\u0131\u011f\u0131n ba\u015flang\u0131c\u0131n\u0131n g\u00f6stergeleridir. Bu nedenle, AS'nin patogenezine yan\u0131t olarak, bu \u00e7al\u0131\u015fma \"kalbi beslemek, kan staz\u0131n\u0131 gidermek ve balgam\u0131 \u00e7\u00f6zmek\" temel y\u00f6ntemini benimser ve AS'yi \u00f6nlemek ve tedavi etmek i\u00e7in modifiye edilmi\u015f Buyang Huanwu Tang kullan\u0131r. Buyang Huanwu Tang, Qing Hanedanl\u0131\u011f\u0131 d\u00f6neminde Wang Qingren'in \"Yi Lin Gai Cuo\" adl\u0131 eserinden al\u0131nan, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik eden ve qi'yi tonifiye eden klasik bir form\u00fcld\u00fcr. AS'nin patogeneziyle uyumlu olan Gualou Xiebai Banxia Tang ile birle\u015ftirilmi\u015ftir. Ayr\u0131ca, her ikisinin de klinik uygulamada AS ile ili\u015fkili hastal\u0131klar \u00fczerinde belirgin yan etkiler olmaks\u0131z\u0131n \u00f6nemli terap\u00f6tik etkileri vard\u0131r. Bu nedenle, bu \u00e7al\u0131\u015fma Buyang Huanwu Tang'\u0131 uygun \u015fekilde modifiye etmeyi se\u00e7mi\u015ftir. \u00d6n deneysel sonu\u00e7lar, modifiye Buyang Huanwu Tang'\u0131n imm\u00fcn inflamatuar yan\u0131t\u0131, endoplazmik retikulum stresini d\u00fczenleyerek ve HMGB1 ve Wnt1 gibi sinyal yolaklar\u0131n\u0131 etkileyerek, plak alan\u0131n\u0131 azaltarak ve AS lezyonlar\u0131n\u0131 hafifleterek AS'nin \u00f6nlenmesi ve tedavisi \u00fczerinde belirli bir etkiye sahip oldu\u011funu g\u00f6stermi\u015ftir. Bununla birlikte, spesifik etki mekanizmas\u0131 hen\u00fcz ayd\u0131nlat\u0131lmam\u0131\u015ft\u0131r. Bu nedenle, bu \u00e7al\u0131\u015fma modifiye Buyang Huanwu Tang'\u0131n aterosklerotik plak olu\u015fumu \u00fczerindeki etkisini ara\u015ft\u0131rmak ve modifiye Buyang Huanwu Tang'\u0131n Nrf2\/ARE sinyal yolu arac\u0131l\u0131\u011f\u0131yla aterosklerotik plaklar\u0131 d\u00fczenledi\u011fi spesifik mekanizmay\u0131 ayd\u0131nlatmak i\u00e7in oksidatif stresi ba\u015flang\u0131\u00e7 noktas\u0131 olarak almaktad\u0131r.<\/p>\n

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\nModern t\u0131bb\u0131n bir hastal\u0131k ad\u0131 olarak, geleneksel \u00c7in t\u0131bb\u0131n\u0131n eski kitaplar\u0131nda \"ateroskleroz\" kayd\u0131 yoktur, esas olarak l\u00fcmenin daralmas\u0131, damar duvar\u0131n\u0131n esnekli\u011finin azalmas\u0131 vb. gibi kan dola\u015f\u0131m\u0131n\u0131n t\u0131kanmas\u0131yla kendini g\u00f6sterir, bu nedenle \"g\u00f6\u011f\u00fcs a\u011fr\u0131s\u0131, ba\u015f d\u00f6nmesi, nab\u0131z t\u0131kan\u0131kl\u0131\u011f\u0131\" ve di\u011fer kategoriler olarak s\u0131n\u0131fland\u0131r\u0131l\u0131r. Geleneksel \u00c7in T\u0131bb\u0131, patogenezinin v\u00fccudun do\u011fru qi'sinin eksikli\u011finde yatt\u0131\u011f\u0131na ve bunun da qi ve kan\u0131n zay\u0131f dola\u015f\u0131m\u0131na yol a\u00e7t\u0131\u011f\u0131na inanmaktad\u0131r. \"Yi Lin Gai Cuo\" kitab\u0131nda belirtildi\u011fi gibi: \"E\u011fer qi zay\u0131fsa, kan damarlar\u0131na ula\u015famaz. Kan damarlar\u0131nda qi yoksa, kal\u0131r ve durgunla\u015f\u0131r; \"Compendium of Medicine\", \"felce elveri\u015fsiz nab\u0131z kanallar\u0131 ve kan gaz\u0131 t\u0131kan\u0131kl\u0131\u011f\u0131n\u0131n neden oldu\u011funu\" kaydederek, kan staz\u0131n\u0131n aterosklerozu ind\u00fcklemesine teorik bir temel sa\u011flar. Kalp eksikli\u011fi \u00f6zellikle pozitif qi eksikli\u011finde \u00f6nemlidir; kan staz\u0131 ve balgam bulan\u0131kl\u0131\u011f\u0131 gibi patolojik fakt\u00f6rler hastal\u0131\u011f\u0131n ba\u015flang\u0131c\u0131n\u0131n g\u00f6stergesidir. Bu \u00e7al\u0131\u015fma, AS patogenezi i\u00e7in \"kalbin beslenmesi, kan staz\u0131n\u0131n giderilmesi ve balgam\u0131n \u00e7\u00f6z\u00fclmesi\" temel prensibine dayanmaktad\u0131r. Form\u00fcl Huangqi, Danggui Wei, Chishao, Chuanxiong, Taoren, Honghua, Dilong, Gualou, Xiebai, Banxia, Codonopsis pilosula, Ophiopogon japonicus, Schisandra chinensis ve di\u011fer ila\u00e7lardan olu\u015fmaktad\u0131r. Huangqi, qi'yi beslemek i\u00e7in Codonopsis pilosula, Ophiopogon japonicus ve Schisandra chinensis ile birlikte kral\u0131n ilac\u0131d\u0131r. Qi g\u00fc\u00e7l\u00fc oldu\u011funda kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmek, kan dola\u015f\u0131m\u0131 g\u00fc\u00e7l\u00fc oldu\u011funda kan staz\u0131n\u0131 gidermek ve kan staz\u0131 giderildi\u011finde kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmek i\u00e7in tasarlanm\u0131\u015ft\u0131r; Danggui, qi ve kan\u0131 besleyen \u015fifal\u0131 bir bitkidir. Kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etmek ve kollaterallerin engelini kald\u0131rmak i\u00e7in solucanlar, k\u0131rm\u0131z\u0131 \u015fakay\u0131k, \u015feftali \u00e7ekirdekleri, k\u0131rm\u0131z\u0131 \u00e7i\u00e7ekler ve Chuanxiong e\u015flik eder; Gualou, Xiebai ve Banxia g\u00f6\u011fs\u00fc geni\u015fletmek, nod\u00fclleri da\u011f\u0131tmak ve balgam\u0131 temizlemek ve kollaterallerin engelini kald\u0131rmak i\u00e7in kullan\u0131l\u0131r. \u00c7e\u015fitli ila\u00e7lar\u0131n birlikte kullan\u0131m\u0131 qi'yi besleyici, kalbi besleyici ve bulan\u0131kl\u0131\u011f\u0131 giderici ve kollaterallerin t\u0131kan\u0131kl\u0131\u011f\u0131n\u0131 a\u00e7\u0131c\u0131 etkilere sahiptir. Modern ara\u015ft\u0131rmalar Buyang Huanwu Tang'\u0131n antioksidan stres, anti-enflamatuar, anti endotelyal h\u00fccre hasar\u0131, apoptoz ve di\u011fer y\u00f6nlerden anti AS etkileri g\u00f6sterebilece\u011fini g\u00f6stermi\u015ftir. Gualou, Xiebai ve Banxia, Gualou Xiebai Banxia Tang'dan t\u00fcretilmi\u015ftir. Modern ara\u015ft\u0131rmalar, Gualou Xiebai Banxia Tang'\u0131n oksidatif stresi inhibe ederek, lipid metabolizmas\u0131n\u0131 d\u00fczenleyerek ve enflamatuar reaksiyonlar\u0131 azaltarak AS'yi \u00f6nleyebildi\u011fini ve tedavi edebildi\u011fini g\u00f6stermi\u015ftir.
\nApoE geni nakavt edilmi\u015f (ApoE -\/-) fareler 1992 y\u0131l\u0131nda Kuzey Carolina \u00dcniversitesi Patoloji Geneti\u011fi Laboratuvar\u0131 ve Amerika Birle\u015fik Devletleri'ndeki Rockefeller \u00dcniversitesi Biyokimya Geneti\u011fi ve Metabolizma Laboratuvar\u0131 taraf\u0131ndan ba\u015far\u0131yla \u00fcretilmi\u015ftir. ApoE \u015filomikronlar\u0131n, a\u015f\u0131r\u0131 d\u00fc\u015f\u00fck yo\u011funluklu lipoproteinin ve y\u00fcksek yo\u011funluklu lipoproteinin \u00f6nemli bir bile\u015fenidir ve oksidatif stres, lipid metabolizmas\u0131, sinyal iletimi ve di\u011fer hususlar\u0131n d\u00fczenlenmesinde \u00e7ok \u00f6nemli bir rol oynar. ApoE -\/- farelerdeki patolojik de\u011fi\u015fiklikler insanlardakilere \u00e7ok benzemektedir. Do\u011fal diyet alt\u0131nda kendili\u011finden fibr\u00f6z plaklar ve kompozit plaklar olu\u015fturabilir ve ciddi hiperlipidemi geli\u015ftirebilirler. Erkeklerin AS lezyonlar\u0131 geli\u015ftirme olas\u0131l\u0131\u011f\u0131 daha y\u00fcksektir ve SD s\u0131\u00e7anlarla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda ApoE -\/- fareler daha h\u0131zl\u0131 model olu\u015fturur. Y\u00fcksek ya\u011fl\u0131 diyetle (0,15% kolesterol, 18% hidrojene kakao ya\u011f\u0131) 8 hafta boyunca beslendi\u011finde, rastgele diseke edilen farelerin aortunda lipid plaklar ve inflamatuar infiltrasyon bulunarak ba\u015far\u0131l\u0131 modelleme do\u011frulanm\u0131\u015ft\u0131r. Bu nedenle, erkek ApoE -\/- fareler genellikle deney i\u00e7in ara\u015ft\u0131rma denekleri olarak se\u00e7ilmektedir. Kan lipid seviyesi AS olu\u015fumu ile pozitif korelasyon g\u00f6stermektedir. Patolojik ko\u015fullar alt\u0131nda, arter duvar\u0131nda lipit birikir, monosit makrofajlar oksitlenir ve k\u00f6p\u00fck h\u00fccrelerine fagosite edilir, b\u00f6ylece fibr\u00f6z pla\u011f\u0131n stabilitesini azalt\u0131r ve AS s\u00fcrecini h\u0131zland\u0131r\u0131r. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, Buyang Huanwu Tang grubundaki AS plaklar\u0131ndaki TC, TG ve LDL-C seviyelerinin model grubundakilerden daha d\u00fc\u015f\u00fck oldu\u011funu ve aort k\u00f6k\u00fcnde \u00f6nemli bir lipit birikimi veya plak olu\u015fumu g\u00f6zlenmedi\u011fini g\u00f6stererek Buyang Huanwu Tang'\u0131n anti AS ve plak stabilize edici etkilerini daha da do\u011frulam\u0131\u015ft\u0131r.
\nOksidatif stres hasar\u0131, v\u00fccutta ROS \u00fcretimi ile antioksidan enzim sistemi taraf\u0131ndan ROS'un temizlenmesi aras\u0131ndaki dengesizli\u011fi ifade eder, ROS birikiminde art\u0131\u015fa yol a\u00e7ar ve v\u00fccutta oksidatif hasara neden olur. Arterde \u00e7ok fazla ROS birikti\u011finde, vask\u00fcler duvarda oksidatif hasara neden olacak, k\u00f6p\u00fck h\u00fccrelerinin \u00fcretimini te\u015fvik edecek, sonunda AS'yi ind\u00fckleyecek veya \u015fiddetlendirecek ve hatta insanlar\u0131n ya\u015fam kalitesini ciddi \u015fekilde etkileyecek olan AS pla\u011f\u0131n\u0131n y\u0131rt\u0131lmas\u0131n\u0131 te\u015fvik edecektir. AOPP, \u00e7e\u015fitli mekanizmalar yoluyla AS olu\u015fumuna ve geli\u015fimine kat\u0131labilir. Bir yandan oksidatif metabolizmas\u0131 s\u00fcperoksit (H2O2, O-2, OH -) \u00fcretimine neden olarak endotel disfonksiyonuna yol a\u00e7abilir; di\u011fer yandan AOPP, enflamatuar fakt\u00f6rlerin sentezini ve sal\u0131n\u0131m\u0131n\u0131 te\u015fvik edebilir, AS'nin ilerlemesini ind\u00fckleyebilir ve \u015fiddetlendirebilir. Bu nedenle, antioksidan reaksiyonlar AS'nin \u00f6nlenmesi ve tedavisinde \u00f6zellikle \u00f6nemlidir. Nrf2 sinyal yolu antioksidan stres ile yak\u0131ndan ili\u015fkilidir. V\u00fccuttaki a\u015f\u0131r\u0131 ROS y\u00fck\u00fc Nrf2\/HO sinyal yolunu aktive ederek Nrf2'nin Keap1 ile olu\u015fturdu\u011fu kompleksten ayr\u0131lmas\u0131na ve sitoplazmada serbest halde birikmesine neden olabilir. Ayn\u0131 zamanda fosforile edilerek \u00e7ekirde\u011fe aktar\u0131l\u0131r, HO-1 gen ekspresyonunu te\u015fvik eder ve h\u00fccresel antioksidan stres direncini art\u0131r\u0131r, b\u00f6ylece h\u00fccreler \u00fczerinde koruyucu bir etki g\u00f6sterir. Nrf2 geni, oksijen t\u00fcketen organlarda yayg\u0131n olarak bulunan bir alkalin l\u00f6sin fermuar transkripsiyon fakt\u00f6r\u00fcd\u00fcr. Antioksidan yan\u0131t yollar\u0131na arac\u0131l\u0131k edebilir, h\u00fccresel redoks homeostaz\u0131n\u0131 koruyabilir, \u00e7e\u015fitli antioksidan protein genlerini d\u00fczenleyebilir ve h\u00fccresel oksidatif streste \u00f6nemli bir rol oynayabilir. Nrf2\/ARE sinyal yolunun \u015fu anda h\u00fccresel homeostaz, lipid olu\u015fumu ve inflamatuar sitokin sal\u0131n\u0131m\u0131n\u0131n d\u00fczenlenmesinde rol oynayan en \u00f6nemli endojen antioksidan yol oldu\u011fu bilinmektedir. Ara\u015ft\u0131rmalar, Nrf2'nin oksidatif stres hasar\u0131n\u0131 azaltabildi\u011fini, enflamatuar reaksiyonlar\u0131 hafifletebildi\u011fini, h\u00fccreleri koruyabildi\u011fini ve arac\u0131l\u0131 antioksidan yolu arac\u0131l\u0131\u011f\u0131yla \u00e7e\u015fitli antioksidan enzim aktivitelerini d\u00fczenleyebildi\u011fini g\u00f6stermi\u015ftir. NQO-1, NADPH oksidaz\u0131 azaltabilir, ROS seviyelerini d\u00fc\u015f\u00fcrebilir ve oksidatif stres hasar\u0131n\u0131n olu\u015fumunu azaltabilir. HO-1, hemoglobinin CO, bilirubin ve biliverdin gibi maddelere par\u00e7alanmas\u0131n\u0131 te\u015fvik etti\u011fi ve ateroskleroz olu\u015fumu \u00fczerinde iyi bir \u00f6nleyici etkiye sahip oldu\u011fu ke\u015ffedilen olduk\u00e7a \u00f6nemli bir antioksidan enzimdir. Bu \u00e7al\u0131\u015fmada Buyang Huanwu Tang'\u0131n AS modeli farelerin aortunda Nrf2, ARE, NQO-1 ve HO-1 ekspresyonunu art\u0131rabildi\u011fi bulunmu\u015ftur. Buyang Huanwu Tang'\u0131n AS modeli farelerin aortunu oksidatif stres hasar\u0131ndan korumak i\u00e7in Nrf2\/ARE sinyal yolunu aktive edebilece\u011fi tahmin edilmektedir. Ara\u015ft\u0131rma grubumuz daha ileri \u00e7al\u0131\u015fmalar y\u00fcr\u00fctm\u00fc\u015f ve Buyang Huanwu Tang'\u0131n farelerin aortunda Nrf2 ve ARE proteinlerinin yan\u0131 s\u0131ra NQO-1, HO-1 proteinlerinin ve mRNA'lar\u0131n\u0131n ekspresyonunu art\u0131rabildi\u011fini bulmu\u015ftur. Bu da Buyang Huanwu Tang'\u0131n Nrf2\/ARE sinyal yolunu aktive edebilece\u011fini ve anti AS etkiler g\u00f6sterebilece\u011fini g\u00f6stermektedir. SOD, serbest oksijen radikallerini temizleyerek antioksidan etki g\u00f6sterebilen ve oksidatif stres seviyeleri \u00fczerinde do\u011frudan etkisi olan bir antioksidan enzimdir. MDA, oksidatif stres seviyeleri ile pozitif korelasyon g\u00f6steren ve v\u00fccudun oksidatif stres durumunu yans\u0131tabilen membran lipid peroksidasyonu s\u00fcrecindeki en \u00f6nemli \u00fcr\u00fcnlerden biridir. GSH Px v\u00fccutta \u00f6nemli bir antioksidand\u0131r, oksidatif stres derecesi ile negatif korelasyon g\u00f6sterir ve antioksidan etkiler g\u00f6stermek i\u00e7in ROS'u temizleyebilir. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, Buyang Huanwu Tang grubunun fare plazmas\u0131ndaki GSH Px ve SOD ekspresyon seviyelerini art\u0131rabildi\u011fini ve MDA ekspresyon seviyesini azaltabildi\u011fini g\u00f6stermi\u015ftir; AOPP ve ROS ekspresyon seviyelerini azalt\u0131n. Yukar\u0131dakiler ayr\u0131ca Buyang Huanwu Tang'\u0131n antioksidan ve stres giderici etkilere sahip oldu\u011funu do\u011frulamaktad\u0131r.<\/p>\n

\u00d6zetle, \"Kalbe Fayda Sa\u011flama, Kan Staz\u0131n\u0131 Giderme ve Balgam \u00c7\u00f6zme Y\u00f6ntemine\" dayanan Buyang Huanwu Kaynatma, anti oksidatif stres etkisine sahiptir, aortun patomorfolojik de\u011fi\u015fikliklerini \u00f6nemli \u00f6l\u00e7\u00fcde iyile\u015ftirebilir, aorttaki lipit birikimini azaltabilir ve anti ateroskleroz mekanizmas\u0131 Nrf2\/ARE sinyal yolunun aktivasyonu ile ilgili olabilir.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the Mechanism of Buyang Huanwu Decoction in Preventing and Treating Atherosclerosis through Nrf2\/ARE Signal Pathway Atherosclerosis (AS) is a chronic inflammatory disease. Early onset of AS patients is insidious and there are no obvious clinical manifestations, but as the disease progresses, target organs such as the heart and brain may be affected in […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the Mechanism of Buyang Huanwu Decoction in Preventing and Treating Atherosclerosis through Nrf2\/ARE Signal Pathway - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/prevention-and-treatment-of-atherosclerosis\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the Mechanism of Buyang Huanwu Decoction in Preventing and Treating Atherosclerosis through Nrf2\/ARE Signal Pathway - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the Mechanism of Buyang Huanwu Decoction in Preventing and Treating Atherosclerosis through Nrf2\/ARE Signal Pathway Atherosclerosis (AS) is a chronic inflammatory disease. 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