{"id":3684,"date":"2024-08-02T16:55:19","date_gmt":"2024-08-02T16:55:19","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3684"},"modified":"2024-08-02T16:55:19","modified_gmt":"2024-08-02T16:55:19","slug":"scutellaria-baicalensis-antioxidant-activity","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/scutellaria-baicalensis-antioxidant-activity\/","title":{"rendered":"Scutellaria baicalensis'in farkl\u0131 otantik b\u00f6lgelerdeki ana bile\u015fenleri ve antioksidan aktivitesi \u00fczerine kar\u015f\u0131la\u015ft\u0131rmal\u0131 \u00e7al\u0131\u015fma"},"content":{"rendered":"

Scutellaria baicalensis'in farkl\u0131 otantik b\u00f6lgelerdeki ana bile\u015fenleri ve antioksidan aktivitesi \u00fczerine kar\u015f\u0131la\u015ft\u0131rmal\u0131 \u00e7al\u0131\u015fma
\nScutellaria baicalensis, Lamiaceae familyas\u0131ndan \u00e7ok y\u0131ll\u0131k otsu bir bitki olan Scutellaria baicalensis Georgi'nin kurutulmu\u015f k\u00f6klerinden elde edilir. Da\u011f \u00e7ay\u0131 k\u00f6k\u00fc veya toprak alt\u0131n \u00e7ay\u0131 k\u00f6k\u00fc olarak da bilinir ve yayg\u0131n olarak kullan\u0131lan geleneksel bir \u00c7in ilac\u0131d\u0131r. \u0130lk olarak \"Shennong Bencao Jing \"de kaydedilmi\u015ftir. Scutellaria baicalensis, antibakteriyel, anti yorgunluk, anti-t\u00fcm\u00f6r, antioksidan, anti-enflamatuar ve karaci\u011fer korumas\u0131 gibi \u00e7e\u015fitli fizyolojik aktivitelere sahiptir ve bunlar Scutellaria baicalensis'teki baicalin, baicalin, baicalein ve baicalein gibi flavonoid bile\u015fenlerle yak\u0131ndan ilgilidir.
\nOtantik t\u0131bbi malzemeler, geleneksel \u00c7in t\u0131bb\u0131n\u0131n uzun s\u00fcreli klinik uygulamalar\u0131 yoluyla se\u00e7ilen, belirli b\u00f6lgelerde belirli \u00fcretim s\u00fcre\u00e7leriyle \u00fcretilen, di\u011fer b\u00f6lgelerde \u00fcretilen ayn\u0131 t\u00fcr t\u0131bbi malzemelerden daha iyi kalite ve etkinli\u011fe sahip ve daha y\u00fcksek bir itibara sahip t\u0131bbi malzemeleri ifade eder. Bitkisel kay\u0131tlara g\u00f6re, Yizhou, Hubei, Fuzhou, Shaanxi, Jing County, Gansu ve Yanzhou, Shandong'da \u00fcretilen Scutellaria baicalensis'in kalitesi nispeten iyidir. \u0130klim ve toprak fakt\u00f6rleri gibi ekolojik de\u011fi\u015fiklikler, arazi alanlar\u0131n\u0131n d\u00f6n\u00fc\u015f\u00fcm\u00fcne ve arazi kalitesinin olu\u015fmas\u0131na yol a\u00e7an en \u00f6nemli fakt\u00f6rlerdir. Hebei, Chengde'den Rehe Scutellaria baicalensis her zaman y\u00fcksek kaliteli ve etkili bir otantik Scutellaria baicalensis olarak kabul edilmi\u015ftir. Bununla birlikte, Chengde otantik \u00fcretim alan\u0131ndaki Scutellaria baicalensis t\u0131bbi malzemelerinin a\u015f\u0131r\u0131 kaz\u0131lmas\u0131 nedeniyle, \u015fu anda \u00fclke \u00e7ap\u0131ndaki b\u00fcy\u00fck ve orta \u00f6l\u00e7ekli t\u0131bbi pazarlarda Chengde, Hebei'den otantik Scutellaria baicalensis sat\u0131n almak zordur. \u015eu anda Shandong, Scutellaria baicalensis i\u00e7in y\u00fcksek verim ve iyi kaliteye sahip bir\u00e7ok ekim \u00fcss\u00fcne sahiptir ve giderek Scutellaria baicalensis i\u00e7in modern bir otantik \u00fcretim alan\u0131 haline gelmektedir. \u015eu anda, farkl\u0131 otantik b\u00f6lgelerden elde edilen Scutellaria baicalensis'in kalitesi ve etkinli\u011fi \u00fczerine kar\u015f\u0131la\u015ft\u0131rmal\u0131 bir \u00e7al\u0131\u015fma yap\u0131lmam\u0131\u015ft\u0131r. Bu nedenle, otantik t\u0131bbi malzemelerin \"m\u00fckemmel kalite ve iyi etkinlik\" \u00f6zelliklerine dayanarak, bu makale, farkl\u0131 otantik b\u00f6lgelerden gelen Scutellaria baicalensis'in kalitesinin e\u015fde\u011fer olup olmad\u0131\u011f\u0131n\u0131 \u00f6l\u00e7mek i\u00e7in deneysel destek sa\u011flamak amac\u0131yla, farkl\u0131 otantik b\u00f6lgelerden gelen Scutellaria baicalensis'in kalitesi ve antioksidan aktivitesinde farkl\u0131l\u0131klar olup olmad\u0131\u011f\u0131n\u0131 \"kimyasal bile\u015fim aktivitesi\" nin bir\u00e7ok perspektifinden de\u011ferlendirmektedir.<\/p>\n

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\nGeleneksel \u00c7in t\u0131bb\u0131 bile\u015fenlerinin b\u00fct\u00fcnl\u00fc\u011f\u00fcn\u00fc ve karma\u015f\u0131kl\u0131\u011f\u0131n\u0131 tek veya \u00e7oklu g\u00f6sterge i\u00e7eri\u011fi belirleme yoluyla kapsaml\u0131 ve objektif olarak yans\u0131tmak zordur. Geleneksel \u00c7in t\u0131bb\u0131n\u0131n kimyasal parmak izi, geleneksel \u00c7in t\u0131bb\u0131n\u0131n kimyasal bile\u015fim bilgisinin kapsaml\u0131 bir karakterizasyonu ve \u00c7in t\u0131bbi malzemeleri i\u00e7in \u00f6nemli bir kalite kontrol arac\u0131d\u0131r. Geleneksel \u00c7in t\u0131bb\u0131n\u0131n parmak izi spektrumu, kimyasal bile\u015fenlerinin genel \u00f6zelliklerini yans\u0131tabilse de, yans\u0131tt\u0131\u011f\u0131 bile\u015fenler ilac\u0131n etkinli\u011fi ile ilgili de\u011fildir ve hala s\u0131n\u0131rlamalar vard\u0131r. Antioksidanlar, kanser ve kardiyovask\u00fcler hastal\u0131klar gibi \u00e7e\u015fitli kronik hastal\u0131klar\u0131n yan\u0131 s\u0131ra ya\u015fa ba\u011fl\u0131 \u00e7e\u015fitli hastal\u0131klar\u0131n tedavisinde \u00f6nemli bir rol oynamaktad\u0131r. Geleneksel \u00c7in T\u0131bb\u0131 (TCM) spektrumu ve etkinlik analizi, TCM kalitesi ve etkinli\u011finin kapsaml\u0131 bir de\u011ferlendirmesini elde etmek i\u00e7in TCM parmak izi bilgilerinin ve farmakolojik etkilerinin \u00f6r\u00fcnt\u00fc tan\u0131ma, ikisi aras\u0131ndaki ili\u015fkiyi ve katk\u0131y\u0131 netle\u015ftirme s\u00fcrecidir. \u015eu anda Scutellaria baicalensis'in spektral etkileri hakk\u0131nda az say\u0131da literat\u00fcr raporu bulunmaktad\u0131r. Xu ve ark. ve Jia ve ark. parmak izi spektrumlar\u0131 ile Scutellaria baicalensis ve Scutellaria baicalensis'in anti-enflamatuar aktivitesi aras\u0131nda bir korelasyon \u00e7al\u0131\u015fmas\u0131 olu\u015fturmu\u015ftur; Pang ve ark. Scutellaria baicalensis'in k\u00f6k, g\u00f6vde ve yapraklar\u0131ndaki kimyasal bile\u015fenlerin ya\u015flanma kar\u015f\u0131t\u0131 etkileri \u00fczerine spektral analiz ger\u00e7ekle\u015ftirmi\u015ftir; Bilim insanlar\u0131 ayr\u0131ca farmakolojik madde temelini a\u00e7\u0131kl\u0131\u011fa kavu\u015fturmak i\u00e7in Scutellaria baicalensis'in parmak izi spektrumunu anti-enflamatuar, antipiretik ve anti influenza vir\u00fcs\u00fc etkileriyle ili\u015fkilendirmi\u015ftir. \u015eimdiye kadar hi\u00e7 kimse farkl\u0131 otantik b\u00f6lgelerden elde edilen Scutellaria baicalensis'in kalitesinde farkl\u0131l\u0131klar olup olmad\u0131\u011f\u0131n\u0131 ara\u015ft\u0131rmak i\u00e7in spektral korelasyon kullanmam\u0131\u015ft\u0131r. Bu ama\u00e7la, bu proje Scutellaria baicalensis i\u00e7in bir ultra y\u00fcksek performansl\u0131 s\u0131v\u0131 kromatografisi (UPLC) parmak izi de\u011ferlendirme y\u00f6ntemi olu\u015fturdu, farkl\u0131 b\u00f6lgelerden Scutellaria baicalensis'in kalite de\u011ferlendirme sistemini geli\u015ftirmek i\u00e7in benzerlik de\u011ferlendirmesi ve ortogonal k\u0131smi en k\u00fc\u00e7\u00fck kareler diskriminant analizi (OPLS-DA) ile birle\u015ftirildi; DPPH, ABTS ve O2- serbest radikallerini temizleme yetene\u011fini ara\u015ft\u0131rd\u0131k ve ayr\u0131ca iki de\u011fi\u015fkenli korelasyon analizi kullanarak spektral korelasyon \u00e7al\u0131\u015fmalar\u0131 yapt\u0131k.
\nBu \u00e7al\u0131\u015fmada Acquity UPLC BEH C18 (2,1 mm \u00d7 50 mm, 1,7 \u03bc m) kromatografik kolon ve Acquity UPLC HSS T3 (2,1 mm \u00d7 100 mm, 1,8 \u03bc m) kromatografik kolonun ay\u0131rma performans\u0131 ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r. Acquity UPLC HSS T3 (2.1mm \u00d7 100mm, 1.8 \u03bc m) kromatografik kolonun daha iyi ay\u0131rma verimlili\u011fine ve daha fazla pike sahip oldu\u011fu bulunmu\u015ftur; Ayr\u0131ca metanol su, asetonitril su, metanol-0 gibi farkl\u0131 mobil faz sistemlerini de ara\u015ft\u0131rd\u0131k.1% formik asit su, asetonitril-0.1% formik asit su ve 0.1% formik asit su-0.1% formik asit asetonitril, farkl\u0131 kolon s\u0131cakl\u0131klar\u0131 (30, 35, 40 \u00b0 C), enjeksiyon hacimleri (1, 2 \u03bc L), tespit dalga boylar\u0131 (254, 280nm) ve el\u00fcsyon gradyanlar\u0131. Optimal kromatografik ko\u015fullar sonu\u00e7ta mobil faz 0.1% formik asit su -0.1% formik asit asetonitril, kolon s\u0131cakl\u0131\u011f\u0131 35 \u00b0 C, hacimsel ak\u0131\u015f h\u0131z\u0131 1 \u03bc L ve tespit dalga boyu 280nm olarak belirlenmi\u015ftir.
\nBu \u00e7al\u0131\u015fmada ayr\u0131ca test \u00e7\u00f6zeltisinin ekstraksiyon y\u00f6ntemleri (ultrason, refl\u00fc), \u00e7\u00f6z\u00fcc\u00fc konsantrasyonlar\u0131 (30%, 50%, 70%, 90% etanol) ve ekstraksiyon s\u00fcreleri (10, 30, 60, 90 dakika) incelenmi\u015ftir. Sonu\u00e7lar, ekstraksiyon \u00e7\u00f6z\u00fcc\u00fcs\u00fc olarak 70% metanol ve 60 dakika boyunca ultrasonik ekstraksiyon kullan\u0131ld\u0131\u011f\u0131nda, Scutellaria baicalensis \u00f6rnek \u00e7\u00f6zeltisindeki ortak piklerin pik alanlar\u0131n\u0131n daha y\u00fcksek oldu\u011funu ve pik \u015fekillerinin daha iyi oldu\u011funu g\u00f6stermi\u015ftir.
\nBu \u00e7al\u0131\u015fmada, Scutellaria baicalensis'in kalite de\u011ferlendirmesinde kullan\u0131labilecek, iyi bir hassasiyet, stabilite ve tekrarlanabilirli\u011fe sahip bir parmak izi olu\u015fturmak i\u00e7in UPLC teknolojisi kullan\u0131lm\u0131\u015ft\u0131r. Laiwu, Shandong ve Chengde, Hebei'den gelen 25 parti Scutellaria baicalensis ile kontrol parmak izi spektrumu aras\u0131ndaki benzerlik 0,983'\u00fcn \u00fczerindedir ve bu da Scutellaria baicalensis'in kimyasal bile\u015fiminde Laiwu, Shandong ve Chengde, Hebei aras\u0131nda \u00f6nemli bir fark olmad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir. OPLS-DA analizi ile baicalin, quercetin A-7-O - \u03b2 - D-glucuronide ve baicalein'in Laiwu, Shandong ve Chengde, Hebei'de Scutellaria baicalensis'in kalitesini etkileyen ay\u0131r\u0131c\u0131 belirte\u00e7ler olabilece\u011fi bulunmu\u015ftur. Kutu grafi\u011fi sonu\u00e7lar\u0131, Laiwu, Shandong'daki Scutellaria baicalensis'te bu \u00fc\u00e7 bile\u015fenin pik alanlar\u0131n\u0131n Chengde, Hebei'dekilerden daha y\u00fcksek oldu\u011funu g\u00f6stermi\u015ftir. Li ve arkada\u015flar\u0131 ile Yang ve arkada\u015flar\u0131, Hebei, Chengde'deki Scutellaria baicalensis'in kimyasal bile\u015fim i\u00e7eri\u011finin di\u011fer \u00fcretim alanlar\u0131ndan (Shandong gibi) daha d\u00fc\u015f\u00fck oldu\u011funu bulmu\u015flard\u0131r ki bu da bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131yla tutarl\u0131d\u0131r. \u0130ki emlak alan\u0131ndan elde edilen Scutellaria baicalensis g\u00fc\u00e7l\u00fc DP-PH, ABTS ve O2- radikal s\u00fcp\u00fcrme yeteneklerine sahiptir ve Shandong Laiwu Scutellaria baicalensis, Hebei Chengde Scutellaria baicalensis'ten daha iyi antioksidan kapasiteye sahiptir. Ayr\u0131ca OPLS-DA modeli kullan\u0131larak, \u00fc\u00e7 antioksidan g\u00f6stergeye dayal\u0131 olarak iki gayrimenkul alan\u0131 ay\u0131rt edilebilir. \u0130ki de\u011fi\u015fkenli korelasyon analizi yoluyla, Scutellaria baicalensis'in DPPH, ABTS ve O-radikallerine kar\u015f\u0131 temizleme yetene\u011finin, Scutellaria baicalensis'teki \u00e7e\u015fitli flavonoidler ve flavonoid glikozitler ile \u00f6nemli \u00f6l\u00e7\u00fcde pozitif korelasyon g\u00f6sterdi\u011fini ve antioksidan aktiviteyi destekledi\u011fini bulduk; Sadece bir bile\u015fen (5,7-dihidroksi-2 '- metoksiflavon-7-O-glukuronik asit) \u00f6nemli bir negatif korelasyon g\u00f6sterdi ve antioksidan aktiviteyi engelledi.
\n\u00d6zetle, Shandong Eyaletindeki Laiwu \u00fcretim alan\u0131ndan elde edilen Scutellaria baicalensis'in kimyasal bile\u015fim ve antioksidan kapasitesi a\u00e7\u0131s\u0131ndan Hebei Eyaletindeki Chengde alan\u0131ndan elde edilen Scutellaria baicalensis'ten \u00fcst\u00fcn oldu\u011fu ve ikisi aras\u0131nda bile\u015fim ve antioksidan kapasitesi a\u00e7\u0131s\u0131ndan belirli farkl\u0131l\u0131klar oldu\u011fu g\u00f6r\u00fclebilir. Bununla birlikte, bu \u00e7al\u0131\u015fman\u0131n k\u00fc\u00e7\u00fck \u00f6rneklem b\u00fcy\u00fckl\u00fc\u011f\u00fc g\u00f6z \u00f6n\u00fcne al\u0131nd\u0131\u011f\u0131nda, \u00f6rneklem b\u00fcy\u00fckl\u00fc\u011f\u00fcn\u00fc art\u0131rmak i\u00e7in daha fazla ara\u015ft\u0131rmaya ihtiya\u00e7 vard\u0131r ve toprak ve iklim fakt\u00f6rlerinin farkl\u0131 \u00fcretim alanlar\u0131nda Scutellaria baicalensis'in kalite olu\u015fumu \u00fczerindeki etkisi \u00fczerine daha fazla \u00e7al\u0131\u015fma yap\u0131lacakt\u0131r. Ekolojik fakt\u00f6rler perspektifinden bak\u0131ld\u0131\u011f\u0131nda, farkl\u0131 \u00fcretim alanlar\u0131ndaki Scutellaria baicalensis kalitesindeki farkl\u0131l\u0131klar\u0131n temel nedenleri a\u00e7\u0131klanacakt\u0131r; Ayr\u0131ca, farkl\u0131 b\u00f6lgelerden Scutellaria baicalensis'in kalitesi ve etkinli\u011finde farkl\u0131l\u0131klar olup olmad\u0131\u011f\u0131n\u0131 kapsaml\u0131 bir \u015fekilde a\u00e7\u0131klamak i\u00e7in ara\u015ft\u0131rma stratejileri sa\u011flamak ve geleneksel \u00c7in t\u0131bb\u0131 materyalleri \u00fczerine \u00f6zg\u00fcn ara\u015ft\u0131rmalar\u0131n bilimsel \u00e7a\u011fr\u0131\u015f\u0131m\u0131n\u0131 daha da zenginle\u015ftirmek i\u00e7in anti-enflamatuar, antiviral ve antibakteriyel gibi \u00e7e\u015fitli farmakolojik etkiler \u00fczerine ara\u015ft\u0131rmalar g\u00fc\u00e7lendirilmelidir. Ayn\u0131 zamanda, Scutellaria baicalensis t\u0131bbi malzemelerinin b\u00f6lgesel uyum \u00f6zellikleri \u00fczerine ara\u015ft\u0131rmalar\u0131n g\u00fc\u00e7lendirilmesi, ekim alanlar\u0131n\u0131n makul bir \u015fekilde se\u00e7ilmesi, ekim tekniklerinin optimize edilmesi, otantik t\u0131bbi malzemeler i\u00e7in bilimsel ve makul kalite de\u011ferlendirme standartlar\u0131n\u0131n olu\u015fturulmas\u0131, y\u00fcksek kaliteli otantik t\u0131bbi malzemeler \u00fcretilmesi ve bunlar\u0131n geleneksel \u00c7in t\u0131bb\u0131 end\u00fcstrisine daha iyi uygulanmas\u0131 gerekmektedir.<\/p>\n

 <\/p>","protected":false},"excerpt":{"rendered":"

Comparative study on the main components and antioxidant activity of Scutellaria baicalensis in different authentic regions Scutellaria baicalensis comes from the dried roots of Scutellaria baicalensis Georgi, a perennial herbaceous plant in the family Lamiaceae. It is also known as mountain tea root or earth gold tea root and is a commonly used traditional Chinese […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nComparative study on the main components and antioxidant activity of Scutellaria baicalensis in different authentic regions - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/scutellaria-baicalensis-antioxidant-activity\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Comparative study on the main components and antioxidant activity of Scutellaria baicalensis in different authentic regions - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Comparative study on the main components and antioxidant activity of Scutellaria baicalensis in different authentic regions Scutellaria baicalensis comes from the dried roots of Scutellaria baicalensis Georgi, a perennial herbaceous plant in the family Lamiaceae. 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