{"id":3648,"date":"2024-08-02T15:59:52","date_gmt":"2024-08-02T15:59:52","guid":{"rendered":"https:\/\/longchangextracts.com\/?p=3648"},"modified":"2024-08-02T15:59:52","modified_gmt":"2024-08-02T15:59:52","slug":"seabuckthorn-flavone","status":"publish","type":"post","link":"https:\/\/longchangextracts.com\/tr\/seabuckthorn-flavone\/","title":{"rendered":"Seabuckthorn flavonoidlerinin uzun s\u00fcreli yorgunluk egzersizi yapan s\u0131\u00e7anlar \u00fczerindeki kardiyoprotektif etkisi \u00fczerine mekanizma \u00e7al\u0131\u015fmas\u0131"},"content":{"rendered":"

Seabuckthorn flavonoidlerinin uzun s\u00fcreli yorgunluk egzersizi yapan s\u0131\u00e7anlar \u00fczerindeki kardiyoprotektif etkisi \u00fczerine mekanizma \u00e7al\u0131\u015fmas\u0131
\nAra\u015ft\u0131rmalar, orta d\u00fczeyde fiziksel egzersizin kalbin \u015fekli, yap\u0131s\u0131 ve i\u015flevinde iyi huylu de\u011fi\u015fikliklere neden olabilece\u011fini, ancak uzun s\u00fcreli yorucu egzersizin kardiyovask\u00fcler sistem \u00fczerinde olumsuz etkileri olabilece\u011fini ve hatta egzersize ba\u011fl\u0131 miyokardiyal hasara yol a\u00e7abilece\u011fini do\u011frulam\u0131\u015ft\u0131r. S\u00fcrekli yorucu egzersiz s\u0131ras\u0131nda, endojen reaktif oksijen t\u00fcrleri (ROS) \u00fcretiminde bir art\u0131\u015f olur ve bu da ROS'u temizleme yetene\u011fini s\u0131n\u0131rlar. A\u015f\u0131r\u0131 ROS, miyokardiyal h\u00fccrelerin i\u015flev bozuklu\u011funa, protein ve lipid peroksidasyonuna ve DNA hasar\u0131na neden olur. Buna ek olarak, uzun s\u00fcreli yorucu egzersiz v\u00fccutta yayg\u0131n bir enflamatuar yan\u0131ta neden olabilir ve enflamatuar h\u00fccrelerin infiltrasyonu miyokardiyal h\u00fccrelerin yap\u0131sal ve i\u015flevsel bozulmas\u0131na neden olabilir. Yorucu egzersizin neden oldu\u011fu oksidatif stres ve enflamatuar yan\u0131t, \u00e7e\u015fitli kardiyak hipertrofi sinyal kinazlar\u0131n\u0131 ve transkripsiyon fakt\u00f6rlerini aktive eder ve DNA ve mitokondriyal hasar\u0131n yan\u0131 s\u0131ra pro apoptotik sinyallerin aktivasyonu yoluyla h\u00fccre apoptozunu ind\u00fckler. Bir \u00e7al\u0131\u015fmada, 6 haftal\u0131k yorgunluk egzersizinin miyokardiyal h\u00fccrelerin apoptoz program\u0131n\u0131 aktive edebilece\u011fi ve s\u0131\u00e7an miyokardiyal h\u00fccrelerinde Bcl-2 ili\u015fkili X proteini (Bax)\/B h\u00fccre iymfoma-2 geninin (Bcl-2) ekspresyon oran\u0131n\u0131 y\u00fckselterek kardiyak yap\u0131n\u0131n fonksiyonel \"yeniden \u015fekillenme\" s\u00fcrecini h\u0131zland\u0131rabilece\u011fi bulunmu\u015ftur. Buna ek olarak, \u00e7al\u0131\u015fmalar uzun s\u00fcreli yorucu egzersizin neden oldu\u011fu h\u00fccre d\u0131\u015f\u0131 matris bile\u015fenlerinin birikimi ve fibrozisinin h\u00fccre apoptozisi ile yak\u0131ndan ili\u015fkili olabilece\u011fini do\u011frulam\u0131\u015ft\u0131r.<\/p>\n

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\nDeniz topalak Elapidae familyas\u0131na aittir ve \u00c7in'de geleneksel bir t\u0131bbi ve yenilebilir bitkidir. Antioksidan, anti-t\u00fcm\u00f6r ve anti apoptotik etkileri geni\u015f \u00e7apta do\u011frulanm\u0131\u015ft\u0131r. Deniz topalak flavonoidleri (SF) deniz topala\u011f\u0131n\u0131n en \u00f6nemli aktif bile\u015fenidir. 50-250 \u03bcg\/mL SF, fare h\u00fccrelerinin fagositik yetene\u011fini geli\u015ftirebilir ve Raw 264.7 h\u00fccrelerinde oksidatif stres ve enflamatuar belirte\u00e7lerin olu\u015fumunu etkili bir \u015fekilde inhibe edebilir; aerobik egzersizle birlikte 4g\/kg SF gavaj\u0131, s\u0131\u00e7an hipokampal dokusunun apoptoz yan\u0131t\u0131n\u0131 inhibe edebilir. Bununla birlikte, SF'nin uzun s\u00fcreli yorgun egzersiz yapan s\u0131\u00e7anlar \u00fczerindeki kardiyoprotektif etkileri konusunda hen\u00fcz bir ara\u015ft\u0131rma bulunmamaktad\u0131r. Buna dayanarak, bu \u00e7al\u0131\u015fma uzun s\u00fcreli yorucu egzersiz yoluyla egzersize ba\u011fl\u0131 miyokardiyal hasar\u0131n s\u0131\u00e7an modelini olu\u015fturmay\u0131 ve egzersize ba\u011fl\u0131 miyokardiyal hasar\u0131n \u00f6nlenmesi ve rehabilitasyonu i\u00e7in deneysel kan\u0131t sa\u011flamak amac\u0131yla SF'nin uzun s\u00fcreli yorucu egzersiz s\u0131\u00e7anlar\u0131nda miyokardiyal hasar \u00fczerindeki m\u00fcdahale etkisini ara\u015ft\u0131rmay\u0131 ama\u00e7lamaktad\u0131r.<\/p>\n

Sistematik ve bilimsel egzersiz e\u011fitimi kalpte faydal\u0131 adaptif de\u011fi\u015fikliklere neden olabilir, ancak uzun s\u00fcreli yorucu egzersizin enflamatuar reaksiyonlar, oksidatif stres yan\u0131tlar\u0131, h\u00fccre apoptozunun aktivasyonu ve fibrozis yoluyla miyokardiyal doku \u00fczerinde olumsuz etkileri olabilir. Uzun s\u00fcreli yorucu egzersizin miyokardiyal h\u00fccrelerin oksidatif stres yan\u0131t\u0131n\u0131 aktive edebilece\u011fini ve apoptoz program\u0131na arac\u0131l\u0131k edebilece\u011fini do\u011frulayan ara\u015ft\u0131rmalar vard\u0131r. ROS ve Caspase-3 yolaklar\u0131n\u0131n aktivasyon s\u00fcreci yak\u0131ndan ili\u015fkilidir, bu da mitokondriyal hasar\u0131 ind\u00fckleyebilir ve miyokardiyal mekanik disfonksiyona yol a\u00e7abilir. Bu arada, sitokin sal\u0131n\u0131m\u0131 ve n\u00f6trofil infiltrasyonunun neden oldu\u011fu enflamatuar yan\u0131t, h\u00fccre apoptozunun ba\u015flat\u0131c\u0131 fakt\u00f6rleri olabilir ve apoptozun meydana gelmesi de doku enflamatuar yan\u0131t\u0131n\u0131n \u015fiddetlenmesi i\u00e7in ko\u015fullar sa\u011flar. Ara\u015ft\u0131rmalar, miyokardiyal apoptoz genlerinin ifade profilinin yorucu egzersizden sonra de\u011fi\u015fti\u011fini, miyokardiyal pro apoptotik gen ifadesinin ve Bax\/Bcl-2 oran\u0131n\u0131n \u00f6nemli \u00f6l\u00e7\u00fcde y\u00fckseldi\u011fini bulmu\u015ftur. Uzun s\u00fcreli yorucu egzersizin s\u0131\u00e7an miyokard\u0131nda MDA, IL-1 \u03b2, IL-6, TNF - \u03b1 seviyelerinde, Kaspaz-3, Bax protein ekspresyonunda ve Bcl-2\/Bax oran\u0131nda \u00f6nemli art\u0131\u015flara yol a\u00e7t\u0131\u011f\u0131 bu deneyde de benzer sonu\u00e7lar g\u00f6zlenmi\u015ftir. SOD, GSH Px seviyeleri ve Bcl-2 protein ekspresyonunun \u00f6nemli \u00f6l\u00e7\u00fcde azalmas\u0131, uzun s\u00fcreli yorucu egzersizin oksidatif stres ve enflamatuar yan\u0131tlar\u0131 \u015fiddetlendirdi\u011fini ve s\u0131\u00e7an miyokardiyal doku apoptoz program\u0131n\u0131n aktivasyonunu ind\u00fckledi\u011fini g\u00f6stermi\u015ftir.<\/p>\n

Ara\u015ft\u0131rmalar, a\u015f\u0131r\u0131 egzersiz uyar\u0131m\u0131n\u0131n \u00e7e\u015fitli yollarla miyokardiyal doku fibrozisini ind\u00fckleyebilece\u011fini ve miyokardiyal doku apoptozunun aktivasyonunun kolajen sentezini ve miyokardiyal fibrozis s\u00fcrecini h\u0131zland\u0131rabilece\u011fini bulmu\u015ftur. Uzun s\u00fcreli yorucu egzersiz, v\u00fccutta mikro\u00e7evresel hasar\u0131 (enflamasyon, h\u00fccre apoptozu, vb.) ind\u00fckleyerek miyokard enfarkt\u00fcs\u00fcn\u00fc ve fibrozisi te\u015fvik eder. Uzun s\u00fcreli yorucu egzersiz, s\u0131\u00e7anlarda TNF - \u03b1 ve h\u00fccreler aras\u0131 adezyon molek\u00fcl\u00fc-1 gibi pro-inflamatuar sitokinlerin ekspresyonu yoluyla miyokardiyal doku inflamasyonunu ind\u00fckleyebilir ve egzersize ba\u011fl\u0131 miyokardiyal doku yap\u0131sal mikro hasar\u0131na ve atriyal fibrozise yol a\u00e7abilir. Yorucu egzersizin ind\u00fckledi\u011fi miyokardiyal oksidatif stres yan\u0131t\u0131 miyokardiyal fibrozu daha da tetikleyebilir, ancak do\u011frudan kan\u0131tlar \u015fu anda eksiktir. Buna ek olarak, \u00e7al\u0131\u015fmalar 6 haftal\u0131k yorucu egzersizin s\u0131\u00e7an miyokard dokusunda Bax\/Bcl-2 oran\u0131n\u0131 y\u00fckselterek ve p38 MAPK\/Smad2\/3 sinyal yolunu aktive ederek miyokardiyal fibrozisi ve fibroblast proliferasyonunu ind\u00fckleyebilece\u011fini bulmu\u015ftur. Bu deney \u00f6nceki \u00e7al\u0131\u015fmalarla tutarl\u0131d\u0131r. Egzersize ba\u011fl\u0131 miyokardiyal hasar\u0131n hayvan modelini olu\u015fturmak i\u00e7in uzun s\u00fcreli yorgunluk ko\u015fu band\u0131 egzersizi kullan\u0131lm\u0131\u015ft\u0131r. Sonu\u00e7lar, uzun s\u00fcreli yorgunluk egzersizine tabi tutulan s\u0131\u00e7anlar\u0131n serum miyokardiyal hasar belirte\u00e7lerinin yukar\u0131 reg\u00fclasyonu, artm\u0131\u015f oksidatif stres, enflamatuar yan\u0131t ve miyokardiyal dokuda h\u00fccre apoptozunun yan\u0131 s\u0131ra doku morfolojisi ve fibrozis de\u011fi\u015fiklikleri sergiledi\u011fini g\u00f6stermi\u015ftir.<\/p>\n

\u015eu anda, SF'nin egzersize ba\u011fl\u0131 miyokardiyal hasar \u00fczerindeki m\u00fcdahale etkisi konusunda ara\u015ft\u0131rma eksikli\u011fi bulunmaktad\u0131r. Bununla birlikte, bitki kaynakl\u0131 flavonoid \u00f6z\u00fctlerinin baz\u0131 yan m\u00fcdahale kan\u0131tlar\u0131, \u00e7e\u015fitli bitki kaynakl\u0131 flavonoid \u00f6z\u00fctlerinin egzersize ba\u011fl\u0131 miyokardiyal hasar \u00fczerinde \u00f6nleyici ve tedavi edici etkileri oldu\u011funu g\u00f6stermektedir. Bu deneyde, model grupla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, SF'nin orta ve y\u00fcksek dozlar\u0131 (200, 400 mg\/kg) s\u0131\u00e7anlarda serum miyokardiyal hasar belirte\u00e7lerini etkili bir \u015fekilde azaltm\u0131\u015ft\u0131r. Ayn\u0131 zamanda, miyokardiyal HE boyama, orta ve y\u00fcksek doz SF'nin (200, 400 mg\/kg) uzun s\u00fcreli yorgunluk e\u011fitiminin neden oldu\u011fu miyokardiyal dokunun morfolojik hasar\u0131n\u0131 etkili bir \u015fekilde hafifletti\u011fini g\u00f6stermi\u015ftir. G\u00fcn\u00fcm\u00fczde, SF'nin antioksidan ve anti-enflamatuar aktiviteleri yayg\u0131n olarak kabul g\u00f6rm\u00fc\u015ft\u00fcr ve bu \u00e7al\u0131\u015fma da \u00f6nceki ara\u015ft\u0131rma sonu\u00e7lar\u0131n\u0131 desteklemektedir. Bu \u00e7al\u0131\u015fmada, 200 ve 400 mg\/(kg - d) SF takviyesinin miyokardiyal dokuda oksidatif stresi, enflamatuar yan\u0131t\u0131 ve serum miyokardiyal hasar belirte\u00e7 ekspresyonunu etkili bir \u015fekilde \u00f6nleyebilece\u011fi de do\u011frulanm\u0131\u015ft\u0131r. Model grupla kar\u015f\u0131la\u015ft\u0131r\u0131ld\u0131\u011f\u0131nda, 100 mg\/kg SF gavaj\u0131 da uzun s\u00fcreli yorgun e\u011fitim s\u0131\u00e7anlar\u0131n\u0131n miyokard dokusundaki enflamatuar fakt\u00f6rler ve oksidatif stres seviyelerini azaltabilir, ancak etkisi anlaml\u0131 de\u011fildir. Ara\u015ft\u0131rmalar, deniz topalak suyu \u00f6z\u00fct\u00fcn\u00fcn apoptozu inhibe edebildi\u011fini ve insan \u00f6l\u00fcms\u00fczle\u015ftirilmi\u015f keratinositlerinin proliferasyonunu te\u015fvik edebildi\u011fini ve ayn\u0131 zamanda \u00e7ok hedefli a\u015fa\u011f\u0131 ak\u0131\u015f apoptoz sinyal yolu d\u00fczenlemesine kat\u0131ld\u0131\u011f\u0131n\u0131 g\u00f6stermi\u015ftir. Buna ek olarak, deniz topalak polisakkaritlerinin (200mg\/kg) oral uygulamas\u0131, septik kaynakl\u0131 karaci\u011fer hasar\u0131 farelerinde karaci\u011fer h\u00fccrelerinin apoptozunu inhibe edebilir, septik fare karaci\u011ferinde peroksizom proliferat\u00f6r aktive resept\u00f6r gama ve Bcl-2 ekspresyonunu yukar\u0131 do\u011fru d\u00fczenleyebilir ve NF - \u03ba B, Bax ve Caspase-3 ekspresyonunu a\u015fa\u011f\u0131 do\u011fru d\u00fczenleyebilir.
\nBu \u00e7al\u0131\u015fma, SF m\u00fcdahalesinden sonra, yorgun egzersiz s\u0131\u00e7anlar\u0131n\u0131n miyokard\u0131nda Caspase-3 ve Bax proteinlerinin ekspresyonunun ve Bcl-2\/Bax oran\u0131n\u0131n \u00f6nemli \u00f6l\u00e7\u00fcde artt\u0131\u011f\u0131n\u0131, Bcl-2 proteininin ekspresyonunun ise \u00f6nemli \u00f6l\u00e7\u00fcde azald\u0131\u011f\u0131n\u0131 bulmu\u015ftur. Bu, SF'nin (100, 200, 400 mg\/(kg - d)) uzun s\u00fcreli bitkin egzersizin neden oldu\u011fu kardiyomiyosit apoptoz yan\u0131t\u0131n\u0131 engelleyebilece\u011fini kan\u0131tlamaktad\u0131r. Ara\u015ft\u0131rmalar, deniz topalaklar\u0131ndan elde edilen toplam flavonoidlerin, tav\u015fan kula\u011f\u0131 hipertrofik skar dokusunda enflamatuar ve oksidatif stres tepkilerini inhibe ederek fibrozla ilgili proteinlerin ekspresyonunu azaltabildi\u011fini, b\u00f6ylece fibrotik dokuda fibroblast d\u00f6n\u00fc\u015f\u00fcm\u00fcn\u00fcn etkinli\u011fini azaltt\u0131\u011f\u0131n\u0131 ve hipertrofik skarlar\u0131n ilerlemesini engelledi\u011fini g\u00f6stermi\u015ftir. Flavonoid aktif maddeler fibroblast b\u00fcy\u00fcme fakt\u00f6r\u00fc 21 proteininin ekspresyonunu art\u0131r\u0131r, transformasyon b\u00fcy\u00fcme fakt\u00f6r\u00fc - \u03b2 1 sinyal yolunu inhibe eder, miyokardiyal fibrozis belirte\u00e7leri CTGF, Kolajen-I ve Kolajen-III ekspresyonunun a\u015fa\u011f\u0131 reg\u00fclasyonunu ind\u00fckler, b\u00f6ylece miyokardiyal fibrozisi, oksidatif stresi ve h\u00fccre apoptozunu azalt\u0131r ve sonu\u00e7ta miyokardiyal fibrozisli farelerde kardiyak fonksiyonu iyile\u015ftirir. Uzun s\u00fcreli yorucu egzersizin s\u0131\u00e7an miyokard dokusunda CTGF ve Kolajen-I proteinlerinin ekspresyonunun yan\u0131 s\u0131ra miyokard dokusu CVF'sini \u00f6nemli \u00f6l\u00e7\u00fcde art\u0131rd\u0131\u011f\u0131 bu deneyde de benzer sonu\u00e7lar elde edilmi\u015ftir. SF (100, 200, 400 mg\/(kg - d)) miyokardiyal doku fibrozisini etkili bir \u015fekilde inhibe edebilmi\u015ftir.
\n\u00d6zetle, bu \u00e7al\u0131\u015fma 6 haftal\u0131k s\u00fcrekli yorucu egzersizin s\u0131\u00e7an miyokard dokusunda oksidatif stresi ve artan inflamatuar yan\u0131t\u0131 ind\u00fckledi\u011fini, miyokard h\u00fccre apoptozuna ve fibrozise yol a\u00e7arak miyokardiyal doku hasar\u0131na neden oldu\u011funu g\u00f6stermektedir. SF, uzun s\u00fcreli yorucu egzersiz yapan s\u0131\u00e7anlar\u0131n miyokard dokusundaki oksidatif stresi ve enflamatuar yan\u0131t\u0131 etkili bir \u015fekilde hafifletebilir, miyokardiyal h\u00fccre apoptozunu ve fibrozisi inhibe edebilir ve b\u00f6ylece miyokardiyal koruyucu etkiler g\u00f6sterebilir.<\/p>","protected":false},"excerpt":{"rendered":"

Mechanism study on the cardioprotective effect of seabuckthorn flavonoids on long-term exhaustion exercise rats Research has confirmed that moderate physical exercise can induce benign changes in the shape, structure, and function of the heart, but long-term exhaustive exercise may have negative effects on the cardiovascular system and even lead to exercise-induced myocardial injury. During continuous […]<\/p>","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[20],"tags":[],"yoast_head":"\nMechanism study on the cardioprotective effect of seabuckthorn flavonoids on long-term exhaustion exercise rats - China Chemical Manufacturer<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/longchangextracts.com\/tr\/seabuckthorn-flavone\/\" \/>\n<meta property=\"og:locale\" content=\"tr_TR\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mechanism study on the cardioprotective effect of seabuckthorn flavonoids on long-term exhaustion exercise rats - China Chemical Manufacturer\" \/>\n<meta property=\"og:description\" content=\"Mechanism study on the cardioprotective effect of seabuckthorn flavonoids on long-term exhaustion exercise rats Research has confirmed that moderate physical exercise can induce benign changes in the shape, structure, and function of the heart, but long-term exhaustive exercise may have negative effects on the cardiovascular system and even lead to exercise-induced myocardial injury. 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