{"id":3852,"date":"2024-08-03T08:22:31","date_gmt":"2024-08-03T08:22:31","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3852"},"modified":"2024-08-03T08:22:31","modified_gmt":"2024-08-03T08:22:31","slug":"fermentation-broth-of-guantu-sporangium","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/fermentation-broth-of-guantu-sporangium\/","title":{"rendered":"Guantu San Nang bakterilerinin fermantasyon suyunun y\u00fcksek ya\u011fl\u0131 diyetle beslenen s\u0131\u00e7anlarda obezite ve ba\u011f\u0131rsak mikrobiyotas\u0131 \u00fczerine etkisi"},"content":{"rendered":"<p>Guantu San Nang bakterilerinin fermantasyon suyunun y\u00fcksek ya\u011fl\u0131 diyetle beslenen s\u0131\u00e7anlarda obezite ve ba\u011f\u0131rsak mikrobiyotas\u0131 \u00fczerine etkisi<br \/>\nObezite, anormal enerji metabolizmas\u0131 nedeniyle v\u00fccutta a\u015f\u0131r\u0131 ya\u011f birikmesi anlam\u0131na gelir. Y\u00fcksek ya\u011fl\u0131 ve y\u00fcksek \u015fekerli beslenme, g\u00fcn\u00fcm\u00fczde d\u00fcnyada en yayg\u0131n beslenme \u015fekli haline gelmi\u015ftir. Y\u00fcksek ya\u011f ve y\u00fcksek \u015feker bile\u015fenlerinin a\u015f\u0131r\u0131 al\u0131m\u0131 ya\u011f birikimine ve obeziteye yol a\u00e7acakt\u0131r. A\u015f\u0131r\u0131 obezite sadece insanlar\u0131n ruh sa\u011fl\u0131\u011f\u0131n\u0131 etkilemekle kalmaz, ayn\u0131 zamanda diyabet, kardiyovask\u00fcler hastal\u0131k, hiperlipidemi, hipertansiyon ve benzeri gibi \u00e7e\u015fitli metabolik hastal\u0131klara da yol a\u00e7abilir. Obezite, insan sa\u011fl\u0131\u011f\u0131 i\u00e7in ciddi bir tehdit olu\u015fturarak k\u00fcresel bir halk sa\u011fl\u0131\u011f\u0131 sorunu haline gelmi\u015ftir. Ba\u011f\u0131rsak mikrobiyotas\u0131, kona\u011f\u0131n ba\u011f\u0131rsa\u011f\u0131nda bulunan ve \u00f6ncelikle v\u00fccuttaki homeostaz\u0131n korunmas\u0131ndan sorumlu olan b\u00fcy\u00fck bir mikrobiyal topluluktur. Ara\u015ft\u0131rmalar, ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131n v\u00fccudun metabolizmas\u0131n\u0131 ve enerji dengesini etkili bir \u015fekilde d\u00fczenleyebildi\u011fini ve obezitenin olu\u015fumunu ve geli\u015fimini \u00f6nlemede \u00f6nemli bir rol oynad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir.<br \/>\n\"Alt\u0131n \u00c7i\u00e7ek Mantar\u0131\" olarak da bilinen Eurotium cristatum, Ascomycota tak\u0131m\u0131na, Aspergillus familyas\u0131na ve Ascomycota cinsine ait potansiyel bir probiyotik mantard\u0131r. Geleneksel Fuzhuan \u00e7ay\u0131n\u0131n \"\u00e7i\u00e7eklenme\" s\u00fcrecinde anahtar bir mikroorganizmad\u0131r. Fermantasyon s\u00fcreci s\u0131ras\u0131nda Guantu San Nang bakterileri, lipit d\u00fc\u015f\u00fcr\u00fcc\u00fc ve kilo kayb\u0131, ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131 d\u00fczenleme ve bakterileri inhibe etme etkilerine sahip flavonoidler, alkaloidler, piperazinedion t\u00fcrevleri ve mantar polisakkaritleri gibi \u00e7e\u015fitli biyoaktif metabolitler \u00fcretebilir ve insan metabolizmas\u0131n\u0131 etkili bir \u015fekilde d\u00fczenleyebilir. Guantu sporangium, g\u0131da ve geleneksel \u00c7in t\u0131bb\u0131 fermantasyon alanlar\u0131nda yayg\u0131n olarak kullan\u0131lmaktad\u0131r. G\u00fcvenli ve \u00e7evre dostu bir probiyotik mantar olan Candida albicans, yaln\u0131zca substrat\u0131n lezzetini iyile\u015ftirmekle kalmaz, ayn\u0131 zamanda kolesterol d\u00fc\u015f\u00fcr\u00fcc\u00fc, antioksidan ve kan \u015fekerini d\u00fc\u015f\u00fcr\u00fcc\u00fc gibi biyolojik aktivitelere de sahiptir. \u00c7ok say\u0131da \u00e7al\u0131\u015fma, Streptococcus pneumoniae'nin hem h\u00fccre i\u00e7i hem de h\u00fccre d\u0131\u015f\u0131 polisakkaritlerinin ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131 d\u00fczenleyerek ve ba\u011f\u0131rsak bariyerini iyile\u015ftirerek v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonunu art\u0131rabildi\u011fini ve iyi lipit d\u00fc\u015f\u00fcr\u00fcc\u00fc ve kilo kayb\u0131 etkilerine sahip oldu\u011funu g\u00f6stermi\u015ftir. \u015eu anda, Colletotrichum coronatum'un fermantasyon s\u00fcreci esas olarak kat\u0131 formdad\u0131r ve daha az s\u0131v\u0131 formdad\u0131r. Bu \u00e7al\u0131\u015fma, Colletotrichum coronatum'un fermantasyon suyunu s\u0131v\u0131 k\u00fclt\u00fcr y\u00f6ntemiyle elde etmeyi ama\u00e7lamaktad\u0131r. Ayn\u0131 zamanda, Streptococcus pneumoniae fermantasyon suyunun obez s\u0131\u00e7anlarda metabolizma ve ba\u011f\u0131rsak mikrobiyota bozukluklar\u0131 \u00fczerindeki etkilerini ara\u015ft\u0131rmak i\u00e7in g\u0131da kaynakl\u0131 obez s\u0131\u00e7an modeli olu\u015fturulmu\u015ftur.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3853\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-15.png\" alt=\"\" width=\"954\" height=\"368\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-15.png 954w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-15-768x296.png 768w\" sizes=\"(max-width: 954px) 100vw, 954px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3854\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-14.png\" alt=\"\" width=\"1042\" height=\"376\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-14.png 1042w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-14-768x277.png 768w\" sizes=\"(max-width: 1042px) 100vw, 1042px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3855\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-13.png\" alt=\"\" width=\"974\" height=\"490\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-13.png 974w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-13-768x386.png 768w\" sizes=\"(max-width: 974px) 100vw, 974px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3856\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-14.png\" alt=\"\" width=\"1002\" height=\"248\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-14.png 1002w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-14-768x190.png 768w\" sizes=\"(max-width: 1002px) 100vw, 1002px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3857\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-12.png\" alt=\"\" width=\"978\" height=\"396\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-12.png 978w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-12-768x311.png 768w\" sizes=\"(max-width: 978px) 100vw, 978px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3858\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-11.png\" alt=\"\" width=\"896\" height=\"908\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-11.png 896w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-11-768x778.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-11-710x720.png 710w\" sizes=\"(max-width: 896px) 100vw, 896px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3859\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-10.png\" alt=\"\" width=\"954\" height=\"518\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-10.png 954w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-10-768x417.png 768w\" sizes=\"(max-width: 954px) 100vw, 954px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3860\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-8.png\" alt=\"\" width=\"1020\" height=\"470\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-8.png 1020w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-8-768x354.png 768w\" sizes=\"(max-width: 1020px) 100vw, 1020px\" \/><br \/>\nObezite, v\u00fccuttaki kronik ve d\u00fc\u015f\u00fck dereceli enflamasyonla yak\u0131ndan ili\u015fkili olan, daha az fiziksel efor ve daha y\u00fcksek kalori al\u0131m\u0131ndan kaynakland\u0131\u011f\u0131na inan\u0131lan, bir\u00e7ok sa\u011fl\u0131k sorunuyla ili\u015fkili bir hastal\u0131kt\u0131r. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, y\u00fcksek ya\u011fl\u0131 bir diyetin s\u0131\u00e7anlar\u0131n v\u00fccut a\u011f\u0131rl\u0131\u011f\u0131n\u0131 ve ya\u011f birikimini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rd\u0131\u011f\u0131n\u0131 ve metabolik bozukluklar\u0131 \u015fiddetlendirdi\u011fini g\u00f6stermi\u015ftir. Candida albicans'\u0131n b\u00fcy\u00fcme d\u00f6neminde, obezite \u00fczerinde g\u00fc\u00e7l\u00fc inhibit\u00f6r etkileri olan ve obez farelerin kan lipit seviyeleri \u00fczerinde belirli bir d\u00fczenleyici etkiye sahip olan ramnoz ve galaktoz gibi mantar polisakkaritleri gibi \u00e7e\u015fitli faydal\u0131 metabolitler \u00fcretilebilir. \u00c7al\u0131\u015fma ayr\u0131ca Colletotrichum coronatum'un fermente \u00f6z\u00fct\u00fcn\u00fcn, karaci\u011ferdeki IL-6\/STAT3 sinyal yolunu mod\u00fcle ederek g\u0131da kaynakl\u0131 obezitenin neden oldu\u011fu karaci\u011fer iltihab\u0131n\u0131 ve ya\u011f birikimini daha da d\u00fczenleyebilece\u011fini buldu. Bu deney ayr\u0131ca Candida albicans fermantasyon suyunun diyetle ind\u00fcklenen obezite seviyeleri \u00fczerinde inhibe edici bir etkiye sahip oldu\u011funu, ya\u011f birikimini de\u011fi\u015fen derecelerde hafifletti\u011fini ve s\u0131\u00e7an serumundaki TG, TC ve LDH-C seviyelerini azaltt\u0131\u011f\u0131n\u0131 ve bu da kolesterol\u00fcn metabolik dengesini d\u00fczenlemeye yard\u0131mc\u0131 oldu\u011funu g\u00f6stermi\u015ftir. Serumdaki LDH-C seviyesi ateroskleroz i\u00e7in risk fakt\u00f6rlerinden biridir. Lipid peroksidasyonu da aterosklerozun olu\u015fumu ve geli\u015fimi ile ili\u015fkilidir. Bu nedenle, Sarcocystis coronarius'un fermantasyon s\u0131v\u0131s\u0131 sadece y\u00fcksek ya\u011fl\u0131 diyetin neden oldu\u011fu metabolik bozuklu\u011fu etkili bir \u015fekilde d\u00fczenlemekle kalmaz, ayn\u0131 zamanda aterosklerozu da \u00f6nleyebilir.<br \/>\nBa\u011f\u0131rsak mikrobiyotas\u0131n\u0131n \u00e7e\u015fitlili\u011findeki azalma obezite i\u00e7in y\u00fcksek risk fakt\u00f6r\u00fcd\u00fcr. 16S rDNA amplifikasyon dizileme teknolojisi kullan\u0131larak yap\u0131lan analiz, y\u00fcksek ya\u011fl\u0131 diyet ind\u00fcksiyonu alt\u0131nda, s\u0131\u00e7anlarda ba\u011f\u0131rsak mikrobiyota \u00e7e\u015fitlili\u011finin \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131n\u0131 ve F \/ B oran\u0131n\u0131n da \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Bu sonu\u00e7, Lin, Zhang ve di\u011ferlerinin ba\u011f\u0131rsaktaki F\/B oran\u0131 dengesizli\u011finin konak\u00e7\u0131 obezitesinin olu\u015fumunu desteklemeye yard\u0131mc\u0131 oldu\u011fu y\u00f6n\u00fcndeki ara\u015ft\u0131rmalar\u0131yla tutarl\u0131d\u0131r. Firmicutes bollu\u011fundaki azalma, daha y\u00fcksek bir polisakkarit diyeti ve lipopolisakkarit \u00fcretimi ile ilgilidir. Guantu San Nang bakterilerinin fermantasyon suyu ile yap\u0131lan m\u00fcdahaleden sonra, F\/B oran\u0131 yeniden d\u00fczenlenmi\u015f ve mikrobiyotan\u0131n \u00e7e\u015fitlili\u011fi yeniden sa\u011flanarak ya\u011f al\u0131m\u0131n\u0131n neden oldu\u011fu ba\u011f\u0131rsak mikrobiyotas\u0131 dengesizli\u011fi etkili bir \u015fekilde iyile\u015ftirilmi\u015ftir. Helicobacter pylori'nin ba\u011f\u0131rsakta bilinen faydal\u0131 bir bakteri oldu\u011funu g\u00f6steren \u00e7al\u0131\u015fmalar vard\u0131r ve ayr\u0131ca NK4A214_grubu bollu\u011fundaki art\u0131\u015f\u0131n ba\u011f\u0131rsakta antimikrobiyal peptitlerin sal\u0131n\u0131m\u0131n\u0131 art\u0131rarak savunma ve koruyucu i\u015flevlerini geli\u015ftirdi\u011fine dair raporlar da vard\u0131r. Christensennellacee_R-7 grubu, ba\u011f\u0131rsakta ve mukozada yayg\u0131n olarak bulunan, pro-enflamatuar sitokinleri azaltabilen ve ba\u011f\u0131rsak mukozal bariyer i\u015flevini iyile\u015ftirebilen potansiyel bir probiyotiktir. Ba\u011f\u0131rsak mukozas\u0131yla ili\u015fkili bu mikroorganizmalar, ba\u011f\u0131rsak iltihab\u0131n\u0131 ve ba\u011f\u0131rsak mukozal bariyer bozulmas\u0131n\u0131 azaltarak obezite kar\u015f\u0131t\u0131 etkilerini g\u00f6sterebilir. Lactobacillus, y\u00fcksek doz grubunun ay\u0131rt edici bir mikrobiyotas\u0131d\u0131r ve insan ve hayvan ba\u011f\u0131rsak mikrobiyotas\u0131ndaki en \u00f6nemli probiyotiktir. \u0130nsanlarda ve hayvanlarda y\u00fcksek ya\u011fl\u0131 diyetlerin neden oldu\u011fu obeziteyi hafifletti\u011fi kan\u0131tlanm\u0131\u015ft\u0131r. Turicibacter cinsi bakteriler patojenik bir ya\u015fam tarz\u0131na sahiptir ve bolluklar\u0131ndaki art\u0131\u015f, bozulmu\u015f ba\u011f\u0131rsak mikrobiyota yap\u0131s\u0131n\u0131n belirtilerinden biridir. Bacteroidetes cinsinde asetik asit \u00fcretebilen \u00e7ok say\u0131da patojenik bakteri oldu\u011funu g\u00f6steren \u00e7al\u0131\u015fmalar da vard\u0131r. Bunlar\u0131n bollu\u011fundaki bir art\u0131\u015f, ba\u011f\u0131rsakta peroksidasyon inflamatuar fakt\u00f6rlerinin ve lipid inhibit\u00f6r fakt\u00f6rlerinin \u00fcretimini uyarabilir, lipid oksidasyon metabolizmas\u0131n\u0131 inhibe edebilir ve v\u00fccutta lipid birikimini te\u015fvik edebilir. Patojenlerin zenginle\u015fmesi, obezite ve ilgili metabolik bozukluklarla ili\u015fkili olan konak\u00e7\u0131 sistemik enflamasyonuna neden olabilir. Colletotrichum coronatum fermantasyon suyu, y\u00fcksek ya\u011fl\u0131 diyetin neden oldu\u011fu obeziteyi iyile\u015ftirebilir, ba\u011f\u0131rsak savunma i\u015flevini geli\u015ftirebilir ve ba\u011f\u0131rsakta NK4A214_group, UCG-005, Christensennellacee_R-7_group ve Lactobacillus gibi yararl\u0131 bakterilerin bollu\u011funu art\u0131rarak ve Turicibacter ve Bacteroides'in bollu\u011funu azaltarak iltihab\u0131 azaltabilir.<br \/>\n\u00d6zetle, obezitenin olu\u015fumu ve geli\u015fimi ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131n dengesizli\u011fi ile yak\u0131ndan ili\u015fkilidir. Guantu San Nang bakterilerinin fermantasyon suyu, y\u00fcksek ya\u011fl\u0131 diyet s\u0131\u00e7anlar\u0131n\u0131n obezite durumunu etkili bir \u015fekilde iyile\u015ftirebilir, kona\u011f\u0131n ba\u011f\u0131rsak yolundaki faydal\u0131 mikrobiyal topluluklar\u0131n bollu\u011funu d\u00fczenleyebilir, faydal\u0131 canl\u0131l\u0131klar\u0131n\u0131 uygulayabilir ve zararl\u0131 mikrobiyal topluluklar\u0131n bollu\u011funu azaltabilir, kilo kayb\u0131 ve lipit d\u00fc\u015f\u00fcr\u00fcc\u00fc etki elde edebilir. Bununla birlikte, v\u00fccuttaki ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131n yap\u0131s\u0131 ve bile\u015fimi nispeten karma\u015f\u0131kt\u0131r ve Colletotrichum coronatum fermantasyon suyunun ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131 d\u00fczenledi\u011fi spesifik molek\u00fcler mekanizmalar\u0131n yan\u0131 s\u0131ra hangi bile\u015fenlerin obezite kar\u015f\u0131t\u0131 aktiviteye sahip oldu\u011fu hala daha fazla ara\u015ft\u0131rma gerektirmektedir.<\/p>","protected":false},"excerpt":{"rendered":"<p>Guantu San Nang bakterilerinin fermantasyon suyunun y\u00fcksek ya\u011fl\u0131 diyetle beslenen s\u0131\u00e7anlarda obezite ve ba\u011f\u0131rsak mikrobiyotas\u0131 \u00fczerindeki etkisi Obezite, anormal enerji metabolizmas\u0131 nedeniyle v\u00fccutta a\u015f\u0131r\u0131 ya\u011f birikmesi anlam\u0131na gelir. Y\u00fcksek ya\u011fl\u0131 ve y\u00fcksek \u015fekerli diyet, g\u00fcn\u00fcm\u00fczde d\u00fcnyada en yayg\u0131n diyet \u015fekli haline gelmi\u015ftir. A\u015f\u0131r\u0131 miktarda [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The effect of fermentation broth of Guantu San Nang bacteria on obesity and intestinal microbiota in high-fat diet rats - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/fermentation-broth-of-guantu-sporangium\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The effect of fermentation broth of Guantu San Nang bacteria on obesity and intestinal microbiota in high-fat diet rats - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"The effect of fermentation broth of Guantu San Nang bacteria on obesity and intestinal microbiota in high-fat diet rats Obesity refers to the excessive accumulation of fat in the body due to abnormal energy metabolism. 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