{"id":3748,"date":"2024-08-03T07:42:11","date_gmt":"2024-08-03T07:42:11","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3748"},"modified":"2024-08-03T07:42:11","modified_gmt":"2024-08-03T07:42:11","slug":"trichothecium-roseum-diterpene","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/trichothecium-roseum-diterpene\/","title":{"rendered":"Pembe trichoderma fermantasyon \u00fcr\u00fcnlerinde sitotoksik aktiviteye sahip diterpenler"},"content":{"rendered":"<p>Pembe trichoderma fermantasyon \u00fcr\u00fcnlerinde sitotoksik aktiviteye sahip diterpenler<br \/>\nDeuteromycotina alt filumunun Hyphomyceales tak\u0131m\u0131na ait pembe trichothecium roseum 2008 y\u0131l\u0131nda ke\u015ffedilmi\u015f ve adland\u0131r\u0131lm\u0131\u015ft\u0131r. Bu mantar \u00e7\u00fcr\u00fcyen bitki g\u00f6vdelerinden, topraktan ve havadan kolayl\u0131kla izole edilebilmekte ve d\u00fcnya \u00e7ap\u0131nda yayg\u0131n olarak bulunan bitki ve sebze patojeni bir mantard\u0131r. Pembe trichoderma'n\u0131n metabolitleri \u00fczerine laboratuvar k\u00fclt\u00fcr\u00fc ko\u015fullar\u0131nda seskiterpenler, seskiterpenler, diterpenler ve siklik peptidleri i\u00e7eren temsili yap\u0131larla bir\u00e7ok \u00e7al\u0131\u015fma yap\u0131lm\u0131\u015ft\u0131r. Bunlar aras\u0131nda en yayg\u0131n olarak \u00e7al\u0131\u015f\u0131lan\u0131 trikotesendir. Tang ve arkada\u015flar\u0131, monotrichothecene bile\u015fiklerinin elma \u00e7ekirdeklerinde \u00e7\u00fcr\u00fcmeye neden olabilece\u011fini, monotrichothecene toksinlerinin ise hem insanlarda hem de hayvanlarda protein ve n\u00fckleik asit sentezini engelledi\u011fini ve m\u00fcdahale etti\u011fini, bunun da insan ve hayvan sa\u011fl\u0131\u011f\u0131nda ba\u011f\u0131\u015f\u0131kl\u0131k bask\u0131lanmas\u0131na yol a\u00e7t\u0131\u011f\u0131n\u0131 bildirmi\u015ftir. Bu toksinlerle kirlenmi\u015f g\u0131da ve \u00fcr\u00fcnlerin t\u00fcketilmesi insan ve hayvanlarda yayg\u0131n toksik etkilere neden olabilir.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3749\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-4.png\" alt=\"\" width=\"882\" height=\"360\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-4.png 882w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-4-768x313.png 768w\" sizes=\"(max-width: 882px) 100vw, 882px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3750\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-3.png\" alt=\"\" width=\"814\" height=\"226\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-3.png 814w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-3-768x213.png 768w\" sizes=\"(max-width: 814px) 100vw, 814px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3751\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-3.png\" alt=\"\" width=\"838\" height=\"236\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-3.png 838w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3-3-768x216.png 768w\" sizes=\"(max-width: 838px) 100vw, 838px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3752\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-4.png\" alt=\"\" width=\"450\" height=\"220\" \/><br \/>\nToksin bile\u015fiklerine ek olarak, bu fermantasyon suyunda sitotoksik aktiviteye sahip bile\u015fikler de bulunmu\u015ftur, \u00f6rne\u011fin bu cinste bulunan ve 11 \u03bcg\/mL IC50 de\u011feri ile MLR deneylerinde g\u00fc\u00e7l\u00fc imm\u00fcnosupresif aktivite g\u00f6steren seskiterpen bile\u015fi\u011fi cuspidatol; Monotrichothecin A, HL-60, SMMC-7721, A549, MCF-7 ve SW480 h\u00fccrelerinin b\u00fcy\u00fcmesi \u00fczerinde g\u00fc\u00e7l\u00fc bir inhibit\u00f6r etkiye sahiptir ve IC50 de\u011ferleri 0.022, 0.020, 0.015, 0.006 ve 0.Pozitif kontrol paklitaksel ile kar\u015f\u0131la\u015ft\u0131r\u0131labilir olan s\u0131ras\u0131yla 011 \u03bc mol\/L; Diterpen bile\u015fi\u011fi rosonolakton, insan servikal kanseri HeLa h\u00fccreleri \u00fczerinde g\u00fc\u00e7l\u00fc anti proliferatif ve pro apoptotik etkilere sahiptir; Bir siklik ester peptit bile\u015fi\u011fi olan roseocardin, s\u0131\u00e7an miyokard\u0131 \u00fczerinde pozitif inotropik etkiye sahiptir; Siklik peptit bile\u015fi\u011fi tricomide D, \u00fc\u00e7 insan kanser h\u00fccre hatt\u0131na (MCF-7, SW480, HL-6) kar\u015f\u0131 \u00f6nemli sitotoksisite sergilemi\u015ftir ve IC50 de\u011ferleri 0.S\u0131ras\u0131yla 079, 0.107 ve 0.149 \u03bc mol\/L. Bu, siklik peptitlerin sitotoksik aktivitesine ili\u015fkin ilk rapordur. Sitotoksik aktiviteye sahip yeni bile\u015fikler aramaya devam etmek amac\u0131yla, ara\u015ft\u0131rma grubumuz Baise'de (Ganoderma lucidum'un memleketi) yabani Ganoderma lucidum'un yeti\u015fti\u011fi topraktan bir pembe trichothecus su\u015fu izole etti ve tan\u0131mlad\u0131. Yeni yap\u0131lara ve iyi biyolojik aktiviteye sahip bile\u015fikler ke\u015ffetmek ve ila\u00e7 \u00f6nc\u00fcs\u00fc yap\u0131lar sa\u011flamak amac\u0131yla fermantasyon s\u00fcrecini geni\u015fletmek i\u00e7in pirin\u00e7 k\u00fclt\u00fcr\u00fc ortam\u0131 kulland\u0131k.<\/p>\n<p>Bu \u00e7al\u0131\u015fmada, T. roseum'un fermantasyon \u00fcr\u00fcnlerinden hepsi diterpen olan be\u015f bile\u015fik izole edilmi\u015f ve tan\u0131mlanm\u0131\u015ft\u0131r. Bunlar aras\u0131nda, bile\u015fik 1 yeni bir diterpenoid bile\u015fiktir. Bu sonu\u00e7 pembe trichoderma taraf\u0131ndan \u00fcretilen metabolitlerin \u00e7e\u015fitlili\u011fini zenginle\u015ftirmektedir. Be\u015f bile\u015fik MCF-7 h\u00fccreleri \u00fczerinde farkl\u0131 derecelerde inhibit\u00f6r etki g\u00f6stermi\u015f olup, bile\u015fik 1 ve 5 en iyi aktiviteyi sergilemi\u015ftir. Bunun, 1 ve 5 numaral\u0131 bile\u015fiklerin benzer A ve B halka yap\u0131lar\u0131ndan kaynaklanabilece\u011fi tahmin edilirken, 5 numaral\u0131 bile\u015fik, zincir benzeri olmas\u0131na ra\u011fmen, bile\u015fik 1'e benzer uzamsal uzant\u0131ya sahip bask\u0131n bir konformasyona sahiptir. Bu yap\u0131sal \u00f6zelli\u011fe sahip bile\u015fikler, bu makalede se\u00e7ilen aktivite ara\u015ft\u0131rma modelinde daha iyi aktivite g\u00f6stermi\u015ftir. Bu \u00e7al\u0131\u015fma, Trichothecaum mantarlar\u0131ndaki ikincil metabolit yap\u0131lar\u0131n\u0131n \u00e7e\u015fitlili\u011fini zenginle\u015ftirmekte ve anti-t\u00fcm\u00f6r aktif bile\u015fiklerin taranmas\u0131 i\u00e7in bir referans sa\u011flamaktad\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"<p>Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma The pink trichothecium roseum, belonging to the Hyphomyceales order of the Deuteromycotina subphylum, was discovered and named in 2008. This fungus is easily isolated from decaying plant bodies, soil, and air, and is a widely distributed plant and vegetable pathogenic fungus worldwide. There have [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/trichothecium-roseum-diterpene\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma The pink trichothecium roseum, belonging to the Hyphomyceales order of the Deuteromycotina subphylum, was discovered and named in 2008. This fungus is easily isolated from decaying plant bodies, soil, and air, and is a widely distributed plant and vegetable pathogenic fungus worldwide. There have [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/longchangextracts.com\/tr\/trichothecium-roseum-diterpene\/\" \/>\n<meta property=\"og:site_name\" content=\"China Chemical Manufacturer\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-03T07:42:11+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-4.png\" \/>\n<meta name=\"author\" content=\"longcha9\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Yazan:\" \/>\n\t<meta name=\"twitter:data1\" content=\"longcha9\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tahmini okuma s\u00fcresi\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 dakika\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/longchangextracts.com\/trichothecium-roseum-diterpene\/\",\"url\":\"https:\/\/longchangextracts.com\/trichothecium-roseum-diterpene\/\",\"name\":\"Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma - China Chemical Manufacturer\",\"isPartOf\":{\"@id\":\"https:\/\/longchangextracts.com\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\/\/longchangextracts.com\/trichothecium-roseum-diterpene\/#primaryimage\"},\"image\":{\"@id\":\"https:\/\/longchangextracts.com\/trichothecium-roseum-diterpene\/#primaryimage\"},\"thumbnailUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-4.png\",\"datePublished\":\"2024-08-03T07:42:11+00:00\",\"dateModified\":\"2024-08-03T07:42:11+00:00\",\"author\":{\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\"},\"breadcrumb\":{\"@id\":\"https:\/\/longchangextracts.com\/trichothecium-roseum-diterpene\/#breadcrumb\"},\"inLanguage\":\"tr\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/longchangextracts.com\/trichothecium-roseum-diterpene\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/trichothecium-roseum-diterpene\/#primaryimage\",\"url\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-4.png\",\"contentUrl\":\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-4.png\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/longchangextracts.com\/trichothecium-roseum-diterpene\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/longchangextracts.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/longchangextracts.com\/#website\",\"url\":\"https:\/\/longchangextracts.com\/\",\"name\":\"China Chemical Manufacturer\",\"description\":\"\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/longchangextracts.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"tr\"},{\"@type\":\"Person\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/80933ac6926ad63fea74ec33f8d04869\",\"name\":\"longcha9\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"tr\",\"@id\":\"https:\/\/longchangextracts.com\/#\/schema\/person\/image\/\",\"url\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"contentUrl\":\"https:\/\/secure.gravatar.com\/avatar\/c1e84ee0759373263198c58e8f338f80?s=96&d=mm&r=g\",\"caption\":\"longcha9\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Pembe trichoderma fermantasyon \u00fcr\u00fcnlerinde sitotoksik aktiviteye sahip diterpenler - \u00c7in Kimya \u00dcreticisi","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/longchangextracts.com\/tr\/trichothecium-roseum-diterpene\/","og_locale":"tr_TR","og_type":"article","og_title":"Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma - China Chemical Manufacturer","og_description":"Diterpenes with cytotoxic activity in the fermentation products of pink trichoderma The pink trichothecium roseum, belonging to the Hyphomyceales order of the Deuteromycotina subphylum, was discovered and named in 2008. 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