{"id":3705,"date":"2024-08-03T07:29:04","date_gmt":"2024-08-03T07:29:04","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3705"},"modified":"2024-08-03T07:29:04","modified_gmt":"2024-08-03T07:29:04","slug":"leech-polypeptide","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/leech-polypeptide\/","title":{"rendered":"Farkl\u0131 ilkel s\u00fcl\u00fcklerden karakteristik peptitlerin tan\u0131mlanmas\u0131"},"content":{"rendered":"<p>Farkl\u0131 ilkel s\u00fcl\u00fcklerden karakteristik peptitlerin tan\u0131mlanmas\u0131<br \/>\n\u00c7in Halk Cumhuriyeti Farmakopesi'nin (bundan b\u00f6yle \"Farmakope\" olarak an\u0131lacakt\u0131r) 2020 bask\u0131s\u0131, geleneksel \u00c7in t\u0131bb\u0131 s\u00fcl\u00fc\u011f\u00fcn\u00fcn, s\u00fcl\u00fck ailesi hayvan\u0131 olan s\u00fcl\u00fck Whitman pigra Whitman, s\u00fcl\u00fck Hirudo nipponica Whitman veya s\u00f6\u011f\u00fct yapra\u011f\u0131 s\u00fcl\u00fc\u011f\u00fc Whitman acranulata Whitman'\u0131n kurutulmu\u015f bir b\u00fct\u00fcn\u00fc oldu\u011funu belirtmektedir. Tad\u0131 tuzlu, ac\u0131 ve hafiftir; karaci\u011fer meridyenine ait k\u00fc\u00e7\u00fck bir toksin vard\u0131r. Kan\u0131 k\u0131rma ve dola\u015f\u0131m\u0131 te\u015fvik etme, kan staz\u0131n\u0131 giderme ve durgunlu\u011fu ortadan kald\u0131rma i\u015flevine sahiptir. Genellikle kan staz\u0131 ve meridyen t\u0131kan\u0131kl\u0131\u011f\u0131, kitlelerin tedavisi, inme hemiplejisi ve d\u00fc\u015fme ve yaralanmalar i\u00e7in kullan\u0131l\u0131r. Son y\u0131llarda, kardiyovask\u00fcler ve serebrovask\u00fcler hastal\u0131klar\u0131 olan hastalar\u0131n say\u0131s\u0131 \u00f6nemli \u00f6l\u00e7\u00fcde artm\u0131\u015f, bu da s\u00fcl\u00fck t\u0131bbi malzemelerine olan talebin artmas\u0131na neden olmu\u015ftur. Bununla birlikte, piyasada \u00e7ok say\u0131da karma\u015f\u0131k ve farkl\u0131 kalitede s\u00fcl\u00fck t\u0131bbi malzemesi bulunmaktad\u0131r. S\u00fcl\u00fcklerin yan\u0131 s\u0131ra piyasada Poecilobdra manillensis Lesson ad\u0131nda sahte bir \u00fcr\u00fcn de bulunmaktad\u0131r. \u015eu anda, s\u00fcl\u00fckler ve s\u00fcl\u00fcklerin her ikisi de g\u00f6r\u00fcn\u00fc\u015f ve \u00f6zellik bak\u0131m\u0131ndan \u00f6nemli farkl\u0131l\u0131klara sahip kurutulmu\u015f \u00fcr\u00fcnlerdir ve ay\u0131rt edilmelerini kolayla\u015ft\u0131r\u0131r. Bu nedenle, bu \u00e7al\u0131\u015fma sadece s\u00fcl\u00fcklerin farkl\u0131 k\u00f6kenlerini incelemeye odaklanmaktad\u0131r. Literat\u00fcr taramas\u0131 sonucunda, s\u00fcl\u00fckler \u00fczerine yap\u0131lan mevcut ara\u015ft\u0131rmalar\u0131n antikoag\u00fclan mekanizmalar ve amino asit tayini \u00fczerine odakland\u0131\u011f\u0131, farkl\u0131 ilkel s\u00fcl\u00fcklerin ve bunlar\u0131n kar\u0131\u015f\u0131mlar\u0131n\u0131n kalitesi \u00fczerine nispeten az kapsaml\u0131 \u00e7al\u0131\u015fma oldu\u011fu g\u00f6r\u00fclm\u00fc\u015ft\u00fcr. Farkl\u0131 ilkel s\u00fcl\u00fckler aras\u0131ndaki tan\u0131mlama \u00e7al\u0131\u015fmalar\u0131 \u00e7o\u011funlukla \u00c7in Farmakopesi'nin 2020 bask\u0131s\u0131 kapsam\u0131nda \u00f6zellik tan\u0131mlamas\u0131na dayanmaktad\u0131r. Baz\u0131 \u00e7al\u0131\u015fmalar, DNA molek\u00fcler tan\u0131mlama ve protein analiz teknikleri arac\u0131l\u0131\u011f\u0131yla, s\u00fcl\u00fck DNA molek\u00fcler tan\u0131mlama teknolojisinin PCR yoluyla kurulabilece\u011fini ve farkl\u0131 ilkel s\u00fcl\u00fcklerin proteinlerinin SDS-PAGE ve 2-DE kullan\u0131larak ay\u0131rt edilebilece\u011fini bulmu\u015ftur. Ayr\u0131ca, HPLC karakteristik spektrum y\u00f6ntemlerine veya y\u00fcksek verimli dizileme y\u00f6ntemlerine dayanarak da ay\u0131rt edebilen \u00e7al\u0131\u015fmalar vard\u0131r, ancak bu t\u00fcr y\u00f6ntemlerin uzun tespit s\u00fcresi ve tespit cihazlar\u0131n\u0131n pop\u00fclerli\u011finin d\u00fc\u015f\u00fck olmas\u0131 gibi sorunlar\u0131 vard\u0131r. Bu \u00e7al\u0131\u015fmada s\u00fcl\u00fck peptidi I ve s\u00fcl\u00fck peptidi II'yi tespit etmek i\u00e7in LC-MS y\u00f6ntemi kullan\u0131lm\u0131\u015ft\u0131r. Olu\u015fturulan y\u00f6ntem g\u00fc\u00e7l\u00fc \u00f6zg\u00fcll\u00fc\u011fe, y\u00fcksek duyarl\u0131l\u0131\u011fa, k\u0131sa analiz s\u00fcresine sahiptir ve farkl\u0131 k\u00f6kenlere sahip s\u00fcl\u00fckleri ay\u0131rt etmek, kalite kontrol seviyelerini iyile\u015ftirmek ve ilgili ila\u00e7lar\u0131n klinik kullan\u0131m\u0131n\u0131n g\u00fcvenli\u011fi ve etkinli\u011fi i\u00e7in referans sa\u011flamak i\u00e7in kullan\u0131labilir.<\/p>\n<p><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3706\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/1-1.png\" alt=\"\" width=\"455\" height=\"634\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3707\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2.png\" alt=\"\" width=\"950\" height=\"292\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2.png 950w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/2-768x236.png 768w\" sizes=\"(max-width: 950px) 100vw, 950px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3708\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/3.png\" alt=\"\" width=\"731\" height=\"566\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3709\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-1.png\" alt=\"\" width=\"996\" height=\"312\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-1.png 996w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/4-1-768x241.png 768w\" sizes=\"(max-width: 996px) 100vw, 996px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3710\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-1.png\" alt=\"\" width=\"994\" height=\"744\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-1.png 994w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-1-768x575.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/5-1-962x720.png 962w\" sizes=\"(max-width: 994px) 100vw, 994px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3711\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-1.png\" alt=\"\" width=\"982\" height=\"580\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-1.png 982w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/6-1-768x454.png 768w\" sizes=\"(max-width: 982px) 100vw, 982px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3712\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7.png\" alt=\"\" width=\"936\" height=\"568\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7.png 936w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/7-768x466.png 768w\" sizes=\"(max-width: 936px) 100vw, 936px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3713\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8.png\" alt=\"\" width=\"918\" height=\"564\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8.png 918w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/8-768x472.png 768w\" sizes=\"(max-width: 918px) 100vw, 918px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3714\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9.png\" alt=\"\" width=\"962\" height=\"1300\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9.png 962w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-768x1038.png 768w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/9-533x720.png 533w\" sizes=\"(max-width: 962px) 100vw, 962px\" \/><img loading=\"lazy\" decoding=\"async\" class=\"alignnone size-full wp-image-3715\" src=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10.png\" alt=\"\" width=\"948\" height=\"450\" srcset=\"https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10.png 948w, https:\/\/longchangextracts.com\/wp-content\/uploads\/2024\/08\/10-768x365.png 768w\" sizes=\"(max-width: 948px) 100vw, 948px\" \/><br \/>\nHayvansal t\u0131bbi malzemelerin tan\u0131mlanmas\u0131, geleneksel \u00c7in t\u0131bb\u0131 ara\u015ft\u0131rmalar\u0131nda her zaman \u00f6nemli ve zor bir konu olmu\u015ftur. Bununla birlikte, mevcut tan\u0131mlama y\u00f6ntemleri esas olarak g\u00fc\u00e7l\u00fc \u00f6znelli\u011fe sahip olan ve ay\u0131rt ediciden g\u00fc\u00e7l\u00fc mesleki bilgi ve deneyim gerektiren geleneksel tan\u0131mlama y\u00f6ntemlerine dayanmaktad\u0131r. Modern tespit y\u00f6ntemlerine dayal\u0131 bilimsel, etkili ve do\u011fru tan\u0131mlama y\u00f6ntemlerinin eksikli\u011fi s\u00f6z konusudur. S\u00fcl\u00fck, g\u00fc\u00e7l\u00fc t\u0131bbi ve ara\u015ft\u0131rma de\u011feri olan de\u011ferli bir geleneksel \u00c7in ilac\u0131d\u0131r. S\u00fcl\u00fcklerin t\u0131bbi de\u011feri d\u00fcnya \u00e7ap\u0131nda da kabul g\u00f6rm\u00fc\u015ft\u00fcr ve s\u00fcl\u00fckler Avrupa, M\u0131s\u0131r ve Hindistan'da hastal\u0131klar\u0131 tedavi etmek i\u00e7in kullan\u0131lm\u0131\u015ft\u0131r. \u00c7in Farmakopesi'nin 2020 bask\u0131s\u0131, s\u00fcl\u00fcklerin \u00fc\u00e7 temel element i\u00e7erdi\u011fini kaydetmektedir, ancak \u015fu anda \u00c7in Farmakopesi bunlar\u0131 yaln\u0131zca nem, toplam k\u00fcl i\u00e7eri\u011fi, asitlik ve alkalilik ve antitrombin aktivitesi gibi testlerle kontrol etmektedir. Halihaz\u0131rda, bilimsel temelden yoksun olan ve kaynat\u0131ld\u0131ktan sonra t\u0131bbi malzemelerin kaynatma veya form\u00fclasyonunu tan\u0131mlayamayan farkl\u0131 temel unsurlar aras\u0131nda farkl\u0131 karakterizasyon kayd\u0131 yoktur.<br \/>\nBu \u00e7al\u0131\u015fmada 15 parti s\u00fcl\u00fck, 2 parti s\u00f6\u011f\u00fct yapra\u011f\u0131 s\u00fcl\u00fc\u011f\u00fc ve 5 parti s\u00fcl\u00fck olmak \u00fczere farkl\u0131 k\u00f6kenlere sahip 22 parti s\u00fcl\u00fck test edilmi\u015ftir. Sonu\u00e7lar, 15 parti s\u00fcl\u00fc\u011f\u00fcn tamam\u0131n\u0131n s\u00fcl\u00fck peptidi I ve s\u00fcl\u00fck peptidi II kromatografik piklerini tespit edebildi\u011fini, 2 parti s\u00f6\u011f\u00fct yapra\u011f\u0131 s\u00fcl\u00fc\u011f\u00fcn\u00fcn sadece s\u00fcl\u00fck peptidi II'yi tespit edebildi\u011fini ve 5 parti s\u00fcl\u00fc\u011f\u00fcn sadece s\u00fcl\u00fck peptidi I'i tespit edebildi\u011fini g\u00f6stermi\u015ftir. \u0130nceleme sonu\u00e7lar\u0131ndan, farkl\u0131 k\u00f6kenlere sahip s\u00fcl\u00fcklerin s\u00fcl\u00fck peptidi I ve s\u00fcl\u00fck peptidi II \u00f6l\u00e7\u00fclerek ay\u0131rt edilebilece\u011fi g\u00f6r\u00fclebilir. PLS-DA analizi sayesinde, farkl\u0131 k\u00f6kenlere sahip s\u00fcl\u00fcklerin net bir \u015fekilde \u00fc\u00e7 kategoriye ayr\u0131labildi\u011fi ve analiz sonu\u00e7lar\u0131n\u0131n k\u00f6kenlerin tan\u0131mlama sonu\u00e7lar\u0131yla tutarl\u0131 oldu\u011fu g\u00f6r\u00fclebilir. Di\u011fer belgelere g\u00f6re, hirudo polipeptidinin aktivitesi esas olarak antikoag\u00fclan aktivitedir ve ayr\u0131ca proteaz inhibisyonu, anti-enflamatuar, hidrolaz, aterosklerozda makrofaj g\u00f6\u00e7\u00fcn\u00fcn inhibisyonu ve di\u011fer farmakolojik aktiviteleri i\u00e7erir. Bu, amino asitler ve n\u00fckleozitlere ek olarak, hirudo polipeptidin de farmakolojik etkisinin ana bile\u015fenlerinden biri oldu\u011funu g\u00f6stermektedir. Bununla birlikte, yukar\u0131daki belgeler polipeptidin farmakolojik \u00e7al\u0131\u015fmas\u0131na odaklanm\u0131\u015ft\u0131r ve polipeptid i\u00e7in herhangi bir tespit y\u00f6ntemi olu\u015fturulmam\u0131\u015ft\u0131r. Bu makale, di\u011fer polipeptit \u00e7e\u015fitlerinin ekstraksiyon ve inceleme y\u00f6ntemlerine at\u0131fta bulunarak hirudo polipeptidi belirlemek i\u00e7in LC-MS y\u00f6ntemini kullanmakta ve hirudo polipeptidin pik alan\u0131n\u0131 \u00f6l\u00e7erek farmakolojik etkisinin kalitesini yans\u0131tabilen kalite kontrol i\u00e7in bilimsel ve teknik bir ara\u00e7 sa\u011flamaktad\u0131r; Ayr\u0131ca, \u00c7in Farmakopesi'nde s\u00fcl\u00fcklerin i\u00e7erik belirleme maddesi alt\u0131nda, \"s\u00fcl\u00fcklerin anti trombin aktivitesi 16'dan az olmamal\u0131d\u0131r.1g ba\u015f\u0131na 0U; s\u00fcl\u00fckler ve s\u00f6\u011f\u00fct yapra\u011f\u0131 s\u00fcl\u00fckleri 3.0U'dan az olmamal\u0131d\u0131r\". Bu, s\u00fcl\u00fcklerin anti trombin aktivitesinde s\u00fcl\u00fck ve s\u00f6\u011f\u00fct yapra\u011f\u0131 s\u00fcl\u00fcklerine k\u0131yasla \u00f6nemli farkl\u0131l\u0131klar oldu\u011funu, yani farkl\u0131 k\u00f6kenlere sahip s\u00fcl\u00fcklerin \u00f6nemli kalite farkl\u0131l\u0131klar\u0131na sahip oldu\u011funu g\u00f6stermektedir. Bu nedenle, farkl\u0131 k\u00f6kenlere sahip s\u00fcl\u00fck t\u0131bbi malzemelerini ve bunlar\u0131n temel \u00f6zelliklerini kaybetmi\u015f su kaynatmalar\u0131n\u0131, form\u00fcl preparatlar\u0131n\u0131 vb. h\u0131zl\u0131 ve do\u011fru bir \u015fekilde ay\u0131rt etmek i\u00e7in bu y\u00f6ntemi kullanmak, s\u00fcl\u00fcklerin ve ilgili \u00fcr\u00fcnlerin kalitesini art\u0131rmak i\u00e7in b\u00fcy\u00fck \u00f6nem ta\u015f\u0131maktad\u0131r.<br \/>\nBu ara\u015ft\u0131rma enstit\u00fcs\u00fc taraf\u0131ndan olu\u015fturulan y\u00f6ntem, kalite kontrol seviyesini art\u0131rabilecek ve s\u00fcl\u00fckle ilgili ila\u00e7lar\u0131n klinik kullan\u0131m\u0131n\u0131n g\u00fcvenli\u011fi ve etkinli\u011fi i\u00e7in referans sa\u011flayabilecek h\u0131z, etkinlik ve tekrarlanabilirlik \u00f6zelliklerine sahiptir. Uzun s\u00fcredir sadece geleneksel tan\u0131mlama y\u00f6ntemleriyle farkl\u0131 k\u00f6kenleri ay\u0131rt edilebilen s\u00fcl\u00fck sorununu etkili bir \u015fekilde \u00e7\u00f6zmektedir.<\/p>","protected":false},"excerpt":{"rendered":"<p>Identification of characteristic peptides from different primitive leeches The 2020 edition of the Pharmacopoeia of the People&#8217;s Republic of China (hereinafter referred to as the &#8220;Pharmacopoeia&#8221;) stipulates that the traditional Chinese medicine leech is a dried whole of the leech family animal, the leech Whitman pigra Whitman, the leech Hirudo nipponica Whitman, or the willow [&hellip;]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v23.0 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Identification of characteristic peptides from different primitive leeches - 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