{"id":3754,"date":"2024-08-03T07:47:30","date_gmt":"2024-08-03T07:47:30","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3754"},"modified":"2024-08-03T07:47:30","modified_gmt":"2024-08-03T07:47:30","slug":"inflammation-ma-qian-zi-processed-to-reduce-toxicity","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/","title":{"rendered":"Enflamatuar s\u0131\u00e7anlar\u0131n metabolomiklerine dayal\u0131 olarak i\u015flenmi\u015f Ma Qian Zi'nin toksisite azaltma ve koruma mekanizmas\u0131 \u00fczerine \u00e7al\u0131\u015fma"},"content":{"rendered":"

Enflamatuar s\u0131\u00e7anlar\u0131n metabolomiklerine dayal\u0131 olarak i\u015flenmi\u015f Ma Qian Zi'nin toksisite azaltma ve koruma mekanizmas\u0131 \u00fczerine \u00e7al\u0131\u015fma
\nMa Qian Zi, ilk olarak Compendium of Materia Medica'da kaydedilen, \u00c7in'de \u00f6nemli ve yayg\u0131n olarak kullan\u0131lan bir geleneksel \u00c7in ilac\u0131d\u0131r. Kollaterallerin t\u0131kan\u0131kl\u0131\u011f\u0131n\u0131 a\u00e7ma, a\u011fr\u0131y\u0131 hafifletme, nod\u00fclleri da\u011f\u0131tma ve \u015fi\u015fli\u011fi azaltma etkilerine sahiptir; Esas olarak \u015fi\u015flik, g\u00f6\u011f\u00fcs apsesi ve skrofula gibi hastal\u0131klar\u0131n tedavisinde kullan\u0131l\u0131r. Ham at k\u0131l\u0131n\u0131n ciddi toksisitesi klinik uygulamas\u0131n\u0131 b\u00fcy\u00fck \u00f6l\u00e7\u00fcde s\u0131n\u0131rlar. Geleneksel \u00c7in t\u0131bb\u0131, i\u015flemenin toksisiteyi azaltma ve etkinli\u011fi koruma etkisine ula\u015fabilece\u011fine inanmaktad\u0131r. Yaban turpunu i\u015flemek i\u00e7in kumda ha\u015flama, derin k\u0131zartma, kar\u0131\u015ft\u0131rarak k\u0131zartma, tofu yap\u0131m\u0131 vb. dahil olmak \u00fczere bir\u00e7ok y\u00f6ntem vard\u0131r. Modern ara\u015ft\u0131rmalar, y\u00fcksek s\u0131cakl\u0131kta k\u0131zartma i\u015flemi s\u0131ras\u0131nda, striknin ve strikninin ana toksik bile\u015fenlerinin, daha d\u00fc\u015f\u00fck toksisite ve daha iyi terap\u00f6tik etkilere sahip nitrojen oksitlerin \u00fcretiminde etkili bir \u015fekilde azald\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. \u015eu anda, ara\u015ft\u0131rmalar hala karakteristik bile\u015fen analizi d\u00fczeyinde kalmaktad\u0131r. Fructus Strychni'nin i\u015flenmesinde toksisiteyi azaltma mekanizmas\u0131 \u00f6nceden a\u00e7\u0131klanm\u0131\u015f olsa da, Fructus Strychni'nin karma\u015f\u0131k kimyasal bile\u015fimi ve insan v\u00fccuduna girdikten sonra emilim, d\u00f6n\u00fc\u015f\u00fcm, metabolizma ve d\u00fczenleme mekanizmalar\u0131n\u0131n belirsizli\u011fi, farmakolojik etkilerinin ve aktif maddelerinin derinlemesine yorumlanmas\u0131n\u0131 engellemektedir.<\/p>\n

Son y\u0131llarda metabolomik, \u00f6zellikle yayg\u0131n olarak uyguland\u0131\u011f\u0131 geleneksel \u00c7in t\u0131bb\u0131 alan\u0131nda, y\u00fcksek verimli ve y\u00fcksek \u00e7\u00f6z\u00fcn\u00fcrl\u00fckl\u00fc cihazlar\u0131n yard\u0131m\u0131yla h\u0131zla geli\u015fmi\u015ftir. Endojen k\u00fc\u00e7\u00fck molek\u00fcll\u00fc kalitatif ve kantitatif de\u011fi\u015fiklikler izlenerek, v\u00fccudun fonksiyonel durumundaki de\u011fi\u015fikliklerle birlikte, geleneksel \u00c7in t\u0131bb\u0131 etkinli\u011finin molek\u00fcler mekanizmalar\u0131 ayd\u0131nlat\u0131labilir. Bu \u00e7al\u0131\u015fmada, i\u015flenmi\u015f Semen Strychni'nin i\u015flenmeden \u00f6nce ve sonra toksisite de\u011fi\u015fiklikleri \u00f6l\u00fcm oran\u0131na g\u00f6re \u00f6nceden de\u011ferlendirilmi\u015f; \u015fi\u015fme oran\u0131 ve enflamatuar fakt\u00f6r seviyelerine g\u00f6re i\u015flenmeden \u00f6nce ve sonra anti-enflamatuar etkisi de\u011ferlendirilmi\u015f; daha sonra kan dola\u015f\u0131m\u0131na girdikten sonra etkili maddeler plazma ila\u00e7 kimyas\u0131 ile analiz edilmi\u015ftir. Son olarak, plazmadaki endojen metabolitler analiz edilmi\u015f ve Ma Qian Zi ile bir inflamasyon m\u00fcdahale modeli kullan\u0131larak tan\u0131mlanm\u0131\u015ft\u0131r. Ma Qian Zi'nin i\u015flem \u00f6ncesi ve sonras\u0131 detoksifikasyon ve etkinlik mekanizmas\u0131 kimyasal, molek\u00fcler ve metabolik seviyelerde ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r.<\/p>\n

\u00d6n toksisite deneyleri, y\u00fcksek dozlarda kumda ha\u015flama grubunun \u00f6l\u00fcm oran\u0131n\u0131n ham gruptan \u00f6nemli \u00f6l\u00e7\u00fcde daha d\u00fc\u015f\u00fck oldu\u011funu g\u00f6stermi\u015ftir; bu da kurutulmu\u015f at tohumlar\u0131n\u0131n toksisitesinin y\u00fcksek s\u0131cakl\u0131kta i\u015flemden sonra ger\u00e7ekten \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131n\u0131 g\u00f6stermektedir. Plantar \u015fi\u015fme oran\u0131 \u00fczerine yap\u0131lan deney, y\u00fcksek dozlarda hem ham \u00fcr\u00fcn grubunun hem de kumlu \u00fcr\u00fcn grubunun \u015fi\u015fme oran\u0131n\u0131n \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131n\u0131 g\u00f6stererek ham \u00fcr\u00fcn\u00fcn ve kumlu \u00fcr\u00fcn\u00fcn belirli anti-enflamatuar etkilere sahip oldu\u011funu kan\u0131tlam\u0131\u015ft\u0131r. Kumda ha\u015flama grubu ile ham \u00fcr\u00fcn grubu aras\u0131nda \u015fi\u015fme oran\u0131nda istatistiksel olarak anlaml\u0131 bir fark bulunmam\u0131\u015ft\u0131r, bu da i\u015flem \u00f6ncesi ve sonras\u0131 anti-enflamatuar etkinlikte \u00f6nemli bir de\u011fi\u015fiklik olmad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir. Enflamatuar fakt\u00f6rlerin tespit sonu\u00e7lar\u0131 \u015fi\u015fme oran\u0131 deneyi ile kabaca tutarl\u0131d\u0131r. Yaban turpu yapmak i\u00e7in kumda ha\u015flama, derin k\u0131zartma, kar\u0131\u015ft\u0131rarak k\u0131zartma, patlay\u0131c\u0131 presleme, f\u0131r\u0131nlama, mikrodalgada pi\u015firme, kaynatma vb. dahil olmak \u00fczere \u00e7e\u015fitli i\u015fleme y\u00f6ntemleri vard\u0131r. \u0130\u015fleme ad\u0131mlar\u0131n\u0131n \u00e7o\u011fu \u0131s\u0131tmay\u0131 i\u00e7erir ve genellikle \u0131s\u0131tman\u0131n ana toksik bile\u015fenler olan brusin ve striknin i\u00e7eri\u011fini azaltaca\u011f\u0131na inan\u0131l\u0131r. Ancak, izobrukin, izobrukin, striknin nitrojen oksitleri ve brusin nitrojen oksitleri gibi daha etkili i\u015flemlerin i\u00e7eri\u011fi artacakt\u0131r. Liu Jun ve arkada\u015flar\u0131 \u0131s\u0131tma i\u015fleminin alkaloid ayr\u0131\u015fmas\u0131 ve oksidasyon reaksiyonlar\u0131n\u0131n bir sonucu oldu\u011funa inanm\u0131\u015f ve H2O2 kullanarak bunu do\u011frulam\u0131\u015ft\u0131r. Bu \u00e7al\u0131\u015fma ayr\u0131ca \u00f6n toksisite deneyleri ve farmakolojik deneyler yoluyla kumda ha\u015flama i\u015fleminin Semen Strychni'nin toksisitesini ger\u00e7ekten azaltabilece\u011fini ve belirli bir anti-enflamatuar terap\u00f6tik etkiyi koruyabilece\u011fini do\u011frulam\u0131\u015ft\u0131r.<\/p>\n

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\nPlazma metabolitlerinin incelenmesiyle, ila\u00e7 i\u00e7eren plazmada tan\u0131mlanan alkaloidlerin, ge\u00e7i\u015f bile\u015fenlerinin 77%'sini olu\u015fturdu\u011fu bulunmu\u015ftur, bu da alkaloidlerin esas olarak anti-enflamatuar etkilerden sorumlu oldu\u011funu g\u00f6stermektedir; hareketli bile\u015fenlerde daha iyi terap\u00f6tik etkilere ve daha d\u00fc\u015f\u00fck toksisiteye sahip nitrojen oksitlerin tan\u0131mlanmas\u0131, Semen Strychni'nin i\u015fleme mekanizmas\u0131 \u00fczerine yap\u0131lan \u00f6nceki \u00e7al\u0131\u015fmalarla tutarl\u0131d\u0131r. Tan\u0131mlanan 60 metabolitten sadece 7'si faz II reaksiyonlar\u0131ndan ge\u00e7mi\u015ftir, bu da bu hareketli bile\u015fenlerin faz I reaksiyonlar\u0131ndan ge\u00e7tikten sonra v\u00fccut taraf\u0131ndan kolayca temizlendi\u011fini g\u00f6stermektedir. \u0130la\u00e7 i\u00e7eren plazman\u0131n diferansiyel analizi yoluyla, alkaloidlerin tan\u0131mlama sonu\u00e7lar\u0131n\u0131n \u00e7o\u011funu olu\u015fturdu\u011fu ve kum ha\u015flama grubunun madde kalitesinin ham \u00fcr\u00fcn grubundan \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek oldu\u011fu bulunmu\u015ftur; Brusin ve strikninin azot oksitleri de kum ha\u015flama grubunda tan\u0131mlanm\u0131\u015ft\u0131r; Diferansiyel analizde, sadece Shidianing tespit edilmi\u015ftir ve literat\u00fcr raporlar\u0131na g\u00f6re, Shidianing'in farmakolojik g\u00fcc\u00fc strikninin 40 kat\u0131d\u0131r; Yukar\u0131daki sonu\u00e7lar, i\u015flenmi\u015f \u00fcr\u00fcnlerin anti-enflamatuar terap\u00f6tik etkisinin ham \u00fcr\u00fcnlerden daha d\u00fc\u015f\u00fck olmamas\u0131 gerekti\u011fini do\u011frulamaktad\u0131r. Diferansiyel analizde, \u00fc\u00e7 organik asit de tan\u0131mlanm\u0131\u015ft\u0131r ve kum ha\u015flama grubunun k\u00fctlesi ham grubunkinden daha d\u00fc\u015f\u00fckt\u00fcr, bu da organik asit bile\u015fenlerinin y\u00fcksek s\u0131cakl\u0131klarda kolay ayr\u0131\u015fmas\u0131yla ilgili olabilir. Yukar\u0131daki plazma t\u0131bbi kimya ara\u015ft\u0131rmas\u0131, Fructus Strychni'nin i\u015flenmi\u015f \u00fcr\u00fcnlerinin in vivo fonksiyonel madde temelini a\u00e7\u0131kl\u0131\u011fa kavu\u015fturmak i\u00e7in veri referans\u0131 sa\u011flamaktad\u0131r.
\nMetabolomik ara\u015ft\u0131rma yoluyla, deksametazon grubu hari\u00e7, Ma Qian Zi kum ha\u015flama grubunun metabolik profilinin normal grubunkine en yak\u0131n oldu\u011fu bulunmu\u015ftur; bu da i\u015flenmi\u015f \u00fcr\u00fcn\u00fcn v\u00fccuttaki iltihaplanman\u0131n neden oldu\u011fu metabolik bozukluklar \u00fczerinde iyi bir d\u00fczenleyici etkiye sahip oldu\u011funu g\u00f6stermektedir. Biyobelirte\u00e7lerin analizi, i\u015flenmi\u015f Ma Qian Zi \u00fcr\u00fcnlerinin anti-enflamatuar mekanizmas\u0131n\u0131n esas olarak amino asit metabolizmas\u0131 ve lipid metabolizmas\u0131 ile ilgili oldu\u011funu kan\u0131tlamaktad\u0131r. Karaci\u011fer, hayvanlarda amino asit metabolizmas\u0131 i\u00e7in ana organd\u0131r ve karaci\u011fer hasar\u0131 metabolik bozukluklara ve fonksiyonel bozukluklara neden olabilir. Karaci\u011fer h\u00fccrelerindeki amino asit metabolizmas\u0131ndaki azalma, kandaki amino asit konsantrasyonunda bir art\u0131\u015fa yol a\u00e7abilir ve b\u00f6ylece kan, idrar ve safradaki amino asit seviyelerindeki de\u011fi\u015fiklikleri etkileyebilir. Glutamat \u00f6nemli bir uyar\u0131c\u0131 n\u00f6rotransmitterdir. Glutamat metabolizmas\u0131 bozulursa, \"glutamat glutamin d\u00f6ng\u00fcs\u00fc\" bozulur. H\u00fccre d\u0131\u015f\u0131 s\u0131v\u0131da a\u015f\u0131r\u0131 glutamat konsantrasyonu \u00e7ok fazla uyar\u0131c\u0131 amino asidi aktive ederek toksik reaksiyonlara yol a\u00e7abilir. Glutamin, \u03b1 - ketoglutarat sentezi i\u00e7in \u00f6nemli bir hammaddedir. \u03b1 - ketoglutarat, stresteki enflamatuar fakt\u00f6rlerin seviyelerini belirli bir dereceye kadar azaltabilir ve enflamasyonu modelledikten sonra dokularda glutamat\u0131n metabolik bozukluklar\u0131na neden olarak toksik etkilere yol a\u00e7abilir. Deneysel sonu\u00e7lar, kum ha\u015flama grubunun plazmas\u0131ndaki glutamat i\u00e7eri\u011finin \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131n\u0131, b\u00f6ylece beyin sinirlerinin uyar\u0131labilirli\u011fini azaltt\u0131\u011f\u0131n\u0131 ve yat\u0131\u015ft\u0131r\u0131c\u0131 bir etki g\u00f6sterdi\u011fini g\u00f6stermi\u015ftir. Ayn\u0131 zamanda, anti-enflamatuar terap\u00f6tik etkiler elde etmek i\u00e7in glutamin i\u00e7eri\u011fi yukar\u0131 do\u011fru d\u00fczenlenmi\u015ftir. Fenilalanin esas olarak karaci\u011fer gibi dokularda tirozine metabolize edilir ve daha sonra sinir sisteminde ve adrenal medullada dopamin, norepinefrin, adrenalin vb. gibi sentezlenir. Fenilalaninin metabolik durumu v\u00fccudun b\u00fcy\u00fcmesini, geli\u015fimini ve normal fizyolojik i\u015flevlerini do\u011frudan etkileyecektir. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, fenilalaninin normal grupta \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131n\u0131, ham \u00fcr\u00fcn grubunda ve kum ha\u015flama grubunda ise hafif\u00e7e azald\u0131\u011f\u0131n\u0131 g\u00f6stermektedir. Kum ha\u015flama grubunun normal gruba daha yak\u0131n olmas\u0131, kum ha\u015flama grubunun enflamasyonun neden oldu\u011fu fenilalanin metabolizmas\u0131 bozuklu\u011funu daha iyi d\u00fczenleyebilece\u011fini g\u00f6stermektedir. Sitr\u00fclin, arginin ve prolinin metabolik yollar\u0131nda \u00fcretilir ve ilgili enzimlerin etkisi alt\u0131nda arginin, ornitin vb. \u00fcretir. Kan amonyak seviyelerini etkili bir \u015fekilde azaltabilir, organ hasar\u0131n\u0131 \u00f6nleyebilir ve v\u00fccuttaki a\u011fr\u0131 reaksiyonlar\u0131n\u0131 hafifletebilir. Model gruptaki sitr\u00fclin i\u00e7eri\u011fi normal gruba k\u0131yasla \u00f6nemli \u00f6l\u00e7\u00fcde azal\u0131rken, hem ham \u00fcr\u00fcn grubunda hem de kum ha\u015flama grubunda artm\u0131\u015ft\u0131r; bu da kum ha\u015flaman\u0131n arginin metabolizmas\u0131n\u0131 etkili bir \u015fekilde d\u00fczenleyebildi\u011fini, kan damarlar\u0131n\u0131 geni\u015fletebildi\u011fini ve iltihaplanman\u0131n neden oldu\u011fu a\u011fr\u0131y\u0131 hafifletebildi\u011fini g\u00f6stermektedir. Tirozin esas olarak tirozin hidrojenaz taraf\u0131ndan dihidroksifenilalanin \u00fcretmek \u00fczere metabolize edilir ve daha sonra tirozin hidroksilaz\u0131n etkisi alt\u0131nda dopa ve di\u011fer sempatik n\u00f6rotransmitterlere d\u00f6n\u00fc\u015ft\u00fcr\u00fcl\u00fcr. S\u0131\u00e7an yumurta ak\u0131 kaynakl\u0131 plantar \u015fi\u015fme iltihab\u0131 modeli, iltihapl\u0131 reaksiyonlar ve a\u011fr\u0131n\u0131n e\u015flik etti\u011fi yerel kan ak\u0131\u015f\u0131nda h\u0131zl\u0131 bir d\u00fc\u015f\u00fc\u015fe neden olabilir ve a\u011fr\u0131 duyarl\u0131l\u0131\u011f\u0131 yan\u0131t\u0131 giderek artacakt\u0131r. Dopamin i\u00e7eri\u011fi model grupta yukar\u0131 do\u011fru d\u00fczenlenirken, sandhot grubunda \u00f6nemli \u00f6l\u00e7\u00fcde a\u015fa\u011f\u0131 do\u011fru d\u00fczenlenmi\u015ftir, bu da sandhot \u00fcr\u00fcnlerinin dopamin metabolizmas\u0131n\u0131 d\u00fczenleyerek a\u011fr\u0131 duyarl\u0131l\u0131\u011f\u0131n\u0131 azaltabilece\u011fini g\u00f6stermektedir. Gliserofosfolipidlerin metabolizmas\u0131, Semen Strychni'nin hepatotoksisitesi ve i\u015flem zay\u0131flamas\u0131 i\u00e7in kilit bir metabolik yoldur. Gliserofosfolipid metabolizmas\u0131nda yer alan iki temel hedef vard\u0131r: fosfatidilkolin ve fosfatidiletanolamin, bunlar esas olarak karaci\u011fer dokusunda birbirlerine d\u00f6n\u00fc\u015ft\u00fcr\u00fclebilir. \u00d6nceki \u00e7al\u0131\u015fmalar, at k\u0131l\u0131n\u0131n neden oldu\u011fu karaci\u011fer hasar\u0131n\u0131n, gliseridler, a\u00e7ilgliseroller, fosfatidiletanolaminler, fosfatidilkolin gibi maddelerin yan\u0131 s\u0131ra ilgili enflamatuar fakt\u00f6r seviyelerinde de\u011fi\u015fiklikleri i\u00e7eren lipid metabolizmas\u0131 bozukluklar\u0131na yol a\u00e7abilece\u011fini g\u00f6stermi\u015ftir. Fosfatidilkolin, anti-enflamatuar ve ba\u011f\u0131\u015f\u0131kl\u0131k artt\u0131r\u0131c\u0131 etkilere sahiptir ve anti-enflamatuar ve potansiyel terap\u00f6tik etkileri, n\u00f6trofiller taraf\u0131ndan ind\u00fcklenen mikrosirk\u00fclatuar enflamatuar yan\u0131t\u0131 azaltmakla ili\u015fkili olabilir; Lizofosfatidilkolin, ekstrahepatik dokular\u0131n plazma havuzunda da\u011f\u0131lan fosfatidilkolinin bir \u00fcr\u00fcn\u00fc veya metabolitidir ve \u00e7e\u015fitli pro-enflamatuar reaksiyonlar\u0131 ind\u00fckleyebilir. Deneysel sonu\u00e7lara g\u00f6re, fosfatidilkolin ve lizofosfatidilkolin seviyeleri model grupta artarken, ham \u00fcr\u00fcn grubu ve kum ha\u015flama grubunda azalm\u0131\u015f ve normal gruba yak\u0131n seyretmi\u015ftir. Bu, Malvaceae \u00f6z\u00fct\u00fcn\u00fcn dengeyi sa\u011flamak i\u00e7in fosfatidilkolin ve lizofosfatidilkolin seviyelerini etkili bir \u015fekilde d\u00fczenleyebilece\u011fini g\u00f6stermektedir. Karaci\u011fer, v\u00fccuttaki gliserofosfolipidlerin sentezi i\u00e7in en aktif b\u00f6lgedir ve bu da bir dereceye kadar Malvaceae'nin hepatotoksisitesinin nesnel varl\u0131\u011f\u0131n\u0131 do\u011frular; Ayn\u0131 zamanda, Ma Qian Zi Sha Hot Pot'un iyi anti-enflamatuar ve detoksifiye edici etkilere sahip oldu\u011funu da do\u011frular.
\n\u00d6zetle, bu \u00e7al\u0131\u015fmada, i\u015flenmi\u015f Ma Qian Zi'nin toksisitesinin azalt\u0131ld\u0131\u011f\u0131n\u0131 ve buna ra\u011fmen iyi anti-enflamatuar terap\u00f6tik etkilerini korudu\u011funu do\u011frulamak i\u00e7in metabolomikler kullan\u0131lm\u0131\u015ft\u0131r. V\u00fccudundaki aktif maddeler \u00e7o\u011funlukla alkaloidler olmal\u0131d\u0131r; Ma Qian Zi'nin anti-enflamatuar ve analjezik etkilerinin yan\u0131 s\u0131ra karaci\u011fer ve b\u00f6brek toksisitesi, glutamin glutamat metabolizmas\u0131, fenilalanin metabolizmas\u0131, tiyometabolizma, gliserofosfolipid metabolizmas\u0131, arginin ve prolin metabolizmas\u0131 gibi yollar\u0131n bozulmas\u0131yla yak\u0131ndan ilgilidir. Ara\u015ft\u0131rma sonu\u00e7lar\u0131, alkaloid i\u00e7eren toksik geleneksel \u00c7in t\u0131bbi malzemelerinin i\u015flenmesinde toksisiteyi azaltma, etkinli\u011fi art\u0131rma veya etkinli\u011fi koruma mekanizmalar\u0131n\u0131 ara\u015ft\u0131rmak i\u00e7in yararl\u0131 bilimsel referanslar sa\u011flamaktad\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

Study on the mechanism of toxicity reduction and preservation of processed Ma Qian Zi based on metabolomics of inflammatory rats Ma Qian Zi is an important and commonly used traditional Chinese medicine in China, first recorded in the Compendium of Materia Medica. It has the effects of unblocking collaterals, relieving pain, dispersing nodules, and reducing […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nStudy on the mechanism of toxicity reduction and preservation of processed Ma Qian Zi based on metabolomics of inflammatory rats - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/inflammation-ma-qian-zi-processed-to-reduce-toxicity\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Study on the mechanism of toxicity reduction and preservation of processed Ma Qian Zi based on metabolomics of inflammatory rats - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Study on the mechanism of toxicity reduction and preservation of processed Ma Qian Zi based on metabolomics of inflammatory rats Ma Qian Zi is an important and commonly used traditional Chinese medicine in China, first recorded in the Compendium of Materia Medica. 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