{"id":3806,"date":"2024-08-03T08:05:12","date_gmt":"2024-08-03T08:05:12","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3806"},"modified":"2024-08-03T08:05:12","modified_gmt":"2024-08-03T08:05:12","slug":"danpi-ethanol-extract-antioxidant-and-anti-diabetes","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/danpi-etanol-ekstresi-antioksidan-ve-anti-diyabet\/","title":{"rendered":"Cortex Moutan'dan Elde Edilen Etanol Ekstraktlar\u0131n\u0131n Antioksidan ve Anti Diyabet Aktiviteleri \u00dczerine \u00c7al\u0131\u015fma"},"content":{"rendered":"

Cortex Moutan'dan Elde Edilen Etanol Ekstraktlar\u0131n\u0131n Antioksidan ve Anti Diyabet Aktiviteleri \u00dczerine \u00c7al\u0131\u015fma
\nDiyabet, y\u00fcksek kan \u015fekeri ile karakterize kronik bir metabolik hastal\u0131kt\u0131r. Modern ya\u015fam standartlar\u0131n\u0131n geli\u015fmesi ve ya\u015fam tarz\u0131n\u0131n de\u011fi\u015fmesiyle birlikte diyabet, kardiyovask\u00fcler hastal\u0131klar ve t\u00fcm\u00f6rlerden sonra insan sa\u011fl\u0131\u011f\u0131n\u0131 etkileyen \u00fc\u00e7\u00fcnc\u00fc b\u00fcy\u00fck fakt\u00f6r haline gelmi\u015ftir. 2021 y\u0131l\u0131na kadar \u00c7in'de 140 milyon diyabet hastas\u0131 olacak ve d\u00fcnyadaki toplam diyabet hastas\u0131 say\u0131s\u0131 537 milyona ula\u015farak k\u00fcresel n\u00fcfusun 10,5%'sini olu\u015fturacakt\u0131r. Diyabetin insan sa\u011fl\u0131\u011f\u0131na zarar\u0131 sadece kendi i\u00e7inde de\u011fil, ayn\u0131 zamanda arteriyel ateroskleroz, diyabet ayak hastal\u0131\u011f\u0131, g\u00f6rme kayb\u0131 ve hatta optik sinir hasar\u0131n\u0131n neden oldu\u011fu k\u00f6rl\u00fck gibi \u00e7e\u015fitli komplikasyonlara da neden olmaktad\u0131r. \u00c7al\u0131\u015fmalar, oksidatif stresin anormal art\u0131\u015f\u0131n\u0131n diyabet ve komplikasyonlar\u0131n\u0131n olu\u015fumunu te\u015fvik edece\u011fini g\u00f6stermi\u015ftir. Ayn\u0131 zamanda, diyabet hastalar\u0131nda y\u00fcksek kan \u015fekeri konsantrasyonu, h\u00fccreler taraf\u0131ndan emilen glikozun normal ihtiya\u00e7lar\u0131n\u0131 \u00e7ok a\u015fmas\u0131na neden olarak h\u00fccrelerde a\u015f\u0131r\u0131 glikoz birikmesine yol a\u00e7acak, h\u00fccrelerdeki mitokondriyal membran potansiyel fark\u0131n\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rarak koenzim Q'nun oksijen molek\u00fcllerinin azalmas\u0131n\u0131 h\u0131zland\u0131rmas\u0131n\u0131 sa\u011flayacakt\u0131r, B\u00f6ylece h\u00fccrelerde \u00e7ok say\u0131da reaktif oksijen t\u00fcr\u00fc olu\u015fur, adac\u0131k B h\u00fccrelerinin ve mitokondrinin normal i\u015flevi bozulur, ileri glikasyon son \u00fcr\u00fcnlerinin (AGE'ler) olu\u015fumu te\u015fvik edilir, oksidatif stres durumu artar, diyabet s\u00fcreci ve komplikasyonlar\u0131n olu\u015fumu h\u0131zlan\u0131r. Antioksidanlar, a\u015f\u0131r\u0131 serbest radikalleri temizleyerek veya endojen antioksidan savunma sistemini aktive ederek oksidatif stresi hafifletebilir, b\u00f6ylece diyabetin ilerlemesini ve ilgili komplikasyonlar\u0131n\u0131 hafifletebilir. Bu nedenle, oksidatif stresin azalt\u0131lmas\u0131 diyabet ve komplikasyonlar\u0131n\u0131n \u00f6nlenmesi ve kontrol\u00fc i\u00e7in b\u00fcy\u00fck \u00f6nem ta\u015f\u0131maktad\u0131r.
\nRanunculaceae familyas\u0131ndan \u015fakay\u0131\u011f\u0131n kurutulmu\u015f k\u00f6k kabu\u011fu olan Moutan Cortex (MC), ac\u0131 ve hafif keskin bir tada sahiptir. Is\u0131y\u0131 temizleme ve kan dola\u015f\u0131m\u0131n\u0131 te\u015fvik etme etkilerine sahip geleneksel bir \u00c7in \u015fifal\u0131 bitkisidir ve binlerce y\u0131ld\u0131r kullan\u0131lmaktad\u0131r. \u00c7al\u0131\u015fma, paeonia \u00f6z\u00fct\u00fcn\u00fcn anti-t\u00fcm\u00f6r, antibakteriyel, antioksidan, anti diyabet ve di\u011fer \u00f6zellikler gibi \u00e7e\u015fitli farmakolojik aktivitelere sahip oldu\u011funu ve bunlar\u0131n aras\u0131nda paeonol, fitosteroller, \u015fekerler ve flavonoidlerin ana aktif bile\u015fenler oldu\u011funu buldu. Zhang ve arkada\u015flar\u0131 paeonol\u00fcn \u00f6nemli in vitro antioksidan kapasiteye sahip oldu\u011funu ve n\u00fckleer fakt\u00f6r E2 ile ili\u015fkili fakt\u00f6r 2 (Nrf2)\/Kelch like ECH associated protein 1 (Keap1) - antioksidan yan\u0131t elementi (ARE) sinyal yolunu (Nrf2\/Keap1-ARE) aktive ederek oksidatif stresi ind\u00fckleyebildi\u011fini bulmu\u015ftur. Lian ve arkada\u015flar\u0131, korteks moutan'daki aktif polisakkarit bile\u015feninin diyabet komplikasyonlar\u0131n\u0131n nefropatisini iyile\u015ftirebilece\u011fini bulmu\u015flard\u0131r. Wu ve arkada\u015flar\u0131 Danpi'nin aktif bile\u015fenlerinin \u00f6nemli bir hipoglisemik etkiye sahip oldu\u011funu ve mekanizmas\u0131n\u0131n glukoneogenezi inhibe etmek, glikojen sentezini te\u015fvik etmek ve antioksidan aktivite ile ili\u015fkili oldu\u011funu belirtmi\u015ftir. Bununla birlikte, korteks moutandan elde edilen farkl\u0131 polar \u00e7\u00f6z\u00fcc\u00fc ekstraktlar\u0131n\u0131n in vitro ve in vivo antioksidan ve hipoglisemik aktivitelerinin yan\u0131 s\u0131ra diyabet komplikasyonlar\u0131nda sinirler \u00fczerindeki koruyucu etkisi hakk\u0131nda bir rapor bulunmamaktad\u0131r.
\nBu makalede, Danpi'nin ultrasonik ekstraksiyonu i\u00e7in 40%, 70% ve 95% etanol kullan\u0131lm\u0131\u015f, Danpi'nin farkl\u0131 konsantrasyonlardaki etanol ekstraktlar\u0131ndaki toplam fenol ve toplam flavonoid i\u00e7eri\u011fi kar\u015f\u0131la\u015ft\u0131r\u0131lm\u0131\u015f, DPPH serbest radikal ve ABTS serbest radikal s\u00fcp\u00fcrme yetene\u011fi deneyleri ile \u00f6rneklerin antioksidan kapasitesi belirlenmi\u015ftir, floresan spektroskopisi kullanarak ekstraktlar\u0131n anti glikozilasyon yetene\u011fini incelemekte, akarboz ile kar\u015f\u0131la\u015ft\u0131rarak \u00f6rneklerin \u03b1-glukozidaz \u00fcretim yetene\u011fini de\u011ferlendirmekte ve son olarak hiperglisemik bir hayvan modeli kullanarak \u00f6rneklerin hayvanlarda hipoglisemik yetene\u011fini ve periferik motor sinirler \u00fczerindeki koruyucu etkisini de\u011ferlendirmektedir. Paeonia ekstrakt\u0131n\u0131n anti diyabet ve anti-oksidasyonda kapsaml\u0131 uygulamas\u0131 i\u00e7in teorik bir temel sa\u011flamas\u0131 beklenmektedir.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\u0130lgili raporlara g\u00f6re, \u00c7in'deki diyabet hastalar\u0131n\u0131n say\u0131s\u0131 b\u00fcy\u00fck ve gen\u00e7tir, bu da vatanda\u015flar\u0131m\u0131z\u0131n hayat\u0131n\u0131 ve sa\u011fl\u0131\u011f\u0131n\u0131 ciddi \u015fekilde tehlikeye atmaktad\u0131r. G\u00fcn\u00fcm\u00fczde, piyasadaki diyabet ila\u00e7lar\u0131n\u0131n \u00e7o\u011fu, belirli yan etkileri olan kimyasal sentezlerdir, bitkilerden elde edilen \u00f6z\u00fctler ise do\u011fal, etkili ve d\u00fc\u015f\u00fck yan etki \u00f6zelliklerine sahiptir. Bu makalede, Cortex Moutan'\u0131n farkl\u0131 konsantrasyonlardaki etanol \u00e7\u00f6zeltisinden elde edilen ultrasonik ekstraktlar\u0131n anti diyabet ve antioksidan aktiviteleri kar\u015f\u0131la\u015ft\u0131r\u0131lm\u0131\u015f ve Cortex Moutan'\u0131n anti diyabetteki uygulama potansiyeli analiz edilmi\u015ftir. Ara\u015ft\u0131rma, \u00e7\u00f6z\u00fcc\u00fc olarak 70% etanol kullan\u0131ld\u0131\u011f\u0131nda verimin 4.98% oldu\u011funu g\u00f6stermi\u015ftir. Danpi ekstresi, s\u0131ras\u0131yla 59.17mg GAE\/g ve 82.59mg QUE\/g ile en y\u00fcksek toplam fenolik ve flavonoid i\u00e7eri\u011fine sahiptir. \u0130yi bir in vitro antioksidan ve hipoglisemik aktiviteye sahiptir. DPPH serbest radikali, ABTS serbest radikal s\u00fcp\u00fcrme yetene\u011fi ve \u03b1-glukozidaz inhibisyon yetene\u011fi i\u00e7in IC50 de\u011ferleri s\u0131ras\u0131yla 16.30, 34.20 ve 2.10 \u03bc g\/mL'dir ve glikozilasyon inhibisyon oran\u0131 81.44%'dir. Hiperglisemik bir hayvan modeli \u00fczerinde yap\u0131lan deneylerle, MC70'in kan glikoz seviyelerini d\u00fc\u015f\u00fcrme etkisine sahip oldu\u011fu ayr\u0131ca g\u00f6sterilmi\u015ftir; Danpi ekstresi konsantrasyonu 2mg\/mL oldu\u011funda, yard\u0131mc\u0131 hipoglisemik etki 52%'dir ve MC70 bu konsantrasyonda 56%'lik bir periferik motor n\u00f6roprotektif etkiye sahiptir. 70% etanol \u00e7\u00f6zeltisi ile ultrasonla ekstrakte edilen korteks moutan ekstresi iyi antioksidan, anti diyabet yetene\u011fi ve yard\u0131mc\u0131 hipoglisemik etkiye sahiptir. Anti diyabette ara\u015ft\u0131rma potansiyeline ve uygulama de\u011ferine sahiptir.<\/p>","protected":false},"excerpt":{"rendered":"

Cortex Moutan'dan Elde Edilen Etanol Ekstraktlar\u0131n\u0131n Antioksidan ve Anti diyabet Aktiviteleri \u00dczerine \u00c7al\u0131\u015fma Diyabet, y\u00fcksek kan \u015fekeri ile karakterize kronik bir metabolik hastal\u0131kt\u0131r. Modern ya\u015fam standartlar\u0131n\u0131n geli\u015fmesi ve ya\u015fam tarz\u0131n\u0131n de\u011fi\u015fmesiyle birlikte diyabet, kardiyovask\u00fcler hastal\u0131klar ve t\u00fcm\u00f6rlerden sonra insan sa\u011fl\u0131\u011f\u0131n\u0131 etkileyen \u00fc\u00e7\u00fcnc\u00fc b\u00fcy\u00fck fakt\u00f6r haline gelmi\u015ftir. 2021 y\u0131l\u0131na kadar [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on Antioxidant and Anti diabetes Activities of Ethanol Extracts from Cortex Moutan - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/danpi-etanol-ekstresi-antioksidan-ve-anti-diyabet\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on Antioxidant and Anti diabetes Activities of Ethanol Extracts from Cortex Moutan - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on Antioxidant and Anti diabetes Activities of Ethanol Extracts from Cortex Moutan Diabetes is a chronic metabolic disease characterized by high blood sugar. 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