{"id":3822,"date":"2024-08-03T08:10:56","date_gmt":"2024-08-03T08:10:56","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3822"},"modified":"2024-08-03T08:10:56","modified_gmt":"2024-08-03T08:10:56","slug":"salvianolic-acid-b-liver-injury","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/salvianolik-asit-b-karaciger-hasari\/","title":{"rendered":"Karaci\u011fer hasar\u0131 olan farelerde salvianolik asit B'nin ba\u011f\u0131rsak mikrobiyotas\u0131 ve k\u0131sa zincirli ya\u011f asidi metabolizmas\u0131 \u00fczerine etkisi"},"content":{"rendered":"<p>Karaci\u011fer hasar\u0131 olan farelerde salvianolik asit B'nin ba\u011f\u0131rsak mikrobiyotas\u0131 ve k\u0131sa zincirli ya\u011f asidi metabolizmas\u0131 \u00fczerine etkisi<br \/>\nKaraci\u011fer hasar\u0131, \u00e7e\u015fitli fakt\u00f6rlerin neden oldu\u011fu karaci\u011fer h\u00fccresi hasar\u0131 ve anormal karaci\u011fer fonksiyonunu ifade eder. Klinik uygulamada yayg\u0131n patojenik fakt\u00f6rler aras\u0131nda ila\u00e7 stim\u00fclasyonu, viral enfeksiyon, alkol veya kimyasal toksinler yer almaktad\u0131r. Ara\u015ft\u0131rmalar, ciddi veya kal\u0131c\u0131 karaci\u011fer hasar\u0131n\u0131n nihayetinde siroz ve hepatosel\u00fcler karsinoma yol a\u00e7abilece\u011fini g\u00f6stermi\u015ftir.<br \/>\nDanshen do\u011fas\u0131 gere\u011fi hafif so\u011fuk, tad\u0131 ac\u0131d\u0131r ve kalp ve karaci\u011fer meridyenlerine girer. Klinik uygulamada yayg\u0131n olarak kullan\u0131lan kan aktive edici ve staz giderici bir ila\u00e7t\u0131r ve tarih boyunca t\u0131p uygulay\u0131c\u0131lar\u0131 taraf\u0131ndan karaci\u011fer hastal\u0131klar\u0131n\u0131n tedavisinde yayg\u0131n olarak kullan\u0131lm\u0131\u015ft\u0131r. Salvianolik asit B (Sal B), Danshen'in suda \u00e7\u00f6z\u00fcnen ekstresindeki ana aktif bile\u015fenlerden biridir. Ara\u015ft\u0131rmalar, Sal B'nin oksidatif stresi, TGF - \u03b2 sinyal yolunu ve di\u011fer mekanizmalar\u0131 inhibe ederek karaci\u011fer hasar\u0131n\u0131 hafifletebilece\u011fini g\u00f6stermi\u015ftir. \u00c7al\u0131\u015fmalar, oral Sal B'nin d\u00fc\u015f\u00fck biyoyararlan\u0131ma sahip oldu\u011funu g\u00f6stermi\u015ftir, bu da ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131 d\u00fczenlemenin biyolojik aktivitesi i\u00e7in \u00f6nemli bir hedef olabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir.<br \/>\nBa\u011f\u0131rsak karaci\u011fer d\u00f6ng\u00fcs\u00fcn\u00fcn varl\u0131\u011f\u0131 ba\u011f\u0131rsa\u011f\u0131 karaci\u011fere ba\u011flar ve ba\u011f\u0131rsak ve karaci\u011fer sadece fizyolojik olarak birbirine ba\u011fl\u0131 de\u011fil, ayn\u0131 zamanda fizyolojik i\u015flev a\u00e7\u0131s\u0131ndan da yak\u0131ndan ili\u015fkilidir. Ba\u011f\u0131rsak mikrobiyota bile\u015fimi ve oran\u0131n\u0131n dengesizli\u011finin yan\u0131 s\u0131ra k\u0131sa zincirli ya\u011f asitleri (SCFA'lar) ve safra asitleri gibi mikrobiyal metabolitlerdeki de\u011fi\u015fiklikler de dahil olmak \u00fczere ba\u011f\u0131rsak karaci\u011fer ekseninin bozuklu\u011fu, \u00e7e\u015fitli nedenlerden kaynaklanan karaci\u011fer hasar\u0131 ile yak\u0131ndan ili\u015fkilidir. Son y\u0131llarda, literat\u00fcrde karaci\u011fer hasar\u0131n\u0131 hafifletmek i\u00e7in ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131 hedef alan ve SCFA seviyelerini d\u00fczenleyen \u00e7ok say\u0131da do\u011fal \u00fcr\u00fcn bildirilmi\u015ftir. Bu \u00e7al\u0131\u015fma, SalB'nin ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131 ve SCFA bozukluklar\u0131n\u0131 d\u00fczenleyerek karaci\u011fer hasar\u0131n\u0131 \u00f6nleyici etkiler g\u00f6sterdi\u011fini ortaya koymakta ve SalB'nin karaci\u011fer hasar\u0131n\u0131 \u00f6nleme ara\u015ft\u0131rmas\u0131n\u0131n mekanizmas\u0131 i\u00e7in yeni bilimsel kan\u0131tlar sa\u011flamaktad\u0131r.<\/p>\n<p>Karaci\u011fer hasar\u0131, \u00e7e\u015fitli karaci\u011fer hastal\u0131klar\u0131 i\u00e7in ortak bir patolojik temeldir ve anti akut ve kronik karaci\u011fer hasar\u0131 ila\u00e7lar\u0131n\u0131n potansiyel mekanizmalar\u0131n\u0131n anla\u015f\u0131lmas\u0131, karaci\u011fer hasar\u0131n\u0131n klinik tedavisine katk\u0131da bulunabilir. Son y\u0131llarda, ba\u011f\u0131rsak mikrobiyotas\u0131ndaki de\u011fi\u015fikliklerin karaci\u011fer fonksiyon hasar\u0131n\u0131 tetiklemede ve te\u015fvik etmede \u00f6nemli bir rol oynad\u0131\u011f\u0131 d\u00fc\u015f\u00fcn\u00fclmektedir. Ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131n dengesizli\u011fi, ba\u011f\u0131rsak duvar\u0131 bariyerindeki hasar ve ba\u011f\u0131rsak ge\u00e7irgenli\u011finin artmas\u0131n\u0131n neden oldu\u011fu ba\u011f\u0131rsak endotoksemisi, ba\u011f\u0131rsak ve karaci\u011fer aras\u0131ndaki dengeyi bozabilir ve b\u00f6ylece ba\u011f\u0131rsak karaci\u011fer ekseni yoluyla \u00e7e\u015fitli karaci\u011fer hastal\u0131klar\u0131n\u0131 etkileyebilir.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3823\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-12.png\" alt=\"\" width=\"578\" height=\"448\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3824\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-11.png\" alt=\"\" width=\"1084\" height=\"462\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-11.png 1084w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-11-768x327.png 768w\" sizes=\"(max-width: 1084px) 100vw, 1084px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3825\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-10.png\" alt=\"\" width=\"1102\" height=\"844\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-10.png 1102w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-10-768x588.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-10-940x720.png 940w\" sizes=\"(max-width: 1102px) 100vw, 1102px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3826\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-11.png\" alt=\"\" width=\"1074\" height=\"792\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-11.png 1074w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-11-768x566.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-11-976x720.png 976w\" sizes=\"(max-width: 1074px) 100vw, 1074px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3827\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-9.png\" alt=\"\" width=\"1092\" height=\"770\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-9.png 1092w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-9-768x542.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-9-1021x720.png 1021w\" sizes=\"(max-width: 1092px) 100vw, 1092px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3828\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-8.png\" alt=\"\" width=\"1070\" height=\"512\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-8.png 1070w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-8-768x367.png 768w\" sizes=\"(max-width: 1070px) 100vw, 1070px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3829\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-7.png\" alt=\"\" width=\"1138\" height=\"452\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-7.png 1138w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-7-768x305.png 768w\" sizes=\"(max-width: 1138px) 100vw, 1138px\" \/>Sal B, karaci\u011fer hasar\u0131n\u0131 tedavi etmek i\u00e7in klinik uygulamada yayg\u0131n olarak kullan\u0131lan geleneksel bir \u00c7in ilac\u0131 olan Danshen'in ana aktif bile\u015fenlerinden biridir. \u015eu anda, ara\u015ft\u0131rmalar Sal B'nin CCl4, y\u00fcksek ya\u011fl\u0131 diyet, tiyoasetamid vb. ile ind\u00fcklenen karaci\u011fer hasar\u0131 \u00fczerinde \u00f6nemli bir inhibit\u00f6r etkiye sahip olabilece\u011fini bildirmi\u015ftir. \u0130lgili mekanizma ara\u015ft\u0131rmas\u0131 \u00e7o\u011funlukla hepatik stellat h\u00fccrelerin aktivasyonunu ve proliferasyonunu, karaci\u011fer inflamasyonunu, oksidatif stresi vb. inhibe etmeye odaklanm\u0131\u015ft\u0131r. Bu \u00e7al\u0131\u015fma, Sal B'nin karbon tetraklor\u00fcr kaynakl\u0131 karaci\u011fer hasar\u0131 \u00fczerindeki m\u00fcdahale etkisini in vivo deneylerle daha da netle\u015ftirmi\u015f ve aktivitesinin Sal B taraf\u0131ndan ba\u011f\u0131rsak mikrobiyotas\u0131 ve SCFA'lar\u0131n d\u00fczenlenmesiyle ili\u015fkili oldu\u011funu bulmu\u015ftur. 16S rRNA dizileme sonu\u00e7lar\u0131, Sal B'nin ba\u011f\u0131rsak mikrobiyota da\u011f\u0131l\u0131m\u0131n\u0131n Con grubu ile Mod grubu aras\u0131nda oldu\u011funu g\u00f6stermi\u015ftir. Karaci\u011fer hasar\u0131 s\u0131ras\u0131nda, Firmicutes'in Bacteroidetes'e oran\u0131 genellikle de\u011fi\u015fmekte, birincisi azal\u0131rken ikincisi artmaktad\u0131r. Bu \u00e7al\u0131\u015fmadaki Mod grubu bu disbiyozu ya\u015fam\u0131\u015f ve Sal B m\u00fcdahalesinden sonra bu disbiyoz \u00f6nemli \u00f6l\u00e7\u00fcde d\u00fczelmi\u015ftir. Cins d\u00fczeyinde, Sal B m\u00fcdahalesi Lactobacillus'un g\u00f6receli bollu\u011funu \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rm\u0131\u015f ve Fecal ve Bifidobacterium'un g\u00f6receli bollu\u011funu azaltm\u0131\u015ft\u0131r. Bunlar aras\u0131nda, Lactobacillus cinsinin karaci\u011feri koruma yetene\u011fine sahip oldu\u011fu ve hasarl\u0131 karaci\u011ferin iltihaplanmas\u0131n\u0131 ve fibrozisini hafifletebilece\u011fi bildirilmi\u015ftir. T\u00fcm bu sonu\u00e7lar SalB'nin ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131 d\u00fczenleyerek karaci\u011fer hasar\u0131n\u0131 hafifletebilece\u011fini kan\u0131tlamaktad\u0131r.<br \/>\nSCFA'lar kolon h\u00fccreleri i\u00e7in ana enerji kayna\u011f\u0131d\u0131r, lokal enflamasyonu azalt\u0131r ve ba\u011f\u0131rsak bariyerini korumaya ve ba\u011f\u0131rsak ge\u00e7irgenli\u011fini azaltmaya yard\u0131mc\u0131 olan antimikrobiyal peptitlerin \u00fcretimini te\u015fvik eder. SCFA'lar ile takviye, bakteriyel endotoksinler de dahil olmak \u00fczere patojenik molek\u00fcler kal\u0131plar\u0131n portal ven iletimini azaltarak karaci\u011fer hasar\u0131n\u0131n ilerlemesini geciktirebilir. Farelerin ba\u011f\u0131rsaklar\u0131ndaki SCFA'lar\u0131n kantitatif analizinden sonra, bu \u00e7al\u0131\u015fma Mod grubunda asetik asit, hekzanoik asit, izob\u00fctirik asit, izovalerik asit, propiyonik asit ve valerik asit seviyelerinin \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131n\u0131, Sal B m\u00fcdahalesinin ise izob\u00fctirik asit, izovalerik asit, propiyonik asit ve valerik asit seviyelerini geri kazand\u0131rd\u0131\u011f\u0131n\u0131 bulmu\u015ftur. Bu durum, Sal B grubunun ba\u011f\u0131rsak mikrobiyotas\u0131nda daha \u00f6nce tespit etti\u011fimiz Firmicutes bollu\u011fundaki art\u0131\u015fla ili\u015fkili olabilir. Firmicutes'in ba\u011f\u0131rsak bakterilerinin yakla\u015f\u0131k 60%'sini olu\u015fturdu\u011funa ve SCFA'lar\u0131n \u00fcretimiyle yak\u0131ndan ili\u015fkili oldu\u011funa dair ara\u015ft\u0131rma raporlar\u0131 bulunmaktad\u0131r. Hem Mod grubunda hem de Sal B grubunda asetik asit seviyelerindeki d\u00fc\u015f\u00fc\u015f\u00fcn, Parabacterioides cinsi gibi asetik asit salg\u0131layan bakteri topluluklar\u0131n\u0131n g\u00f6receli olarak azalmas\u0131yla ili\u015fkili oldu\u011fu tahmin edilmektedir. Ba\u011f\u0131rsak bariyerini iyile\u015ftirerek karaci\u011fer hasar\u0131n\u0131 hafifletmenin yan\u0131 s\u0131ra, son literat\u00fcr SCFA'lar\u0131n karaci\u011fer dokusunda makrofaj pro-inflamatuar aktivasyonunu inhibe ederek ve inflamatuar yan\u0131tlar\u0131 azaltarak NASH gibi karaci\u011fer hastal\u0131klar\u0131n\u0131 iyile\u015ftirebilece\u011fini de g\u00f6stermi\u015ftir. \u00d6nceki ara\u015ft\u0131rmam\u0131zda Sal B'nin karaci\u011fer hasar\u0131 olan farelerin ba\u011f\u0131rsak bariyeri \u00fczerindeki etkisi g\u00f6zlemlenmemi\u015ftir. Bu nedenle, SCFA'lar\u0131n karaci\u011fer hasar\u0131n\u0131 iyile\u015ftirmesinin, portal ven yoluyla karaci\u011fere girdikten sonra karaci\u011fer dokusundaki h\u00fccreler \u00fczerindeki do\u011frudan etkileriyle ilgili olabilece\u011fini d\u00fc\u015f\u00fcn\u00fcyoruz.<br \/>\n\u00d6zetle, Sal B ba\u011f\u0131rsak mikrobiyotas\u0131n\u0131n dengesini yeniden sa\u011flayarak farelerde CCl4 kaynakl\u0131 karaci\u011fer hasar\u0131n\u0131 engelleyebilir. Bu arada, Sal B karaci\u011fer hasar\u0131 olan farelerde ba\u011f\u0131rsak SCFA'lar\u0131n\u0131n i\u00e7eri\u011fini k\u0131smen geri y\u00fckleyebilir, ancak bu geri y\u00fcklenen SCFA'lar\u0131n Sal B'nin anti karaci\u011fer hasar\u0131 s\u00fcrecine nas\u0131l kat\u0131ld\u0131\u011f\u0131 konusunda daha fazla ara\u015ft\u0131rmaya ihtiya\u00e7 vard\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"<p>The effect of salvianolic acid B on gut microbiota and short chain fatty acid metabolism in mice with liver injury Liver injury refers to liver cell damage and abnormal liver function caused by various factors. Common pathogenic factors in clinical practice include drug stimulation, viral infection, alcohol or chemical toxins. Research has shown that severe [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>The effect of salvianolic acid B on gut microbiota and short chain fatty acid metabolism in mice with liver injury - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/salvianolik-asit-b-karaciger-hasari\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The effect of salvianolic acid B on gut microbiota and short chain fatty acid metabolism in mice with liver injury - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"The effect of salvianolic acid B on gut microbiota and short chain fatty acid metabolism in mice with liver injury Liver injury refers to liver cell damage and abnormal liver function caused by various factors. Common pathogenic factors in clinical practice include drug stimulation, viral infection, alcohol or chemical toxins. 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