{"id":3831,"date":"2024-08-03T08:17:48","date_gmt":"2024-08-03T08:17:48","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3831"},"modified":"2024-08-03T08:17:48","modified_gmt":"2024-08-03T08:17:48","slug":"total-caffeoylquinic-acid-of-lamplighter-xixin","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/lamplighter-xixinin-toplam-kafeoilkinik-asidi\/","title":{"rendered":"Scutellaria baicalensis'te PI3K\/Akt\/FoxO3a Yola\u011f\u0131n\u0131 D\u00fczenleyen ve Ya\u015flanmay\u0131 Geciktiren Toplam Kafeoilkinik Asit Mekanizmas\u0131 \u00dczerine \u00c7al\u0131\u015fma"},"content":{"rendered":"

Scutellaria baicalensis'te PI3K\/Akt\/FoxO3a Yola\u011f\u0131n\u0131 D\u00fczenleyen ve Ya\u015flanmay\u0131 Geciktiren Toplam Kafeoilkinik Asit Mekanizmas\u0131 \u00dczerine \u00c7al\u0131\u015fma
\nYa\u015flanma, ya\u015fa ba\u011fl\u0131 kademeli bir fizyolojik gerilemedir ve hayatta kalma yetene\u011finin kayb\u0131na ve k\u0131r\u0131lganl\u0131\u011f\u0131n artmas\u0131na neden olur. Ya\u015flanma \u00e7evresel ve genetik fakt\u00f6rlerden etkilenir ve on iki ana \u00f6zelli\u011fe sahiptir: genomik istikrars\u0131zl\u0131k, epigenetik de\u011fi\u015fiklikler, telomer t\u00fckenmesi, beslenme alg\u0131s\u0131 bozukluklar\u0131, protein homeostaz dengesizlikleri, mitokondriyal disfonksiyon, h\u00fccresel ya\u015flanma, anormal h\u00fccreler aras\u0131 ileti\u015fim, k\u00f6k h\u00fccre t\u00fckenmesi, makrootofaji inaktivasyonu, kronik inflamasyon ve ba\u011f\u0131rsak mikrobiyota disbiyozu. Bu \u00f6zellikler aras\u0131nda, ins\u00fclin ve ins\u00fclin benzeri b\u00fcy\u00fcme fakt\u00f6r\u00fc-1'in (IGF-1) ins\u00fclin resept\u00f6rlerine ba\u011flanmas\u0131 yoluyla a\u015fa\u011f\u0131 ak\u0131\u015f sinyal yollar\u0131n\u0131 d\u00fczenleyerek ya\u015fam s\u00fcresini etkileyen 'beslenme d\u00fczensizli\u011fi' molek\u00fcler d\u00fczeyde do\u011frulanm\u0131\u015f ilk \u00f6zelliktir. \u0130ns\u00fclin\/IGF-1, 4,5-difosfat fosfatidilinositolden (PIP2) 3,4,5-trifosfat fosfatidilinositol (PIP3) \u00fcretimini katalize eden fosfatidilinositol 3-kinaz\u0131 (PI3K) aktive etmek i\u00e7in ins\u00fclin resept\u00f6rlerine ba\u011flan\u0131r. Ard\u0131ndan, protein kinaz B (Akt\/protein kinaz B, Akt\/PKB) plazma membran\u0131na al\u0131n\u0131r ve Akt'deki treonin s\u0131ras\u0131yla PIP3 ba\u011f\u0131ml\u0131 kinaz-1 ve -2 (PDK-1 ve PDK-2) arac\u0131l\u0131\u011f\u0131yla ifade edilir. Fosforilasyon, serinin 308 (Thr308) ve 473 (Ser473) pozisyonlar\u0131nda ger\u00e7ekle\u015ferek fosforile Akt (t phosphop Akt, p-Akt) olu\u015fturur ve Akt'yi aktive eder. Forkhead box class O3a (FOXO3a), forkhead box transkripsiyon fakt\u00f6r\u00fc O alt ailesinin d\u00f6rt \u00fcyesinden biridir. Aktive Akt, FoxO3a'n\u0131n treonin 32 b\u00f6lgesini (Thr32) ve serin 253 b\u00f6lgesini (Ser253) fosforile ederek fosforile FOXO3'\u00fc (bir fosfop-FOXO3a, p-FOXO3a) olu\u015fturur, bu da FoxO3a'n\u0131n 14-3-3 proteinine ba\u011flanmas\u0131n\u0131 te\u015fvik eder, b\u00f6ylece FoxO3a'n\u0131n \u00e7ekirde\u011fe girmesini ve transkripsiyonel aktiviteyi kaybetmesini \u00f6nler. FoxO3a, otofajiyi te\u015fvik ederek, oksidatif direnci art\u0131rarak ve k\u00f6k h\u00fccre pluripotensini koruyarak uzun \u00f6m\u00fcrl\u00fcl\u00fc\u011f\u00fc te\u015fvik etmede rol oynayabilen, ya\u015flanmay\u0131 d\u00fczenleyen \u00f6nemli bir transkripsiyon fakt\u00f6r\u00fcd\u00fcr. Oksidatif diren\u00e7 a\u00e7\u0131s\u0131ndan, FoxO3a transkripsiyonel aktivasyonu s\u00fcperoksit dismutaz (SOD), glutatyon peroksidaz (GSH Px) ve katalaz (CAT) gibi genlerin ekspresyonunu art\u0131r\u0131r, reaktif oksijen t\u00fcrlerini (ROS) temizler ve lipid peroksidasyon \u00fcr\u00fcn\u00fc malondialdehit (MDA) seviyesini azalt\u0131r, b\u00f6ylece v\u00fccut ya\u015flanmas\u0131n\u0131 geciktirir ve ya\u015fam s\u00fcresini uzat\u0131r. Omurgas\u0131z ve omurgal\u0131 modellerinde yap\u0131lan \u00e7al\u0131\u015fmalar, ins\u00fclin\/IGF-1 seviyelerinin azalt\u0131lmas\u0131n\u0131n ve ins\u00fclin resept\u00f6rleri, PI3K ve Akt'nin mutasyona u\u011frat\u0131lmas\u0131n\u0131n FoxO3a n\u00fckleer translokasyonunu te\u015fvik edebilece\u011fini, transkripsiyonel aktivitesini art\u0131rabilece\u011fini ve ya\u015flanmay\u0131 geciktirebilece\u011fini g\u00f6stermi\u015ftir.
\nErigeron breviscapus (Vant.) Hand- Mazz.)\uff0c Dengzhan Hua olarak da bilinir, ilk olarak \"Dian Nan Ben Cao\" da kaydedilmi\u015ftir, kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etme, meridyenlerin t\u0131kan\u0131kl\u0131\u011f\u0131n\u0131 a\u00e7ma, a\u011fr\u0131y\u0131 hafifletme, r\u00fczgar\u0131 giderme ve so\u011fu\u011fu giderme etkilerine sahiptir. Esas olarak inme hemiplejisi, g\u00f6\u011f\u00fcs a\u011fr\u0131s\u0131, romatizma a\u011fr\u0131s\u0131, ba\u015f a\u011fr\u0131s\u0131 ve di\u015f a\u011fr\u0131s\u0131 tedavisinde kullan\u0131l\u0131r. Flavonoidler ve kafeoilkinik asit (CQA) Scutellaria baicalensis'in ana aktif bile\u015fenleridir. A\u011f farmakolojisi ve molek\u00fcler yerle\u015ftirme kullan\u0131larak yap\u0131lan \u00f6nceki \u00e7al\u0131\u015fmalar, flavonoidlerin ve CQA bile\u015fiklerinin Scutellaria baicalensis'in ya\u015flanma kar\u015f\u0131t\u0131 \u00f6zelliklerinde potansiyel aktif bile\u015fenler oldu\u011funu ve d\u00f6rt temel hedefi d\u00fczenleyerek ya\u015flanma kar\u015f\u0131t\u0131 etkiler g\u00f6sterebilece\u011fini bulmu\u015ftur: p53, AKT, HDAC1 ve SIRT1. Molek\u00fcler kenetlenmede, tek CQA bile\u015fenleri 4-CQA, 5-CQA, klorojenik asit ve dikafeoilkinik asit (DCQA) bile\u015fenleri 4,5-DCQA, 3,4-DCQA, 3,5-DCQA, 1,3-DCQA ve 1,5-DCQA i\u00e7eren kafeoil bile\u015fikleri, AKT ile inhibit\u00f6r ligandlar\u0131ndan daha y\u00fcksek kenetlenme skorlar\u0131na sahiptir. Ya\u015fam s\u00fcresi deneyi, bu bile\u015fenlerin hepsinin nematodlar\u0131n ya\u015fam s\u00fcresini uzatma etkisine sahip oldu\u011funu ortaya koymu\u015ftur. Bunlar aras\u0131nda, mutant su\u015flar ve transgenik nematodlar arac\u0131l\u0131\u011f\u0131yla 3,5-DCQA'n\u0131n nematodlarda PI3K ve AKT homologlar\u0131 AGE-1 ve AKT-1'in aktivitesini inhibe etti\u011fi, FoxO3a homologu DAF-16'n\u0131n \u00e7ekirde\u011fe giri\u015fini te\u015fvik etti\u011fi ve b\u00f6ylece uzun \u00f6m\u00fcrl\u00fcl\u00fc\u011f\u00fc te\u015fvik edici bir etki g\u00f6sterdi\u011fi do\u011frulanm\u0131\u015ft\u0131r. Yukar\u0131daki bulgular, Scutellaria baicalensis'teki CQA bile\u015fenlerinin AKT aktivitesini inhibe ederek ve PI3K\/Akt\/FoxO3a yolunu d\u00fczenleyerek ya\u015flanmay\u0131 geciktirebilece\u011fini g\u00f6stermektedir. Bu \u00e7al\u0131\u015fman\u0131n amac\u0131, \u00f6nceki ara\u015ft\u0131rmalara dayanarak Erigeron breviscapus'tan (EBCQA) elde edilen toplam kafeoilkinik asidin ya\u015flanma kar\u015f\u0131t\u0131 etkisini g\u00f6zlemlemek ve PI3K\/Akt\/FoxO3a yola\u011f\u0131na dayal\u0131 olarak EBCQA'n\u0131n ya\u015flanma kar\u015f\u0131t\u0131 mekanizmas\u0131n\u0131 ara\u015ft\u0131rmakt\u0131r.<\/p>\n

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\nYa\u015flanma ya\u015fam\u0131n do\u011fal bir s\u00fcrecidir ve ka\u00e7\u0131n\u0131lmaz olmas\u0131na ra\u011fmen beslenme d\u00fczenlemesi, genetik manip\u00fclasyon, ila\u00e7 m\u00fcdahalesi ve di\u011fer yollarla geciktirilebilir. Daha da \u00f6nemlisi, bu ya\u015flanma kar\u015f\u0131t\u0131 m\u00fcdahaleler yaln\u0131zca ya\u015fam s\u00fcresini uzatmakla kalmaz, ayn\u0131 zamanda v\u00fccudun genel sa\u011fl\u0131\u011f\u0131n\u0131 da \u00f6nemli \u00f6l\u00e7\u00fcde iyile\u015ftirir. \u00d6nceki \u00e7al\u0131\u015fmalarda, EBCQA'n\u0131n potansiyel ya\u015flanma kar\u015f\u0131t\u0131 etkilere sahip oldu\u011funu ve AKT aktivitesini d\u00fczenlemekle ili\u015fkili olabilece\u011fini bulmu\u015ftuk. Bu \u00e7al\u0131\u015fmada, EBCQA'n\u0131n nematodlar\u0131n \u00f6mr\u00fcn\u00fc uzatma, oksidatif ve \u0131s\u0131 direncini art\u0131rma ve hareketlili\u011fi iyile\u015ftirme etkilerine sahip oldu\u011funu do\u011frulad\u0131k. Nematodlar\u0131n mutant su\u015flar\u0131 arac\u0131l\u0131\u011f\u0131yla, EBCQA'n\u0131n ya\u015flanma kar\u015f\u0131t\u0131 etkisinin PI3K\/Akt\/FoxO3a yola\u011f\u0131n\u0131n d\u00fczenlenmesi, antioksidan enzim aktivitesinin art\u0131r\u0131lmas\u0131 ve MDA seviyelerinin azalt\u0131lmas\u0131 ile ili\u015fkili oldu\u011funu do\u011frulad\u0131k; D-galaktoz ile ya\u015fland\u0131r\u0131lan s\u0131\u00e7anlarda, EBCQA \u00f6\u011frenme ve haf\u0131za yeteneklerini, timus ve dalak katsay\u0131lar\u0131n\u0131 art\u0131r\u0131r, PI3K ve Akt aktivasyonunun yan\u0131 s\u0131ra FoxO3a fosforilasyonunu inhibe eder, antioksidan enzim aktivitesini art\u0131r\u0131r ve MDA seviyelerini azalt\u0131r.
\nCQA s\u0131n\u0131f\u0131 bile\u015fenler Scutellaria baicalensis'teki fenolik aktif bile\u015fenlerin \u00f6nemli bir s\u0131n\u0131f\u0131d\u0131r ve ayn\u0131 zamanda bir\u00e7ok g\u0131dada (mor tatl\u0131 patates, ye\u015fil kahve gibi) ve \u015fifal\u0131 bitkilerde de bulunur. CQA bile\u015fikleri n\u00f6roprotektif, kardiyovask\u00fcler koruyucu, antioksidan, anti-inflamatuar, anti-diyabet ve di\u011fer etkilere sahiptir. Ya\u015flanma kar\u015f\u0131t\u0131 olarak, CQA bile\u015fenleri bak\u0131m\u0131ndan zengin ye\u015fil kahve ekstresi ve han\u0131meli ekstresi nematodlar\u0131n \u00f6mr\u00fcn\u00fc uzatm\u0131\u015ft\u0131r, ancak ya\u015flanma kar\u015f\u0131t\u0131 mekanizmalar\u0131n\u0131n PI3K\/Akt\/FoxO3a yolunu i\u00e7erip i\u00e7ermedi\u011fi hala belirsizdir; Memelilerde CQA bile\u015fenlerinin ya\u015flanma kar\u015f\u0131t\u0131 etkileri nadiren bildirilmi\u015ftir. CQA bile\u015fenlerinin nematod \u00f6mr\u00fcn\u00fc uzatma yetene\u011fine sahip oldu\u011funa dair \u00f6nceki raporlarla tutarl\u0131 olarak, EBCQA'n\u0131n nematod \u00f6mr\u00fcn\u00fc maksimum 17.7% uzama oran\u0131yla uzatt\u0131\u011f\u0131n\u0131 ve oksidatif direnci, \u0131s\u0131 direncini ve hareketlili\u011fi art\u0131rd\u0131\u011f\u0131n\u0131 bulduk. D-galaktoz ile ind\u00fcklenen ya\u015flanan s\u0131\u00e7an modelinin do\u011fal ya\u015flanmay\u0131 etkili bir \u015fekilde sim\u00fcle etti\u011fi kan\u0131tlanm\u0131\u015ft\u0131r ve bu nedenle ya\u015flanma mekanizmalar\u0131n\u0131 incelemek ve ya\u015flanmay\u0131 geciktiren ila\u00e7lar\u0131 taramak i\u00e7in yayg\u0131n olarak kullan\u0131lmaktad\u0131r. Azalan \u00f6\u011frenme ve haf\u0131za yetenekleri ya\u015flanmayla ili\u015fkili yayg\u0131n fizyolojik olaylard\u0131r ve baz\u0131lar\u0131 Alzheimer hastal\u0131\u011f\u0131 gibi n\u00f6rodejeneratif hastal\u0131klara d\u00f6n\u00fc\u015febilir. Ya\u015f artt\u0131k\u00e7a veya hastal\u0131klar ortaya \u00e7\u0131kt\u0131k\u00e7a, v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k kapasitesi genellikle yava\u015f yava\u015f azal\u0131r. Timus ve dalak \u00f6nemli ba\u011f\u0131\u015f\u0131kl\u0131k organlar\u0131d\u0131r ve organ endeksleri bir dereceye kadar v\u00fccudun ba\u011f\u0131\u015f\u0131kl\u0131k kapasitesinin boyutunu yans\u0131tabilir. Bu nedenle, \u00f6\u011frenme ve haf\u0131za yetene\u011finin yan\u0131 s\u0131ra timus\/dalak organ indeksi, ya\u015flanmay\u0131 ve ya\u015flanmay\u0131 geciktirmeyi de\u011ferlendirmek i\u00e7in yayg\u0131n olarak kullan\u0131lan g\u00f6stergelerdir. D-galaktoz ile ya\u015fland\u0131r\u0131lan s\u0131\u00e7anlarda \u00f6\u011frenme ve haf\u0131za yeteneklerinin yan\u0131 s\u0131ra timus ve dalak katsay\u0131lar\u0131nda da azalma g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. EBCQA uygulamas\u0131 \u00f6\u011frenme ve haf\u0131za yeteneklerini etkili bir \u015fekilde geli\u015ftirmi\u015f, timus ve dalak katsay\u0131lar\u0131n\u0131 art\u0131rm\u0131\u015ft\u0131r. Bu sonu\u00e7lar, EBCQA'n\u0131n hem omurgas\u0131z nematodlarda hem de omurgal\u0131 D-galaktoz kaynakl\u0131 ya\u015flanan s\u0131\u00e7anlarda ya\u015flanma kar\u015f\u0131t\u0131 bir etkiye sahip oldu\u011funu g\u00f6stermektedir.
\nPI3K\/Akt\/FoxO3a yolu, ins\u00fclin, IGF-1 ve di\u011fer fakt\u00f6rler taraf\u0131ndan d\u00fczenlenen evrimsel olarak korunmu\u015f bir sinyal yoludur. Ya\u015flanma d\u00fczenlemesinde PI3K ve Akt ya\u015flanma yanl\u0131s\u0131 bir rol oynarken, FOXO3a ya\u015flanma kar\u015f\u0131t\u0131 bir rol oynar. Nematodlarda AGE-1, AKT-1 ve DAF-16 s\u0131ras\u0131yla memeli PI3K, Akt ve FoxO3a'n\u0131n homologlar\u0131d\u0131r. AGE-1 mutasyonlar\u0131na sahip nematodlar\u0131n ortalama ya\u015fam s\u00fcresi 40% ila 65% aras\u0131nda uzar, AKT-1 mutasyonlar\u0131na sahip olanlar\u0131n da ya\u015fam s\u00fcreleri \u00f6nemli \u00f6l\u00e7\u00fcde uzar ve DAF-16 mutasyonlar\u0131 ya\u015fam s\u00fcrelerini \u00f6nemli \u00f6l\u00e7\u00fcde k\u0131salt\u0131r. Memelilerde, AKT-1'in a\u015f\u0131r\u0131 ekspresyonu h\u00fccresel ya\u015flanmaya neden olur. AKT-1 mutasyonlu farelerde (Akt1+\/-) erkeklerin ya\u015fam s\u00fcresinde 8%, di\u015filerin ya\u015fam s\u00fcresinde ise 15% art\u0131\u015f g\u00f6r\u00fclmektedir. Uzun \u00f6m\u00fcrl\u00fc pop\u00fclasyonlar \u00fczerinde yap\u0131lan ara\u015ft\u0131rmalar, IGF-1 resept\u00f6rlerinin, ins\u00fclin resept\u00f6rlerinin veya bunlar\u0131n a\u015fa\u011f\u0131 ak\u0131\u015f fakt\u00f6rlerinin (PI3K, AKT gibi) i\u015flev kayb\u0131na yol a\u00e7an genetik polimorfizmlerin\/mutasyonlar\u0131n insan \u00f6mr\u00fcn\u00fcn uzamas\u0131yla ili\u015fkili oldu\u011funu da ortaya koymu\u015ftur. Japon Amerikal\u0131lar, Han \u00c7inlileri, Kaliforniyal\u0131lar, New Englandl\u0131lar, A\u015fkenaz Yahudileri, Danimarkal\u0131lar, Almanlar ve \u0130talyanlar aras\u0131nda uzun \u00f6m\u00fcrl\u00fc pop\u00fclasyonlar\u0131n incelenmesi, FOXO3a'n\u0131n rs2764264, rs2802292 vb. genetik polimorfizmlerinin uzun \u00f6m\u00fcr ve sa\u011fl\u0131kl\u0131 ya\u015flanma ile ili\u015fkili oldu\u011funu g\u00f6stermektedir. PI3K\/Akt\/FoxO3a yola\u011f\u0131n\u0131n d\u00fczenlenmesinde Akt, Thr308 ve Ser473'\u00fcn fosforilasyonu \u00fczerine aktive olurken, FoxO3a Thr32 ve Ser253'\u00fcn fosforilasyonu \u00fczerine inhibe olur. Bu \u00e7al\u0131\u015fmada, EBCQA vah\u015fi tip nematod N2'nin \u00f6mr\u00fcn\u00fc uzatm\u0131\u015f ve DAF-16 n\u00fckleer translokasyonunu te\u015fvik etmi\u015ftir, ancak AGE-1, AKT-1 ve DAF-16 mutantlar\u0131n\u0131n \u00f6mr\u00fc \u00fczerinde hi\u00e7bir etkisi olmam\u0131\u015ft\u0131r, bu da EBCQA'n\u0131n \u00f6mr\u00fcn\u00fc uzatmadaki rol\u00fcn\u00fcn PI3K\/Akt\/FoxO3a yolunun d\u00fczenlenmesine ba\u011fl\u0131 oldu\u011funu g\u00f6stermektedir. D-galaktoz ile tedavi edilen s\u0131\u00e7anlar PI3K, Akt, p-Akt ve p-FOXO3a ekspresyonunun yukar\u0131 reg\u00fclasyonunu g\u00f6sterirken, FOXO3a ekspresyonu a\u015fa\u011f\u0131 reg\u00fcle edilmi\u015ftir. Bu durum, D-galaktoz ile ind\u00fcklenen ya\u015flanan s\u0131\u00e7anlar ve do\u011fal olarak ya\u015flanan k\u00fc\u00e7\u00fck\/b\u00fcy\u00fck s\u0131\u00e7anlardaki de\u011fi\u015fikliklere ili\u015fkin \u00f6nceki raporlarla tutarl\u0131d\u0131r. Protein ekspresyonundaki bu de\u011fi\u015fiklikler, \u00f6\u011frenme ve haf\u0131za yeteneklerinin azalmas\u0131n\u0131n yan\u0131 s\u0131ra timus ve dalak katsay\u0131lar\u0131n\u0131n azalmas\u0131na ve dolay\u0131s\u0131yla ya\u015flanmaya neden olabilir. EBCQA uygulamas\u0131ndan sonra, bu de\u011fi\u015fiklikler engellenmi\u015ftir ve bu da ya\u015flanmay\u0131 geciktirici bir etkiye sahip olabilir.
\n1956 y\u0131l\u0131nda \u0130ngiliz bilim adam\u0131 Harmna, biyomolek\u00fcllere serbest radikal sald\u0131r\u0131lar\u0131n\u0131n neden oldu\u011fu h\u00fccresel i\u015flev bozuklu\u011funun v\u00fccuttaki ya\u015flanman\u0131n temel nedenlerinden biri oldu\u011funa inanarak ilk kez serbest radikal ya\u015flanmas\u0131 teorisini \u00f6ne s\u00fcrm\u00fc\u015ft\u00fcr. Bu \u00e7al\u0131\u015fmada EBCQA, paraquat ile muamele edilen nematodlarda ve D-galaktoz ile muamele edilen s\u0131\u00e7anlarda SOD, GSH Px ve CAT aktivitelerini art\u0131r\u0131rken MDA seviyelerini d\u00fc\u015f\u00fcrm\u00fc\u015ft\u00fcr. Bu antioksidan enzimlerin aktivitesindeki art\u0131\u015f, ROS ve oksidatif hasarda azalmaya yol a\u00e7arak ya\u015flanmay\u0131 geciktirmeye yard\u0131mc\u0131 olabilir. PI3K\/Akt\/FoxO3a yola\u011f\u0131n\u0131n ya\u015fam s\u00fcresini etkiledi\u011fi a\u015fa\u011f\u0131 ak\u0131\u015f mekanizmalar\u0131ndan biri oksidatif direncin d\u00fczenlenmesidir. Nematodlarda, daf-2 (e1368) ve age-1 (hx546) gibi baz\u0131 uzun \u00f6m\u00fcrl\u00fc mutant su\u015flar, DAF-16'ya ba\u011fl\u0131 olan antioksidan enzimler SOD, GSH Px ve CAT'nin geli\u015fmi\u015f aktivitelerini sergiler. DAF-16 mutasyonundan sonra, bu mutant su\u015flar\u0131n antioksidan enzim aktivitesi, vah\u015fi tip nematod N2'ninkine neredeyse benzerdir. Memelilerde FoxO3a, SOD, GSH Px, CAT gibi antioksidan enzimlerin ekspresyonunu d\u00fczenler ve FoxO3a'n\u0131n aktivitesini inhibe ederek h\u00fccrelerde ROS birikimine yol a\u00e7ar, aterosklerozu h\u0131zland\u0131r\u0131r ve kanser riskini art\u0131r\u0131r. EBCQA, nematod DAF-16'n\u0131n n\u00fckleer giri\u015fini te\u015fvik eder ve s\u0131\u00e7an FoxO3a'n\u0131n fosforilasyonunu inhibe eder, bu da EBCQA'n\u0131n FoxO3a transkripsiyonel aktivitesini ve antioksidan enzim aktivitesini art\u0131rarak ya\u015flanma kar\u015f\u0131t\u0131 bir rol oynayabilece\u011fini g\u00f6sterir.
\n\u00d6zet olarak, EBCQA nematodlar\u0131n \u00f6mr\u00fcn\u00fc etkili bir \u015fekilde uzatabilir ve s\u0131\u00e7anlarda D-galaktoz kaynakl\u0131 ya\u015flanmay\u0131 antagonize edebilir. Etki mekanizmas\u0131 PI3K ve Akt aktivasyonunu inhibe ederek, FOXO3a fosforilasyonunu azaltarak, FOXO3a n\u00fckleer ve transkripsiyonel aktivitesini te\u015fvik ederek, antioksidan enzim aktivitesini art\u0131rarak, oksidatif stresi inhibe ederek ve b\u00f6ylece ya\u015flanmay\u0131 geciktirerek olabilir.<\/p>","protected":false},"excerpt":{"rendered":"

Scutellaria baicalensis'te PI3K\/Akt\/FoxO3a Yola\u011f\u0131n\u0131 D\u00fczenleyen ve Ya\u015flanmay\u0131 Geciktiren Toplam Kafeoilkinik Asit Mekanizmas\u0131 \u00dczerine \u00c7al\u0131\u015fma Ya\u015flanma, ya\u015fla ilgili kademeli bir fizyolojik d\u00fc\u015f\u00fc\u015ft\u00fcr, hayatta kalma yetene\u011finin kayb\u0131na ve k\u0131r\u0131lganl\u0131\u011f\u0131n artmas\u0131na neden olur. Ya\u015flanma \u00e7evresel ve genetik fakt\u00f6rlerden etkilenir ve on iki ana \u00f6zelli\u011fe sahiptir: genomik karars\u0131zl\u0131k, epigenetik de\u011fi\u015fiklikler, telomer t\u00fckenmesi, beslenme [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the Mechanism of Total Caffeoylquinic Acid Regulating PI3K\/Akt\/FoxO3a Pathway and Delaying Aging in Scutellaria baicalensis - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/lamplighter-xixinin-toplam-kafeoilkinik-asidi\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the Mechanism of Total Caffeoylquinic Acid Regulating PI3K\/Akt\/FoxO3a Pathway and Delaying Aging in Scutellaria baicalensis - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the Mechanism of Total Caffeoylquinic Acid Regulating PI3K\/Akt\/FoxO3a Pathway and Delaying Aging in Scutellaria baicalensis Aging is a gradual physiological decline related to age, leading to loss of survival ability and increased vulnerability. 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