{"id":3656,"date":"2024-08-02T16:16:47","date_gmt":"2024-08-02T16:16:47","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3656"},"modified":"2024-08-02T16:17:00","modified_gmt":"2024-08-02T16:17:00","slug":"resveratrol-diabetic-nephropathy","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/resveratrol-diabetic-nephropathy\/","title":{"rendered":"Aerobik egzersiz ve resveratrol\u00fcn diyabet nefropatisi s\u0131\u00e7anlar\u0131nda renal inflamasyon ve apoptoz \u00fczerine etkileri"},"content":{"rendered":"

Aerobik egzersiz ve resveratrol\u00fcn diyabet nefropatisi s\u0131\u00e7anlar\u0131nda renal inflamasyon ve apoptoz \u00fczerine etkileri
\nDiyabet nefropatisi (DKD) diyabetin en \u00f6nemli komplikasyonlar\u0131ndan biridir ve fizyolojik ve patolojik mekanizmalar\u0131 \u00e7ok karma\u015f\u0131kt\u0131r. Erken patolojik de\u011fi\u015fiklikler, glomer\u00fcler hipertrofi, artan h\u00fccre eks\u00fcdasyonu, enflamatuar reaksiyonu ve b\u00f6bre\u011fin interstisyel fibrozunu tetikleyen, \u00e7ok say\u0131da enflamatuar fakt\u00f6r \u00fcreten, h\u00fccre apoptozunu te\u015fvik eden ve daha sonra b\u00f6brek dokusu hasar\u0131n\u0131 \u015fiddetlendiren h\u00fccre d\u0131\u015f\u0131 matris birikimi olarak kendini g\u00f6sterir. Resveratrol (RSV) bitki polifenollerinin bir kar\u0131\u015f\u0131m\u0131d\u0131r. \u00c7ok say\u0131da \u00e7al\u0131\u015fma resveratrol\u00fcn diyabet nefropatisinin \u00f6nlenmesi ve tedavisinde \u00f6nemli bir rol oynad\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Resveratrol, \u00e7oklu sinyal yollar\u0131n\u0131 d\u00fczenleyerek diyabet s\u0131\u00e7anlar\u0131nda serum inflamatuar fakt\u00f6rlerinin seviyesini \u00f6nemli \u00f6l\u00e7\u00fcde azaltabilir ve diyabet s\u0131\u00e7anlar\u0131nda renal vask\u00fcler ge\u00e7irgenli\u011fi azaltabilir, b\u00f6ylece renal patolojik hasardaki de\u011fi\u015fiklikleri azaltabilir. Y\u00fcksek oranda indirgeyici bir polifenolik madde olan resveratrol\u00fcn, DKD ko\u015fullar\u0131 alt\u0131nda b\u00f6breklerdeki serbest oksijen radikallerinin metabolizmas\u0131n\u0131 d\u00fczenledi\u011fi g\u00f6sterilmi\u015ftir. B\u00f6breklerdeki malondialdehit i\u00e7eri\u011fini azaltabilir, antioksidan enzim aktivitesinin artmas\u0131n\u0131 te\u015fvik edebilir ve antioksidan stres direnci uygulayabilir. Ayr\u0131ca resveratrol, AMPK\/NOX4\/ROS yolunu d\u00fczenleyerek mezangial h\u00fccre proliferasyonunu ve h\u00fccre d\u0131\u015f\u0131 matris birikimini de inhibe edebilir, renal fibrozu geciktirebilir ve b\u00f6ylece b\u00f6brekler \u00fczerinde koruyucu bir etkiye sahip olabilir. Ara\u015ft\u0131rmalar, egzersizin antioksidan stres, lipid metabolizmas\u0131 d\u00fczenlemesi ve inflamasyon kontrol\u00fcne sahip olan ve diyabette b\u00f6brek fonksiyonunun iyile\u015fmesini destekleyen tip 2 diyabetin adjuvan tedavisinde iyi bir role sahip oldu\u011funu do\u011frulam\u0131\u015ft\u0131r. DKD tedavisi i\u00e7in geleneksel \u00c7in t\u0131bb\u0131 ve aerobik egzersiz kombinasyonu \u015fu anda akademisyenler taraf\u0131ndan ara\u015ft\u0131r\u0131lan ara\u015ft\u0131rma y\u00f6nlerinden biridir. Li ve arkada\u015flar\u0131n\u0131n ara\u015ft\u0131rmas\u0131, Lanzhou Lily polisakkaritleri ve aerobik egzersiz kombinasyonunun s\u0131\u00e7anlarda ins\u00fclin salg\u0131lanmas\u0131n\u0131 te\u015fvik edebilece\u011fini, kan lipit seviyelerini etkili bir \u015fekilde azaltabilece\u011fini, antioksidan enzim aktivitesini art\u0131rabilece\u011fini, b\u00f6brek h\u00fccresi apoptozunu inhibe edebilece\u011fini ve b\u00f6ylece b\u00f6brek dokusunun yap\u0131sal hasar\u0131n\u0131 iyile\u015ftirebilece\u011fini g\u00f6stermektedir. Bununla birlikte, diyabetik b\u00f6brek hastal\u0131\u011f\u0131nda (DKH) resveratrol ile birlikte aerobik egzersizin b\u00f6brek fonksiyonu \u00fczerindeki koruyucu etkileri hakk\u0131nda s\u0131n\u0131rl\u0131 ara\u015ft\u0131rma bulunmaktad\u0131r. Bu nedenle, bu \u00e7al\u0131\u015fma diyabet s\u0131\u00e7anlar\u0131nda resveratrol ve aerobik egzersiz m\u00fcdahalesinin uygulanmas\u0131 yoluyla resveratrol ve aerobik egzersizin diyabet s\u0131\u00e7anlar\u0131nda renal inflamatuar reaksiyon ve h\u00fccre apoptozu \u00fczerindeki etkilerini ara\u015ft\u0131rmay\u0131 ve b\u00f6ylece diyabet nefropatisinin kapsaml\u0131 tedavisi i\u00e7in referans sa\u011flamay\u0131 ama\u00e7lamaktad\u0131r.<\/p>\n

\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"\"Diyabet nefropatisinin erken \u00f6nlenmesi ve tedavisi \u00e7ok \u00f6nemlidir. Diyabet nefropatisini tedavi etmek i\u00e7in geleneksel y\u00f6ntemlerle birlikte \u00c7in bitkisel ila\u00e7lar\u0131 ve egzersiz terapisi \u015fu anda akademisyenlerin ara\u015ft\u0131rma y\u00f6nlerinden biridir. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, model gruptaki Scr, BUN, kan \u015fekeri ve 24 saatlik idrar protein konsantrasyonunun kontrol grubundakilerden \u00f6nemli \u00f6l\u00e7\u00fcde daha y\u00fcksek oldu\u011funu ve ba\u015far\u0131l\u0131 modellemeye i\u015faret etti\u011fini g\u00f6stermi\u015ftir. Model grupla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, egzersiz grubu, ila\u00e7 grubu ve egzersiz ilac\u0131 grubundaki Scr, BUN, kan \u015fekeri ve 24 saatlik idrar proteini konsantrasyonu \u00f6nemli \u00f6l\u00e7\u00fcde azalm\u0131\u015ft\u0131r, bu da aerobik egzersiz ve resveratrol m\u00fcdahalesinin diyabetin b\u00f6brek hasar\u0131n\u0131 azaltabilece\u011fini ve b\u00f6brek \u00fczerinde belirli bir koruyucu etkiye sahip olabilece\u011fini d\u00fc\u015f\u00fcnd\u00fcrmektedir, \u00f6zellikle aerobik egzersiz ve resveratrol\u00fcn ortak m\u00fcdahalesi b\u00f6brek hasar\u0131n\u0131 azaltmada daha belirgin bir iyile\u015ftirme etkisi g\u00f6stermektedir.
\nDiyabet nefropatisinin patogenezinde, b\u00f6brek dokusunda \u00e7ok say\u0131da enflamatuar fakt\u00f6r bulunmaktad\u0131r. B\u00f6bre\u011fin yap\u0131sal ve i\u015flevsel hasar\u0131, enflamatuar fakt\u00f6rlerin anormal ekspresyonu ile yak\u0131ndan ili\u015fkilidir. Ara\u015ft\u0131rmalar, hasarl\u0131 b\u00f6brek epitel h\u00fccrelerinin TNF - \u03b1, IL-1 \u03b2, IL-6 gibi \u00e7e\u015fitli enflamatuar arac\u0131lar \u00fcretti\u011fini, bunlar\u0131n enflamatuar reaksiyonlar\u0131n \u015fiddetlenmesine neden oldu\u011funu ve b\u00f6ylece renal patolojik hasar\u0131 k\u00f6t\u00fcle\u015ftirdi\u011fini do\u011frulam\u0131\u015ft\u0131r. Shi ve arkada\u015flar\u0131, berbaminin diyabet nefropatisi olan s\u0131\u00e7anlar \u00fczerindeki koruyucu etkisini incelemi\u015f ve berbamin tedavisinden sonra serum inflamatuar sitokinleri IL-6, TNF - \u03b1 ve IL-1 \u03b2 ekspresyonunun \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131n\u0131 ve b\u00f6ylece b\u00f6brek podositlerini inflamatuar hasardan korudu\u011funu do\u011frulam\u0131\u015ft\u0131r. Bu \u00e7al\u0131\u015fman\u0131n sonu\u00e7lar\u0131, model grubun b\u00f6brek dokusundaki TNF - \u03b1, IL-6 ve IL-1 \u03b2 seviyelerinin kontrol grubuna k\u0131yasla \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Aerobik egzersiz ve resveratrol ile m\u00fcdahaleden sonra, b\u00f6brek dokusundaki TNF - \u03b1, IL-6 ve IL-1 \u03b2 seviyeleri egzersiz grubunda, ila\u00e7 grubunda ve egzersiz ilac\u0131 grubunda \u00f6nemli \u00f6l\u00e7\u00fcde azalm\u0131\u015ft\u0131r ve azalma egzersiz ilac\u0131 grubunda daha belirgindir. Aerobik egzersiz ve resveratrol\u00fcn tek ba\u015f\u0131na veya kombinasyon halinde inflamatuar yolak \u00fczerinde etkili olabilece\u011fi, inflamatuar ili\u015fkili fakt\u00f6rler IL-6, TNF - \u03b1 ve IL-1 \u03b2 ekspresyonunun azalmas\u0131n\u0131 te\u015fvik edebilece\u011fi, b\u00f6ylece diyabet s\u0131\u00e7anlar\u0131nda renal patolojik hasar\u0131 azaltabilece\u011fi ve kombine m\u00fcdahale etkisinin tek ba\u015f\u0131na aerobik egzersiz ve resveratrolden daha iyi oldu\u011fu \u00f6nerilmektedir.
\nB\u00f6brek h\u00fccre apoptozu, diyabette b\u00f6brek fonksiyonlar\u0131n\u0131n bozulmas\u0131n\u0131n geli\u015fiminde \u00f6nemli bir rol oynar ve diyabetteki b\u00f6brek patolojik hasar\u0131n\u0131n mekanizmalar\u0131ndan biridir. Caspase ve Bcl-2 protein aileleri, h\u00fccre apoptozu s\u00fcrecindeki ana d\u00fczenleyici fakt\u00f6rlerdir. Bax ve Bcl-2 s\u0131ras\u0131yla apoptozun te\u015fvik edilmesinde ve inhibe edilmesinde rol oynar. Kaspaz-3, apoptoz yola\u011f\u0131nda \u00f6nemli bir terminal kesme enzimidir. Zhou ve arkada\u015flar\u0131n\u0131n ara\u015ft\u0131rmas\u0131 Ganoderma sporlar\u0131n\u0131n PINK1\/Parkin yolunu aktive etti\u011fini, b\u00f6brek h\u00fccrelerinde otofajiyi ba\u015flatt\u0131\u011f\u0131n\u0131, pro apoptotik proteinlerin ekspresyonunu \u00f6nemli \u00f6l\u00e7\u00fcde azaltt\u0131\u011f\u0131n\u0131, hipergliseminin neden oldu\u011fu b\u00f6breklerdeki patolojik hasar\u0131 hafifletti\u011fini ve b\u00f6ylece b\u00f6brek h\u00fccresi apoptozunun olu\u015fumunu engelledi\u011fini g\u00f6stermi\u015ftir. Song ve arkada\u015flar\u0131 ayr\u0131ca Jiawei Shengjiang Tozunun diyabet nefropatisi s\u0131\u00e7anlar\u0131nda b\u00f6brek hasar\u0131n\u0131 iyile\u015ftirebilece\u011fini ve mekanizmas\u0131n\u0131n RIP1\/RIP3\/MLKL sinyal yolunun a\u015fa\u011f\u0131 reg\u00fclasyonu ve b\u00f6brek dokusunun nekrotik apoptozunun \u00f6nlenmesi ile ilgili olabilece\u011fini do\u011frulam\u0131\u015ft\u0131r. Bu deneysel \u00e7al\u0131\u015fma, model gruptaki b\u00f6brek h\u00fccrelerinin apoptoz oran\u0131n\u0131n \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131n\u0131, b\u00f6brek dokusundaki Bax ve Caspase-3'\u00fcn \u00f6nemli \u00f6l\u00e7\u00fcde yukar\u0131 reg\u00fcle oldu\u011funu ve Bcl-2'nin \u00f6nemli \u00f6l\u00e7\u00fcde a\u015fa\u011f\u0131 reg\u00fcle oldu\u011funu ve b\u00f6brek dokusunda apoptotik hasar\u0131n meydana geldi\u011fini do\u011frulad\u0131\u011f\u0131n\u0131 bulmu\u015ftur. Aerobik egzersiz ve resveratrol ile m\u00fcdahaleden sonra, b\u00f6brek h\u00fccrelerinin apoptoz oran\u0131 egzersiz grubunda, ila\u00e7 grubunda ve egzersiz ilac\u0131 grubunda \u00f6nemli \u00f6l\u00e7\u00fcde azal\u0131rken, Bax ve Caspase-3 \u00f6nemli \u00f6l\u00e7\u00fcde a\u015fa\u011f\u0131 reg\u00fcle edildi ve Bcl-2 \u00f6nemli \u00f6l\u00e7\u00fcde yukar\u0131 reg\u00fcle edildi. De\u011fi\u015fiklikler egzersiz ilac\u0131 grubunda daha belirgindi. Aerobik egzersiz ve resveratrol\u00fcn tek ba\u015f\u0131na veya kombinasyon halinde apoptoz sinyal yolu \u00fczerinde etkili olabilece\u011fi, Bax, Bcl-2 ve Caspase-3 ekspresyon seviyelerini d\u00fczenleyebilece\u011fi ve b\u00f6brek h\u00fccresi apoptozunu azaltabilece\u011fi d\u00fc\u015f\u00fcn\u00fclmektedir. Bunlar aras\u0131nda, aerobik egzersiz ve resveratrol kombinasyonunun h\u00fccre apoptozunu inhibe etme \u00fczerinde daha belirgin etkileri vard\u0131r ve diyabet b\u00f6brek hasar\u0131n\u0131n prognozunu daha iyi iyile\u015ftirir.
\nN\u00fckleer bir transkripsiyon fakt\u00f6r\u00fc olan NF - \u03ba B, inflamasyon, h\u00fccre apoptozu ve oksidatif stres gibi patolojik s\u00fcre\u00e7lerde yayg\u0131n olarak yer almaktad\u0131r. Ara\u015ft\u0131rmalar, aktive edilmi\u015f NF - \u03ba B'nin sitoplazmadan \u00e7ekirde\u011fe g\u00f6\u00e7 etti\u011fini, a\u015fa\u011f\u0131 ak\u0131\u015f enflamatuar fakt\u00f6rlerini aktive etti\u011fini, genlerin a\u015f\u0131r\u0131 ekspresyonuna ve enflamatuar yan\u0131tlar\u0131n \u015fiddetlenmesine yol a\u00e7t\u0131\u011f\u0131n\u0131 ve b\u00f6ylece enflamatuar hasar\u0131n derecesini artt\u0131rd\u0131\u011f\u0131n\u0131 bulmu\u015ftur. Buna ek olarak, aktive edilmi\u015f NF - \u03ba B, \u00e7ekirde\u011fe girdikten sonra a\u015fa\u011f\u0131 ak\u0131\u015f apoptotik genleri Bax, Bcl-2 ve Caspase-3'\u00fcn transkripsiyonunu d\u00fczenleyebilir, h\u00fccre apoptozunu te\u015fvik edebilir ve b\u00f6brek yap\u0131sal ve fonksiyonel hasar\u0131n\u0131 \u015fiddetlendirebilir. Sui ve arkada\u015flar\u0131, s\u0131\u00e7anlarda sepsis kaynakl\u0131 akut b\u00f6brek hasar\u0131 hayvan modeli olu\u015fturmu\u015f ve hesperidinin NF - \u03ba B yola\u011f\u0131n\u0131n aktivasyonunu inhibe edebilece\u011fini, a\u015fa\u011f\u0131 ak\u0131\u015f inflamasyonunu ve oksidatif stres yan\u0131tlar\u0131n\u0131 daha da bask\u0131layabilece\u011fini, h\u00fccre apoptozunu azaltabilece\u011fini ve sepsis kaynakl\u0131 b\u00f6brek hasar\u0131n\u0131 hafifletebilece\u011fini bulmu\u015ftur. Diao ve arkada\u015flar\u0131, TIR\/BB halka analo\u011fu AS-1'in farelerde renal iskemi-reperf\u00fczyon hasar\u0131 \u00fczerinde koruyucu bir etkiye sahip oldu\u011funu ve etki mekanizmas\u0131n\u0131n NF - \u03ba B sinyal yolunun aktivasyonunu azaltarak anti-enflamatuar ve anti apoptotik etkiler \u00fcretmesiyle ili\u015fkili olabilece\u011fini bulmu\u015ftur. Deneyimiz, model grubun b\u00f6brek dokusunda NF - \u03ba Bp65 proteininin ekspresyonunun kontrol grubuna k\u0131yasla \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131n\u0131 do\u011frulam\u0131\u015ft\u0131r. Aerobik egzersiz ve resveratrol m\u00fcdahalesinden sonra, b\u00f6brekteki NF - \u03ba Bp65 proteininin ekspresyonu azalm\u0131\u015f, inflamasyon ve h\u00fccre apoptozu azalm\u0131\u015f ve egzersiz ilac\u0131 grubundaki de\u011fi\u015fiklikler daha anlaml\u0131 olmu\u015ftur. Aerobik egzersiz ve resveratrol\u00fcn enflamatuar yan\u0131t\u0131 ve apoptozu hafifletme mekanizmas\u0131, NF - \u03ba Bp65 aktivasyonunun inhibisyonu ile yak\u0131ndan ili\u015fkilidir. Bununla birlikte, NF - \u03ba B sinyal yolu birden fazla fakt\u00f6rden etkilenir ve d\u00fczenleyici mekanizma \u00e7ok karma\u015f\u0131kt\u0131r. Spesifik mekanizman\u0131n gelecekteki deneylerde hala ara\u015ft\u0131r\u0131lmas\u0131 gerekmektedir.
\nSonu\u00e7 olarak, aerobik egzersiz ve resveratrol tek ba\u015f\u0131na veya birlikte diyabet nefropatisi s\u0131\u00e7anlar\u0131n\u0131n b\u00f6bre\u011fi \u00fczerinde belirli bir koruyucu etkiye sahiptir ve aerobik egzersiz ve resveratrol kombinasyonu tek fakt\u00f6rl\u00fc m\u00fcdahaleden daha \u00f6nemli bir etkiye sahiptir. Etki mekanizmas\u0131, NF - \u03ba Bp65 aktivasyonunu inhibe ederek, inflamatuar fakt\u00f6rler IL-6, TNF - \u03b1 ve IL-1 \u03b2'n\u0131n ekspresyonunu azaltarak ve inflamatuar yan\u0131t seviyesini d\u00fc\u015f\u00fcrerek olabilir; Ayr\u0131ca apoptoz ile ilgili fakt\u00f6rleri d\u00fczenleyerek, b\u00f6brek dokusunda Bax ve Caspase-3 ekspresyon seviyesini d\u00fc\u015f\u00fcrerek, Bcl-2 ekspresyon seviyesini y\u00fckselterek, b\u00f6brek h\u00fccresi apoptozunu azaltarak ve b\u00f6brek dokusunun patolojik hasar\u0131n\u0131 hafifleterek diyabet nefropatisi s\u0131\u00e7anlar\u0131n\u0131n b\u00f6bre\u011fi \u00fczerinde \u00f6nemli bir koruyucu etkiye sahip olabilir. Bu makale, aerobik egzersiz ve resveratrol\u00fcn m\u00fcdahale mekanizmas\u0131n\u0131, diyabet nefropatisinin egzersiz ve kombine \u00c7in bitkisel ila\u00e7 tedavisi i\u00e7in deneysel temel sa\u011flamay\u0131 ama\u00e7layarak, NF - \u03ba B sinyal yolunun enflamatuar yan\u0131t ve apoptozunun \u00e7ift y\u00f6nl\u00fc d\u00fczenlenmesi perspektifinden tart\u0131\u015fmaktad\u0131r.<\/p>","protected":false},"excerpt":{"rendered":"

Effects of aerobic exercise and resveratrol on renal inflammation and apoptosis in diabetes nephropathy rats Diabetes nephropathy (DKD) is one of the most important complications of diabetes, and its physiological and pathological mechanisms are very complex. The early pathological changes are manifested as glomerular hypertrophy, increased cell exudation, accumulation of extracellular matrix, which triggers inflammatory […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nEffects of aerobic exercise and resveratrol on renal inflammation and apoptosis in diabetes nephropathy rats - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/resveratrol-diabetic-nephropathy\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Effects of aerobic exercise and resveratrol on renal inflammation and apoptosis in diabetes nephropathy rats - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Effects of aerobic exercise and resveratrol on renal inflammation and apoptosis in diabetes nephropathy rats Diabetes nephropathy (DKD) is one of the most important complications of diabetes, and its physiological and pathological mechanisms are very complex. 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