{"id":3862,"date":"2024-08-03T08:25:42","date_gmt":"2024-08-03T08:25:42","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3862"},"modified":"2024-08-03T08:25:42","modified_gmt":"2024-08-03T08:25:42","slug":"fucoidan","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/fucoidan\/","title":{"rendered":"S\u0131\u00e7anlarda fukoidan\u0131n oksidatif stres \u00fczerindeki hafifletici etkisi \u00fczerine \u00e7al\u0131\u015fma"},"content":{"rendered":"

S\u0131\u00e7anlarda fukoidan\u0131n oksidatif stres \u00fczerindeki hafifletici etkisi \u00fczerine \u00e7al\u0131\u015fma
\nNormal fizyolojik faaliyetler s\u0131ras\u0131nda v\u00fccut, ba\u011f\u0131\u015f\u0131kl\u0131k tepkilerine ve bilgi sunum s\u00fcre\u00e7lerine kat\u0131lmak i\u00e7in uygun miktarda reaktif oksijen t\u00fcr\u00fc (ROS) \u00fcretir. Ayn\u0131 zamanda, v\u00fccutta ROS reaksiyonlar\u0131n\u0131 engelleyen, fazla ROS'u temizleyebilen ve v\u00fccudun fizyolojik durumunun dengesini koruyabilen bir mekanizma da vard\u0131r. V\u00fccudun antioksidan i\u015flevi bozulur ve artan ROS zaman\u0131nda temizlenmeden uyar\u0131l\u0131rsa, v\u00fccudun n\u00fckleik asitler, proteinler, fosfolipitler, steroller ve ya\u011flar gibi biyolojik makromolek\u00fcllerine zarar vererek oksidatif stres reaksiyonlar\u0131na neden olur. V\u00fccuttaki normal h\u00fccreler, ROS istilas\u0131na direnmek i\u00e7in \u00e7ok say\u0131da enzim ve enzim olmayan endojen savunma sistemine sahiptir. \u00d6rne\u011fin, hayvan v\u00fccutlar\u0131nda bulunan s\u00fcperoksit dismutaz (SOD), katalaz (CAT) ve glutatyon peroksidaz (GPx) gibi enzim sistemleri O2- ve H2O2 gibi ROS'lar\u0131 molek\u00fcler oksijen ve suya d\u00f6n\u00fc\u015ft\u00fcr\u00fcr. Ara\u015ft\u0131rmalar, eksojen do\u011fal antioksidanlar\u0131n h\u00fccre i\u00e7i enzimatik ve enzimatik olmayan sistemleri iyile\u015ftirerek v\u00fccuttaki oksidatif stres kaynakl\u0131 hasar\u0131 hafifletmeye yard\u0131mc\u0131 oldu\u011funu bulmu\u015ftur. Do\u011fal antioksidanlar\u0131n \u00e7o\u011fu sebze, meyve ve bitkisel bitkilerden izole edilmektedir ve son zamanlarda deniz organizmalar\u0131ndan, \u00f6zellikle de deniz yosunundan izole edilen fukoidanlar da potansiyel antioksidan aktiviteye sahiptir.
\nFukoid polisakkaritler, esas olarak L-fukoz ve s\u00fclfat gruplar\u0131n\u0131n yan\u0131 s\u0131ra az miktarda \u00e7e\u015fitli protein formlar\u0131, monosakkaritler, \u00fcronik asitler ve asetil gruplar\u0131ndan olu\u015fan heterolog do\u011fal polisakkaritlerin karma\u015f\u0131k bir kar\u0131\u015f\u0131m\u0131d\u0131r. Ara\u015ft\u0131rmalar, farkl\u0131 kaynaklardan elde edilen fukoidan\u0131n ana aktif gruplar\u0131 olan s\u00fclfat gruplar\u0131n\u0131n i\u00e7eri\u011finin ve b\u00f6lgelerinin de\u011fi\u015fti\u011fini g\u00f6stermi\u015ftir. S\u00fclfat gruplar\u0131 \u00e7o\u011funlukla fukoidan kal\u0131nt\u0131lar\u0131n\u0131n C2, C4 veya her iki pozisyonunda, bazen de fukoidan\u0131n aktivitesini ve etkinli\u011fini b\u00fcy\u00fck \u00f6l\u00e7\u00fcde etkileyen C3 pozisyonunda bulunur. Son y\u0131llarda yap\u0131lan ara\u015ft\u0131rmalar, fukoidan\u0131n antikoag\u00fclan, antibakteriyel, antiviral, anti obezite, anti t\u00fcm\u00f6r, anti artrit, n\u00f6roproteksiyon, ba\u011f\u0131\u015f\u0131kl\u0131k d\u00fczenlemesi ve ba\u011f\u0131rsak bariyer fonksiyonunun korunmas\u0131 gibi bir\u00e7ok biyolojik aktiviteye sahip oldu\u011funu g\u00f6stermi\u015ftir. Ara\u015ft\u0131rmalar, fukoidan\u0131n hem in vivo hem de in vitro olarak m\u00fckemmel antioksidan aktivite sergiledi\u011fini g\u00f6stermi\u015ftir. Ayr\u0131ca fukoidan, antioksidan i\u015flevi arac\u0131l\u0131\u011f\u0131yla mide \u00fclserlerini \u00f6nleme, yara iyile\u015fmesini te\u015fvik etme ve n\u00f6roproteksiyon gibi biyolojik aktiviteler de g\u00f6sterir.
\nYukar\u0131daki sonu\u00e7lar, fukoidan\u0131n potansiyel bir do\u011fal antioksidan oldu\u011funu ve g\u0131da katk\u0131 maddesi olarak kullan\u0131lmak \u00fczere do\u011fal bir antioksidan olarak geli\u015ftirilme potansiyeline sahip oldu\u011funu g\u00f6stermektedir. Buna dayanarak, bu deneyde Diclofenae'nin intraperitoneal enjeksiyonu ile bir oksidatif stres s\u0131\u00e7an modeli olu\u015fturulmu\u015f ve bu do\u011fal antioksidan\u0131n oksidatif stres \u00fczerindeki hafifletici etkisini incelemek i\u00e7in fukoidan ile beslenmi\u015ftir.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"
\nNormal hayvan organizmalar\u0131nda, ROS'un \u00fcretimi ve temizlenmesi dinamik bir denge s\u00fcrecidir. \u0130\u00e7 ve d\u0131\u015f ortamda ciddi de\u011fi\u015fiklikler veya a\u015f\u0131r\u0131 stres oldu\u011funda, v\u00fccutta b\u00fcy\u00fck miktarda ROS birikmesine yol a\u00e7abilir, bu da kolayca h\u00fccre \u00f6l\u00fcm\u00fcne veya doku hasar\u0131na neden olabilir ve b\u00f6ylece hayvanlar\u0131n normal ya\u015fam aktivitelerini etkileyebilir. Karaci\u011fer v\u00fccutta \u00f6nemli bir metabolik organd\u0131r ve dalak \u00f6nemli bir ba\u011f\u0131\u015f\u0131kl\u0131k organ\u0131d\u0131r. \u00c7e\u015fitli kimyasal reaktifler ve ila\u00e7lar karaci\u011fer ve dalakta hasara ve hatta patolojik hasara neden olabilir. Oksidatif stres, \u00e7e\u015fitli karaci\u011fer ve dalak hastal\u0131klar\u0131nda yayg\u0131n olarak bulunur ve ROS, birden fazla fakt\u00f6r\u00fcn neden oldu\u011fu karaci\u011fer ve dalak hastal\u0131klar\u0131n\u0131n patogenezinde \u00f6nemli bir rol oynar. ALT ve AST'nin karaci\u011fer taraf\u0131ndan sentezlenmesi ve salg\u0131lanmas\u0131, karaci\u011fer fonksiyonunu de\u011ferlendirmek i\u00e7in \u00f6nemli g\u00f6stergelerdir. Karaci\u011fer h\u00fccreleri hasar g\u00f6rd\u00fc\u011f\u00fcnde, \u00fcretilen ROS h\u00fccre membranlar\u0131na ve organellerine zarar vererek karaci\u011fer h\u00fccrelerinin \u015fi\u015fmesine ve hatta \u00f6lmesine neden olabilir, bu da ALT ve AST'nin h\u00fccrelerden kan dola\u015f\u0131m\u0131na sal\u0131nmas\u0131na ve serum ALT ve AST aktivitesinde art\u0131\u015fa yol a\u00e7ar. Bu \u00e7al\u0131\u015fma, Diclofenae taraf\u0131ndan ind\u00fcklenen oksidatif stresin s\u0131\u00e7anlarda serum AST aktivitesini art\u0131rd\u0131\u011f\u0131n\u0131, oksidatif stresin ise serum total bilirubin seviyelerinde art\u0131\u015fa yol a\u00e7t\u0131\u011f\u0131n\u0131 bulmu\u015ftur. Buna ek olarak, oksidatif stres s\u0131\u00e7anlarda karaci\u011fer ve dalak a\u011f\u0131rl\u0131\u011f\u0131n\u0131 azaltarak oksidatif stresin karaci\u011fer ve dalakta hasara neden oldu\u011funu g\u00f6stermektedir. ROS olu\u015fumunu ve lipid peroksidasyonunu \u00f6nlemek, do\u011fal karaci\u011fer koruyucu bile\u015fiklerin en yayg\u0131n mekanizmas\u0131d\u0131r. Son y\u0131llarda, \u00e7e\u015fitli deniz yosunlar\u0131ndan ve baz\u0131 deniz omurgas\u0131zlar\u0131ndan izole edilen fukoidanlar\u0131n, v\u00fccuttaki oksidatif stres \u00fczerinde belirli bir hafifletici etkiye sahip potansiyel ROS temizleyicileri oldu\u011fu ve antioksidan aktivite yoluyla karaci\u011fer ve dalak koruyucu etkiler g\u00f6sterme potansiyeline sahip oldu\u011fu g\u00f6sterilmi\u015ftir. Ara\u015ft\u0131rmalar, fukoidan ile tedavinin farelerde asetaminofen (APAP), siklofosfamid, alkole maruz kalma, CCl4 ve D-galaktosamin+lipopolisakkarit taraf\u0131ndan ind\u00fcklenen serum ALT ve AST aktivitesinin y\u00fckselmesini \u00f6nemli \u00f6l\u00e7\u00fcde engelledi\u011fini ve karaci\u011fer hasar\u0131 \u00fczerinde iyi bir koruyucu etkiye sahip oldu\u011funu g\u00f6stermi\u015ftir. Yukar\u0131daki sonu\u00e7larla tutarl\u0131 olarak, s\u0131\u00e7anlar\u0131n fukoidan ile beslenmesi serum AST aktivitesini \u00f6nemli \u00f6l\u00e7\u00fcde azaltm\u0131\u015ft\u0131r, bu da fukoidan\u0131n s\u0131\u00e7anlarda karaci\u011fer hasar\u0131n\u0131 etkili bir \u015fekilde hafifletebilece\u011fini g\u00f6stermektedir.
\nBuna ek olarak, oksidatif hasar v\u00fccuttaki antioksidan enzimlerin a\u015f\u0131r\u0131 t\u00fcketimine yol a\u00e7abilir veya antioksidan enzimlerin sentezini ve aktivasyonunu inhibe ederek v\u00fccuttaki oksidatif hasar\u0131 \u015fiddetlendirebilir. Bu \u00e7al\u0131\u015fmada, Diklofenak'\u0131n intraperitoneal enjeksiyonundan sonra, karaci\u011fer dokusundaki GSH, CAT, SOD ve GPx aktivitelerinin seviyeleri \u00f6nemli \u00f6l\u00e7\u00fcde azalm\u0131\u015f ve dalak dokusundaki CAT, SOD ve GPx aktiviteleri de \u00f6nemli \u00f6l\u00e7\u00fcde azalm\u0131\u015ft\u0131r. Bu durum, oksidatif stresin v\u00fccutta CAT, SOD, GPx ve GSH'nin t\u00fckenmesine, antioksidan kapasitenin azalmas\u0131na, h\u00fccre zar\u0131 lipidlerinin a\u015f\u0131r\u0131 oksidasyonuna ve MDA i\u00e7eri\u011finde art\u0131\u015fa yol a\u00e7t\u0131\u011f\u0131n\u0131 g\u00f6stermektedir. Fukoidan ile \u00f6n muamele, Diclofenae'nin intraperitoneal enjeksiyonundan sonra SOD ve GPx aktivitesindeki azalmay\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde hafifletmi\u015f, v\u00fccudun genel antioksidan kapasitesini art\u0131rm\u0131\u015f ve lipid peroksidasyonunu azaltm\u0131\u015ft\u0131r. \u00d6zetle, fukoidan ile beslenme s\u0131\u00e7an karaci\u011feri ve dala\u011f\u0131n\u0131n antioksidan kapasitesini art\u0131rabilir. Benzer \u015fekilde, fukoidan APAP ile muamele edilmi\u015f fare karaci\u011fer dokusunda GSH seviyelerini artt\u0131rm\u0131\u015f ve SOD ve CAT aktivitelerini artt\u0131rarak ROS ve MDA seviyelerini inhibe etmi\u015ftir. Tian ve arkada\u015flar\u0131n\u0131n ara\u015ft\u0131rmas\u0131 da fukoidan\u0131n fare karaci\u011ferinde SOD, GPx ve CAT aktivitelerini art\u0131rd\u0131\u011f\u0131n\u0131, MDA seviyelerini d\u00fc\u015f\u00fcrd\u00fc\u011f\u00fcn\u00fc ve farelerde siklofosfamid kaynakl\u0131 karaci\u011fer hasar\u0131n\u0131 hafifletti\u011fini g\u00f6stermi\u015ftir. Fukoidan polisakkaritleri ayr\u0131ca CCl4 ve D-galaktosamin+lipopolisakkarit kaynakl\u0131 karaci\u011fer hasar\u0131 fare modellerinde serum SOD ve GPx aktivitesindeki azalmay\u0131 etkili bir \u015fekilde hafifletebilir, MDA i\u00e7eri\u011fini azaltabilir ve ROS'un neden oldu\u011fu lipid peroksidasyonunu inhibe edebilir, b\u00f6ylece karaci\u011feri koruyabilir. Ayr\u0131ca fukoidan, siklosporin A'n\u0131n ind\u00fckledi\u011fi s\u0131\u00e7an b\u00f6brek dokusunda NO i\u00e7eri\u011findeki art\u0131\u015f\u0131 azaltm\u0131\u015f, dalak GSH i\u00e7eri\u011fini art\u0131rm\u0131\u015f, siklosporin A'n\u0131n SOD aktivitesi \u00fczerindeki inhibit\u00f6r etkisini tersine \u00e7evirmi\u015f ve b\u00f6ylece b\u00f6brek dokusu hasar\u0131n\u0131 iyile\u015ftirmi\u015ftir. Bu sonu\u00e7lar, fukoidan\u0131n antioksidan enzimlerin aktivitesini art\u0131rarak v\u00fccuttaki lipid peroksidasyonunu ve oksidatif hasar\u0131 hafifletebilece\u011fini g\u00f6stermektedir.
\nHayvan v\u00fccutlar\u0131nda birden fazla oksidatif stres yolu vard\u0131r ve bunlardan biri Keap1 (Kelch like epichlorohydrin associated protein-1) - Nrf2 ARE (antioksidan yan\u0131t elementi) sinyal yoludur. H\u00fccreler uyar\u0131lmad\u0131\u011f\u0131nda, inhibit\u00f6r proteinler Keap1 ve Nrf2, Nrf2'yi sitoplazmada ayr\u0131 olarak izole eden bir kompleks olu\u015fturmak \u00fczere ba\u011flan\u0131r. V\u00fccut stres fakt\u00f6rlerine veya ind\u00fckleyicilere maruz kald\u0131\u011f\u0131nda, Nrf2 spesifik serin veya treonin b\u00f6lgesinde fosforilasyona u\u011frar ve Nrf2 Keap1\/Nrf2 kompleksinden ayr\u0131l\u0131r ve \u00e7ekirde\u011fe g\u00f6\u00e7 eder. Daha sonra, Nrf2 ARE'ye ba\u011flan\u0131r ve h\u00fccrenin ROS'u temizleme yetene\u011fini art\u0131ran HO-1, kinon oksidored\u00fcktaz 1 (NQO1), glutatyon S-transferaz (GST), CAT, SOD ve GPx dahil olmak \u00fczere h\u00fccre i\u00e7i detoksifiye edici enzimleri kodlayan bir dizi a\u015fa\u011f\u0131 ak\u0131\u015f koruyucu genin ekspresyonunu d\u00fczenler. Ara\u015ft\u0131rmalar, fukoidan\u0131n Nrf2 sinyal yolunu d\u00fczenleyerek v\u00fccuttaki oksidatif hasar\u0131 hafifletebilece\u011fini bulmu\u015ftur. Fukoidanla beslenme, s\u0131\u00e7an karaci\u011fer dokusunda dimetilnitrozamin taraf\u0131ndan ind\u00fcklenen Nrf2 ekspresyonundaki azalmay\u0131 yukar\u0131 do\u011fru d\u00fczenleyebilir, GST, NQO1 ve SOD gibi genlerin transkripsiyonunu yukar\u0131 do\u011fru d\u00fczenleyebilir, b\u00f6ylece karaci\u011fer ve serumda SOD ve GPx aktivitesini art\u0131rabilir ve v\u00fccuttaki lipid peroksidasyon derecesini hafifletebilir. Ara\u015ft\u0131rmalar, fukoidan\u0131n ayr\u0131ca Nrf2\/HO-1 yolunu d\u00fczenleyerek Nrf2, HO-1, glutamat sistein ligaz (GCLM) ve NQO1 protein seviyelerini art\u0131rabildi\u011fini, b\u00f6ylece karaci\u011fer ve b\u00f6breklerde CAT, SOD ve GPx aktivitelerini art\u0131rd\u0131\u011f\u0131n\u0131, MDA seviyelerini azaltt\u0131\u011f\u0131n\u0131 ve ICR farelerinde siklofosfamid kaynakl\u0131 karaci\u011fer ve b\u00f6brek hasar\u0131n\u0131 iyile\u015ftirdi\u011fini bulmu\u015ftur. Fukoidan\u0131n karaci\u011fer dokusunda total Nrf2 ve \u00e7ekirdekte Nrf2 ekspresyonunu art\u0131rd\u0131\u011f\u0131n\u0131, SOD ve CAT aktivitesini ve GSH i\u00e7eri\u011fini art\u0131rd\u0131\u011f\u0131n\u0131 ve karaci\u011fer dokusunda APAP taraf\u0131ndan ind\u00fcklenen ROS ve MDA seviyelerindeki art\u0131\u015f\u0131 hafifletti\u011fini g\u00f6steren \u00e7al\u0131\u015fmalar da vard\u0131r. Yukar\u0131daki sonu\u00e7lar, fukoidan\u0131n karaci\u011fer koruyucu mekanizmas\u0131n\u0131n Nrf2 arac\u0131l\u0131 oksidatif stres ile ili\u015fkili oldu\u011funu g\u00f6stermektedir. fukoidan, Nrf2'nin sitoplazmadan \u00e7ekirde\u011fe translokasyonunu etkili bir \u015fekilde uyar\u0131r, v\u00fccudun antioksidan kapasitesini art\u0131r\u0131r ve ROS birikimini engeller. Yukar\u0131daki bak\u0131\u015f a\u00e7\u0131s\u0131yla tutarl\u0131 olarak, bu deneyde, oksidatif stres s\u0131\u00e7an karaci\u011fer ve dalak dokular\u0131nda Nrf2'nin gen ekspresyonunu inhibe etmi\u015f ve a\u015fa\u011f\u0131 ak\u0131\u015f CAT, SOD1, SOD2 ve GPx'in gen ekspresyonunu a\u015fa\u011f\u0131 d\u00fczenlemi\u015ftir. Fukoidan ile beslenmenin karaci\u011fer ve dalak dokular\u0131nda Nrf2, GPx ve SOD2 gen ekspresyonunu yukar\u0131 y\u00f6nl\u00fc d\u00fczenlemesi, fukoidan\u0131n Nrf2 sinyal yolunu ve SOD ve GPx gibi a\u015fa\u011f\u0131 y\u00f6nl\u00fc antioksidan enzimleri aktive etti\u011fini, b\u00f6ylece antioksidan etkiler g\u00f6sterdi\u011fini ve v\u00fccuttaki oksidatif hasar\u0131 engelledi\u011fini g\u00f6stermektedir.
\n\u00d6zetle, fukoidan antioksidan enzim genlerinin ekspresyonunu artt\u0131r\u0131r ve Nrf2 yolu arac\u0131l\u0131\u011f\u0131yla s\u0131\u00e7an karaci\u011fer ve dalak dokular\u0131nda antioksidan enzim aktivitesini d\u00fczenler, b\u00f6ylece s\u0131\u00e7anlarda oksidatif stres yan\u0131t\u0131n\u0131 hafifletir.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the alleviating effect of fucoidan on oxidative stress in rats During normal physiological activities, the body produces an appropriate amount of reactive oxygen species (ROS) to participate in immune responses and information presentation processes. At the same time, there is also a mechanism in the body that inhibits ROS reactions, which can clear […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the alleviating effect of fucoidan on oxidative stress in rats - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/fucoidan\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the alleviating effect of fucoidan on oxidative stress in rats - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the alleviating effect of fucoidan on oxidative stress in rats During normal physiological activities, the body produces an appropriate amount of reactive oxygen species (ROS) to participate in immune responses and information presentation processes. At the same time, there is also a mechanism in the body that inhibits ROS reactions, which can clear […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/tr\/fucoidan\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-03T08:25:42+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-16.png\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"8 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/fucoidan\/\",\"url\":\"https:\/\/longchangextracts.com\/fucoidan\/\",\"name\":\"Study on the alleviating effect of fucoidan on oxidative stress in rats - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangextracts.com\/fucoidan\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangextracts.com\/fucoidan\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-16.png\",\"datePublished\":\"2024-08-03T08:25:42+00:00\",\"dateModified\":\"2024-08-03T08:25:42+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/fucoidan\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/fucoidan\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/fucoidan\/#primaryimage\",\"url\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-16.png\",\"contentUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-16.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/fucoidan\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Study on the alleviating effect of fucoidan on oxidative stress in rats\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Fukoidan\u0131n s\u0131\u00e7anlarda oksidatif stres \u00fczerindeki hafifletici etkisi \u00fczerine \u00e7al\u0131\u015fma - \u00c7in Kimya \u00dcreticisi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/tr\/fucoidan\/","og_locale":"tr_TR","og_type":"article","og_title":"Study on the alleviating effect of fucoidan on oxidative stress in rats - China Chemical Manufacturer","og_description":"Study on the alleviating effect of fucoidan on oxidative stress in rats During normal physiological activities, the body produces an appropriate amount of reactive oxygen species (ROS) to participate in immune responses and information presentation processes. At the same time, there is also a mechanism in the body that inhibits ROS reactions, which can clear […]","og_url":"https:\/\/longchangextracts.com\/tr\/fucoidan\/","og_site_name":"China Chemical Manufacturer","article_published_time":"2024-08-03T08:25:42+00:00","og_image":[{"url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-16.png"}],"author":"longcha9","twitter_card":"summary_large_image","twitter_misc":{"Yazan:":"longcha9","Tahmini okuma s\u00fcresi":"8 dakika"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/longchangextracts.com\/fucoidan\/","url":"https:\/\/longchangextracts.com\/fucoidan\/","name":"Fukoidan\u0131n s\u0131\u00e7anlarda oksidatif stres \u00fczerindeki hafifletici etkisi \u00fczerine \u00e7al\u0131\u015fma - \u00c7in Kimya \u00dcreticisi","isPartOf":{"@id":"https:\/\/longchangextracts.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/longchangextracts.com\/fucoidan\/#primaryimage"},"image":{"@id":"https:\/\/longchangextracts.com\/fucoidan\/#primaryimage"},"thumbnailUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-16.png","datePublished":"2024-08-03T08:25:42+00:00","dateModified":"2024-08-03T08:25:42+00:00","author":{"@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869"},"breadcrumb":{"@id":"https:\/\/longchangextracts.com\/fucoidan\/#breadcrumb"},"inLanguage":"tr","potentialAction":[{"@type":"ReadAction","target":["https:\/\/longchangextracts.com\/fucoidan\/"]}]},{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/fucoidan\/#primaryimage","url":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-16.png","contentUrl":"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-16.png"},{"@type":"BreadcrumbList","@id":"https:\/\/longchangextracts.com\/fucoidan\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/longchangextracts.com\/"},{"@type":"ListItem","position":2,"name":"Study on the alleviating effect of fucoidan on oxidative stress in rats"}]},{"@type":"WebSite","@id":"https:\/\/longchangextracts.com\/#website","url":"https:\/\/longchangextracts.com\/","name":"\u00c7in Kimyasal \u00dcreticisi","description":"","potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/longchangextracts.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"tr"},{"@type":"Person","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869","name":"longcha9","image":{"@type":"ImageObject","inLanguage":"tr","@id":"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/","url":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g","caption":"longcha9"}}]}},"_links":{"self":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/3862"}],"collection":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/comments?post=3862"}],"version-history":[{"count":1,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/3862\/revisions"}],"predecessor-version":[{"id":3870,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/posts\/3862\/revisions\/3870"}],"wp:attachment":[{"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/media?parent=3862"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/categories?post=3862"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/longchangextracts.com\/tr\/wp-json\/wp\/v2\/tags?post=3862"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}