{"id":3676,"date":"2024-08-02T16:46:01","date_gmt":"2024-08-02T16:46:01","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3676"},"modified":"2024-08-02T16:46:01","modified_gmt":"2024-08-02T16:46:01","slug":"buckwheat-bee-pollen-polyphenols","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/karabugday-ari-poleni-polifenolleri\/","title":{"rendered":"Karabu\u011fday ar\u0131 polen polifenollerinin alfa amilaz \u00fczerindeki inhibit\u00f6r etkisi"},"content":{"rendered":"

Karabu\u011fday ar\u0131 polen polifenollerinin alfa amilaz \u00fczerindeki inhibit\u00f6r etkisi
\nAr\u0131 poleni, i\u015f\u00e7i ar\u0131lar\u0131n bitki polenlerini toplay\u0131p t\u00fck\u00fcr\u00fck ve nektar ile kar\u0131\u015ft\u0131rmas\u0131yla olu\u015fan tanecikli bir maddedir. Ar\u0131 poleni besinler a\u00e7\u0131s\u0131ndan zengindir ve \"evrensel besin bankas\u0131\" olarak bilinir, bu da onu y\u00fcksek kaliteli do\u011fal bir besin takviyesi haline getirir. Ara\u015ft\u0131rmalar, ar\u0131 poleninin kan \u015fekerini ve ya\u011f\u0131n\u0131 azaltmada, ba\u011f\u0131\u015f\u0131kl\u0131\u011f\u0131 art\u0131rmada, prostat hastal\u0131\u011f\u0131n\u0131 engellemede, kanseri \u00f6nlemede ve kanser kar\u015f\u0131t\u0131 vb. \u00f6nemli bir rol oynad\u0131\u011f\u0131n\u0131 g\u00f6stermektedir. \u00d6rne\u011fin, tecav\u00fcz ar\u0131s\u0131 poleni in vitro kan \u015fekerini d\u00fc\u015f\u00fcrme etkisine sahiptir ve kamelya ar\u0131s\u0131 poleni diyabet modeli farelerde kan \u015fekerini d\u00fc\u015f\u00fcrme etkisine sahiptir; Ar\u0131 poleni \u00f6z\u00fc ayr\u0131ca iyi huylu prostat hiperplazisi olan farelerde prostat hiperplazisini inhibe edebilir. Ar\u0131 poleni peptidleri, ba\u011f\u0131\u015f\u0131kl\u0131k sistemi bask\u0131lanm\u0131\u015f farelerde humoral ve h\u00fccresel ba\u011f\u0131\u015f\u0131kl\u0131k fonksiyonunu art\u0131rabilir. Ar\u0131 poleninin i\u015flevi, i\u00e7erdi\u011fi polifenoller, flavonoidler, polisakkaritler, peptitler vb. gibi \u00e7e\u015fitli biyoaktif bile\u015fenlerle ilgilidir. Bunlar aras\u0131nda polifenolik bile\u015fikler ar\u0131 poleninin en \u00f6nemli aktif bile\u015fenlerinden biridir.
\nPolifenolik bile\u015fikler temel olarak antosiyaninler, flavonoidler, flavonoller, fenolik asitler, tanenler ve klinik uygulama beklentileri olan di\u011fer maddeleri i\u00e7erir. En \u00f6nemli uygulamalardan biri, kan \u015fekerini d\u00fc\u015f\u00fcrmeye yard\u0131mc\u0131 olan fonksiyonel g\u0131dalar\u0131n geli\u015ftirilmesidir. Bir\u00e7ok rapor, bitki polifenollerinin diyabet farelerinde kan \u015fekerini d\u00fc\u015f\u00fcrebildi\u011fini ortaya koymu\u015ftur, \u00f6rne\u011fin sophora japonica polifenolleri, yabani Lonicera japonica polifenolleri, yaban mersini yapra\u011f\u0131 polifenolleri vb. Kan \u015fekeri metabolizmas\u0131ndaki anahtar enzimleri inhibe ederek kan \u015fekerini d\u00fc\u015f\u00fcrebilirler. Ar\u0131 polenindeki \u00f6nemli aktif bile\u015fenler olan polifenoller de hipoglisemik aktiviteye sahiptir. Flavonoidler, alfa amilaz ve alfa glukozidaz gibi kan \u015fekeri kontrol\u00fcnde yer alan \u00e7e\u015fitli anahtar enzimlerin katalitik aktivitesini inhibe ederek hipoglisemik etkiler \u00fcretebilir.<\/p>\n

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\nAlfa amilaz, ni\u015fastan\u0131n i\u00e7indeki alfa-1,4-glikozit ba\u011flar\u0131na etki ederek ni\u015fastay\u0131 maltoz ve glikoza d\u00f6n\u00fc\u015ft\u00fcren ve yemek sonras\u0131 kan \u015fekeri seviyelerinde h\u0131zl\u0131 bir art\u0131\u015fa yol a\u00e7an kan \u015fekerini kontrol etmede anahtar bir enzimdir. Ni\u015fasta sindirilebilirli\u011fini azaltmak i\u00e7in \u03b1 - amilaz aktivitesini inhibe ederek, ni\u015fasta sindirimini geciktirebilir, glikozun ba\u011f\u0131rsaktan emilimini engelleyebilir, v\u00fccuttaki kan \u015fekeri seviyesini etkili bir \u015fekilde d\u00fczenleyebilir ve b\u00f6ylece diyabet semptomlar\u0131n\u0131 hafifletebilir. Bu nedenle, \u03b1 - amilaz\u0131n tip 2 diyabetin terap\u00f6tik hedefi olarak al\u0131nmas\u0131, klinik uygulamada kullan\u0131lan akarboz, voglilitse, miglitol vb. gibi \u00e7e\u015fitli hipoglisemik ila\u00e7lar \u00fcretmi\u015ftir. Bununla birlikte, bu ila\u00e7lar\u0131n hepsinin belirli yan etkileri vard\u0131r, bu nedenle do\u011fal \u00fcr\u00fcnlerden do\u011fal hipoglisemik ila\u00e7lar geli\u015ftirmeye acil ihtiya\u00e7 vard\u0131r. Do\u011fal hipoglisemik ila\u00e7lar\u0131n geli\u015ftirilmesinde ar\u0131 poleninden elde edilen toplam polifenoller gibi do\u011fal \u00fcr\u00fcnlerin uygulanabilirli\u011fini a\u00e7\u0131kl\u0131\u011fa kavu\u015fturmak i\u00e7in, ar\u0131 polen polifenollerinin \u015feker metabolizmas\u0131 enzimleri \u00fczerindeki inhibit\u00f6r etkileri ve molek\u00fcler mekanizmalar\u0131 hakk\u0131nda derinlemesine ara\u015ft\u0131rma yap\u0131lmas\u0131 gerekmektedir.
\n\u00d6nemli bir tah\u0131l \u00fcr\u00fcn\u00fc olan karabu\u011fday\u0131n hipoglisemik etkileri oldu\u011fu bildirilmi\u015ftir ve karabu\u011fday ar\u0131 polen polisakkaritlerinin de hipoglisemik aktiviteye sahip oldu\u011fu g\u00f6sterilmi\u015ftir. Bununla birlikte, karabu\u011fday ar\u0131 polenindeki ana aktif madde olan polifenoller, hipoglisemik etkileri a\u00e7\u0131s\u0131ndan incelenmemi\u015ftir. Bunu g\u00f6z \u00f6n\u00fcnde bulundurarak, bu \u00e7al\u0131\u015fma karabu\u011fday ar\u0131 polen polifenollerini (BBPP) ara\u015ft\u0131rma nesnesi olarak almakta ve alfa amilaz \u00fczerindeki inhibit\u00f6r etkisini ve mekanizmas\u0131n\u0131 \u00fc\u00e7 a\u00e7\u0131dan ara\u015ft\u0131rmaktad\u0131r: enzim kineti\u011fi, floresan spektroskopisi ve ultraviyole spektroskopisi. BBPP'nin alfa amilaz aktivitesi \u00fczerindeki inhibit\u00f6r etkisi \u00fczerinde y\u00fcksek s\u0131cakl\u0131k, g\u00fc\u00e7l\u00fc alkali, \u0131\u015f\u0131k ve y\u00fcksek konsantrasyonda oksidan ve indirgeyici ajanlar\u0131n etkileri de ara\u015ft\u0131r\u0131lm\u0131\u015ft\u0131r. Bu deney, karabu\u011fday ar\u0131 poleninin kapsaml\u0131 kullan\u0131m\u0131 ve do\u011fal hipoglisemik ila\u00e7lar\u0131n ve alfa amilaz inhibit\u00f6rlerinin bile\u015fik form\u00fclasyonlar\u0131n\u0131n geli\u015ftirilmesi i\u00e7in teorik temel sa\u011flayabilir.
\nBu deneyde, BBPP'nin alfa amilaz \u00fczerindeki inhibit\u00f6r mekanizmas\u0131n\u0131 ara\u015ft\u0131rmak i\u00e7in \u00e7e\u015fitli spektroskopik analizler ve inhibisyon kineti\u011fi kullan\u0131lm\u0131\u015ft\u0131r. Sonu\u00e7lar, BBPP'nin alfa amilaz \u00fczerinde g\u00fc\u00e7l\u00fc ve geri d\u00f6n\u00fc\u015f\u00fcml\u00fc kar\u0131\u015f\u0131k rekabet\u00e7i bir inhibit\u00f6r etki sergiledi\u011fini ve inhibit\u00f6r etkinli\u011finin 2.00 \u00b1 0.06mg\/mL IC50 ile doza ba\u011fl\u0131 oldu\u011funu g\u00f6stermi\u015ftir. BBPP'nin farkl\u0131 ko\u015fullar alt\u0131ndaki stabilite analizi, y\u00fcksek s\u0131cakl\u0131k, g\u00fc\u00e7l\u00fc alkali, \u0131\u015f\u0131k ve y\u00fcksek konsantrasyonlarda oksidan ve indirgeyici ajanlar\u0131n hepsinin BBPP'nin alfa amilaz \u00fczerindeki inhibit\u00f6r etkisini azaltabilece\u011fini g\u00f6stermi\u015ftir. Floresan spektrum s\u00f6nd\u00fcrme analizi, BBPP'nin 273-298K'de statik s\u00f6nd\u00fcrme ve 298-310K'de dinamik s\u00f6nd\u00fcrme sergiledi\u011fini ve ikisi aras\u0131nda sadece bir ba\u011flanma b\u00f6lgesi oldu\u011funu g\u00f6stermektedir. E\u015fzamanl\u0131 floresan spektroskopisi, BBPP'nin \u03b1-amilaz tirozin kal\u0131nt\u0131lar\u0131n\u0131n ortam\u0131nda katlanma de\u011fi\u015fikliklerine neden oldu\u011funu ve hidrofobikli\u011fi art\u0131rd\u0131\u011f\u0131n\u0131 g\u00f6stermektedir. Bu makale, yemek sonras\u0131 hiperglisemiyi hafifletmek i\u00e7in hipoglisemik bir aktif bile\u015fen olarak BBPP'nin \u03b1 - amilaz \u00fczerindeki inhibit\u00f6r etkisinin incelenmesine odaklanmaktad\u0131r. Daha sonra, diyabet modeli hayvanlarda BBPP'nin hipoglisemik i\u015flevini inceleyece\u011fiz ve hipoglisemik bir ila\u00e7 olarak geli\u015ftirilmesinin fizibilitesini analiz edip de\u011ferlendirece\u011fiz.<\/p>\n

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Karabu\u011fday ar\u0131 poleni polifenollerinin alfa amilaz \u00fczerindeki inhibit\u00f6r etkisi Ar\u0131 poleni, i\u015f\u00e7i ar\u0131lar\u0131n bitki polenlerini toplay\u0131p t\u00fck\u00fcr\u00fck ve nektarla kar\u0131\u015ft\u0131rmas\u0131yla olu\u015fan gran\u00fcler bir maddedir. Ar\u0131 poleni besinler a\u00e7\u0131s\u0131ndan zengindir ve \"evrensel besin bankas\u0131\" olarak bilinir, bu da onu y\u00fcksek kaliteli do\u011fal bir besin takviyesi haline getirir. Ara\u015ft\u0131rma g\u00f6steriyor ki [...]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nThe inhibitory effect of buckwheat bee pollen polyphenols on alpha amylase - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/karabugday-ari-poleni-polifenolleri\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"The inhibitory effect of buckwheat bee pollen polyphenols on alpha amylase - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"The inhibitory effect of buckwheat bee pollen polyphenols on alpha amylase Bee pollen is a granular substance formed by worker bees collecting plant pollen and mixing it with saliva and nectar. 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